SK287545B6 - Spôsob prípravy 16,17-[(cyklohexylmetylén)bis(oxy)]-11,21- dihydroxy-pregna-1,4-dién-3,20-diónu a podobných zlúčenín - Google Patents

Spôsob prípravy 16,17-[(cyklohexylmetylén)bis(oxy)]-11,21- dihydroxy-pregna-1,4-dién-3,20-diónu a podobných zlúčenín Download PDF

Info

Publication number
SK287545B6
SK287545B6 SK555-2003A SK5552003A SK287545B6 SK 287545 B6 SK287545 B6 SK 287545B6 SK 5552003 A SK5552003 A SK 5552003A SK 287545 B6 SK287545 B6 SK 287545B6
Authority
SK
Slovakia
Prior art keywords
oxy
bis
dihydroxy
formula
pregna
Prior art date
Application number
SK555-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK5552003A3 (en
Inventor
Beate Schmidt
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of SK5552003A3 publication Critical patent/SK5552003A3/sk
Publication of SK287545B6 publication Critical patent/SK287545B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK555-2003A 2000-11-10 2001-11-06 Spôsob prípravy 16,17-[(cyklohexylmetylén)bis(oxy)]-11,21- dihydroxy-pregna-1,4-dién-3,20-diónu a podobných zlúčenín SK287545B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00124626 2000-11-10
PCT/EP2001/012808 WO2002038584A1 (en) 2000-11-10 2001-11-06 Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation

Publications (2)

Publication Number Publication Date
SK5552003A3 SK5552003A3 (en) 2003-08-05
SK287545B6 true SK287545B6 (sk) 2011-01-04

Family

ID=8170345

Family Applications (1)

Application Number Title Priority Date Filing Date
SK555-2003A SK287545B6 (sk) 2000-11-10 2001-11-06 Spôsob prípravy 16,17-[(cyklohexylmetylén)bis(oxy)]-11,21- dihydroxy-pregna-1,4-dién-3,20-diónu a podobných zlúčenín

Country Status (23)

Country Link
US (1) US7468433B2 (xx)
EP (1) EP1335929B1 (xx)
JP (1) JP4456811B2 (xx)
KR (2) KR100809510B1 (xx)
CN (1) CN1264855C (xx)
AT (1) ATE478888T1 (xx)
AU (1) AU2953602A (xx)
BR (1) BR0115220A (xx)
CA (1) CA2430196C (xx)
CZ (1) CZ303885B6 (xx)
DE (1) DE60142920D1 (xx)
EA (1) EA006231B1 (xx)
ES (1) ES2351184T3 (xx)
HK (1) HK1058043A1 (xx)
HU (1) HU228432B1 (xx)
IL (1) IL155274A0 (xx)
MX (1) MXPA03004123A (xx)
NO (1) NO325286B1 (xx)
NZ (1) NZ525707A (xx)
PL (1) PL205674B1 (xx)
SK (1) SK287545B6 (xx)
WO (1) WO2002038584A1 (xx)
ZA (1) ZA200303121B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
CN100404545C (zh) * 2003-03-27 2008-07-23 尼科梅德有限责任公司 具有规定粒径的结晶环缩松的制备方法
CN100338089C (zh) * 2004-08-12 2007-09-19 重庆医药工业研究院有限责任公司 一种哮喘病治疗药物环索奈德的新的制备方法
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
WO2007054974A2 (en) * 2005-09-28 2007-05-18 Arch Pharmalab Limited A green chemistry process for the preparation of pregnadiene esters
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
JP2010503722A (ja) 2006-09-19 2010-02-04 シプラ・リミテッド シクレソニドとその結晶変異体の調製方法
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
US10233210B2 (en) 2015-01-30 2019-03-19 Coral Drugs Pvt. Ltd. Process for preparation of glucocorticoid steroids
US20180126000A1 (en) 2016-06-02 2018-05-10 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
KR20200095477A (ko) 2017-12-01 2020-08-10 애브비 인코포레이티드 글루코코르티코이드 수용체 작용제 및 이의 면역접합체

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880368A (en) * 1983-10-24 1989-11-14 Siegfried C. Hasl In-mold label transfer apparatus
ES527509A0 (es) 1983-11-24 1985-08-01 Frumtost Zyma S A Procedimiento para la obtencion de un corticoide de accion antipsoriatica
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
FR2675146A1 (fr) 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
EP0701565B1 (de) * 1993-04-02 1998-10-28 Byk Gulden Lomberg Chemische Fabrik GmbH Neue prednisolonderivate
DE19635498A1 (de) 1996-09-03 1998-03-26 Byk Gulden Lomberg Chem Fab Verfahren zur Epimerenanreicherung

