SK283860B6 - Sírne deriváty azetidínových zlúčenín, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents
Sírne deriváty azetidínových zlúčenín, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie Download PDFInfo
- Publication number
- SK283860B6 SK283860B6 SK616-97A SK61697A SK283860B6 SK 283860 B6 SK283860 B6 SK 283860B6 SK 61697 A SK61697 A SK 61697A SK 283860 B6 SK283860 B6 SK 283860B6
- Authority
- SK
- Slovakia
- Prior art keywords
- fluorophenyl
- azetidinone
- phenyl
- formula
- hydroxyphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/342,197 US5624920A (en) | 1994-11-18 | 1994-11-18 | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US08/463,619 US5633246A (en) | 1994-11-18 | 1995-06-05 | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
PCT/US1995/014134 WO1996016037A1 (en) | 1994-11-18 | 1995-11-15 | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
SK61697A3 SK61697A3 (en) | 1997-12-10 |
SK283860B6 true SK283860B6 (sk) | 2004-03-02 |
Family
ID=26992866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK616-97A SK283860B6 (sk) | 1994-11-18 | 1995-11-15 | Sírne deriváty azetidínových zlúčenín, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
Country Status (25)
Country | Link |
---|---|
US (2) | US5633246A (ja) |
EP (1) | EP0792264B1 (ja) |
JP (1) | JP2908031B2 (ja) |
KR (1) | KR100235806B1 (ja) |
CN (1) | CN1083833C (ja) |
AT (1) | ATE213726T1 (ja) |
AU (1) | AU698750B2 (ja) |
BR (1) | BR9509669A (ja) |
CA (1) | CA2205202C (ja) |
CZ (1) | CZ289033B6 (ja) |
DE (1) | DE69525643T2 (ja) |
DK (1) | DK0792264T3 (ja) |
ES (1) | ES2169162T3 (ja) |
FI (1) | FI116220B (ja) |
HK (1) | HK1002558A1 (ja) |
HU (1) | HU227672B1 (ja) |
MX (1) | MX9703577A (ja) |
NO (1) | NO308468B1 (ja) |
NZ (1) | NZ296720A (ja) |
PL (1) | PL184310B1 (ja) |
PT (1) | PT792264E (ja) |
RU (1) | RU2159243C2 (ja) |
SK (1) | SK283860B6 (ja) |
UA (1) | UA54381C2 (ja) |
WO (1) | WO1996016037A1 (ja) |
Families Citing this family (61)
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US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
US6297268B1 (en) | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
US6584357B1 (en) * | 2000-10-17 | 2003-06-24 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
EP1510521A1 (en) * | 2000-12-20 | 2005-03-02 | Schering Corporation | Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents |
CZ302193B6 (cs) * | 2000-12-20 | 2010-12-08 | Schering Corporation | 2-azetidinonové deriváty, substituované zbytkem cukru |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
PL205343B1 (pl) * | 2001-01-26 | 2010-04-30 | Schering Corp | Zastosowanie inhibitora wchłaniania sterolu |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
ES2290562T3 (es) * | 2001-01-26 | 2008-02-16 | Schering Corporation | Combinaciones del activador del receptor activado por el proliferador de los peroxisomas (ppar) fenofibrato con el inhibidor de la absorcion de esteroles ezetimiba para indicaciones vasculares. |
WO2002079174A2 (en) | 2001-03-28 | 2002-10-10 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
EP1859796A3 (en) * | 2001-09-21 | 2008-07-02 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
EP1429756B1 (en) * | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
GB0215579D0 (en) * | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
US7208486B2 (en) | 2003-03-07 | 2007-04-24 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
GB2423927A (en) * | 2003-08-29 | 2006-09-13 | Cotherix Inc | Combination Of Cicletanine And An Oral Antidiabetic And/Or Blood Lipid-Lowering Agent For Treating Diabetes And Metabolic Syndrome |
