SI9600053B - Substituted benzensulphonyl ureas and thioureas, process for the preparation thereof and use thereof for the preparation of pharmaceutical preparations as well as pharmaceutical preparations containing them - Google Patents
Substituted benzensulphonyl ureas and thioureas, process for the preparation thereof and use thereof for the preparation of pharmaceutical preparations as well as pharmaceutical preparations containing them Download PDFInfo
- Publication number
- SI9600053B SI9600053B SI9600053A SI9600053A SI9600053B SI 9600053 B SI9600053 B SI 9600053B SI 9600053 A SI9600053 A SI 9600053A SI 9600053 A SI9600053 A SI 9600053A SI 9600053 B SI9600053 B SI 9600053B
- Authority
- SI
- Slovenia
- Prior art keywords
- atoms
- alkyl
- cycloalkyl
- carbon atoms
- replaced
- Prior art date
Links
- -1 benzensulphonyl ureas Chemical class 0.000 title claims abstract 4
- 238000002360 preparation method Methods 0.000 title claims 8
- 238000000034 method Methods 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 2
- 235000013877 carbamide Nutrition 0.000 title 1
- 150000003585 thioureas Chemical class 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 44
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 44
- 125000000217 alkyl group Chemical group 0.000 claims abstract 37
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 35
- 125000003709 fluoroalkyl group Chemical group 0.000 claims abstract 17
- 125000005348 fluorocycloalkyl group Chemical group 0.000 claims abstract 17
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 17
- 125000003118 aryl group Chemical group 0.000 claims abstract 15
- 125000005842 heteroatom Chemical group 0.000 claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 125000005358 mercaptoalkyl group Chemical group 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 93
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 10
- 239000001301 oxygen Substances 0.000 claims 10
- 239000011593 sulfur Substances 0.000 claims 10
- 125000004429 atom Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 8
- GHDLZGOOOLEJKI-UHFFFAOYSA-N benzenesulfonylurea Chemical class NC(=O)NS(=O)(=O)C1=CC=CC=C1 GHDLZGOOOLEJKI-UHFFFAOYSA-N 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 125000002541 furyl group Chemical group 0.000 claims 6
- 125000001624 naphthyl group Chemical group 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 125000000168 pyrrolyl group Chemical group 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 125000001544 thienyl group Chemical group 0.000 claims 6
- PVMBGVAQRSHDBB-UHFFFAOYSA-N benzenesulfonylthiourea Chemical compound NC(=S)NS(=O)(=O)C1=CC=CC=C1 PVMBGVAQRSHDBB-UHFFFAOYSA-N 0.000 claims 5
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 239000002516 radical scavenger Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- UPQQXPKAYZYUKO-UHFFFAOYSA-N 2,2,2-trichloroacetamide Chemical class OC(=N)C(Cl)(Cl)Cl UPQQXPKAYZYUKO-UHFFFAOYSA-N 0.000 claims 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- NONOKGVFTBWRLD-UHFFFAOYSA-N isocyanatosulfanylimino(oxo)methane Chemical class O=C=NSN=C=O NONOKGVFTBWRLD-UHFFFAOYSA-N 0.000 claims 1
- UJYAZVSPFMJCLW-UHFFFAOYSA-N n-(oxomethylidene)benzenesulfonamide Chemical compound O=C=NS(=O)(=O)C1=CC=CC=C1 UJYAZVSPFMJCLW-UHFFFAOYSA-N 0.000 claims 1
- ZACBJJDJJBGIDC-UHFFFAOYSA-N n-(sulfanylidenemethylidene)benzenesulfonamide Chemical compound S=C=NS(=O)(=O)C1=CC=CC=C1 ZACBJJDJJBGIDC-UHFFFAOYSA-N 0.000 claims 1
- 230000033764 rhythmic process Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 239000004202 carbamide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19505910A DE19505910A1 (de) | 1995-02-21 | 1995-02-21 | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung zur Herstellung pharmazeutischer Präparate und sie enthaltende Medikamente |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9600053A SI9600053A (en) | 1996-12-31 |
| SI9600053B true SI9600053B (en) | 2001-12-31 |
Family
ID=7754593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9600053A SI9600053B (en) | 1995-02-21 | 1996-02-20 | Substituted benzensulphonyl ureas and thioureas, process for the preparation thereof and use thereof for the preparation of pharmaceutical preparations as well as pharmaceutical preparations containing them |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5633239A (cs) |
| EP (1) | EP0728741B1 (cs) |
| JP (1) | JP3905570B2 (cs) |
| KR (1) | KR100446566B1 (cs) |
| CN (1) | CN1060767C (cs) |
