SK284142B6 - Farmaceutická kompozícia na reguláciu koncentrácie lipidov, stabilizáciu aterosklerotických lézií a na prevenciu pretrhnutia aterosklerotického plaku - Google Patents
Farmaceutická kompozícia na reguláciu koncentrácie lipidov, stabilizáciu aterosklerotických lézií a na prevenciu pretrhnutia aterosklerotického plaku Download PDFInfo
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- SK284142B6 SK284142B6 SK557-98A SK55798A SK284142B6 SK 284142 B6 SK284142 B6 SK 284142B6 SK 55798 A SK55798 A SK 55798A SK 284142 B6 SK284142 B6 SK 284142B6
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- Slovakia
- Prior art keywords
- phenyl
- methylethyl
- atorvastatin
- acetyl
- tris
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US615595P | 1995-11-02 | 1995-11-02 | |
| PCT/US1996/015854 WO1997016184A1 (en) | 1995-11-02 | 1996-10-02 | Method and pharmaceutical composition for regulating lipid concentration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK55798A3 SK55798A3 (en) | 1999-06-11 |
| SK284142B6 true SK284142B6 (sk) | 2004-10-05 |
Family
ID=21719566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK557-98A SK284142B6 (sk) | 1995-11-02 | 1996-10-02 | Farmaceutická kompozícia na reguláciu koncentrácie lipidov, stabilizáciu aterosklerotických lézií a na prevenciu pretrhnutia aterosklerotického plaku |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US6124309A (https=) |
| EP (1) | EP0858336B1 (https=) |
| JP (1) | JPH11515025A (https=) |
| KR (2) | KR100449604B1 (https=) |
| CN (2) | CN1679953A (https=) |
| AR (1) | AR004527A1 (https=) |
| AT (1) | ATE348607T1 (https=) |
| AU (1) | AU720853B2 (https=) |
| BG (1) | BG64018B1 (https=) |
| BR (1) | BR9611410A (https=) |
| CZ (1) | CZ127198A3 (https=) |
| DE (1) | DE69636783T2 (https=) |
| EA (1) | EA000514B1 (https=) |
| ES (1) | ES2279526T3 (https=) |
| GE (1) | GEP20001898B (https=) |
| HU (1) | HUP9901865A3 (https=) |
| IL (1) | IL123902A (https=) |
| IS (1) | IS4720A (https=) |
| NO (1) | NO981961L (https=) |
| NZ (2) | NZ512484A (https=) |
| PL (1) | PL186714B1 (https=) |
| RO (1) | RO120816B1 (https=) |
| SK (1) | SK284142B6 (https=) |
| UA (1) | UA46069C2 (https=) |
| WO (1) | WO1997016184A1 (https=) |
| ZA (1) | ZA969187B (https=) |
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| US6268392B1 (en) * | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| AU720853B2 (en) * | 1995-11-02 | 2000-06-15 | Warner-Lambert Company | Method and pharmaceutical composition for regulating lipid concentration |
| GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| EP1514543A1 (en) * | 1997-08-29 | 2005-03-16 | Pfizer Inc. | Combination therapy comprising atorvastatin and an antihypertensive agent |
| GT199800127A (es) * | 1997-08-29 | 2000-02-01 | Combinaciones terapeuticas. | |
| EP1063991A1 (en) * | 1998-03-17 | 2001-01-03 | Warner-Lambert Company Llc | Statin-matrix metalloproteinase inhibitor combinations |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| YU23901A (sh) * | 1998-09-30 | 2003-07-07 | Warner-Lambert Company | Upotreba sredstva za snižavanje holesterola u sprečavanju i odlaganju revaskularizacije pomoću katetera |
| CO5140104A1 (es) * | 1999-02-16 | 2002-03-22 | Novartis Ag | Derivados de mevinolina y preparacion farmaceuticas que los contienen |
| US20010006656A1 (en) * | 1999-02-17 | 2001-07-05 | University Of Washington | Methods and compositions for inhibiting inflammation associated with pulmonary disease |
| WO2001022962A1 (en) * | 1999-09-30 | 2001-04-05 | Merck & Co., Inc. | Anti-hypercholesterolemic drug combination |
| EP1092432A1 (fr) * | 1999-10-15 | 2001-04-18 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) | Composes anti-ischemiques |
| HUP0203160A3 (en) * | 1999-11-05 | 2006-02-28 | Warner Lambert Co | Prevention of plaque rupture by acat inhibitors |
