SK174799A3 - Process for reducing the concentration of viral and molecular pathogens in a biological material - Google Patents
Process for reducing the concentration of viral and molecular pathogens in a biological material Download PDFInfo
- Publication number
- SK174799A3 SK174799A3 SK1747-99A SK174799A SK174799A3 SK 174799 A3 SK174799 A3 SK 174799A3 SK 174799 A SK174799 A SK 174799A SK 174799 A3 SK174799 A3 SK 174799A3
- Authority
- SK
- Slovakia
- Prior art keywords
- biological material
- pathogens
- virus
- biological
- ion exchanger
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title claims abstract description 28
- 244000052769 pathogen Species 0.000 title claims abstract description 28
- 230000003612 virological effect Effects 0.000 title claims abstract description 8
- 238000000034 method Methods 0.000 title claims description 52
- 239000000126 substance Substances 0.000 claims abstract description 23
- 239000003960 organic solvent Substances 0.000 claims abstract description 12
- 241000700605 Viruses Species 0.000 claims description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 150000002500 ions Chemical class 0.000 claims description 20
- 235000019441 ethanol Nutrition 0.000 claims description 16
- 150000001450 anions Chemical class 0.000 claims description 11
- 229920005654 Sephadex Polymers 0.000 claims description 7
- 239000012507 Sephadex™ Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000011534 incubation Methods 0.000 claims description 6
- 238000005342 ion exchange Methods 0.000 claims description 6
- 230000001717 pathogenic effect Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 4
- 238000010923 batch production Methods 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 abstract description 8
- 239000000243 solution Substances 0.000 description 10
- 108060003951 Immunoglobulin Proteins 0.000 description 8
- 102000018358 immunoglobulin Human genes 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 238000001179 sorption measurement Methods 0.000 description 7
- 238000005571 anion exchange chromatography Methods 0.000 description 6
- 230000002779 inactivation Effects 0.000 description 6
- 230000002458 infectious effect Effects 0.000 description 6
- 241000709721 Hepatovirus A Species 0.000 description 5
- 241000725303 Human immunodeficiency virus Species 0.000 description 5
- 241000125945 Protoparvovirus Species 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 108010047303 von Willebrand Factor Proteins 0.000 description 5
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 4
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 4
- 229960000182 blood factors Drugs 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000012460 protein solution Substances 0.000 description 4
- 102100023804 Coagulation factor VII Human genes 0.000 description 3
- 229920002271 DEAE-Sepharose Polymers 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 108010023321 Factor VII Proteins 0.000 description 3
- 241000531123 GB virus C Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229940012413 factor vii Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000004255 ion exchange chromatography Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 244000052613 viral pathogen Species 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 2
- 102100022641 Coagulation factor IX Human genes 0.000 description 2
- 108010032597 Cohn fraction II Proteins 0.000 description 2
- 108010076282 Factor IX Proteins 0.000 description 2
- 108010054218 Factor VIII Proteins 0.000 description 2
- 102000001690 Factor VIII Human genes 0.000 description 2
- 108010014173 Factor X Proteins 0.000 description 2
- 241000700721 Hepatitis B virus Species 0.000 description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 101800004937 Protein C Proteins 0.000 description 2
- 102000017975 Protein C Human genes 0.000 description 2
- 229940096437 Protein S Drugs 0.000 description 2
- 108010066124 Protein S Proteins 0.000 description 2
- 102000029301 Protein S Human genes 0.000 description 2
- 108010094028 Prothrombin Proteins 0.000 description 2
- 239000012564 Q sepharose fast flow resin Substances 0.000 description 2
- 239000012614 Q-Sepharose Substances 0.000 description 2
- 101800001700 Saposin-D Proteins 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000002156 adsorbate Substances 0.000 description 2
- 238000005349 anion exchange Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 229960004222 factor ix Drugs 0.000 description 2
- 229960000301 factor viii Drugs 0.000 description 2
