SK117597A3 - Water-based topical cream containing nitroglycerin; method of preparation and use thereof - Google Patents
Water-based topical cream containing nitroglycerin; method of preparation and use thereof Download PDFInfo
- Publication number
- SK117597A3 SK117597A3 SK1175-97A SK117597A SK117597A3 SK 117597 A3 SK117597 A3 SK 117597A3 SK 117597 A SK117597 A SK 117597A SK 117597 A3 SK117597 A3 SK 117597A3
- Authority
- SK
- Slovakia
- Prior art keywords
- cream
- topical
- water
- nitroglycerin
- amount
- Prior art date
Links
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 title claims abstract description 30
- 239000000006 Nitroglycerin Substances 0.000 title claims abstract description 28
- 229960003711 glyceryl trinitrate Drugs 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 26
- 229940100611 topical cream Drugs 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title description 9
- 239000006071 cream Substances 0.000 claims abstract description 47
- 201000001881 impotence Diseases 0.000 claims abstract description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 18
- 208000010228 Erectile Dysfunction Diseases 0.000 claims abstract description 15
- 201000010099 disease Diseases 0.000 claims abstract description 13
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 12
- 239000002562 thickening agent Substances 0.000 claims abstract description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 28
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 230000035515 penetration Effects 0.000 claims description 15
- 229920000609 methyl cellulose Polymers 0.000 claims description 11
- 239000001923 methylcellulose Substances 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 239000003205 fragrance Substances 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- -1 polyoxyethylene Polymers 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 206010052428 Wound Diseases 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 210000004392 genitalia Anatomy 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 208000002847 Surgical Wound Diseases 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 2
- 230000036961 partial effect Effects 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 210000001215 vagina Anatomy 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 208000037869 female anorgasmia Diseases 0.000 abstract description 8
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- 230000001568 sexual effect Effects 0.000 description 20
- 230000000699 topical effect Effects 0.000 description 14
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 10
- 210000003029 clitoris Anatomy 0.000 description 10
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 10
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 9
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 8
- 210000003899 penis Anatomy 0.000 description 8
- 239000004353 Polyethylene glycol 8000 Substances 0.000 description 7
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 7
- 229940085678 polyethylene glycol 8000 Drugs 0.000 description 7
- 235000019446 polyethylene glycol 8000 Nutrition 0.000 description 7
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 6
- 229910021538 borax Inorganic materials 0.000 description 6
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 6
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 235000010339 sodium tetraborate Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000004936 stimulating effect Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 6
- 230000037007 arousal Effects 0.000 description 5
- 238000004040 coloring Methods 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 5
- JKXYOQDLERSFPT-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO JKXYOQDLERSFPT-UHFFFAOYSA-N 0.000 description 4
- 206010002652 Anorgasmia Diseases 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
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- 230000007794 irritation Effects 0.000 description 4
- 239000002550 vasoactive agent Substances 0.000 description 4
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 3
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 3
- 201000001880 Sexual dysfunction Diseases 0.000 description 3
