SK44795A3 - Composition based on polyoxyethylene-polyoxypropylene block copolymers and container containing it - Google Patents
Composition based on polyoxyethylene-polyoxypropylene block copolymers and container containing it Download PDFInfo
- Publication number
- SK44795A3 SK44795A3 SK447-95A SK44795A SK44795A3 SK 44795 A3 SK44795 A3 SK 44795A3 SK 44795 A SK44795 A SK 44795A SK 44795 A3 SK44795 A3 SK 44795A3
- Authority
- SK
- Slovakia
- Prior art keywords
- container
- solution
- molecular weight
- daltons
- block copolymer
- Prior art date
Links
- 229920001400 block copolymer Polymers 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title description 9
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 title description 9
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 11
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 8
- 239000012298 atmosphere Substances 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 25
- 229920001577 copolymer Polymers 0.000 claims description 18
- 238000002347 injection Methods 0.000 claims description 18
- 239000007924 injection Substances 0.000 claims description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 8
- 230000002209 hydrophobic effect Effects 0.000 claims description 7
- 239000006172 buffering agent Substances 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- -1 polyoxypropylene Polymers 0.000 abstract description 5
- 229920001451 polypropylene glycol Polymers 0.000 abstract description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract description 2
- 229940102223 injectable solution Drugs 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 description 12
- 229920001993 poloxamer 188 Polymers 0.000 description 12
- 229940044519 poloxamer 188 Drugs 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 238000001802 infusion Methods 0.000 description 6
- 239000008215 water for injection Substances 0.000 description 6
- 239000000306 component Substances 0.000 description 5
- 229910001873 dinitrogen Inorganic materials 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 102000009123 Fibrin Human genes 0.000 description 3
- 108010073385 Fibrin Proteins 0.000 description 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 3
- 239000012503 blood component Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229950003499 fibrin Drugs 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 description 2
- 208000001738 Nervous System Trauma Diseases 0.000 description 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000002399 angioplasty Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000003749 cleanliness Effects 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical group CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- MDAYVWUZDJCCFN-UHFFFAOYSA-N CCC=O.[F] Chemical compound CCC=O.[F] MDAYVWUZDJCCFN-UHFFFAOYSA-N 0.000 description 1
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
- 206010008132 Cerebral thrombosis Diseases 0.000 description 1
- 206010069729 Collateral circulation Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000002296 eclampsia Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000005308 flint glass Substances 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 201000005857 malignant hypertension Diseases 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001987 poloxamine Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- NBBJYMSMWIIQGU-UHFFFAOYSA-N propionic aldehyde Natural products CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Packages (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929221883A GB9221883D0 (en) | 1992-10-19 | 1992-10-19 | Novel formulation |
| PCT/GB1993/002141 WO1994008596A1 (en) | 1992-10-19 | 1993-10-18 | Composition based on polyoxyethylene-polyoxypropylene block copolymers and container containing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK44795A3 true SK44795A3 (en) | 1996-05-08 |
Family