EP1522541A1 (en) * | 2003-10-07 | 2005-04-13 | Lipideon Biotechnology AG | Novel hypocholesterolemic compounds |
EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
AU2004308332B2 (en) * | 2003-12-23 | 2008-04-10 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
US7871998B2 (en) * | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
GB0329778D0 (en) * | 2003-12-23 | 2004-01-28 | Astrazeneca Ab | Chemical compounds |
WO2005069900A2 (en) * | 2004-01-16 | 2005-08-04 | Merck & Co., Inc. | Npc1l1 (npc3) and methods of identifying ligands thereof |
JP2008514718A (ja) * | 2004-09-29 | 2008-05-08 | シェーリング コーポレイション | 置換アゼチドノンおよびcb1アンタゴニストの組み合わせ |
ES2435790T3 (es) | 2004-12-03 | 2013-12-23 | Intervet International B.V. | Piperazinas sustituidas como antagonistas de CB1 |
WO2007001975A1 (en) * | 2005-06-20 | 2007-01-04 | Schering Corporation | Piperidine derivatives useful as histamine h3 antagonists |
UY29607A1 (es) * | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
MY148538A (en) * | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
AR057383A1 (es) * | 2005-06-22 | 2007-12-05 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
AR057380A1 (es) * | 2005-06-22 | 2007-11-28 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos |
AR054482A1 (es) * | 2005-06-22 | 2007-06-27 | Astrazeneca Ab | Derivados de azetidinona para el tratamiento de hiperlipidemias |
SA06270191B1 (ar) * | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
AR056866A1 (es) * | 2005-06-22 | 2007-10-31 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, una formulacion farmaceutica y un proceso de preparacion del compuesto |
AU2006331770A1 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and H3 receptor antagonist/inverse agonist |
CA2637565A1 (en) | 2006-01-18 | 2007-07-26 | Schering Corporation | Cannibinoid receptor modulators |
EP1986489A2 (en) * | 2006-02-24 | 2008-11-05 | Schering Corporation | Npc1l1 orthologues |
WO2007103453A1 (en) * | 2006-03-06 | 2007-09-13 | Teva Pharmaceutical Industries Ltd. | Ezetimibe compositions |
TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
WO2008030382A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
JP2010503675A (ja) * | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 疼痛、糖尿病および脂質代謝の障害の治療に有用なスピロ縮合アゼチジン誘導体 |
WO2008033465A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
CN101528746A (zh) * | 2006-09-15 | 2009-09-09 | 先灵公司 | 治疗脂质代谢障碍、疼痛、糖尿病和其它障碍的螺环氮杂环丁酮衍生物 |
EP2061792A2 (en) * | 2006-09-15 | 2009-05-27 | Schering Corporation | Azetidinone derivatives for the treatment of disorders of the lipid metabolism |
MX2009002922A (es) | 2006-09-15 | 2009-04-01 | Schering Corp | Derivados de azetidina y azetidona utiles en el tratamiento del dolor y de trastornos del metabolismo lipidico. |
JPWO2008108486A1 (ja) | 2007-03-06 | 2010-06-17 | 帝人ファーマ株式会社 | 1−ビアリールアゼチジノン誘導体 |
WO2008130616A2 (en) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
KR20100051625A (ko) * | 2007-06-28 | 2010-05-17 | 인터벳 인터내셔널 비.브이. | Cb1 길항제로서의 치환된 피페라진 |
EP2170847A2 (en) * | 2007-06-28 | 2010-04-07 | Intervet International BV | Substituted piperazines as cb1 antagonists |
US9212175B2 (en) | 2009-03-06 | 2015-12-15 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
DK2844233T3 (da) | 2012-05-01 | 2020-07-13 | Althera Life Sciences Llc | Oral tabletformulering bestående af en fastsat kombination af rosuvastatin og ezetimib til behandling af hyperlipidæmi og kardiovaskulære sygdomme |
WO2020191163A1 (en) | 2019-03-20 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (scap) inhibitors |
EP3942048A1 (en) | 2019-03-20 | 2022-01-26 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (srebf1) inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