- 230000001856 erectile effect Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 210000000578 peripheral nerve Anatomy 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229940099429 polyoxyl 40 stearate Drugs 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 238000011471 prostatectomy Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 229940124549 vasodilator Drugs 0.000 description 3
- 239000003071 vasodilator agent Substances 0.000 description 3
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 229940030600 antihypertensive agent Drugs 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 229960001747 cinchocaine Drugs 0.000 description 2
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 208000003532 hypothyroidism Diseases 0.000 description 2
- 230000002989 hypothyroidism Effects 0.000 description 2
- 238000009802 hysterectomy Methods 0.000 description 2
- 229960003639 laurocapram Drugs 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 229940100615 topical ointment Drugs 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 230000024883 vasodilation Effects 0.000 description 2
- ZMFYVHJRZFYCRL-UHFFFAOYSA-N 1,3-dinitrooxypropan-2-yl nitrate hydrate Chemical compound O.[O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O ZMFYVHJRZFYCRL-UHFFFAOYSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010065558 Aortic arteriosclerosis Diseases 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010021067 Hypopituitarism Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
- 206010061533 Myotonia Diseases 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 206010061538 Pituitary tumour benign Diseases 0.000 description 1
- 206010040483 Sexual inhibition Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 208000007474 aortic aneurysm Diseases 0.000 description 1
- 201000001962 aortic atherosclerosis Diseases 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000007211 cardiovascular event Effects 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 125000006159 dianhydride group Chemical group 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 208000031424 hyperprolactinemia Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007926 intracavernous injection Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229940059904 light mineral oil Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 210000001577 neostriatum Anatomy 0.000 description 1
- 230000001272 neurogenic effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 description 1
- 229960001999 phentolamine Drugs 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- LLSAJKYQVXGWEE-UHFFFAOYSA-N propane-1,2,3-triol;propan-2-yl hexadecanoate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(=O)OC(C)C LLSAJKYQVXGWEE-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 230000009329 sexual behaviour Effects 0.000 description 1
- 231100000872 sexual dysfunction Toxicity 0.000 description 1
- 230000036332 sexual response Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000000050 smooth muscle relaxant Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- OJWJPGKJNYPFRX-UHFFFAOYSA-N trisodium 2-[bis(2-hydroxyethyl)amino]ethanol borate Chemical compound N(CCO)(CCO)CCO.B([O-])([O-])[O-].[Na+].[Na+].[Na+] OJWJPGKJNYPFRX-UHFFFAOYSA-N 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39887295A | 1995-03-06 | 1995-03-06 | |
| US08/594,304 US5698589A (en) | 1993-06-01 | 1996-01-30 | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| PCT/US1996/002989 WO1996027372A1 (en) | 1995-03-06 | 1996-03-05 | Water-based topical cream containing nitroglycerin; method of preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK117597A3 true SK117597A3 (en) | 1998-01-14 |
Family
ID=27016409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1175-97A SK117597A3 (en) | 1995-03-06 | 1996-03-05 | Water-based topical cream containing nitroglycerin; method of preparation and use thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5698589A (ru) |
| EP (1) | EP0814800B1 (ru) |
| JP (1) | JPH11501629A (ru) |
| KR (1) | KR19980702766A (ru) |
| CN (1) | CN1139380C (ru) |
| AP (1) | AP691A (ru) |
| AT (1) | ATE209895T1 (ru) |
| AU (1) | AU701328B2 (ru) |
| BR (1) | BR9607974A (ru) |
| CZ (1) | CZ281897A3 (ru) |
| DE (1) | DE69617654T2 (ru) |
| EA (1) | EA000566B1 (ru) |
