SK283662B6 - Kompetetívne progesterónantagonisty na kontrolu samičej fertility zameranú podľa potreby - Google Patents

Kompetetívne progesterónantagonisty na kontrolu samičej fertility zameranú podľa potreby Download PDF

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Publication number
SK283662B6
SK283662B6 SK518-97A SK51897A SK283662B6 SK 283662 B6 SK283662 B6 SK 283662B6 SK 51897 A SK51897 A SK 51897A SK 283662 B6 SK283662 B6 SK 283662B6
Authority
SK
Slovakia
Prior art keywords
hydroxy
phenyl
competitive progesterone
progesterone antagonist
methyl
Prior art date
Application number
SK518-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK51897A3 (en
Inventor
Kristof Chwalisz
Klaus St�Ckemann
Karin Schmidt-Gollwitzer
Walter Klemann
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SK51897A3 publication Critical patent/SK51897A3/sk
Publication of SK283662B6 publication Critical patent/SK283662B6/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SK518-97A 1994-10-24 1995-10-24 Kompetetívne progesterónantagonisty na kontrolu samičej fertility zameranú podľa potreby SK283662B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4438820 1994-10-24
PCT/EP1995/004191 WO1996012494A1 (de) 1994-10-24 1995-10-24 Kompetitive progesteronantagonisten zur bedarfsorientierten weiblichen fertilitätskontrolle

Publications (2)

Publication Number Publication Date
SK51897A3 SK51897A3 (en) 1997-09-10
SK283662B6 true SK283662B6 (sk) 2003-11-04

Family

ID=6532105

Family Applications (1)

Application Number Title Priority Date Filing Date
SK518-97A SK283662B6 (sk) 1994-10-24 1995-10-24 Kompetetívne progesterónantagonisty na kontrolu samičej fertility zameranú podľa potreby

Country Status (25)

Country Link
US (1) US6143754A (cs)
EP (1) EP0787002B1 (cs)
JP (1) JPH10507461A (cs)
KR (1) KR970706827A (cs)
CN (1) CN1211087C (cs)
AT (1) ATE347894T1 (cs)
AU (1) AU707235B2 (cs)
BG (1) BG62877B1 (cs)
BR (1) BR9509478A (cs)
CA (1) CA2203541A1 (cs)
CZ (1) CZ290690B6 (cs)
DE (1) DE59511071D1 (cs)
DK (1) DK0787002T3 (cs)
ES (1) ES2279515T3 (cs)
FI (1) FI971742A0 (cs)
HU (1) HU226566B1 (cs)
IL (1) IL115738A (cs)
NO (1) NO314437B1 (cs)
NZ (1) NZ295365A (cs)
PL (1) PL319869A1 (cs)
PT (1) PT787002E (cs)
RO (1) RO120606B1 (cs)
SK (1) SK283662B6 (cs)
WO (1) WO1996012494A1 (cs)
ZA (1) ZA959008B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19745085A1 (de) * 1997-10-11 1999-04-15 Jenapharm Gmbh 11ß-Benzaldoxim-9alpha,10alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
DE19809845A1 (de) * 1998-03-03 1999-09-09 Jenapharm Gmbh S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
US7629334B1 (en) 1999-08-31 2009-12-08 Bayer Schering Pharma Aktiengesellschaft Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
MXPA02002186A (es) * 1999-08-31 2002-09-02 Jenapharm Gmbh Mesoprogestinas (moduladores del receptor de progesterona) como un componente de los anticonceptivos femeninos.
PE20010581A1 (es) * 1999-08-31 2001-06-04 Schering Ag Mesoprogestinas (modulares de receptores de progesterona) como componentes de composiciones utilizadas para la terapia de sustitucion hormonal (hrt)
DE102005050729A1 (de) * 2005-10-19 2007-04-26 Schering Ag Verfahren zur präventiven bedarfsweisen hormonalen Kontrazeption
BRPI0819571A2 (pt) * 2007-12-20 2019-09-24 Teva Womenss Health Inc "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica"
EP2419109B1 (en) * 2009-04-14 2016-04-13 Laboratoire HRA-Pharma Method for on-demand contraception using levonorgestrel or norgestrel
EP2419108B1 (en) 2009-04-14 2016-08-17 Laboratoire HRA Pharma Method for on-demand contraception
MA38606A1 (fr) 2013-05-23 2017-03-31 Bayer Pharma AG Composition pharmaceutique et son utilisation, ainsi que schéma d'emploi de cette composition pharmaceutique pour la contraception à la demande
MX391191B (es) * 2014-11-17 2025-03-21 Context Biopharma Inc Composiciones de liberación extendida de onapristona y métodos.
JP2018528944A (ja) 2015-09-25 2018-10-04 コンテクスト バイオファーマ インコーポレイテッド オナプリストン中間体の製造方法
JP2019503353A (ja) * 2015-12-15 2019-02-07 コンテキスト・バイオファーマ・インコーポレイテッド 非晶質オナプリストン組成物およびそれを作製する方法
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439913A (en) * 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein

Also Published As

Publication number Publication date
NO971869L (no) 1997-04-23
EP0787002B1 (de) 2006-12-13
CZ118097A3 (en) 1997-07-16
CN1211087C (zh) 2005-07-20
ES2279515T3 (es) 2007-08-16
NO314437B1 (no) 2003-03-24
SK51897A3 (en) 1997-09-10
KR970706827A (ko) 1997-12-01
MX9703018A (es) 1997-10-31
HUT77518A (hu) 1998-05-28
JPH10507461A (ja) 1998-07-21
ATE347894T1 (de) 2007-01-15
IL115738A (en) 2002-05-23
NO971869D0 (no) 1997-04-23
WO1996012494A1 (de) 1996-05-02
EP0787002A1 (de) 1997-08-06
PT787002E (pt) 2007-03-30
AU3869695A (en) 1996-05-15
DE59511071D1 (de) 2007-01-25
CZ290690B6 (cs) 2002-09-11
FI971742A7 (fi) 1997-04-23
RO120606B1 (ro) 2006-05-30
CN1161649A (zh) 1997-10-08
HU226566B1 (en) 2009-04-28
FI971742L (fi) 1997-04-23
ZA959008B (en) 1996-09-16
NZ295365A (en) 1999-07-29
DK0787002T3 (da) 2007-04-10
BR9509478A (pt) 1997-09-30
BG101427A (en) 1997-11-28
FI971742A0 (fi) 1997-04-23
BG62877B1 (bg) 2000-10-31
PL319869A1 (en) 1997-09-01
CA2203541A1 (en) 1996-05-02
IL115738A0 (en) 1996-01-19
AU707235B2 (en) 1999-07-08
US6143754A (en) 2000-11-07

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