| AR (1) | AR001352A1 (cs) |
| AT (1) | ATE196467T1 (cs) |
| AU (1) | AU701278B2 (cs) |
| BR (1) | BR9600773A (cs) |
| CA (1) | CA2169695C (cs) |
| CZ (1) | CZ291219B6 (cs) |
| DE (2) | DE19505910A1 (cs) |
| DK (1) | DK0728741T3 (cs) |
| ES (1) | ES2151614T3 (cs) |
| FI (1) | FI120392B (cs) |
| GR (1) | GR3034646T3 (cs) |
| HR (1) | HRP960081B1 (cs) |
| HU (1) | HU227308B1 (cs) |
| IL (1) | IL117179A (cs) |
| MY (1) | MY113432A (cs) |
| NO (1) | NO305792B1 (cs) |
| NZ (1) | NZ286013A (cs) |
| PL (1) | PL181628B1 (cs) |
| PT (1) | PT728741E (cs) |
| RU (1) | RU2159763C2 (cs) |
| SI (1) | SI9600053B (cs) |
| SK (1) | SK281876B6 (cs) |
| TR (1) | TR199600129A2 (cs) |
| TW (1) | TW357140B (cs) |
| ZA (1) | ZA961314B (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| CZ301165B6 (cs) * | 1998-09-10 | 2009-11-25 | Sanofi - Aventis Deutschland GmbH | Použití benzensulfonyl(thio)mocovin pro lécení a profylaxi dysfunkcí autonomní nervové soustavy a použití benzensulfonyl(thio)mocovin v kombinaci s beta-receptorovými blokátory |
| US6436864B1 (en) | 1999-10-06 | 2002-08-20 | Sri International | Unsaturated nitrogenous compounds as electron donors for use with ziegler-natta catalysts |
| DE10129704A1 (de) * | 2001-06-22 | 2003-01-02 | Aventis Pharma Gmbh | Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks |
| JP4521463B2 (ja) * | 2005-03-17 | 2010-08-11 | ファイザー株式会社 | 疼痛の治療に有用なｎ−（ｎ−スルホニルアミノメチル）シクロプロパンカルボキサミド誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL141381B (nl) * | 1963-09-25 | 1974-03-15 | Hoechst Ag | Werkwijze voor het bereiden van geneesmiddelen met bloedsuikerspiegel verlagende werkzaamheid. |
| DE1198354B (de) * | 1963-09-25 | 1965-08-12 | Hoechst Ag | Verfahren zur Herstellung von Benzol-sulfonylharnstoffen |
| BE754454A (fr) * | 1969-08-06 | 1971-02-05 | Bayer Ag | Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide |
| EP0612724B1 (de) * | 1993-02-23 | 1996-12-27 | Hoechst Aktiengesellschaft | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| DE4341655A1 (de) * | 1993-12-07 | 1995-06-08 | Hoechst Ag | Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
-
1994
- 1994-02-20 ZA ZA961314A patent/ZA961314B/xx unknown
-
1995
- 1995-02-21 DE DE19505910A patent/DE19505910A1/de not_active Withdrawn
- 1995-12-29 HU HU9503931A patent/HU227308B1/hu not_active IP Right Cessation
-
1996
- 1996-01-29 PL PL96312529A patent/PL181628B1/pl not_active IP Right Cessation
- 1996-02-13 CN CN96102002A patent/CN1060767C/zh not_active Expired - Fee Related
- 1996-02-15 AT AT96102255T patent/ATE196467T1/de active
- 1996-02-15 PT PT96102255T patent/PT728741E/pt unknown
- 1996-02-15 DK DK96102255T patent/DK0728741T3/da active
- 1996-02-15 ES ES96102255T patent/ES2151614T3/es not_active Expired - Lifetime
- 1996-02-15 DE DE59605898T patent/DE59605898D1/de not_active Expired - Lifetime
- 1996-02-15 EP EP96102255A patent/EP0728741B1/de not_active Expired - Lifetime
- 1996-02-16 TR TR96/00129A patent/TR199600129A2/xx unknown
- 1996-02-16 CA CA002169695A patent/CA2169695C/en not_active Expired - Fee Related
- 1996-02-16 BR BR9600773A patent/BR9600773A/pt not_active IP Right Cessation
- 1996-02-16 US US08/601,109 patent/US5633239A/en not_active Expired - Lifetime
- 1996-02-17 MY MYPI96000635A patent/MY113432A/en unknown
- 1996-02-19 NZ NZ286013A patent/NZ286013A/en not_active IP Right Cessation
- 1996-02-19 IL IL11717996A patent/IL117179A/xx not_active IP Right Cessation
- 1996-02-19 FI FI960740A patent/FI120392B/fi not_active IP Right Cessation
- 1996-02-19 SK SK222-96A patent/SK281876B6/sk not_active IP Right Cessation
- 1996-02-19 CZ CZ1996486A patent/CZ291219B6/cs not_active IP Right Cessation
- 1996-02-19 HR HR960081A patent/HRP960081B1/xx not_active IP Right Cessation
- 1996-02-19 AU AU45600/96A patent/AU701278B2/en not_active Ceased
- 1996-02-19 AR AR33545296A patent/AR001352A1/es unknown
- 1996-02-20 NO NO960664A patent/NO305792B1/no not_active IP Right Cessation
- 1996-02-20 RU RU96103250/04A patent/RU2159763C2/ru not_active IP Right Cessation
- 1996-02-20 SI SI9600053A patent/SI9600053B/sl not_active IP Right Cessation
- 1996-02-21 KR KR1019960004021A patent/KR100446566B1/ko not_active Expired - Fee Related
- 1996-02-21 JP JP03327496A patent/JP3905570B2/ja not_active Expired - Fee Related
- 1996-04-22 TW TW085104747A patent/TW357140B/zh not_active IP Right Cessation
-
2000
- 2000-10-20 GR GR20000402333T patent/GR3034646T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20121015 |