| HK (1) | HK1005359A1 (ru) |
| HU (1) | HUP9801234A3 (ru) |
| NO (1) | NO974075L (ru) |
| NZ (1) | NZ305095A (ru) |
| OA (1) | OA10504A (ru) |
| PL (1) | PL322110A1 (ru) |
| SI (1) | SI9620038A (ru) |
| SK (1) | SK117597A3 (ru) |
| TR (1) | TR199700909T1 (ru) |
| WO (1) | WO1996027372A1 (ru) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
| US6294517B1 (en) | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
| US6323211B1 (en) | 1996-02-02 | 2001-11-27 | Nitromed, Inc. | Compositions and methods for treating sexual dysfunctions |
| US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
| US20020143007A1 (en) * | 1996-02-02 | 2002-10-03 | Garvey David S. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
| US6469065B1 (en) | 1996-02-02 | 2002-10-22 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use |
| USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| GB2325855B (en) * | 1997-06-04 | 2001-08-29 | Healthscene Ltd | Preparation for topical application to the male sexual organ |
| EP1535611A3 (en) * | 1997-06-23 | 2009-09-16 | Strakan International Limited | Microdose therapy of vascular conditions by no donors |
| EP0998274B1 (en) | 1997-06-23 | 2006-01-18 | Cellegy Pharmaceuticals, Inc | Microdose therapy of vascular conditions by no donors |
| WO1999002147A1 (en) | 1997-07-09 | 1999-01-21 | Androsolutions, Inc. | Improved methods and compositions for treating male erectile dysfunction |
| US6103765A (en) | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
| US6593369B2 (en) | 1997-10-20 | 2003-07-15 | Vivus, Inc. | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
| US20050070516A1 (en) * | 1997-10-28 | 2005-03-31 | Vivus Inc. | As-needed administration of an androgenic agent to enhance female desire and responsiveness |
| WO1999021562A1 (en) | 1997-10-28 | 1999-05-06 | Asivi, Llc | Treatment of female sexual dysfunction |
| US20040014761A1 (en) * | 1997-10-28 | 2004-01-22 | Place Virgil A. | Treatment of female sexual dysfunction with phosphodiesterase inhibitors |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| GB9802078D0 (en) * | 1998-01-30 | 1998-03-25 | Futura Medical Limited | Preparation for treatment of erectile dysfunction |
| WO1999062533A1 (en) * | 1998-06-04 | 1999-12-09 | Jedco Products, Llc | Preparation for topical application to the male sexual organ |
| US7087240B1 (en) | 1998-06-25 | 2006-08-08 | Lavipharm Laboratories Inc. | Device and method for the treatment of erectile dysfunction |
| GB9818524D0 (en) * | 1998-08-25 | 1998-10-21 | Futura Medical Limited | Inorgasmia treatment |
| IT1303793B1 (it) * | 1998-11-27 | 2001-02-23 | Promefarm S R L | "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)" |
| US6825234B2 (en) | 1998-12-10 | 2004-11-30 | Nexmed (Holdings) , Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| US6486207B2 (en) | 1998-12-10 | 2002-11-26 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
| AU2001261244B2 (en) * | 2000-05-09 | 2006-08-03 | Nitromed, Inc. | Infrared thermography and methods of use |
| KR100452972B1 (ko) | 2000-05-16 | 2004-10-14 | 주식회사 삼양사 | 경피투여용 하이드로젤 조성물 |
| ATE369868T1 (de) * | 2000-06-27 | 2007-09-15 | Qualilife Pharmaceuticals Inc | Zusammensetzungen und verfahren zur behandlung der weiblichen sexuellen reaktion |
| HUP0002628A2 (en) * | 2000-07-14 | 2002-06-29 | Keri Pharma Kft | Pharmaceutical combinations for treating diabetes |
| US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| TR200300776T2 (tr) * | 2000-08-30 | 2005-10-21 | Unimed Pharmaceuticals, Inc. | Erkeklerde cinsel organ sertleşmemesinin tedavi edilmesi ve libidonun arttırılması için yöntem. |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| CA2440141A1 (en) * | 2001-03-06 | 2002-09-12 | Cellegy Pharmaceuticals, Inc. | Compounds and methods for the treatment of urogenital disorders |
| JP2003040763A (ja) * | 2001-05-23 | 2003-02-13 | Taisho Pharmaceut Co Ltd | 多価アルコール含有軟膏剤基剤 |
| SE0103528D0 (sv) * | 2001-10-21 | 2001-10-21 | Jan Faergeman | Topiska kompositioner med förstärkt effekt |
| KR20040082431A (ko) * | 2002-02-15 | 2004-09-24 | 넥스메드 홀딩스 인코포레이티드 | 발기기능장애를 치료하기 위한 프로스타글란딘 조성물 |
| AR036970A1 (es) * | 2002-03-15 | 2004-10-20 | Unimed Pharmaceuticals Inc | Composicion farmaceutica androgenica y metodo para el tratamiento de la depresion |
