SK286727B6 - O-substituované deriváty 6-metyl-tramadolu, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie - Google Patents

O-substituované deriváty 6-metyl-tramadolu, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie Download PDF

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Publication number
SK286727B6
SK286727B6 SK340-2003A SK3402003A SK286727B6 SK 286727 B6 SK286727 B6 SK 286727B6 SK 3402003 A SK3402003 A SK 3402003A SK 286727 B6 SK286727 B6 SK 286727B6
Authority
SK
Slovakia
Prior art keywords
methyl
dimethylaminomethyl
substituted
cyclohexanol
phenyl
Prior art date
Application number
SK340-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK3402003A3 (en
Inventor
Helmut Buschmann
Babette-Yvonne Kgel
Elmar Friderichs
Dagmar Kaulartz
Original Assignee
Grnenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7658871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK286727(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grnenthal Gmbh filed Critical Grnenthal Gmbh
Publication of SK3402003A3 publication Critical patent/SK3402003A3/sk
Publication of SK286727B6 publication Critical patent/SK286727B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
SK340-2003A 2000-09-29 2001-09-28 O-substituované deriváty 6-metyl-tramadolu, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie SK286727B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10049483A DE10049483A1 (de) 2000-09-29 2000-09-29 Substituierte 1-Aminobutan-3-ol-Derivate
PCT/EP2001/011276 WO2002026694A1 (de) 2000-09-29 2001-09-28 O-substituierte 6-methyl-tramadol-derivate

Publications (2)

Publication Number Publication Date
SK3402003A3 SK3402003A3 (en) 2003-09-11
SK286727B6 true SK286727B6 (sk) 2009-04-06

Family

ID=7658871

Family Applications (2)

Application Number Title Priority Date Filing Date
SK338-2003A SK3382003A3 (en) 2000-09-29 2001-09-28 Substituted 1-aminobutan-3-ol derivatives, process for their preparation, medicaments comprising said compounds and their use
SK340-2003A SK286727B6 (sk) 2000-09-29 2001-09-28 O-substituované deriváty 6-metyl-tramadolu, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK338-2003A SK3382003A3 (en) 2000-09-29 2001-09-28 Substituted 1-aminobutan-3-ol derivatives, process for their preparation, medicaments comprising said compounds and their use

Country Status (29)

Country Link
US (2) US7022739B2 (da)
EP (2) EP1322592B2 (da)
JP (2) JP2004509939A (da)
KR (2) KR100835549B1 (da)
CN (2) CN1478067A (da)
AR (1) AR034158A1 (da)
AT (2) ATE272046T1 (da)
AU (4) AU2002220578B2 (da)
BR (2) BR0114380A (da)
CA (2) CA2423860A1 (da)
DE (3) DE10049483A1 (da)
DK (2) DK1322593T3 (da)
EC (2) ECSP034532A (da)
ES (2) ES2225605T5 (da)
HK (2) HK1052924B (da)
HU (2) HUP0303361A3 (da)
IL (2) IL155106A0 (da)
MX (2) MXPA03002738A (da)
NO (2) NO20031387L (da)
NZ (2) NZ525171A (da)
PE (1) PE20020413A1 (da)
PL (2) PL361382A1 (da)
PT (2) PT1322592E (da)
RU (2) RU2286334C2 (da)
SI (2) SI1322592T1 (da)
SK (2) SK3382003A3 (da)
TR (2) TR200402230T4 (da)
WO (2) WO2002028817A1 (da)
ZA (2) ZA200303220B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
CN1599607A (zh) 2001-10-16 2005-03-23 恩都制药公司 用于治疗神经机能障碍的甲醇
BR0306811A (pt) * 2002-01-11 2004-10-26 Sankyo Co Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero
US8128957B1 (en) 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
PT1562567T (pt) * 2002-11-22 2017-08-24 Gruenenthal Gmbh Combinação de analgésicos selecionados e inibidores da cox-ii
KR20110136901A (ko) 2004-02-24 2011-12-21 상꾜 가부시키가이샤 아미노 알코올 화합물
NZ580429A (en) * 2007-05-31 2012-04-27 Sepracor Inc Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
KR20110100241A (ko) * 2008-12-05 2011-09-09 아르퀼 인코포레이티드 Ｒａｆ 억제제 및 이들의 용도
ES2343050B1 (es) * 2008-12-16 2011-06-14 Chemo Iberica, S.A. Procedimiento para la preparacion de desvenlafaxina y sus sales de adicion de acido farmaceuticamente aceptables.
WO2012100423A1 (en) * 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
JP2019502761A (ja) * 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ （（ｒ）−３−［（−１−メチルピロリジン−２−イル）メチル］−５−（２−フェニルスルホニルエチル）−１ｈ−インドールを作製する方法

