SI9300150B - Kristalne oblike endo-2,3-dihidro-N-(8-metil-8-azabicilo/3.2.1./okt-3-il)-2-okso-1H- benzimidazol-1-karboksamid hidroklorid monohidrata in endo-3-etil-2,3-dihidro-N-(8-metil-8-azabiciklo/3.2.1/okt-3-il)-2-okso- 1H-benzimidazol-1-karboksamid hidroklorid monohidrata - Google Patents

Kristalne oblike endo-2,3-dihidro-N-(8-metil-8-azabicilo/3.2.1./okt-3-il)-2-okso-1H- benzimidazol-1-karboksamid hidroklorid monohidrata in endo-3-etil-2,3-dihidro-N-(8-metil-8-azabiciklo/3.2.1/okt-3-il)-2-okso- 1H-benzimidazol-1-karboksamid hidroklorid monohidrata Download PDF

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Publication number
SI9300150B
SI9300150B SI9300150A SI9300150A SI9300150B SI 9300150 B SI9300150 B SI 9300150B SI 9300150 A SI9300150 A SI 9300150A SI 9300150 A SI9300150 A SI 9300150A SI 9300150 B SI9300150 B SI 9300150B
Authority
SI
Slovenia
Prior art keywords
azabicyclo
endo
methyl
oxo
dihydro
Prior art date
Application number
SI9300150A
Other languages
English (en)
Other versions
SI9300150A (en
Inventor
Enzo Cereda
Enrica Dubini
Antoine Ezhaya
Grazia Maffione
Marco Turconi
Original Assignee
Boehringer Ingelheim Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI920723A external-priority patent/IT1254565B/it
Priority claimed from ITMI920720A external-priority patent/IT1254562B/it
Application filed by Boehringer Ingelheim Italia Spa filed Critical Boehringer Ingelheim Italia Spa
Publication of SI9300150A publication Critical patent/SI9300150A/sl
Publication of SI9300150B publication Critical patent/SI9300150B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (3)

  1. o c
    ο ο ο ο ο c- r or- c PATENTNI ZAHTEVKI 1. Kristalni monohidrati endo-2,3-dihidro-N-(8-metil-8-azabiciklo[3.2.1]okt-3-il)-2-okso-lH-benzimidazol-l-karboksamid hidroklorida in endo-3-etil-2,3-di-hidro- N-(8-metil-8-azabiciklo[3.2.1]okt-3-il)-2-okso-lH-benzimidazol-l-karboksamid hidroklorida s formulo
    hcuh2
    0 (spojina 2a: R = H) (spojina 2b: R = C2H5)
  2. 2. Farmacevtski pripravki, označeni s tem, da obsegajo kot učinkovito sestavino terapevtsko učinkovito množino kristalnega monohidrata endo-2,3-dihidro-N-(8-metil-8-azabiciklo[3.2.1]okt-3-il)-2-okso-lH-benzimidazol-l-karboksamid hidroklorida oziroma endo-3-etil-2,3-dihidro-N-(8-metil-8-azabiciklo[3.2. ljokt-3-il)-2-okso-lH-benzimidazol-l-karboksamid hidroklorida po zahtevku 1 skupaj s farmacevtskimi nosilci ali ekscipienti.
  3. 3. Farmacevtski pripravki po zahtevku 2 za uporabo kot sredstva proti 5-HT. Za 22616-X-96-mn Boehringer Ingelheim Italia Spa: PATENTNA riSASNA..,· LJUBLJANA, ČOPO'/A 14 /f
SI9300150A 1992-03-26 1993-03-26 Kristalne oblike endo-2,3-dihidro-N-(8-metil-8-azabicilo/3.2.1./okt-3-il)-2-okso-1H- benzimidazol-1-karboksamid hidroklorid monohidrata in endo-3-etil-2,3-dihidro-N-(8-metil-8-azabiciklo/3.2.1/okt-3-il)-2-okso- 1H-benzimidazol-1-karboksamid hidroklorid monohidrata SI9300150B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI920723A IT1254565B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-2,3-diidro-n-(8 metil-8-azabiciclo-(3.2.1) ott-3-il)-2-oxo-1h-benzimidazolo-1-carbossamide cloridrato
ITMI920720A IT1254562B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato

Publications (2)

Publication Number Publication Date
SI9300150A SI9300150A (en) 1993-09-30
SI9300150B true SI9300150B (sl) 1998-06-30