| KR20050074896A (ko) * | 2002-03-15 | 2005-07-19 | 유니메드 파마슈티칼스, 인크. | 우울증 치료용 안드로겐 제약 조성물 및 방법 |
| US8012472B2 (en) * | 2002-12-23 | 2011-09-06 | William Marsh Rice University | Compositions and methods for suppressing fibrocytes |
| JP4819364B2 (ja) * | 2002-12-23 | 2011-11-24 | ウイリアム、マーシュ、ライス、ユーニヴァーサティ | 線維細胞形成阻害の検出方法、ならびに線維細胞形成を増強する方法および化合物 |
| US7763256B2 (en) * | 2002-12-23 | 2010-07-27 | William Marsh Rice University | Compositions and methods for suppressing fibrocytes and for detecting fibrocyte differentiation |
| US20100297074A1 (en) * | 2002-12-23 | 2010-11-25 | Richard Hans Gomer | Wound healing compositions, systems, and methods |
| US20050031699A1 (en) | 2003-06-26 | 2005-02-10 | L'oreal | Porous particles loaded with cosmetically or pharmaceutically active compounds |
| GB0417675D0 (en) * | 2004-08-09 | 2004-09-08 | Futura Medical Dev Ltd | Composition for promoting vascular smooth muscle relaxation |
| US7740875B2 (en) * | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| US20060078580A1 (en) * | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| AU2005307736A1 (en) * | 2004-11-17 | 2006-05-26 | Lindsey Berkson | Composition and method for facilitating the healing of non-healing and slow-healing wounds and ulcerations |
| US20060127483A1 (en) * | 2004-12-10 | 2006-06-15 | Alan Drizen | Topical drug delivery system |
| GB0602224D0 (en) * | 2006-02-03 | 2006-03-15 | Futura Medical Dev Ltd | Composition for promoting vascular smooth muscle relaxation |
| US8247370B2 (en) * | 2006-12-04 | 2012-08-21 | Promedior, Inc. | Conjoint therapy for treating fibrotic diseases |
| US9884899B2 (en) * | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
| US8497243B2 (en) * | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
| HU227970B1 (en) * | 2007-07-10 | 2012-07-30 | Egis Gyogyszergyar Nyrt | Pharmaceutical compositions containing silicones of high volatility |
| DE202008007318U1 (de) * | 2008-03-14 | 2008-07-31 | G. Pohl-Boskamp Gmbh & Co. Kg | Langzeitstabile pharmazeutische Zubereitung mit dem Wirkstoff Glyceroltrinitrat |
| US20100263675A1 (en) * | 2009-04-21 | 2010-10-21 | Ansell Healthcare Products Llc | Condom with Localized Active Agent |
| US20100035929A1 (en) * | 2008-06-09 | 2010-02-11 | Lindsley Craig W | Unnatural dispyrin analogues, preparation and uses thereof |
| WO2010011650A1 (en) * | 2008-07-21 | 2010-01-28 | Imi International Medical Innovations (D/B/A Procris Pharmaceuticals) | Stable water-based topical pharmaceutical creams and methods of making and using same |
| WO2010057117A2 (en) * | 2008-11-14 | 2010-05-20 | Helm Pharmaceuticals, Inc. | Topical transdermal drug delivery compositions |
| JP5797565B2 (ja) * | 2009-03-11 | 2015-10-21 | プロメディオール， インコーポレイテッド | 過敏性障害（ｈｙｐｅｒｓｅｎｓｉｔｉｖｅ ｄｉｓｏｒｄｅｒ）に対する処置および診断方法 |
| CA2755047C (en) * | 2009-03-11 | 2018-12-04 | Promedior, Inc. | Treatment methods for autoimmune disorders |
| UA110323C2 (en) * | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
| ES2552793T3 (es) | 2009-06-17 | 2015-12-02 | Promedior Inc. | Variantes de SAP y su uso |
| WO2011057386A1 (en) * | 2009-11-13 | 2011-05-19 | Oral Delivery Technology Ltd. | Composition and prophylactic device for enhancing sexual performance or pleasure |
| EP2600837A1 (en) | 2010-08-03 | 2013-06-12 | G. Pohl-Boskamp GmbH & Co. KG | Use of glyceryl trinitrate for treating hematomas |
| PL2678000T3 (pl) | 2011-02-25 | 2018-08-31 | G. Pohl-Boskamp Gmbh & Co. Kg | Stabilizowane granulaty zawierające triazotan glicerolu |
| PL2668947T3 (pl) | 2012-05-31 | 2017-06-30 | G. Pohl-Boskamp Gmbh & Co. Kg | Indukcja arteriogenezy donorem NO, takim jak nitrogliceryna |
| US9248099B2 (en) | 2012-05-31 | 2016-02-02 | Desmoid Aktiengesellschaft | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| US11154535B2 (en) | 2012-07-31 | 2021-10-26 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| US10045935B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| US10045965B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| EP2878310B1 (en) | 2013-11-29 | 2017-01-11 | G. Pohl-Boskamp GmbH & Co. KG | Sprayable aqueous composition comprising glyceryl trinitrate |
| JP2021506958A (ja) | 2017-12-13 | 2021-02-22 | オンクォリティ ファーマシューティカルズ チャイナ エルティーディーＯｎｑｕａｌｉｔｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｈｉｎａ Ｌｔｄ． | Ｅｇｆｒ阻害に関連する疾患を予防又は治療する方法 |