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
ZA732238B (en) * 1972-04-06 1974-01-30 American Home Prod Benzylamine analgesics
US4155935A (en) 1973-03-26 1979-05-22 American Home Products Corporation Benzylamine analgesics
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
US6017963A (en) * 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
DE19547766A1 (de) * 1995-12-20 1997-06-26 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
DE19609847A1 (de) * 1996-03-13 1997-09-18 Gruenenthal Gmbh Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
US5919826A (en) * 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
US6245804B1 (en) * 1997-05-30 2001-06-12 Schering Aktiengesellschaft Nonsteroidal gestagens
EP0996613B1 (en) * 1997-07-15 2002-10-30 Russinsky Limited Pure cis-tramadol hydrochloride production
ATE257147T1 (de) * 1998-05-22 2004-01-15 Mallinckrodt Inc Ein verbessertes synthese- und reinigungsverfahren für (r*,r*)-2- ((dimethylamino)methyl)-1-(3-methoxyphenyl) cyclohexanol hydrochlorid
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
DE19915601A1 (de) * 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
CZ2002524A3 (cs) * 1999-08-20 2002-11-13 Ortho-Mcneil Pharmaceutical, Inc. Kompozice obsahující tramadol a antikonvulziva
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
US6339105B1 (en) * 1999-10-12 2002-01-15 Ortho-Mcneil Pharmaceutical, Inc. Analgesic regimen
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10048714A1 (de) * 2000-09-30 2002-04-11 Gruenenthal Gmbh 5-Amino-1-penlen-3-ol-Derivate
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en) * 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof

Also Published As

Publication number Publication date
PE20020413A1 (es) 2002-05-18
KR100864796B1 (ko) 2008-10-23
NO20031382D0 (no) 2003-03-26
KR100835549B1 (ko) 2008-06-09
RU2288219C2 (ru) 2006-11-27
HK1052925A1 (en) 2003-10-03
AR034158A1 (es) 2004-02-04
DE10049483A1 (de) 2002-05-02
ATE272046T1 (de) 2004-08-15
BR0114381A (pt) 2003-12-30
HK1052925B (zh) 2005-04-01
PT1322592E (pt) 2004-12-31
ECSP034530A (es) 2003-05-26
SK3382003A3 (en) 2003-08-05
RU2286334C2 (ru) 2006-10-27
PT1322593E (pt) 2004-12-31
NO20031382L (no) 2003-05-16
PL361382A1 (en) 2004-10-04
EP1322593A1 (de) 2003-07-02
WO2002026694A1 (de) 2002-04-04
CN1478067A (zh) 2004-02-25
ATE272045T1 (de) 2004-08-15
NO20031387L (no) 2003-05-21
EP1322592A1 (de) 2003-07-02
HUP0303361A3 (en) 2007-03-28
US20030216393A1 (en) 2003-11-20
BR0114380A (pt) 2003-12-30
KR20030059160A (ko) 2003-07-07
PL361632A1 (en) 2004-10-04
NZ525171A (en) 2006-02-24
AU2057802A (en) 2002-04-08
ES2225628T3 (es) 2005-03-16
CN1466567A (zh) 2004-01-07
TR200402230T4 (tr) 2004-10-21
MXPA03002738A (es) 2004-01-26
KR20030077531A (ko) 2003-10-01
ES2225605T5 (es) 2009-11-18
DK1322593T3 (da) 2004-10-11
IL155105A0 (en) 2003-10-31
ZA200303214B (en) 2004-08-31
SI1322592T1 (en) 2005-02-28
HK1052924A1 (en) 2003-10-03
SI1322593T1 (en) 2004-12-31
ZA200303220B (en) 2004-08-19
NZ524976A (en) 2005-01-28
CA2423860A1 (en) 2003-03-27
HUP0303361A2 (hu) 2004-03-01
IL155106A0 (en) 2003-10-31
MXPA03002737A (es) 2004-01-26
TR200402030T4 (tr) 2004-09-21
ES2225605T3 (es) 2005-03-16
US6828345B2 (en) 2004-12-07
CN100391933C (zh) 2008-06-04
DK1322592T4 (da) 2009-10-12
EP1322592B1 (de) 2004-07-28
DE50103036D1 (de) 2004-09-02
EP1322592B2 (de) 2009-06-17
DK1322592T3 (da) 2004-11-22
HUP0303195A2 (hu) 2003-12-29
NO20031387D0 (no) 2003-03-26
HK1052924B (zh) 2005-03-24
AU8993701A (en) 2002-04-15
JP2004509939A (ja) 2004-04-02
DE50103035D1 (de) 2004-09-02
ECSP034532A (es) 2003-05-26
US20030220389A1 (en) 2003-11-27
WO2002028817A1 (de) 2002-04-11
US7022739B2 (en) 2006-04-04
JP2004510755A (ja) 2004-04-08
CA2423903A1 (en) 2003-03-27
SK3402003A3 (en) 2003-09-11
HUP0303195A3 (en) 2007-03-28
EP1322593B1 (de) 2004-07-28
AU2002220578B2 (en) 2006-11-30
AU2001289937B2 (en) 2007-01-18

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100928