Also Published As

Publication number Publication date
KR20030081329A (ko) 2003-10-17
IL155274A0 (en) 2003-11-23
JP4456811B2 (ja) 2010-04-28
ATE478888T1 (de) 2010-09-15
US20050080063A1 (en) 2005-04-14
KR20070116185A (ko) 2007-12-06
EA200300504A1 (ru) 2003-12-25
NO325286B1 (no) 2008-03-17
HUP0302220A3 (en) 2007-11-28
WO2002038584A1 (en) 2002-05-16
PL361616A1 (en) 2004-10-04
US7468433B2 (en) 2008-12-23
AU2953602A (en) 2002-05-21
CA2430196C (en) 2010-01-26
NO20031964L (no) 2003-04-30
CZ303885B6 (cs) 2013-06-12
ZA200303121B (en) 2004-04-23
HK1058043A1 (en) 2004-04-30
JP2004513181A (ja) 2004-04-30
ES2351184T3 (es) 2011-02-01
CN1264855C (zh) 2006-07-19
MXPA03004123A (es) 2004-09-10
DE60142920D1 (de) 2010-10-07
NO20031964D0 (no) 2003-04-30
SK5552003A3 (en) 2003-08-05
PL205674B1 (pl) 2010-05-31
EP1335929A1 (en) 2003-08-20
CA2430196A1 (en) 2002-05-16
HU228432B1 (hu) 2013-03-28
EP1335929B1 (en) 2010-08-25
NZ525707A (en) 2004-11-26
KR100809510B1 (ko) 2008-03-04
CN1473164A (zh) 2004-02-04
EA006231B1 (ru) 2005-10-27
HUP0302220A2 (hu) 2003-10-28
BR0115220A (pt) 2003-10-07

Similar Documents

Publication Publication Date Title
CELLA et al. Steroidal aldosterone blockers. II1
RU2132854C1 (ru) Производные преднизолона, способ их получения и лекарственное средство
EP2392584A1 (en) Crystalline Ciclesonide Methanol Solvate Form C
SK287545B6 (sk) Spôsob prípravy 16,17-[(cyklohexylmetylén)bis(oxy)]-11,21- dihydroxy-pregna-1,4-dién-3,20-diónu a podobných zlúčenín
CA2609021C (en) Compounds useful for treating neurodegenerative disorders
JP2668000B2 (ja) プレグナン誘導体の１６，１７−アセタール製造におけるエピマー分配の調整法
CA2670276A1 (en) Compounds useful for treating neurodegenerative disorders
CA2670284C (en) Synthesis of compounds useful as modulators of amyloid-beta production
EP0200692B1 (en) Androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them
DE2907539A1 (de) 17-alkylthio-(und arylthio)-androsteno eckige klammer auf 17 alpha , 16 alpha -b eckige klammer zu benzopyran- 3-one und - eckige klammer auf 16 alpha , 17 alpha -b eckige klammer zu naphthopyran-3-one sowie deren verwendung als entzuendungshemmende wirkstoffe
DE10055820C1 (de) Verfahren zur Herstellung eines Glucocorticoids
AU2002229536B2 (en) Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-Dihydroxy-pregna-1,4-dien-3,20-dion or its21-isobutyrat by transketalisation
CH632279A5 (en) Process for the preparation of polyhalogenated steroids
AU2002229536A1 (en) Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-Dihydroxy-pregna-1,4-dien-3,20-dion or its21-isobutyrat by transketalisation
EP0994119B1 (en) Stereoselective process for the preparation of the 22R epimer of budesonide
EP0551953B1 (en) 17-(Pyridazine-N-oxide)-substituted steroidal compounds active on the cardiovascular system
JPS6222998B2 (xx)

Legal Events

Date Code Title Description
TC4A Change of owner's name

Owner name: TAKEDA GMBH, KONSTANZ, DE

Effective date: 20130725

PC4A Assignment and transfer of rights

Owner name: NYCOMED GERMANY HOLDING GMBH, KONSTANZ, DE

Free format text: FORMER OWNER: NYCOMED ASSET MANAGEMENT GMBH, KONSTANZ, DE

Effective date: 20151210

Owner name: NYCOMED ASSET MANAGEMENT GMBH, KONSTANZ, DE

Free format text: FORMER OWNER: TAKEDA GMBH, KONSTANZ, DE

Effective date: 20151210

TC4A Change of owner's name

Owner name: TAKEDA GMBH, KONSTANZ, DE

Effective date: 20151210

PC4A Assignment and transfer of rights

Owner name: ASTRAZENECA AB, SOEDERTAELJE, SE

Free format text: FORMER OWNER: TAKEDA GMBH, KONSTANZ, DE

Effective date: 20161028

PC4A Assignment and transfer of rights

Owner name: COVIS PHARMA B.V., ZUG, CH

Free format text: FORMER OWNER: ASTRAZENECA AB, SOEDERTAELJE, SE

Effective date: 20190814

MK4A Expiry of patent

Expiry date: 20211106