Family

ID=26330860

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9300150A SI9300150B (sl) 1992-03-26 1993-03-26 Kristalne oblike endo-2,3-dihidro-N-(8-metil-8-azabicilo/3.2.1./okt-3-il)-2-okso-1H- benzimidazol-1-karboksamid hidroklorid monohidrata in endo-3-etil-2,3-dihidro-N-(8-metil-8-azabiciklo/3.2.1/okt-3-il)-2-okso- 1H-benzimidazol-1-karboksamid hidroklorid monohidrata

Country Status (28)

Country Link
US (1) US5468758A (sl)
EP (1) EP0567767B1 (sl)
JP (1) JP3279707B2 (sl)
AT (1) ATE169016T1 (sl)
AU (1) AU654082B2 (sl)
BR (1) BR1100564A (sl)
CA (1) CA2092510C (sl)
CZ (1) CZ286590B6 (sl)
DE (1) DE69319955T2 (sl)
DK (1) DK0567767T3 (sl)
ES (1) ES2118846T3 (sl)
FI (1) FI113472B (sl)
HK (1) HK1010719A1 (sl)
HR (1) HRP930479B1 (sl)
HU (2) HU211075B (sl)
IL (1) IL105143A (sl)
MX (1) MX9301668A (sl)
NO (1) NO300975B1 (sl)
NZ (1) NZ247234A (sl)
PH (1) PH30413A (sl)
PL (1) PL172890B1 (sl)
RU (1) RU2125054C1 (sl)
SG (1) SG43225A1 (sl)
SI (1) SI9300150B (sl)
SK (1) SK280555B6 (sl)
TW (1) TW385310B (sl)
UA (1) UA37179C2 (sl)
UY (2) UY25938A1 (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2240637T3 (es) 1996-01-17 2005-10-16 Ricoh Company, Ltd. Aparato de fijacion para un aparato de formacion de imagenes.
JPH1039679A (ja) * 1996-05-24 1998-02-13 Ricoh Co Ltd 定着装置
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
US9062042B2 (en) * 2010-01-11 2015-06-23 Astraea Therapeutics, Llc Nicotinic acetylcholine receptor modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223511A (en) * 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
GB9121835D0 (en) * 1991-10-15 1991-11-27 Smithkline Beecham Plc Pharmaceuticals
PH31171A (en) * 1992-02-04 1998-03-20 Esai Co Ltd Aminobenzonic acid derivatives useful for treatinggastrointestinal conditions.

Also Published As

Publication number Publication date
PL172890B1 (pl) 1997-12-31
IL105143A (en) 1996-10-16
DE69319955D1 (de) 1998-09-03
HK1010719A1 (en) 1999-06-25
JP3279707B2 (ja) 2002-04-30
HU211075B (en) 1995-10-30
SG43225A1 (en) 1997-10-17
US5468758A (en) 1995-11-21
CA2092510C (en) 2004-02-03
HUT63846A (en) 1993-10-28
DK0567767T3 (da) 1999-02-01
CZ44393A3 (en) 1994-01-19
AU3541393A (en) 1993-09-30
CA2092510A1 (en) 1993-09-27
CZ286590B6 (cs) 2000-05-17
SK22693A3 (en) 1993-11-10
ES2118846T3 (es) 1998-10-01
HRP930479B1 (en) 1999-10-31
BR1100564A (pt) 2000-06-27
NO931112L (no) 1993-09-27
JPH0673053A (ja) 1994-03-15
NO300975B1 (no) 1997-08-25
UA37179C2 (uk) 2001-05-15
NO931112D0 (no) 1993-03-25
SK280555B6 (sk) 2000-03-13
HRP930479A2 (en) 1995-02-28
PL298263A1 (en) 1994-01-10
EP0567767B1 (en) 1998-07-29
FI113472B (fi) 2004-04-30
ATE169016T1 (de) 1998-08-15
HU211131A9 (en) 1995-10-30
DE69319955T2 (de) 1999-04-15
MX9301668A (es) 1993-09-01
UY25939A1 (es) 2001-08-27
UY25938A1 (es) 2000-09-29
SI9300150A (en) 1993-09-30
RU2125054C1 (ru) 1999-01-20
FI931329A (fi) 1993-09-27
NZ247234A (en) 1995-12-21
PH30413A (en) 1997-05-09
EP0567767A1 (en) 1993-11-03
FI931329A0 (fi) 1993-03-25
HU9300868D0 (en) 1993-06-28
AU654082B2 (en) 1994-10-20
TW385310B (en) 2000-03-21

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