| AU2019254237A1 (en) | 2018-04-16 | 2020-12-03 | Onquality Pharmaceuticals China Ltd. | Method for preventing or treating side effects of cancer therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1163561A (en) * | 1979-11-06 | 1984-03-13 | Cyril Boroda | Preparation containing nitroglycerine and optionally other medicaments and preparation thereof |
| US4336243A (en) * | 1980-08-11 | 1982-06-22 | G. D. Searle & Co. | Transdermal nitroglycerin pad |
| US4521421A (en) * | 1983-09-26 | 1985-06-04 | Eli Lilly And Company | Treatment of sexual dysfunction |
| US5204339A (en) * | 1986-01-31 | 1993-04-20 | Whitby Research, Inc. | Penetration enhancers for transdermal delivery of systemic agents |
| US4801587A (en) * | 1987-03-02 | 1989-01-31 | Gene Voss | Impotence ointment |
| US5001151A (en) * | 1987-08-11 | 1991-03-19 | Fujisawa Usa, Inc. | Aqueous nitroglycerin injection and manufacturing process |
| US5256652A (en) * | 1987-11-12 | 1993-10-26 | Pharmedic Co. | Topical compositions and methods for treatment of male impotence |
| SE463851B (sv) * | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| US5059603A (en) * | 1989-06-12 | 1991-10-22 | Centuries Laboratories, Inc. | Method and composition for treating impotence |
| US5262165A (en) * | 1992-02-04 | 1993-11-16 | Schering Corporation | Transdermal nitroglycerin patch with penetration enhancers |
| US5242391A (en) * | 1990-04-25 | 1993-09-07 | Alza Corporation | Urethral insert for treatment of erectile dysfunction |
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
-
1996
- 1996-01-30 US US08/594,304 patent/US5698589A/en not_active Expired - Lifetime
- 1996-03-05 TR TR97/00909T patent/TR199700909T1/xx unknown
- 1996-03-05 AP APAP/P/1997/001068A patent/AP691A/en active
- 1996-03-05 AT AT96909577T patent/ATE209895T1/de not_active IP Right Cessation
- 1996-03-05 SI SI9620038A patent/SI9620038A/sl unknown
- 1996-03-05 WO PCT/US1996/002989 patent/WO1996027372A1/en not_active Application Discontinuation
- 1996-03-05 NZ NZ305095A patent/NZ305095A/en not_active IP Right Cessation
- 1996-03-05 PL PL96322110A patent/PL322110A1/xx unknown
- 1996-03-05 JP JP8527007A patent/JPH11501629A/ja active Pending
- 1996-03-05 CZ CZ972818A patent/CZ281897A3/cs unknown
- 1996-03-05 KR KR1019970706173A patent/KR19980702766A/ko not_active Application Discontinuation
- 1996-03-05 SK SK1175-97A patent/SK117597A3/sk unknown
- 1996-03-05 DE DE69617654T patent/DE69617654T2/de not_active Expired - Lifetime
- 1996-03-05 EA EA199700213A patent/EA000566B1/ru not_active IP Right Cessation
- 1996-03-05 CN CNB961922737A patent/CN1139380C/zh not_active Expired - Fee Related
- 1996-03-05 EP EP96909577A patent/EP0814800B1/en not_active Expired - Lifetime
- 1996-03-05 BR BR9607974A patent/BR9607974A/pt not_active Application Discontinuation
- 1996-03-05 AU AU53025/96A patent/AU701328B2/en not_active Ceased
- 1996-03-05 HU HU9801234A patent/HUP9801234A3/hu unknown
-
1997
- 1997-08-29 OA OA70069A patent/OA10504A/en unknown
- 1997-09-04 NO NO974075A patent/NO974075L/no not_active Application Discontinuation
-
1998
- 1998-05-27 HK HK98104556A patent/HK1005359A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE209895T1 (de) | 2001-12-15 |
| EA199700213A1 (ru) | 1998-02-26 |
| OA10504A (en) | 2002-04-24 |
| AP9701068A0 (en) | 1997-10-31 |
| NO974075L (no) | 1997-10-27 |
| WO1996027372A1 (en) | 1996-09-12 |
| AU5302596A (en) | 1996-09-23 |
| EP0814800A4 (en) | 1998-07-01 |
| DE69617654D1 (de) | 2002-01-17 |
| PL322110A1 (en) | 1998-01-05 |
| EP0814800A1 (en) | 1998-01-07 |
| HUP9801234A3 (en) | 2000-07-28 |
| EA000566B1 (ru) | 1999-12-29 |
| TR199700909T1 (xx) | 1998-02-21 |
| AU701328B2 (en) | 1999-01-28 |
| SI9620038A (sl) | 1998-04-30 |
| US5698589A (en) | 1997-12-16 |
| AP691A (en) | 1998-10-12 |
| EP0814800B1 (en) | 2001-12-05 |
| KR19980702766A (ko) | 1998-08-05 |
| DE69617654T2 (de) | 2002-08-08 |
| HUP9801234A2 (hu) | 1999-01-28 |
| CN1139380C (zh) | 2004-02-25 |
| BR9607974A (pt) | 1998-01-13 |
| JPH11501629A (ja) | 1999-02-09 |
| CN1177294A (zh) | 1998-03-25 |
| CZ281897A3 (en) | 1997-12-17 |
| HK1005359A1 (en) | 1999-01-08 |
| NZ305095A (en) | 2005-05-27 |
| NO974075D0 (no) | 1997-09-04 |
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