SK119796A3 - Substituted azetidinone compounds useful as hypocholesterolemic agents - Google Patents

Substituted azetidinone compounds useful as hypocholesterolemic agents Download PDF

Info

Publication number
SK119796A3
SK119796A3 SK1197-96A SK119796A SK119796A3 SK 119796 A3 SK119796 A3 SK 119796A3 SK 119796 A SK119796 A SK 119796A SK 119796 A3 SK119796 A3 SK 119796A3
Authority
SK
Slovakia
Prior art keywords
aryl
lower alkyl
formula
substituted
azetidinone
Prior art date
Application number
SK1197-96A
Other languages
English (en)
Slovak (sk)
Inventor
Michael P Kirkup
Sundeep Dugar
Banderpalle B Shankar
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of SK119796A3 publication Critical patent/SK119796A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1197-96A 1994-03-25 1995-03-22 Substituted azetidinone compounds useful as hypocholesterolemic agents SK119796A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21849894A 1994-03-25 1994-03-25
PCT/US1995/003196 WO1995026334A1 (fr) 1994-03-25 1995-03-22 Composes d'azetidinone substituee utiles comme agents hypocholesterolemiques

Publications (1)

Publication Number Publication Date
SK119796A3 true SK119796A3 (en) 1997-05-07

Family

ID=22815366

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1197-96A SK119796A3 (en) 1994-03-25 1995-03-22 Substituted azetidinone compounds useful as hypocholesterolemic agents

Country Status (20)

Country Link
US (2) US5627176A (fr)
EP (1) EP0751934B1 (fr)
JP (1) JP3524927B2 (fr)
KR (1) KR100338171B1 (fr)
CN (1) CN1144522A (fr)
AT (1) ATE183738T1 (fr)
AU (1) AU686361B2 (fr)
CA (1) CA2186364C (fr)
CZ (1) CZ281596A3 (fr)
DE (1) DE69511687T2 (fr)
DK (1) DK0751934T3 (fr)
ES (1) ES2135050T3 (fr)
FI (1) FI963817A0 (fr)
GR (1) GR3031105T3 (fr)
HU (1) HU221309B1 (fr)
NO (1) NO964008L (fr)
NZ (1) NZ283528A (fr)
PL (1) PL316431A1 (fr)
SK (1) SK119796A3 (fr)
WO (1) WO1995026334A1 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5624920A (en) * 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
AU7472896A (en) * 1995-11-02 1997-05-22 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AU4343500A (en) 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
US6584357B1 (en) * 2000-10-17 2003-06-24 Sony Corporation Method and system for forming an acoustic signal from neural timing difference data
DE60106489T2 (de) * 2000-12-20 2005-10-13 Schering Corp. Zuckersubstituierte 2-azetidinone verwendbar als hypocholesterdenische arzneimittel
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1911462A3 (fr) 2001-01-26 2011-11-30 Schering Corporation Combinaisons comprenant un inhibiteur d'absorption de stérol
CA2434504A1 (fr) * 2001-01-26 2002-08-01 Teddy Kosoglou Combinaisons d'inhibiteur(s) de l'absorption des sterols et de modificateurs sanguins pour le traitement de troubles vasculaires
US7417039B2 (en) * 2001-01-26 2008-08-26 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
AU2005246926B2 (en) * 2001-01-26 2008-02-28 Merck Sharp & Dohme Corp. The use of substituted azetidinone compounds for the treatment of sitosterolemia
TWI337083B (en) * 2001-01-26 2011-02-11 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
CA2442219C (fr) 2001-03-28 2007-09-11 Schering Corporation Synthese enantioselective de composes intermediaires d'azetidinone
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
SI1429756T1 (sl) * 2001-09-21 2007-02-28 Schering Corp Zdravljenje ksantomov z azetidinonskimi derivati kot inhibitorji absorpcije sterola
ATE345793T1 (de) * 2001-09-21 2006-12-15 Schering Corp Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption
US20030204096A1 (en) * 2002-03-25 2003-10-30 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
US20040132058A1 (en) 2002-07-19 2004-07-08 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
ES2318274T3 (es) * 2003-03-07 2009-05-01 Schering Corporation Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia.
ATE406364T1 (de) * 2003-03-07 2008-09-15 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
JP2005015434A (ja) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1918000A2 (fr) 2003-11-05 2008-05-07 Schering Corporation Combinaisons d'agents de modulation lipide et azétidinones substitués et traitements pour conditions vasculaires
US20050096307A1 (en) * 2003-11-05 2005-05-05 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
CN100471835C (zh) * 2003-12-23 2009-03-25 默克公司 抗高胆固醇血症化合物
BRPI0418004A (pt) 2003-12-23 2007-04-17 Astrazeneca Ab composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis, métodos para tratar ou prevenir condições hiperlipidêmicas, aterosclerose, mal de alzheimer, e tumores associados com colesterol, formulação farmacêutica, combinação, e, processo para preparar um composto ou um sal, solvato, solvato de um tal sal ou uma pró-droga deste farmaceuticamente aceitáveis
JP4590417B2 (ja) * 2004-01-16 2010-12-01 メルク・シャープ・エンド・ドーム・コーポレイション Ｎｐｃ１ｌ１（ｎｐｃ３）およびこのリガンドの同定方法
EP1807070A1 (fr) * 2004-09-29 2007-07-18 Schering Corporation Combinaisons d'azetidinones substituees et d'antagonistes cb1
NZ555320A (en) 2004-12-03 2010-11-26 Schering Corp Substituted piperazines as CB1 antagonists
ES2337727T3 (es) * 2005-06-20 2010-04-28 Schering Corporation Derivados de piperidina utiles como antagonistas de histamina h3.
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
CA2637565A1 (fr) 2006-01-18 2007-07-26 Schering Corporation Modulateurs de recepteurs de cannibinoides
WO2007100807A2 (fr) 2006-02-24 2007-09-07 Schering Corporation Orthologues de npc1l1
CN101394837A (zh) * 2006-03-06 2009-03-25 特瓦制药工业有限公司 折替米贝组合物
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
WO2008108486A1 (fr) 2007-03-06 2008-09-12 Teijin Pharma Limited Dérivés de 1-biarylazétidinone
US20100197564A1 (en) * 2007-04-19 2010-08-05 Schering Corporation Diaryl morpholines as cb1 modulators
US20090047716A1 (en) * 2007-06-07 2009-02-19 Nurit Perlman Reduction processes for the preparation of ezetimibe
EP2548874A3 (fr) * 2007-06-28 2013-05-15 Intervet International B.V. Pipérazines substituées utilisées en tant qu'antagonistes CB1
JP2010531874A (ja) * 2007-06-28 2010-09-30 インターベット インターナショナル ベー． フェー． Ｃｂ１アンタゴニストとしての置換ピペラジン
US20090093627A1 (en) * 2007-08-30 2009-04-09 Lorand Szabo Process for preparing intermediates of ezetimibe by microbial reduction
CN101200443B (zh) * 2007-10-17 2011-06-29 中国药科大学 氮杂环丁酮衍生物、其制备方法及含有它们的药物组合
CA2754384A1 (fr) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Compositions pharmaceutiques hypocholesterolemiques
CN101993403B (zh) * 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
MX365046B (es) 2012-05-01 2019-05-17 Althera Life Sciencies Llc Formulacion de tableta oral que consiste de una combinacion fija de rosuvastatina y ezetimiba para el tratamiento de hiperlipidemia y enfermedades cardiovasculares.
JP5969958B2 (ja) * 2013-06-27 2016-08-17 国立大学法人お茶の水女子大学 光学活性含フッ素アミノ酸類の製造方法
CN105294426B (zh) 2014-06-09 2019-05-14 浙江海正药业股份有限公司 氮杂环丁酮化合物制备方法及其中间体
CN104860980B (zh) * 2015-04-23 2018-06-19 上海弈柯莱生物医药科技有限公司 一种用于合成依折麦布的中间体及其制备方法和应用
MX2019009213A (es) 2017-01-23 2019-09-27 Dong Wha Pharm Co Ltd Formulación compleja que comprende inhibidor de la hmg-coa reductasa y clopidogrel.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4803266A (en) * 1986-10-17 1989-02-07 Taisho Pharmaceutical Co., Ltd. 3-Oxoalkylidene-2-azetidinone derivatives
NZ228600A (en) * 1988-04-11 1992-02-25 Merck & Co Inc 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives
JPH02268144A (ja) * 1989-04-11 1990-11-01 Ube Ind Ltd β―アミノエステルの製造法
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5120729A (en) * 1990-06-20 1992-06-09 Merck & Co., Inc. Beta-lactams as antihypercholesterolemics
HUT67341A (en) * 1991-07-23 1995-03-28 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof

Also Published As

Publication number Publication date
KR970702246A (ko) 1997-05-13
EP0751934A1 (fr) 1997-01-08
DK0751934T3 (da) 1999-12-13
WO1995026334A1 (fr) 1995-10-05
JPH09510970A (ja) 1997-11-04
CA2186364A1 (fr) 1995-10-05
AU2159695A (en) 1995-10-17
DE69511687T2 (de) 2000-03-16
CZ281596A3 (en) 1997-05-14
US5627176A (en) 1997-05-06
FI963817A (fi) 1996-09-25
HUT74887A (en) 1997-02-28
AU686361B2 (en) 1998-02-05
CA2186364C (fr) 2008-12-30
NO964008L (no) 1996-11-22
DE69511687D1 (de) 1999-09-30
ATE183738T1 (de) 1999-09-15
HU9602616D0 (en) 1996-11-28
GR3031105T3 (en) 1999-12-31
NZ283528A (en) 1997-12-19
JP3524927B2 (ja) 2004-05-10
US5688990A (en) 1997-11-18
CN1144522A (zh) 1997-03-05
MX9604030A (es) 1997-09-30
PL316431A1 (en) 1997-01-06
KR100338171B1 (ko) 2002-11-23
EP0751934B1 (fr) 1999-08-25
FI963817A0 (fi) 1996-09-25
HU221309B1 (en) 2002-09-28
NO964008D0 (no) 1996-09-24
ES2135050T3 (es) 1999-10-16

Similar Documents

Publication Publication Date Title
SK119796A3 (en) Substituted azetidinone compounds useful as hypocholesterolemic agents
KR100235806B1 (ko) 저콜레스테롤혈증 치료제로서 유용한 황 치환된 아제티디논 화합물
US5624920A (en) Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
SK35596A3 (en) Hydroxy-substituted azetidinone compounds and their use as hypocholesterolemic agents
EP0681569B1 (fr) Azetidinones a substitution spirocycloalkyle utilisees comme agents hypocholesterolemiques
US5688785A (en) Substituted azetidinone compounds useful as hypocholesterolemic agents
CZ14294A3 (en) Substituted beta-lactam compounds usable as hypocholesterol pharmaceutical preparations and process for preparing thereof
EP0766667A1 (fr) Composes d'azetidinone substitues utilises comme agent hypercholesterolemiant
EA021484B1 (ru) Азетидиноновые соединения и медицинское применение указанных соединений
MXPA96004030A (en) Azetidinone compounds substituted useful as agents hipocolesterolemi