SK104493A3 - Phthalazinone derivatives acting anti-arrhythmically and analgetically and eliminating the resistance towards cytostatics - Google Patents

Phthalazinone derivatives acting anti-arrhythmically and analgetically and eliminating the resistance towards cytostatics Download PDF

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Publication number
SK104493A3
SK104493A3 SK1044-93A SK104493A SK104493A3 SK 104493 A3 SK104493 A3 SK 104493A3 SK 104493 A SK104493 A SK 104493A SK 104493 A3 SK104493 A3 SK 104493A3
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SK
Slovakia
Prior art keywords
medicament
manufacture
treatment
compound
formula
Prior art date
Application number
SK1044-93A
Other languages
English (en)
Slovak (sk)
Inventor
Jurgen Engel
Bernhard Kutscher
Ilona Fleischhauer
Stefan Szelenyi
Peter Metzenauer
Ulrich Werner
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of SK104493A3 publication Critical patent/SK104493A3/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
SK1044-93A 1992-10-02 1993-09-30 Phthalazinone derivatives acting anti-arrhythmically and analgetically and eliminating the resistance towards cytostatics SK104493A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4233113 1992-10-02

Publications (1)

Publication Number Publication Date
SK104493A3 true SK104493A3 (en) 1994-08-10

Family

ID=6469448

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1044-93A SK104493A3 (en) 1992-10-02 1993-09-30 Phthalazinone derivatives acting anti-arrhythmically and analgetically and eliminating the resistance towards cytostatics

Country Status (18)

Country Link
US (1) US5556856A (zh)
EP (1) EP0590551B1 (zh)
JP (1) JP3623975B2 (zh)
CN (1) CN1088435A (zh)
AT (1) ATE144708T1 (zh)
AU (1) AU666773B2 (zh)
CA (1) CA2107548A1 (zh)
CZ (1) CZ199593A3 (zh)
DE (1) DE59304351D1 (zh)
DK (1) DK0590551T3 (zh)
ES (1) ES2096168T3 (zh)
GR (1) GR3022070T3 (zh)
HU (1) HUT65353A (zh)
MX (1) MX9306120A (zh)
RU (1) RU2106143C1 (zh)
SK (1) SK104493A3 (zh)
UA (1) UA26953C2 (zh)
ZA (1) ZA937315B (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162616A (en) * 1997-04-16 2000-12-19 Millennium Pharmaceuticals, Inc. Multidrug resistance-associated polypeptide
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
EP1451856A2 (en) * 2001-11-07 2004-09-01 Pharmacia Corporation Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
US7196085B2 (en) 2002-04-30 2007-03-27 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7294701B2 (en) * 2003-04-02 2007-11-13 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0428111D0 (en) * 2004-12-22 2005-01-26 Kudos Pharm Ltd Pthalazinone derivatives
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
CA2649029A1 (en) * 2006-04-20 2007-11-01 Glaxo Group Limited 2-substituted 4-benzylphthalazinone derivatives as histamine h1 and h3 antagonists
CN101484421A (zh) * 2006-06-15 2009-07-15 库多斯药物有限公司 作为parp抑制剂的2-氧基苯甲酰胺衍生物
EP2041110A1 (en) * 2006-06-15 2009-04-01 Kudos Pharmaceuticals Limited 2 -oxyheteroarylamide derivatives as parp inhibitors
WO2007144652A2 (en) * 2006-06-15 2007-12-21 Kudos Pharmaceuticals Limited Parp inhibitors
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
EP2091538B1 (en) * 2006-12-20 2010-03-03 Glaxo Group Limited 4-benzyl-1(2h)-phthalazinones as h1 receptor antagonists
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
US20090023727A1 (en) * 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
AU2008299721A1 (en) 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
ATE525370T1 (de) * 2007-10-11 2011-10-15 Glaxo Group Ltd Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten
KR101598231B1 (ko) 2007-10-17 2016-02-26 쿠도스 파마슈티칼스 리미티드 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2ｈ-프탈라진-1-온
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
HUE030800T2 (en) * 2008-10-07 2017-05-29 Astrazeneca Uk Ltd Pharmaceutical Form No. 514
UY32790A (es) * 2009-07-15 2011-02-28 Astrazeneca Ab Compuesto de ftalazinona
BR112015023328A2 (pt) 2013-03-13 2017-07-18 Flatley Discovery Lab compostos de piridazinona e métodos para o tratamento de fibrose cística

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222191B1 (de) * 1985-11-11 1991-01-30 ASTA Pharma AG 4-Benzyl-1-(2H)-phthalazinon-Derivate
JPH0667844B2 (ja) * 1987-03-06 1994-08-31 エーザイ株式会社 虚血性心疾患の治療・予防剤
US5110814A (en) * 1989-01-11 1992-05-05 Asta Pharma Ag Azelastine and its salts used to combat psoriasis

Also Published As

Publication number Publication date
GR3022070T3 (en) 1997-03-31
DE59304351D1 (de) 1996-12-05
AU4876993A (en) 1994-04-14
EP0590551A3 (zh) 1994-08-31
US5556856A (en) 1996-09-17
UA26953C2 (uk) 1999-12-29
CA2107548A1 (en) 1994-04-03
DK0590551T3 (da) 1997-04-21
EP0590551A2 (de) 1994-04-06
ZA937315B (en) 1994-04-22
CN1088435A (zh) 1994-06-29
MX9306120A (es) 1994-04-29
RU2106143C1 (ru) 1998-03-10
JP3623975B2 (ja) 2005-02-23
JPH06312928A (ja) 1994-11-08
HUT65353A (en) 1994-05-02
AU666773B2 (en) 1996-02-22
ATE144708T1 (de) 1996-11-15
ES2096168T3 (es) 1997-03-01
EP0590551B1 (de) 1996-10-30
CZ199593A3 (en) 1994-04-13
HU9302784D0 (en) 1993-12-28

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