SK15832003A3 - Tekutý polymérny prostriedok na prevenciu a liečbu chorôb ústnej dutiny - Google Patents
Tekutý polymérny prostriedok na prevenciu a liečbu chorôb ústnej dutiny Download PDFInfo
- Publication number
- SK15832003A3 SK15832003A3 SK1583-2003A SK15832003A SK15832003A3 SK 15832003 A3 SK15832003 A3 SK 15832003A3 SK 15832003 A SK15832003 A SK 15832003A SK 15832003 A3 SK15832003 A3 SK 15832003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- therapeutic agent
- eudragit
- composition
- polymeric material
- sodium
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 229920000642 polymer Polymers 0.000 title claims abstract description 25
- 239000007788 liquid Substances 0.000 title claims abstract description 17
- 201000010099 disease Diseases 0.000 title claims abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 9
- 210000000214 mouth Anatomy 0.000 title claims description 6
- 230000002265 prevention Effects 0.000 title claims description 3
- 239000003814 drug Substances 0.000 claims abstract description 65
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 18
- 229920003134 Eudragit® polymer Polymers 0.000 claims abstract description 16
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229920001577 copolymer Polymers 0.000 claims abstract description 10
- 230000001476 alcoholic effect Effects 0.000 claims abstract description 4
- 229920003159 Eudragit® RS 100 Polymers 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 12
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 12
- 229920003155 Eudragit® RL 100 Polymers 0.000 claims description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 11
- 239000003242 anti bacterial agent Substances 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 8
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 8
- 229940083542 sodium Drugs 0.000 claims description 6
- 239000011592 zinc chloride Substances 0.000 claims description 6
- 235000005074 zinc chloride Nutrition 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- LIRCDOVJWUGTMW-ZWNOBZJWSA-N Chloramphenicol succinate Chemical compound OC(=O)CCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 LIRCDOVJWUGTMW-ZWNOBZJWSA-N 0.000 claims description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- 210000004268 dentin Anatomy 0.000 claims description 4
- 239000011698 potassium fluoride Substances 0.000 claims description 4
- 235000003270 potassium fluoride Nutrition 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229960002798 cetrimide Drugs 0.000 claims description 3
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 208000004898 Herpes Labialis Diseases 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- 206010067152 Oral herpes Diseases 0.000 claims description 2
- 229960004150 aciclovir Drugs 0.000 claims description 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims description 2
- 229960003805 amantadine Drugs 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 2
- 229920000249 biocompatible polymer Polymers 0.000 claims description 2
- 229960000717 carindacillin Drugs 0.000 claims description 2
- JIRBAUWICKGBFE-MNRDOXJOSA-N carindacillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(=O)OC=1C=C2CCCC2=CC=1)C1=CC=CC=C1 JIRBAUWICKGBFE-MNRDOXJOSA-N 0.000 claims description 2
- 229960002579 chloramphenicol sodium succinate Drugs 0.000 claims description 2
- 229960004357 chloramphenicol succinate Drugs 0.000 claims description 2
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- 229960004716 idoxuridine Drugs 0.000 claims description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
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- 229940013553 strontium chloride Drugs 0.000 claims description 2
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 2
- 229940047908 strontium chloride hexahydrate Drugs 0.000 claims description 2
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 2
- 159000000008 strontium salts Chemical class 0.000 claims description 2