- 229940012426 factor x Drugs 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229960000856 protein c Drugs 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 102100036537 von Willebrand factor Human genes 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000701089 Equid alphaherpesvirus 4 Species 0.000 description 1
- 108010074864 Factor XI Proteins 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 241000724709 Hepatitis delta virus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000702617 Human parvovirus B19 Species 0.000 description 1
- 241000702623 Minute virus of mice Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000156302 Porcine hemagglutinating encephalomyelitis virus Species 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- PPBOKXIGFIBOGK-BDTUAEFFSA-N bvdv Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C1=CN=CN1 PPBOKXIGFIBOGK-BDTUAEFFSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 238000011118 depth filtration Methods 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- -1 factor 11a Proteins 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 244000052637 human pathogen Species 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002941 microtiter virus yield reduction assay Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0017—Filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Saccharide Compounds (AREA)
- General Factory Administration (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0102997A AT407159B (de) | 1997-06-13 | 1997-06-13 | Verfahren zur abreicherung von viralen und molekularen pathogenen aus einem biologischen material |
| PCT/AT1998/000143 WO1998057672A2 (de) | 1997-06-13 | 1998-06-10 | Verfahren zur abreicherung von viralen und molekularen pathogenen aus einem biologischen material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK174799A3 true SK174799A3 (en) | 2000-07-11 |
Family
ID=3505143
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1747-99A SK174799A3 (en) | 1997-06-13 | 1998-06-10 | Process for reducing the concentration of viral and molecular pathogens in a biological material |
| SK1752-99A SK175299A3 (en) | 1997-06-13 | 1998-06-10 | Process for reducing the concentration of viral and molecular pathogens in a biological material |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1752-99A SK175299A3 (en) | 1997-06-13 | 1998-06-10 | Process for reducing the concentration of viral and molecular pathogens in a biological material |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP1004323A1 (ja) |
| JP (1) | JP2002505674A (ja) |
| AT (3) | AT407159B (ja) |
| AU (1) | AU726808B2 (ja) |
| BR (1) | BR9810098A (ja) |
| CA (1) | CA2293401C (ja) |
| CZ (1) | CZ451699A3 (ja) |
| DE (1) | DE59805324D1 (ja) |
| DK (1) | DK0988063T4 (ja) |
| ES (1) | ES2181227T5 (ja) |
| HU (1) | HUP0003610A3 (ja) |
| NO (2) | NO996118L (ja) |
| PT (1) | PT988063E (ja) |
| SI (1) | SI0988063T1 (ja) |
| SK (2) | SK174799A3 (ja) |
| WO (1) | WO1998057672A2 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000074733A1 (en) * | 1999-06-08 | 2000-12-14 | Octapharma Ag | Process for removing viruses from biological samples |
| ATE555666T1 (de) * | 2002-05-23 | 2012-05-15 | Ortho Clinical Diagnostics Inc | Einfang, konzentration und quantifizierung eines abnormalen prionproteins aus biologischen flüssigkeiten mittels tiefenfiltration |
| PL1711513T3 (pl) * | 2003-12-01 | 2014-12-31 | Novo Nordisk Healthcare Ag | Nanofiltracja roztworów czynnika vii w celu usunięcia wirusów |
| US20070049732A1 (en) * | 2005-09-01 | 2007-03-01 | Zurlo Eugene J | Ultra-high yield intravenous immune globulin preparation |
| EP2122367A2 (en) * | 2007-01-12 | 2009-11-25 | allprion AG | Method for removing prion protein |
| EP2249661B1 (en) | 2008-01-22 | 2018-05-16 | Multimerics APS | Products and methods to prevent infection |
| DE102021101099A1 (de) | 2020-03-24 | 2021-09-30 | Mecadi GmbH - Chemicals/ Processing | Verwendung und Verfahren zur Reduktion der Virus-, Bakterien- und/oder Pilzsporenbelastung oder anderen biologischen Kontaminationen in Gasen |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540573A (en) † | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| US4590002A (en) * | 1984-12-10 | 1986-05-20 | Ortho Diagnostic Systems, Inc. | Methods for preparation of highly purified, gamma globulins free of hepatitis-B-virus infectivity |
| EP0367840B1 (de) † | 1988-11-05 | 1993-02-03 | Octapharma AG | Verfahren zur Herstellung eines hochreinen, nicht infektiösen Antihämophiliefaktors mittels Chromatographie |
