SK272003A3 - Piperidine compounds for use as CCR-3 inhibitors - Google Patents
Piperidine compounds for use as CCR-3 inhibitors Download PDFInfo
- Publication number
- SK272003A3 SK272003A3 SK27-2003A SK272003A SK272003A3 SK 272003 A3 SK272003 A3 SK 272003A3 SK 272003 A SK272003 A SK 272003A SK 272003 A3 SK272003 A3 SK 272003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- och
- alkyl
- alkoxy
- compounds
- Prior art date
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- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 title claims description 11
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 title claims description 11
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 110
- -1 cyano, hydroxy Chemical group 0.000 claims abstract description 54
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 41
- 150000003839 salts Chemical group 0.000 claims abstract description 35
- 125000005843 halogen group Chemical group 0.000 claims abstract description 33
- 125000001424 substituent group Chemical group 0.000 claims abstract description 25
- 239000001257 hydrogen Substances 0.000 claims abstract description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 21
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 19
- 150000002367 halogens Chemical class 0.000 claims abstract description 18
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 12
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims abstract description 9
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims abstract description 7
- 125000004423 acyloxy group Chemical group 0.000 claims abstract description 6
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 52
- 238000000034 method Methods 0.000 claims description 38
- 238000002360 preparation method Methods 0.000 claims description 37
- 125000000217 alkyl group Chemical group 0.000 claims description 28
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- 230000035939 shock Effects 0.000 description 1
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- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
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- ZJTYRNPLVNMVPQ-GFCCVEGCSA-N tert-butyl n-[(2r)-1-oxo-3-phenylpropan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H](C=O)CC1=CC=CC=C1 ZJTYRNPLVNMVPQ-GFCCVEGCSA-N 0.000 description 1
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| GB0017174A GB0017174D0 (en) | 2000-07-12 | 2000-07-12 | Organic compounds |
| GB0023326A GB0023326D0 (en) | 2000-09-22 | 2000-09-22 | Organic compounds |
| PCT/EP2001/007941 WO2002004420A1 (en) | 2000-07-12 | 2001-07-10 | Piperidine coumpounds for use as ccr-3 inhibitors |
Publications (1)
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| SK272003A3 true SK272003A3 (en) | 2003-07-01 |
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| SK27-2003A SK272003A3 (en) | 2000-07-12 | 2001-07-10 | Piperidine compounds for use as CCR-3 inhibitors |
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| AT (1) | ATE447553T1 (enExample) |
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| PT (1) | PT1303488E (enExample) |
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Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19952147A1 (de) * | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JP4199539B2 (ja) * | 2000-10-09 | 2008-12-17 | ノバルティス アクチエンゲゼルシャフト | Ｃｃｒ−３受容体アンタゴニストとしてのｎ−（４−アリールオキシピペリジン−１−イルアルキル）桂皮酸アミド |
| GB0114699D0 (en) | 2001-06-15 | 2001-08-08 | Novartis Ag | Organic compounds |
| ES2452691T5 (es) | 2003-09-16 | 2022-09-14 | Covis Pharma Gmbh | Uso de ciclesonida para el tratamiento de enfermedades respiratorias |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| MX364438B (es) * | 2013-03-15 | 2019-04-26 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| EA201792214A1 (ru) | 2015-04-10 | 2018-01-31 | Араксис Фарма Ллк | Соединения замещенного хиназолина |
| JP6789239B2 (ja) | 2015-04-15 | 2020-11-25 | アラクセス ファーマ エルエルシー | Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法 |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058768A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3356347A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058728A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| CA3005089A1 (en) | 2015-11-16 | 2017-05-26 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| JP2019529484A (ja) | 2016-09-29 | 2019-10-17 | アラクセス ファーマ エルエルシー | Ｋｒａｓ ｇ１２ｃ変異体タンパク質の阻害剤 |