| WO2002020009A1 (en) * | 2000-09-01 | 2002-03-14 | Sankyo Company, Limited | Medicinal compositions |
| US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| CA2425311C (en) | 2000-10-11 | 2011-06-14 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| JP2004531459A (ja) | 2000-10-11 | 2004-10-14 | エスペリオン セラピューティクス，インコーポレイテッド | コレステロールマネージメント用スルホキシドおよびビススルホキシド化合物ならびに組成物および関連する使用 |
| CN101426763A (zh) | 2000-10-11 | 2009-05-06 | 埃斯佩里安医疗公司 | 用于胆固醇治疗和相关应用的硫化物和二硫化物化合物和组合物 |
| US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| CN1894195A (zh) | 2000-10-11 | 2007-01-10 | 埃斯佩里安医疗公司 | 用于控制胆固醇以及相关用途的醚化合物以及组合物 |
| CA2369967A1 (en) * | 2001-02-12 | 2002-08-12 | Joseph Anthony Cornicelli | Methods of treating nuclear factor-kappa b mediated diseases and disorders |
| PE20030324A1 (es) * | 2001-07-31 | 2003-04-03 | Warner Lambert Co | Composiciones farmaceuticas de amlodipina y atorvastatina |
| US20050020694A1 (en) * | 2001-10-11 | 2005-01-27 | Dasseux Jean-Louis Henri | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
| US20040192771A1 (en) * | 2001-10-11 | 2004-09-30 | Dasseux Jean-Louis Henri | Ether compounds and compositions for cholesterol management and related uses |
| US20040204502A1 (en) * | 2001-10-11 | 2004-10-14 | Dasseux Jean-Louis Henri | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| CA2478184A1 (en) * | 2002-03-12 | 2003-09-25 | Merck & Co., Inc. | Drug combination therapy |
| JP2005522504A (ja) * | 2002-04-10 | 2005-07-28 | エスペリオン セラピューティクス，インコーポレイテッド | パントラクトンおよびパントテン酸誘導体を含むアシル補酵素−ａのミミック、その組成物、ならびにコレステロール管理の方法および関連の使用 |
| JP4187141B2 (ja) * | 2002-04-12 | 2008-11-26 | 興和株式会社 | 新規なトロンボモジュリン発現促進剤 |
| ES2625429T3 (es) * | 2003-01-23 | 2017-07-19 | Esperion Therapeutics Inc. | Compuestos de hidroxilo y composiciones para el control del colesterol y utilizaciones correspondientes |
| KR20060111898A (ko) | 2003-08-29 | 2006-10-30 | 교와 가부시키가이샤 | 지질-풍부-플라크의 안정화 방법 및 파열 예방방법 |
| JPWO2005046706A1 (ja) * | 2003-11-17 | 2007-05-31 | 株式会社東洋新薬 | 松樹皮抽出物を含む脂質代謝改善剤 |
| JP2007525408A (ja) | 2003-12-24 | 2007-09-06 | エスペリオン セラピューティクス，インコーポレイテッド | コレステロール管理および関連使用のためのケトン化合物および組成物 |
| US20050234068A1 (en) * | 2004-04-19 | 2005-10-20 | Baldwin Dalton D | Composition and method of decreasing renal ischemic damage |
| TW200605890A (en) * | 2004-07-28 | 2006-02-16 | Sankyo Co | Pharmaceutical compositions for inhibiting arteriosclerosis |
| TW200619191A (en) * | 2004-10-27 | 2006-06-16 | Sankyo Co | Phenyl compounds with more than 2 substitutes |
| TW200619204A (en) * | 2004-12-10 | 2006-06-16 | Kowa Co | Method for reduction, stabilization and prevention of rupture of lipid rich plaque |
| JP2009514851A (ja) * | 2005-11-08 | 2009-04-09 | ランバクシー ラボラトリーズ リミテッド | （３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法 |
| RU2308947C1 (ru) * | 2006-02-26 | 2007-10-27 | Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАН (НИОХ СО РАН) | Лекарственное средство с гиполипидемическим эффектом "симваглизин" |
| US9597289B2 (en) | 2006-04-26 | 2017-03-21 | Rosemont Pharmaceuticals Ltd. | Liquid oral simvastatin compositions |
| US20130254787A1 (en) | 2006-05-02 | 2013-09-26 | Invidi Technologies Corporation | Method and apparatus to perform real-time audience estimation and commercial selection suitable for targeted advertising |
| US20070269503A1 (en) * | 2006-05-16 | 2007-11-22 | James Walter Burgess | Combinations of HMG CoA reductase inhibitors and negatively charged phospholipids and uses thereof |
| US8314080B2 (en) | 2010-04-06 | 2012-11-20 | Kuwait University | Method of treating type I diabetes |
| CN103274985B (zh) * | 2010-12-03 | 2016-03-09 | 上海科州药物研发有限公司 | 一种阿托伐他汀氨基酸盐 |
| US8586527B2 (en) * | 2011-10-20 | 2013-11-19 | Jaipal Singh | Cerivastatin to treat pulmonary disorders |
| AU2012328526B2 (en) | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| CN103304496A (zh) * | 2012-03-08 | 2013-09-18 | 南京工业大学 | 一种合成申嗪霉素方法 |