| AT402789B (de) * | 1991-03-25 | 1997-08-25 | Immuno Ag | Pharmazeutische präparation auf basis von plasmaproteinen |
-
1997
- 1997-06-13 AT AT0102997A patent/AT407159B/de not_active IP Right Cessation
-
1998
- 1998-06-10 CA CA002293401A patent/CA2293401C/en not_active Expired - Fee Related
- 1998-06-10 AT AT98925314T patent/ATE222778T1/de active
- 1998-06-10 EP EP00100420A patent/EP1004323A1/de not_active Withdrawn
- 1998-06-10 DK DK98925314.1T patent/DK0988063T4/da active
- 1998-06-10 WO PCT/AT1998/000143 patent/WO1998057672A2/de not_active Application Discontinuation
- 1998-06-10 EP EP98925314A patent/EP0988063B2/de not_active Expired - Lifetime
- 1998-06-10 AU AU77500/98A patent/AU726808B2/en not_active Expired
- 1998-06-10 ES ES98925314T patent/ES2181227T5/es not_active Expired - Lifetime
- 1998-06-10 DE DE59805324T patent/DE59805324D1/de not_active Expired - Lifetime
- 1998-06-10 PT PT98925314T patent/PT988063E/pt unknown
- 1998-06-10 SI SI9830257T patent/SI0988063T1/xx unknown
- 1998-06-10 SK SK1747-99A patent/SK174799A3/sk unknown
- 1998-06-10 BR BR9810098-0A patent/BR9810098A/pt not_active Application Discontinuation
- 1998-06-10 SK SK1752-99A patent/SK175299A3/sk unknown
- 1998-06-10 JP JP50339699A patent/JP2002505674A/ja active Pending
- 1998-06-10 HU HU0003610A patent/HUP0003610A3/hu unknown
-
1999
- 1999-05-28 AT AT0095299A patent/AT407744B/de not_active IP Right Cessation
- 1999-12-10 NO NO996118A patent/NO996118L/no not_active Application Discontinuation
- 1999-12-13 CZ CZ19994516A patent/CZ451699A3/cs unknown
-
2000
- 2000-07-12 NO NO20003584A patent/NO20003584D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1004323A1 (de) | 2000-05-31 |
| AT407159B (de) | 2001-01-25 |
| SK175299A3 (en) | 2000-07-11 |
| NO20003584D0 (no) | 2000-07-12 |
| EP0988063B1 (de) | 2002-08-28 |
| DK0988063T3 (da) | 2002-12-16 |
| DK0988063T4 (da) | 2010-12-06 |
| HUP0003610A3 (en) | 2002-09-30 |
| ATE222778T1 (de) | 2002-09-15 |
| HUP0003610A1 (hu) | 2001-02-28 |
| CA2293401A1 (en) | 1998-12-23 |
| ES2181227T5 (es) | 2011-01-12 |
| NO996118D0 (no) | 1999-12-10 |
| NO20003584L (no) | 2000-02-10 |
| AU7750098A (en) | 1999-01-04 |
| PT988063E (pt) | 2002-12-31 |
| ES2181227T3 (es) | 2003-02-16 |
| EP0988063A2 (de) | 2000-03-29 |
| NO996118L (no) | 2000-02-10 |
| ATA102997A (de) | 2000-05-15 |
| WO1998057672A2 (de) | 1998-12-23 |
| CZ451699A3 (cs) | 2000-05-17 |
| ATA95299A (de) | 2000-10-15 |
| SI0988063T1 (en) | 2002-12-31 |
| CA2293401C (en) | 2005-11-08 |
| BR9810098A (pt) | 2000-08-08 |
| AT407744B (de) | 2001-05-25 |
| JP2002505674A (ja) | 2002-02-19 |
| WO1998057672A3 (de) | 1999-03-18 |
| EP0988063B2 (de) | 2010-08-11 |
| AU726808B2 (en) | 2000-11-23 |
| DE59805324D1 (de) | 2002-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2337109C2 (ru) | ПРЕПАРАТ ИММУНОГЛОБУЛИНА IgG И СПОСОБ ЕГО ПОЛУЧЕНИЯ | |
| US5886154A (en) | Chromatographic method for high yield purification and viral inactivation of antibodies | |
| Yap | The viral safety of intravenous immune globulin | |
| JPH0578532B2 (ja) | ||
| SK582002A3 (en) | Process for the production of human gammaglobulin g and virus-inactivated human gammaglobulin g | |
| US5041537A (en) | Method of preparing a high-purity, virus safe, biologically active transferrin preparation | |
| US6465170B2 (en) | Method for depleting viral and molecular pathogens in a biological material | |
| JP2506370B2 (ja) | 増殖性濾過性病原体の不活化法 | |
| SK174799A3 (en) | Process for reducing the concentration of viral and molecular pathogens in a biological material | |
| FI95778B (fi) | Menetelmä taudinaiheuttajien inaktivoimiseksi biologisessa tai farmaseuttisessa aineessa | |
| EP0771567B1 (en) | A method of inactivating viruses in proteins | |
| JP3735137B2 (ja) | 生物学的活性なタンパク質の溶液における殺ウイルス剤としてのアゾールの使用 | |
| AU3537100A (en) | Process for the inactivation of viruses | |
| AU726999B2 (en) | Process for reducing the concentration of viral and molecular pathogens in a biological material | |
| CZ451599A3 (cs) | Způsob snížení obsahu virálních a molekulárních patogenů z biologického materiálu | |
| EP0973543B1 (de) | Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material | |
| MXPA99011516A (en) | Process for reducing the concentration of viral and molecular pathogens in a biological material | |
| Burnouf et al. | Strategy of virus removal/inactivation of plasma-derived products: Interest of nanofiltration as a new virus elimination method | |
| WO1998009660A1 (en) | Viral inactivation of biological fluids with biomolecule activity retention |