| CN110312711A (zh) | 2016-10-07 | 2019-10-08 | 亚瑞克西斯制药公司 | 作为ras抑制剂的杂环化合物及其使用方法 |
| JP7327802B2 (ja) | 2017-01-26 | 2023-08-16 | アラクセス ファーマ エルエルシー | 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法 |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| US10745385B2 (en) | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| JP2020521740A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | 変異体ｋｒａｓ、ｈｒａｓまたはｎｒａｓの調節因子としてのキナゾリン誘導体 |
| TW201906832A (zh) | 2017-05-25 | 2019-02-16 | 美商亞瑞克西斯製藥公司 | 用於癌症治療之化合物及其使用方法 |
| BR112021001709A2 (pt) | 2018-08-01 | 2021-05-04 | Araxes Pharma Llc | compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer |
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| EP1003514A4 (en) * | 1997-07-25 | 2000-10-11 | Merck & Co Inc | CYCLIC AMINE MODULATORS OF CHEMOKIN RECEPTORS |
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| ATE280157T1 (de) | 1998-11-17 | 2004-11-15 | Hoffmann La Roche | 4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii |
| AU3126700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| SK11822001A3 (sk) * | 1999-03-26 | 2002-09-10 | Astrazeneca Ab | Modulátory chemokínovej aktivity, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie v terapii |
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- 2001-07-10 CZ CZ200375A patent/CZ200375A3/cs unknown
- 2001-07-10 AU AU8197201A patent/AU8197201A/xx active Pending
- 2001-07-10 WO PCT/EP2001/007941 patent/WO2002004420A1/en not_active Ceased
- 2001-07-10 IL IL15366101A patent/IL153661A0/xx unknown
- 2001-07-10 SK SK27-2003A patent/SK272003A3/sk not_active Application Discontinuation
- 2001-07-10 EP EP01960488A patent/EP1303488B1/en not_active Expired - Lifetime
- 2001-07-10 AR ARP010103261A patent/AR031597A1/es unknown
- 2001-07-10 PT PT01960488T patent/PT1303488E/pt unknown
- 2001-07-10 US US10/332,642 patent/US6670379B2/en not_active Expired - Fee Related
- 2001-07-10 MX MXPA02012848A patent/MXPA02012848A/es active IP Right Grant
- 2001-07-10 PE PE2001000683A patent/PE20020616A1/es not_active Application Discontinuation
- 2001-07-10 HU HU0301341A patent/HUP0301341A2/hu unknown
- 2001-07-10 AT AT01960488T patent/ATE447553T1/de not_active IP Right Cessation
- 2001-07-10 ES ES01960488T patent/ES2334886T3/es not_active Expired - Lifetime
- 2001-07-10 MY MYPI20013274A patent/MY126139A/en unknown
- 2001-07-10 NZ NZ523414A patent/NZ523414A/en unknown
- 2001-07-10 JP JP2002509087A patent/JP2004502756A/ja active Pending
- 2001-07-10 DE DE60140366T patent/DE60140366D1/de not_active Expired - Lifetime
- 2001-07-10 PL PL01358673A patent/PL358673A1/xx not_active Application Discontinuation
- 2001-07-10 CN CNB018126111A patent/CN1184204C/zh not_active Expired - Fee Related
- 2001-07-10 KR KR10-2003-7000445A patent/KR20030036603A/ko not_active Withdrawn
- 2001-07-10 BR BR0112456-0A patent/BR0112456A/pt not_active IP Right Cessation
- 2001-07-10 CA CA2412941A patent/CA2412941C/en not_active Expired - Fee Related
-
2003
- 2003-01-10 NO NO20030135A patent/NO324760B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8197201A (en) | 2002-01-21 |
| CN1184204C (zh) | 2005-01-12 |
| NZ523414A (en) | 2004-07-30 |
| US20030176460A1 (en) | 2003-09-18 |
| DE60140366D1 (de) | 2009-12-17 |
| PL358673A1 (en) | 2004-08-09 |
| IL153661A0 (en) | 2003-07-06 |
| JP2004502756A (ja) | 2004-01-29 |
| TWI227231B (en) | 2005-02-01 |
| EP1303488A1 (en) | 2003-04-23 |
| MY126139A (en) | 2006-09-29 |
| NO20030135L (no) | 2003-02-19 |
| MXPA02012848A (es) | 2003-05-15 |
| CN1441780A (zh) | 2003-09-10 |
| BR0112456A (pt) | 2003-07-22 |
| ATE447553T1 (de) | 2009-11-15 |
| ES2334886T3 (es) | 2010-03-17 |
| PT1303488E (pt) | 2010-01-19 |
| NO20030135D0 (no) | 2003-01-10 |
| AR031597A1 (es) | 2003-09-24 |
| WO2002004420A1 (en) | 2002-01-17 |
| CA2412941C (en) | 2011-01-04 |
| US6670379B2 (en) | 2003-12-30 |
| NO324760B1 (no) | 2007-12-10 |
| KR20030036603A (ko) | 2003-05-09 |
| CZ200375A3 (cs) | 2003-04-16 |
| AU2001281972B2 (en) | 2004-06-03 |
| HUP0301341A2 (hu) | 2003-08-28 |
| PE20020616A1 (es) | 2002-08-02 |
| EP1303488B1 (en) | 2009-11-04 |
| CA2412941A1 (en) | 2002-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC9A | Refused patent application |