SK281547B6 - Detekčná rúrka inhibítorov cholínesteráz vo vzduchu a vo vode - Google Patents
Detekčná rúrka inhibítorov cholínesteráz vo vzduchu a vo vode Download PDFInfo
- Publication number
- SK281547B6 SK281547B6 SK736-94A SK73694A SK281547B6 SK 281547 B6 SK281547 B6 SK 281547B6 SK 73694 A SK73694 A SK 73694A SK 281547 B6 SK281547 B6 SK 281547B6
- Authority
- SK
- Slovakia
- Prior art keywords
- substrate
- chromogenic
- air
- water
- layer
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 17
- 239000000544 cholinesterase inhibitor Substances 0.000 title claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 239000003593 chromogenic compound Substances 0.000 claims abstract description 10
- 239000011521 glass Substances 0.000 claims abstract description 10
- 239000001913 cellulose Substances 0.000 claims abstract description 7
- 229920002678 cellulose Polymers 0.000 claims abstract description 7
- 230000000052 comparative effect Effects 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract 2
- 239000000872 buffer Substances 0.000 claims description 10
- 239000012916 chromogenic reagent Substances 0.000 claims description 4
- 108090000371 Esterases Proteins 0.000 claims description 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- 239000000758 substrate Substances 0.000 abstract description 15
- 239000000243 solution Substances 0.000 abstract description 13
- 102100032404 Cholinesterase Human genes 0.000 abstract description 11
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 108090000322 Cholinesterases Proteins 0.000 abstract description 6
- AWBGQVBMGBZGLS-UHFFFAOYSA-N butyrylthiocholine Chemical compound CCCC(=O)SCC[N+](C)(C)C AWBGQVBMGBZGLS-UHFFFAOYSA-N 0.000 abstract description 6
- 229940048961 cholinesterase Drugs 0.000 abstract description 6
- GFFIJCYHQYHUHB-UHFFFAOYSA-N 2-acetylsulfanylethyl(trimethyl)azanium Chemical compound CC(=O)SCC[N+](C)(C)C GFFIJCYHQYHUHB-UHFFFAOYSA-N 0.000 abstract description 5
- KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical compound C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 abstract description 3
- 241000283690 Bos taurus Species 0.000 abstract description 3
- 210000004556 brain Anatomy 0.000 abstract description 3
- 150000003839 salts Chemical class 0.000 abstract description 3
- 102100033639 Acetylcholinesterase Human genes 0.000 abstract description 2
- 108010022752 Acetylcholinesterase Proteins 0.000 abstract description 2
- 108010053652 Butyrylcholinesterase Proteins 0.000 abstract description 2
- 241000283073 Equus caballus Species 0.000 abstract description 2
- 229940022698 acetylcholinesterase Drugs 0.000 abstract description 2
- 239000007853 buffer solution Substances 0.000 abstract description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 description 12
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- 239000003708 ampul Substances 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 238000011534 incubation Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 101710083761 Cholinesterase Proteins 0.000 description 3
- 229940122041 Cholinesterase inhibitor Drugs 0.000 description 3
- QOGIOOCHOQQIGE-UHFFFAOYSA-N S(=O)(=O)(OC)OC.S1C(=NC=C1)N=NC1=C(C=CC(=C1)C)OC(C)=O Chemical compound S(=O)(=O)(OC)OC.S1C(=NC=C1)N=NC1=C(C=CC(=C1)C)OC(C)=O QOGIOOCHOQQIGE-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
- 229960004373 acetylcholine Drugs 0.000 description 2
- 239000002696 acid base indicator Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000001639 phenylmethylene group Chemical group [H]C(=*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- NTBLZMAMTZXLBP-UHFFFAOYSA-M 2-acetylsulfanylethyl(trimethyl)azanium;iodide Chemical compound [I-].CC(=O)SCC[N+](C)(C)C NTBLZMAMTZXLBP-UHFFFAOYSA-M 0.000 description 1
- GALNBQVDMJRFGJ-UHFFFAOYSA-M 2-butanoyloxyethyl(trimethyl)azanium;iodide Chemical compound [I-].CCCC(=O)OCC[N+](C)(C)C GALNBQVDMJRFGJ-UHFFFAOYSA-M 0.000 description 1
- 101000943288 Equus caballus Cholinesterase Proteins 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- TWMCBBMHCFACMM-UHFFFAOYSA-N S-quinolin-2-yl ethanethioate Chemical compound C(C)(=O)SC1=NC2=CC=CC=C2C=C1 TWMCBBMHCFACMM-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- QGLZXHRNAYXIBU-WEVVVXLNSA-N aldicarb Chemical compound CNC(=O)O\N=C\C(C)(C)SC QGLZXHRNAYXIBU-WEVVVXLNSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- DUEPRVBVGDRKAG-UHFFFAOYSA-N carbofuran Chemical compound CNC(=O)OC1=CC=CC2=C1OC(C)(C)C2 DUEPRVBVGDRKAG-UHFFFAOYSA-N 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- OEBRKCOSUFCWJD-UHFFFAOYSA-N dichlorvos Chemical compound COP(=O)(OC)OC=C(Cl)Cl OEBRKCOSUFCWJD-UHFFFAOYSA-N 0.000 description 1
- 229950001327 dichlorvos Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000004457 water analysis Methods 0.000 description 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ931179A CZ285242B6 (cs) | 1993-06-17 | 1993-06-17 | Detekční trubička inhibitorů cholinesteras ve vzduchu a vodě |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK73694A3 SK73694A3 (en) | 1995-01-12 |
| SK281547B6 true SK281547B6 (sk) | 2001-04-09 |
Family
ID=5462878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK736-94A SK281547B6 (sk) | 1993-06-17 | 1994-06-15 | Detekčná rúrka inhibítorov cholínesteráz vo vzduchu a vo vode |
Country Status (2)
| Country | Link |
|---|---|
| CZ (1) | CZ285242B6 (cs) |
| SK (1) | SK281547B6 (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3196315B1 (en) | 2016-01-19 | 2020-02-05 | ORITEST spol. s r.o. | Spherical pellets, manufacturing process of such pellets, use, and a detection tube comprising such pellets |
| CZ2016311A3 (cs) * | 2016-05-26 | 2017-07-12 | Oritest Spol. S R.O. | Obalené sférické pelety, jejich výroba a adjustace v detekčních trubičkách k detekci inhibitorů cholinesteráz |
-
1993
- 1993-06-17 CZ CZ931179A patent/CZ285242B6/cs not_active IP Right Cessation
-
1994
- 1994-06-15 SK SK736-94A patent/SK281547B6/sk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK73694A3 (en) | 1995-01-12 |
| CZ117993A3 (en) | 1995-10-18 |
| CZ285242B6 (cs) | 1999-06-16 |
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