| US10047034B2 (en) | 2012-05-16 | 2018-08-14 | Prairie Berry Europe Gmbh | Polyhydroxylated pentacyclic triterpene acids as HMG-COA reductase inhibitors |
| EP3267989A4 (en) | 2015-03-13 | 2018-11-07 | Esperion Therapeutics, Inc. | Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease |
| MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
| MX2021015936A (es) | 2019-06-21 | 2022-04-26 | Esperion Therapeutics Inc | Metodos para preparar acido bempedoico y composiciones del mismo. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| CA2003478A1 (en) * | 1988-12-12 | 1990-06-12 | Leonard G. Dennick | Combination of an hmg coa reductase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| CA2048395A1 (en) * | 1990-08-23 | 1992-02-24 | Henry Y. Pan | Method for preventing onset of or treating type iii hyperlipoproteinemia employing pravastatin |
| JP2525125B2 (ja) | 1991-07-23 | 1996-08-14 | シェリング・コーポレーション | 血清コレステロ―ル低下薬として有用な置換β−ラクタム化合物およびそれらの製法 |
| AU5538794A (en) * | 1992-10-26 | 1994-05-24 | Merck & Co., Inc. | Biologically active compounds and process therefor |
| LT3300B (en) | 1992-12-23 | 1995-06-26 | Schering Corp | Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor |
| US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
| IL109431A (en) * | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
| AU1095695A (en) * | 1993-11-09 | 1995-05-29 | Brigham And Women's Hospital | Hmg-coa reductase inhibitors in the normalization of vascular endothelial dysfunction |
| AU720853B2 (en) * | 1995-11-02 | 2000-06-15 | Warner-Lambert Company | Method and pharmaceutical composition for regulating lipid concentration |
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- 1996-10-02 GE GEAP19964269A patent/GEP20001898B/en unknown
- 1996-10-02 ES ES96934020T patent/ES2279526T3/es not_active Expired - Lifetime
- 1996-10-02 CZ CZ981271A patent/CZ127198A3/cs unknown
- 1996-10-02 US US09/051,368 patent/US6124309A/en not_active Expired - Fee Related
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- 1996-10-02 HU HU9901865A patent/HUP9901865A3/hu unknown
- 1996-10-02 JP JP9517342A patent/JPH11515025A/ja not_active Ceased
- 1996-10-02 BR BR9611410A patent/BR9611410A/pt not_active Application Discontinuation
- 1996-10-02 UA UA98052811A patent/UA46069C2/uk unknown
- 1996-10-02 EP EP96934020A patent/EP0858336B1/en not_active Revoked
- 1996-10-02 NZ NZ512484A patent/NZ512484A/xx unknown
- 1996-10-02 KR KR10-1998-0703240A patent/KR100449604B1/ko not_active Expired - Fee Related
- 1996-10-02 CN CN961980109A patent/CN1217656C/zh not_active Expired - Fee Related
- 1996-10-02 EA EA199800420A patent/EA000514B1/ru not_active IP Right Cessation
- 1996-10-02 NZ NZ319906A patent/NZ319906A/en unknown
- 1996-10-02 AT AT96934020T patent/ATE348607T1/de not_active IP Right Cessation
- 1996-10-02 DE DE69636783T patent/DE69636783T2/de not_active Expired - Fee Related
- 1996-10-02 KR KR10-2004-7003107A patent/KR20040029459A/ko not_active Ceased
- 1996-10-02 WO PCT/US1996/015854 patent/WO1997016184A1/en not_active Ceased
- 1996-10-02 IL IL12390296A patent/IL123902A/xx not_active IP Right Cessation
- 1996-10-02 PL PL96326365A patent/PL186714B1/pl not_active IP Right Cessation
- 1996-10-02 SK SK557-98A patent/SK284142B6/sk unknown
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- 1996-10-31 ZA ZA969187A patent/ZA969187B/xx unknown
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1998
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- 1998-04-29 BG BG102417A patent/BG64018B1/bg unknown
- 1998-04-30 NO NO981961A patent/NO981961L/no unknown
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1999
- 1999-07-01 US US09/345,944 patent/US6093719A/en not_active Expired - Fee Related
- 1999-07-01 US US09/346,503 patent/US6143755A/en not_active Expired - Fee Related
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