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- ZXBDZLHAHGPXIG-VTXLJDRKSA-N (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;(2r,3 Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ZXBDZLHAHGPXIG-VTXLJDRKSA-N 0.000 claims 1
- OBFSQMXGZIYMMN-UHFFFAOYSA-N 3-chloro-2-hexadecylpyridine Chemical compound CCCCCCCCCCCCCCCCC1=NC=CC=C1Cl OBFSQMXGZIYMMN-UHFFFAOYSA-N 0.000 claims 1
- 229910021627 Tin(IV) chloride Inorganic materials 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
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- OTEANHMVDHZOPB-SLINCCQESA-M flucloxacillin sodium Chemical compound [Na+].N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C([O-])=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl OTEANHMVDHZOPB-SLINCCQESA-M 0.000 claims 1
- POUMFISTNHIPTI-BOMBIWCESA-N hydron;(2s,4r)-n-[(1r,2r)-2-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;chloride Chemical compound Cl.CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 POUMFISTNHIPTI-BOMBIWCESA-N 0.000 claims 1
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- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- SCLZRKVZRBKZCR-SLINCCQESA-M cloxacillin sodium Chemical compound [Na+].N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C([O-])=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl SCLZRKVZRBKZCR-SLINCCQESA-M 0.000 description 1
- 229960003026 cloxacillin sodium Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical class CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229960001731 gluceptate Drugs 0.000 description 1
- KWMLJOLKUYYJFJ-VFUOTHLCSA-N glucoheptonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O KWMLJOLKUYYJFJ-VFUOTHLCSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 description 1
- 238000012148 non-surgical treatment Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 201000006727 periodontosis Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000004848 polyfunctional curative Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112751A EP1262172A1 (fr) | 2001-05-25 | 2001-05-25 | Composition polymère liquide pour prevenir et traiter des maladies de la cavité orale |
| PCT/EP2002/005728 WO2002098464A2 (fr) | 2001-05-25 | 2002-05-24 | Composition polymere liquide destinee a la prevention et au traitement des affections de la cavite buccale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK15832003A3 true SK15832003A3 (sk) | 2004-08-03 |
Family
ID=8177549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1583-2003A SK15832003A3 (sk) | 2001-05-25 | 2002-05-24 | Tekutý polymérny prostriedok na prevenciu a liečbu chorôb ústnej dutiny |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040126333A1 (fr) |
| EP (2) | EP1262172A1 (fr) |
| AT (1) | ATE533511T1 (fr) |
| BG (1) | BG108480A (fr) |
| CZ (1) | CZ20033541A3 (fr) |
| HR (1) | HRP20031016A2 (fr) |
| HU (1) | HUP0401308A2 (fr) |
| PL (1) | PL366903A1 (fr) |
| RU (1) | RU2301056C2 (fr) |
| SK (1) | SK15832003A3 (fr) |
| UA (1) | UA79091C2 (fr) |
| WO (1) | WO2002098464A2 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005050654A1 (de) * | 2005-10-20 | 2007-04-26 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Lippenpflaster |
| CN103463096B (zh) * | 2006-01-27 | 2016-03-16 | 耶鲁大学 | 胃酸分泌的快速作用抑制剂 |
| US8512761B2 (en) | 2006-01-27 | 2013-08-20 | Yale University | Fast acting inhibitor of gastric acid secretion |
| WO2009098531A1 (fr) * | 2008-02-07 | 2009-08-13 | Italmed S.R.L. | Composition dentaire pour la désensibilisation et la désinfection de la dentine exposée |
| ITPI20080025A1 (it) * | 2008-03-31 | 2009-10-01 | Italmed S R L | Composizione ad uso odontoiatrico per il trattamento delle perimplantiti |
| US9504698B2 (en) | 2009-10-29 | 2016-11-29 | Warsaw Orthopedic, Inc. | Flowable composition that sets to a substantially non-flowable state |
| CN103764230A (zh) * | 2010-04-21 | 2014-04-30 | 迪斯卡斯牙科有限责任公司 | 同时清洁和美白牙齿的方法 |
| US20150342839A1 (en) | 2010-04-21 | 2015-12-03 | Oraceutica LLC | Compositions and methods for whitening teeth |