ID=10723654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK447-95A SK44795A3 (en) | 1992-10-19 | 1993-10-18 | Composition based on polyoxyethylene-polyoxypropylene block copolymers and container containing it |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0671919A1 (cs) |
| JP (1) | JPH08502284A (cs) |
| KR (1) | KR950703345A (cs) |
| AU (1) | AU674895B2 (cs) |
| BR (1) | BR9307268A (cs) |
| CA (1) | CA2147889A1 (cs) |
| CZ (1) | CZ63395A3 (cs) |
| GB (1) | GB9221883D0 (cs) |
| HU (1) | HUT75701A (cs) |
| IL (1) | IL107313A0 (cs) |
| MX (1) | MX9306467A (cs) |
| NO (1) | NO951462L (cs) |
| NZ (1) | NZ256890A (cs) |
| PL (1) | PL308459A1 (cs) |
| SI (1) | SI9300545A (cs) |
| SK (1) | SK44795A3 (cs) |
| TW (1) | TW276183B (cs) |
| WO (1) | WO1994008596A1 (cs) |
| ZA (1) | ZA937714B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110212047A1 (en) * | 2007-08-10 | 2011-09-01 | Synth Rx, Inc. | Polymer Therapy for the Treatment of Chronic Microvascular Diseases |
| EP3057598A1 (en) | 2013-10-16 | 2016-08-24 | Mast Therapeutics, Inc. | Diuretic induced alterations of plasma volume |
| US9757411B2 (en) | 2014-07-07 | 2017-09-12 | Aires Pharmaceuticals, Inc. | Poloxamer therapy for heart failure |
| WO2016007542A1 (en) | 2014-07-07 | 2016-01-14 | Mast Therapeutics, Inc. | Poloxamer therapy for heart failure |
| JP6747748B2 (ja) | 2014-07-07 | 2020-08-26 | ライフラフト バイオサイエンシーズ，インコーポレイテッド | 長期循環物質のないポロクサマー組成物、その産生方法およびその使用 |
| CN109432511A (zh) * | 2018-12-29 | 2019-03-08 | 常州乐奥医疗科技股份有限公司 | 一种温敏型水凝胶及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3641240A (en) * | 1968-09-27 | 1972-02-08 | Wyandotte Chemicals Corp | Method for the treatment of an embolus or thrombus |
| DE3234084A1 (de) * | 1982-09-14 | 1984-03-15 | B. Braun Melsungen Ag, 3508 Melsungen | Pharmazeutische zubereitungen zur behandlung von unerwuenschten verwachsungen sowie deren verwendung |
| US4879109A (en) * | 1986-05-15 | 1989-11-07 | Emory University | Method for treating burns |
| US4938961A (en) * | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
-
1992
- 1992-10-19 GB GB929221883A patent/GB9221883D0/en active Pending
-
1993
- 1993-10-18 TW TW082108706A patent/TW276183B/zh active
- 1993-10-18 MX MX9306467A patent/MX9306467A/es unknown
- 1993-10-18 ZA ZA937714A patent/ZA937714B/xx unknown
- 1993-10-18 SI SI9300545A patent/SI9300545A/sl unknown
- 1993-10-18 KR KR1019950701458A patent/KR950703345A/ko not_active Withdrawn
- 1993-10-18 CA CA002147889A patent/CA2147889A1/en not_active Abandoned
- 1993-10-18 BR BR9307268A patent/BR9307268A/pt not_active Application Discontinuation
- 1993-10-18 PL PL93308459A patent/PL308459A1/xx unknown
- 1993-10-18 HU HU9501104A patent/HUT75701A/hu unknown
- 1993-10-18 NZ NZ256890A patent/NZ256890A/en unknown
- 1993-10-18 JP JP6509782A patent/JPH08502284A/ja active Pending
- 1993-10-18 IL IL107313A patent/IL107313A0/xx unknown
- 1993-10-18 WO PCT/GB1993/002141 patent/WO1994008596A1/en not_active Application Discontinuation
- 1993-10-18 AU AU52842/93A patent/AU674895B2/en not_active Expired - Fee Related
- 1993-10-18 SK SK447-95A patent/SK44795A3/sk unknown
- 1993-10-18 EP EP93923008A patent/EP0671919A1/en not_active Withdrawn
- 1993-10-18 CZ CZ95633A patent/CZ63395A3/cs unknown
-
1995
- 1995-04-18 NO NO951462A patent/NO951462L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT75701A (en) | 1997-05-28 |
| AU674895B2 (en) | 1997-01-16 |
| HU9501104D0 (en) | 1995-06-28 |
| KR950703345A (ko) | 1995-09-20 |
| WO1994008596A1 (en) | 1994-04-28 |
| AU5284293A (en) | 1994-05-09 |
| PL308459A1 (en) | 1995-07-24 |
| GB9221883D0 (en) | 1992-12-02 |
| NO951462D0 (no) | 1995-04-18 |
| ZA937714B (en) | 1995-04-18 |
| IL107313A0 (en) | 1994-01-25 |
| SI9300545A (en) | 1994-06-30 |
| EP0671919A1 (en) | 1995-09-20 |
| TW276183B (cs) | 1996-05-21 |
| BR9307268A (pt) | 1999-05-11 |
| JPH08502284A (ja) | 1996-03-12 |
| CZ63395A3 (en) | 1995-07-12 |
| MX9306467A (es) | 1994-05-31 |
| NZ256890A (en) | 1995-10-26 |
| NO951462L (no) | 1995-06-13 |
| CA2147889A1 (en) | 1994-04-28 |
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