SK117392A3 - Rapamycin derivatives and pharmaceutical agents containing them - Google Patents
Rapamycin derivatives and pharmaceutical agents containing them Download PDFInfo
- Publication number
- SK117392A3 SK117392A3 SK1173-92A SK117392A SK117392A3 SK 117392 A3 SK117392 A3 SK 117392A3 SK 117392 A SK117392 A SK 117392A SK 117392 A3 SK117392 A3 SK 117392A3
- Authority
- SK
- Slovakia
- Prior art keywords
- rapamycin
- carbon atoms
- ester
- carbamic acid
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/686,728 US5118678A (en) | 1991-04-17 | 1991-04-17 | Carbamates of rapamycin |
US07/837,048 US5194447A (en) | 1992-02-18 | 1992-02-18 | Sulfonylcarbamates of rapamycin |
Publications (1)
Publication Number | Publication Date |
---|---|
SK117392A3 true SK117392A3 (en) | 1995-04-12 |
Family
ID=27103855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1173-92A SK117392A3 (en) | 1991-04-17 | 1992-04-16 | Rapamycin derivatives and pharmaceutical agents containing them |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0509795A2 (no) |
JP (1) | JPH05112573A (no) |
KR (1) | KR920019798A (no) |
AU (1) | AU642592B2 (no) |
CZ (1) | CZ117392A3 (no) |
FI (1) | FI921595A (no) |
HU (1) | HU9201254D0 (no) |
IE (1) | IE921249A1 (no) |
MX (1) | MX9201710A (no) |
NO (1) | NO921449L (no) |
NZ (1) | NZ242367A (no) |
SK (1) | SK117392A3 (no) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5776943A (en) * | 1991-05-14 | 1998-07-07 | American Home Products Corporation | Rapamycin metabolites |
US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
MX9301188A (es) * | 1992-03-05 | 1994-07-29 | American Home Prod | Nuevos sulfonatos y 42-(n-carboalcoxi)sulfamatos en posicion 42 de la rapamicina, procedimiento para su preparacion y composicion farmaceutica que los comprende. |
GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
EP0729471A1 (en) * | 1993-11-19 | 1996-09-04 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
WO2000041698A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
AU6643200A (en) * | 1999-08-18 | 2001-03-13 | American Home Products Corporation | Water soluble sdz-rad esters |
EP1478358B1 (en) | 2002-02-11 | 2013-07-03 | Bayer HealthCare LLC | Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
EP1626714B1 (en) | 2003-05-20 | 2007-07-04 | Bayer Pharmaceuticals Corporation | Diaryl ureas for diseases mediated by pdgfr |
SI1663978T1 (sl) | 2003-07-23 | 2008-02-29 | Bayer Pharmaceuticals Corp | Fluoro substituirana omega-karboksiaril difenil secnina za zdravljenje ali preprecevanje bolezni instanj |
WO2005042567A1 (en) * | 2003-11-03 | 2005-05-12 | Altachem Pharma Ltd. | Rapamycin peptides conjugates: synthesis and uses thereof |
US8021849B2 (en) | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
WO2006096325A1 (en) | 2005-03-07 | 2006-09-14 | Wyeth | Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin |
US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
CA3126495A1 (en) * | 2019-01-25 | 2020-07-30 | NodThera Limited | Carbamate derivatives and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
US4316885A (en) * | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
EP0487593A1 (en) * | 1989-08-18 | 1992-06-03 | FISONS plc | Macrocyclic compounds |
PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
-
1992
- 1992-04-10 FI FI921595A patent/FI921595A/fi unknown
- 1992-04-10 JP JP4090825A patent/JPH05112573A/ja active Pending
- 1992-04-10 NO NO92921449A patent/NO921449L/no unknown
- 1992-04-11 KR KR1019920006033A patent/KR920019798A/ko not_active Application Discontinuation
- 1992-04-13 MX MX9201710A patent/MX9201710A/es unknown
- 1992-04-13 HU HU9201254A patent/HU9201254D0/hu unknown
- 1992-04-14 AU AU14880/92A patent/AU642592B2/en not_active Ceased
- 1992-04-15 NZ NZ24236792A patent/NZ242367A/en unknown
- 1992-04-15 EP EP19920303401 patent/EP0509795A2/en not_active Withdrawn
- 1992-04-16 SK SK1173-92A patent/SK117392A3/sk unknown
- 1992-04-16 CZ CS921173A patent/CZ117392A3/cs unknown
- 1992-04-16 IE IE124992A patent/IE921249A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IE921249A1 (en) | 1992-10-21 |
HU9201254D0 (en) | 1992-07-28 |
EP0509795A2 (en) | 1992-10-21 |
AU1488092A (en) | 1992-10-22 |
MX9201710A (es) | 1993-01-01 |
EP0509795A3 (no) | 1994-03-23 |
CZ117392A3 (en) | 1993-09-15 |
FI921595A0 (fi) | 1992-04-10 |
NZ242367A (en) | 1994-07-26 |
FI921595A (fi) | 1992-10-18 |
KR920019798A (ko) | 1992-11-20 |
NO921449D0 (no) | 1992-04-10 |
JPH05112573A (ja) | 1993-05-07 |
NO921449L (no) | 1992-10-19 |
AU642592B2 (en) | 1993-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK117392A3 (en) | Rapamycin derivatives and pharmaceutical agents containing them | |
US5118678A (en) | Carbamates of rapamycin | |
US5194447A (en) | Sulfonylcarbamates of rapamycin | |
US5434260A (en) | Carbamates of rapamycin | |
JP3710140B2 (ja) | ラパマイシンのヒンダードエステルおよびそれらの医薬品としての使用 | |
US5177203A (en) | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents | |
US5411967A (en) | Carbamates of rapamycin | |
US5252579A (en) | Macrocyclic immunomodulators | |
US5508285A (en) | Hindered N-oxide esters of rapamycin | |
US5508286A (en) | Rapamycin amidino carbamates | |
US5385909A (en) | Heterocyclic esters of rapamycin | |
HUT74675A (en) | C-22-ring stabilized rapamycin derivatives and pharmaceutical compositions containing them | |
MXPA97003893A (en) | Un-oxido-impaired esters of rapamycin and its uses as a medicine | |
NZ242778A (en) | Amide esters of rapamycin and pharmaceutical compositions thereof | |
JPH06312990A (ja) | 免疫抑制剤として有用なラパマイシンのオキセパン異性体 | |
US5260299A (en) | Rapamycin 42-sulfonates and 42-(N-Carboalkoxy)Sulfamates Useful as Immunosuppressive Agents | |
US5262424A (en) | Composition of sulfonylcarbamates of rapamycin and method of treating diseases requiring immunosuppression therewith | |
HU222575B1 (hu) | Rapamicin-karbamát-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
KR100304327B1 (ko) | 라파마이신의카밤산염및이를포함하는약제학적조성물 |