| RU2427379C1 (ru) | 2010-09-20 | 2011-08-27 | Закрытое акционерное общество "Институт прикладной нанотехнологии" | Состав для профилактики и ухода за диабетической стопой |
| US8888489B2 (en) | 2012-10-23 | 2014-11-18 | Oraceutical Llc | Method of simultaneously cleaning and whitening teeth |
| US9549930B2 (en) | 2013-03-14 | 2017-01-24 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered and/or prodromal stage tissue |
| US9463180B2 (en) | 2013-03-14 | 2016-10-11 | Quadex Pharmaceuticals, Llc | Treatment of molluscum contagiosum |
| US9125911B2 (en) | 2013-03-14 | 2015-09-08 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered tissues |
| US9320580B2 (en) | 2013-04-21 | 2016-04-26 | Oraceutical Llc | Hand-held tooth whitening instrument with applicator reservoir for whitening composition and methods of using same |
| CN105530999B (zh) | 2013-09-11 | 2019-08-16 | 3M创新有限公司 | 口腔组合物、牙齿结构以及递送口腔组合物的方法 |
| CN105530998B (zh) * | 2013-09-11 | 2018-09-21 | 3M创新有限公司 | 口腔组合物 |
| CN105997847A (zh) * | 2016-06-24 | 2016-10-12 | 昆明悟真生物科技有限公司 | 一种抑菌凝胶 |
| RU2729058C2 (ru) * | 2018-08-23 | 2020-08-04 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Способ предупреждения развития вторичного кариеса |
| IT201900018752A1 (it) * | 2019-10-14 | 2021-04-14 | Alessandro Tosetti | Composizione a base di olii essenziali ad uso odontoiatrico per il trattamento della periodontite e della mucosite perimplantare |
| CN111841454B (zh) * | 2020-06-19 | 2022-07-05 | 山西振东泰盛制药有限公司 | 注射用氟氯西林钠凝胶微球、制备装置及其制备方法 |
| CN112076221B (zh) * | 2020-09-24 | 2022-02-22 | 四川天福精细化工有限公司 | 一种脱敏糊剂及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4701320A (en) * | 1984-11-29 | 1987-10-20 | Lederle (Japan), Ltd. | Composition stably containing minocycline for treating periodontal diseases |
| US5160737A (en) * | 1988-05-03 | 1992-11-03 | Perio Products Ltd. | Liquid polymer composition, and method of use |
| DE3822095A1 (de) * | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | Neue arzneimittelformulierung sowie verfahren zu deren herstellung |
| DE4125048A1 (de) * | 1991-07-29 | 1993-02-04 | Peggy Albrecht | Arzneimittel mit verzoegerter freisetzung zur behandlung von periodontitis |
| EP1021204B1 (fr) * | 1997-09-26 | 2005-12-28 | Noven Pharmaceuticals, Inc. | Compositions bioadhesives et methodes d'administration locale d'agents actifs |
| CN1320046A (zh) * | 1999-07-12 | 2001-10-31 | 三得利株式会社 | 局部给药的药用组合物 |
-
2001
- 2001-05-25 EP EP01112751A patent/EP1262172A1/fr not_active Withdrawn
-
2002
- 2002-05-24 AT AT02754586T patent/ATE533511T1/de active
- 2002-05-24 CZ CZ20033541A patent/CZ20033541A3/cs unknown
- 2002-05-24 UA UA20031210980A patent/UA79091C2/uk unknown
- 2002-05-24 EP EP02754586A patent/EP1392364B1/fr not_active Expired - Lifetime
- 2002-05-24 HU HU0401308A patent/HUP0401308A2/hu unknown
- 2002-05-24 RU RU2003137568/15A patent/RU2301056C2/ru not_active IP Right Cessation
- 2002-05-24 PL PL02366903A patent/PL366903A1/xx not_active Application Discontinuation
- 2002-05-24 SK SK1583-2003A patent/SK15832003A3/sk not_active Application Discontinuation
- 2002-05-24 WO PCT/EP2002/005728 patent/WO2002098464A2/fr not_active Application Discontinuation
-
2003
- 2003-11-25 US US10/722,334 patent/US20040126333A1/en not_active Abandoned
- 2003-12-08 HR HR20031016A patent/HRP20031016A2/xx not_active Application Discontinuation
- 2003-12-19 BG BG108480A patent/BG108480A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2003137568A (ru) | 2005-06-10 |
| HUP0401308A2 (hu) | 2004-11-29 |
| UA79091C2 (en) | 2007-05-25 |
| EP1392364A2 (fr) | 2004-03-03 |
| US20040126333A1 (en) | 2004-07-01 |
| HRP20031016A2 (en) | 2005-10-31 |
| ATE533511T1 (de) | 2011-12-15 |
| EP1262172A1 (fr) | 2002-12-04 |
| CZ20033541A3 (cs) | 2004-05-12 |
| BG108480A (bg) | 2004-12-30 |
| RU2301056C2 (ru) | 2007-06-20 |
| WO2002098464A3 (fr) | 2003-03-20 |
| WO2002098464A2 (fr) | 2002-12-12 |
| PL366903A1 (en) | 2005-02-07 |
| EP1392364B1 (fr) | 2011-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC9A | Refused patent application |