SK13632001A3 - C10 karbonátom substituované taxány ako protinádorové činidlá - Google Patents

C10 karbonátom substituované taxány ako protinádorové činidlá Download PDF

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Publication number
SK13632001A3
SK13632001A3 SK1363-2001A SK13632001A SK13632001A3 SK 13632001 A3 SK13632001 A3 SK 13632001A3 SK 13632001 A SK13632001 A SK 13632001A SK 13632001 A3 SK13632001 A3 SK 13632001A3
Authority
SK
Slovakia
Prior art keywords
pyridyl
thienyl
taxane
furyl
coox
Prior art date
Application number
SK1363-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Robert A. Holton
Original Assignee
Florida State University Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University Research Foundation, Inc. filed Critical Florida State University Research Foundation, Inc.
Publication of SK13632001A3 publication Critical patent/SK13632001A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
SK1363-2001A 2000-02-02 2001-02-02 C10 karbonátom substituované taxány ako protinádorové činidlá SK13632001A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17968400P 2000-02-02 2000-02-02
PCT/US2001/003588 WO2001057031A1 (fr) 2000-02-02 2001-02-02 Taxanes a substitution carbonate en c10 utilisees comme agents antitumoraux

Publications (1)

Publication Number Publication Date
SK13632001A3 true SK13632001A3 (sk) 2002-06-04

Family

ID=22657547

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1363-2001A SK13632001A3 (sk) 2000-02-02 2001-02-02 C10 karbonátom substituované taxány ako protinádorové činidlá

Country Status (25)

Country Link
US (3) US6660866B2 (fr)
EP (1) EP1165550A1 (fr)
JP (1) JP2003522171A (fr)
KR (1) KR20010111582A (fr)
CN (1) CN1186340C (fr)
AU (1) AU782028B2 (fr)
BG (1) BG65298B1 (fr)
BR (1) BR0104779A (fr)
CA (1) CA2368151A1 (fr)
CZ (1) CZ20013405A3 (fr)
GE (1) GEP20043239B (fr)
HK (1) HK1053472A1 (fr)
HU (1) HUP0200759A3 (fr)
IL (1) IL145636A0 (fr)
MX (1) MXPA01009902A (fr)
NO (1) NO20014753L (fr)
NZ (1) NZ514074A (fr)
PL (1) PL350028A1 (fr)
RO (1) RO121269B1 (fr)
RU (1) RU2264400C2 (fr)
SK (1) SK13632001A3 (fr)
TR (1) TR200102855T1 (fr)
UA (1) UA75038C2 (fr)
WO (1) WO2001057031A1 (fr)
ZA (2) ZA200108058B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ514380A (en) * 2000-02-02 2005-03-24 Univ Florida State Res Found C7 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
SK13632001A3 (sk) 2000-02-02 2002-06-04 Florida State University Research Foundation, Inc. C10 karbonátom substituované taxány ako protinádorové činidlá
US6638973B2 (en) * 2000-02-02 2003-10-28 Fsu Research Foundation, Inc. Taxane formulations
CA2354478A1 (fr) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. Taxanes substitues avec un carbonate en c10
US20030082229A1 (en) * 2001-11-01 2003-05-01 Board Of Regents, The University Of Texas Systems Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
AU2006214498A1 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
US8242166B2 (en) * 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes

Family Cites Families (48)

* Cited by examiner, † Cited by third party
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
DK0552041T3 (da) 1992-01-15 2000-10-09 Squibb & Sons Inc Enzymatiske fremgangsmåder til spaltning af enantiomerblandinger af forbindelser, der er nyttige som mellemprodukter ved fr
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5698712A (en) 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
US5939561A (en) 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
FR2691460B1 (fr) 1992-05-21 1994-07-22 Rhone Poulenc Rorer Sa Nouveaux derives du taxane, leur preparation et les compositions qui les contiennent.
US5254580A (en) 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
CA2100808A1 (fr) 1992-10-01 1994-04-02 Vittorio Farina Desoxytaxols
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
DE4241664C2 (de) 1992-12-04 1995-04-06 Borus Spezialverfahren Elektronisches Lebensdetektionssystem
CA2109861C (fr) 1992-12-04 1999-03-16 Shu-Hui Chen Paclitaxels modifies en 6,7
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
EP0982302B1 (fr) 1993-06-11 2004-04-14 PHARMACIA & UPJOHN COMPANY Delta 6,7-taxols usage antineoplastique et compositions pharmaceutiques les contenant
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
CA2129288C (fr) 1993-08-17 2000-05-16 Jerzy Golik Esters phosphonooxymethyliques de derives de taxane
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
CA2162759A1 (fr) 1994-11-17 1996-05-18 Kenji Tsujihara Derives de la baccatine et methodes de preparation
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FR2732968B1 (fr) 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
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WO1997009979A1 (fr) 1995-09-13 1997-03-20 Florida State University Taxanes a effet radiosensibilisant et leurs preparations pharmaceutiques
FR2742751B1 (fr) 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EP0927175A4 (fr) 1996-05-06 2002-05-22 Univ Florida State 1-deoxy baccatine iii, 1-deoxy taxol, analogues de 1-deoxy taxol, et procedes de fabrication correspondants
JPH1045583A (ja) 1996-05-14 1998-02-17 Tanabe Seiyaku Co Ltd 医薬組成物
US6025385A (en) 1996-07-15 2000-02-15 Kabushiki Kaisha Yakult Honsha Taxane derivatives and drugs containing the same
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
JP2003026673A (ja) 1999-03-05 2003-01-29 Asahi Kasei Corp 骨形成促進剤
IL145635A0 (en) 2000-02-02 2002-06-30 Univ Florida State Res Found Taxane formulations having improved solubility
SK13632001A3 (sk) * 2000-02-02 2002-06-04 Florida State University Research Foundation, Inc. C10 karbonátom substituované taxány ako protinádorové činidlá

Also Published As

Publication number Publication date
NO20014753L (no) 2001-11-29
CN1429225A (zh) 2003-07-09
CZ20013405A3 (cs) 2002-03-13
US7056946B2 (en) 2006-06-06
BG105964A (en) 2002-08-30
KR20010111582A (ko) 2001-12-19
CN1186340C (zh) 2005-01-26
MXPA01009902A (es) 2003-07-28
HK1053472A1 (en) 2003-10-24
BR0104779A (pt) 2001-12-26
US7256213B2 (en) 2007-08-14
UA75038C2 (en) 2006-03-15
WO2001057031A1 (fr) 2001-08-09
US20060111401A1 (en) 2006-05-25
PL350028A1 (en) 2002-10-21
HUP0200759A3 (en) 2002-10-28
JP2003522171A (ja) 2003-07-22
NZ514074A (en) 2004-03-26
ZA200108058B (en) 2003-12-01
GEP20043239B (en) 2004-05-25
ZA200108054B (en) 2003-12-01
CA2368151A1 (fr) 2001-08-09
EP1165550A1 (fr) 2002-01-02
NO20014753D0 (no) 2001-10-01
US20040122055A1 (en) 2004-06-24
RO121269B1 (ro) 2007-02-28
RU2264400C2 (ru) 2005-11-20
US6660866B2 (en) 2003-12-09
HUP0200759A2 (hu) 2002-07-29
BG65298B1 (bg) 2007-12-28
US20030114493A1 (en) 2003-06-19
AU3330101A (en) 2001-08-14
IL145636A0 (en) 2002-06-30
TR200102855T1 (tr) 2002-06-21
AU782028B2 (en) 2005-06-30

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