US4803266A (en) * | 1986-10-17 | 1989-02-07 | Taisho Pharmaceutical Co., Ltd. | 3-Oxoalkylidene-2-azetidinone derivatives |
GB8719695D0 (en) * | 1987-08-20 | 1987-09-30 | Ici Plc | Chemical process |
IL89835A0 (en) * | 1988-04-11 | 1989-12-15 | Merck & Co Inc | Substituted azetidinones,their preparation and pharmaceutical compositions containing them |
US4983597A (en) * | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
US5120729A (en) * | 1990-06-20 | 1992-06-09 | Merck & Co., Inc. | Beta-lactams as antihypercholesterolemics |
CZ14294A3 (en) * | 1991-07-23 | 1994-07-13 | Schering Corp | Substituted beta-lactam compounds usable as hypocholesterol pharmaceutical preparations and process for preparing thereof |
LT3300B (en) * | 1992-12-23 | 1995-06-26 | Schering Corp | Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor |
US5412092A (en) * | 1993-04-23 | 1995-05-02 | Bristol-Myers Squibb Company | N-substituted 2-azetidinones |
US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5627176A (en) * | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
JPH10501811A (ja) * | 1994-06-20 | 1998-02-17 | シェーリング コーポレイション | 低コレステロール化剤として有用な置換アゼチジノン化合物 |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
HU226822B1 (en) * | 1995-10-31 | 2009-11-30 | Schering Corp | Hypocholesterolemic sugar-substituted 2-azetidinones, and pharmaceutical compns. contg. them |
-
1995
- 1995-06-05 US US08/463,619 patent/US5633246A/en not_active Expired - Lifetime
- 1995-11-15 DE DE69525643T patent/DE69525643T2/de not_active Expired - Lifetime
- 1995-11-15 CZ CZ19971486A patent/CZ289033B6/cs not_active IP Right Cessation
- 1995-11-15 HU HU9701924A patent/HU227672B1/hu not_active IP Right Cessation
- 1995-11-15 UA UA97062853A patent/UA54381C2/uk unknown
- 1995-11-15 DK DK95939677T patent/DK0792264T3/da active
- 1995-11-15 JP JP8516884A patent/JP2908031B2/ja not_active Expired - Fee Related
- 1995-11-15 CA CA002205202A patent/CA2205202C/en not_active Expired - Fee Related
- 1995-11-15 KR KR1019970703280A patent/KR100235806B1/ko not_active IP Right Cessation
- 1995-11-15 SK SK616-97A patent/SK283860B6/sk not_active IP Right Cessation
- 1995-11-15 WO PCT/US1995/014134 patent/WO1996016037A1/en active IP Right Grant
- 1995-11-15 AU AU41401/96A patent/AU698750B2/en not_active Ceased
- 1995-11-15 RU RU97110267/04A patent/RU2159243C2/ru not_active IP Right Cessation
- 1995-11-15 MX MX9703577A patent/MX9703577A/es not_active IP Right Cessation
- 1995-11-15 PT PT95939677T patent/PT792264E/pt unknown
- 1995-11-15 AT AT95939677T patent/ATE213726T1/de active
- 1995-11-15 CN CN95197276A patent/CN1083833C/zh not_active Expired - Fee Related
- 1995-11-15 NZ NZ296720A patent/NZ296720A/xx not_active IP Right Cessation
- 1995-11-15 EP EP95939677A patent/EP0792264B1/en not_active Expired - Lifetime
- 1995-11-15 ES ES95939677T patent/ES2169162T3/es not_active Expired - Lifetime
- 1995-11-15 BR BR9509669A patent/BR9509669A/pt not_active IP Right Cessation
- 1995-11-15 PL PL95320092A patent/PL184310B1/pl not_active IP Right Cessation
-
1997
- 1997-01-08 US US08/813,585 patent/US5744467A/en not_active Expired - Lifetime
- 1997-05-16 FI FI972099A patent/FI116220B/fi not_active IP Right Cessation
- 1997-05-16 NO NO972272A patent/NO308468B1/no not_active IP Right Cessation
-
1998
- 1998-02-10 HK HK98101013A patent/HK1002558A1/xx not_active IP Right Cessation
Also Published As
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US5627176A (en) | Substituted azetidinone compounds useful as hypocholesterolemic agents | |
JP2719445B2 (ja) | コレステロール低下剤として有用なスピロシクロアルキル置換アゼチジノン | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20111115 |