ATE169016T1 - Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonisten - Google Patents
Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonistenInfo
- Publication number
- ATE169016T1 ATE169016T1 AT93104564T AT93104564T ATE169016T1 AT E169016 T1 ATE169016 T1 AT E169016T1 AT 93104564 T AT93104564 T AT 93104564T AT 93104564 T AT93104564 T AT 93104564T AT E169016 T1 ATE169016 T1 AT E169016T1
- Authority
- AT
- Austria
- Prior art keywords
- azabicyclo
- endo
- dihydro
- oct
- methyl
- Prior art date
Links
- 239000003420 antiserotonin agent Substances 0.000 title 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 title 1
- YLEIFZAVNWDOBM-ZTNXSLBXSA-N ac1l9hc7 Chemical compound C([C@H]12)C[C@@H](C([C@@H](O)CC3)(C)C)[C@@]43C[C@@]14CC[C@@]1(C)[C@@]2(C)C[C@@H]2O[C@]3(O)[C@H](O)C(C)(C)O[C@@H]3[C@@H](C)[C@H]12 YLEIFZAVNWDOBM-ZTNXSLBXSA-N 0.000 abstract 1
- SRVFFFJZQVENJC-IHRRRGAJSA-N aloxistatin Chemical compound CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C SRVFFFJZQVENJC-IHRRRGAJSA-N 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920720A IT1254562B (it) | 1992-03-26 | 1992-03-26 | Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato |
| ITMI920723A IT1254565B (it) | 1992-03-26 | 1992-03-26 | Forma cristallina dell'endo-2,3-diidro-n-(8 metil-8-azabiciclo-(3.2.1) ott-3-il)-2-oxo-1h-benzimidazolo-1-carbossamide cloridrato |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE169016T1 true ATE169016T1 (de) | 1998-08-15 |
Family
ID=26330860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93104564T ATE169016T1 (de) | 1992-03-26 | 1993-03-19 | Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonisten |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5468758A (de) |
| EP (1) | EP0567767B1 (de) |
| JP (1) | JP3279707B2 (de) |
| AT (1) | ATE169016T1 (de) |
| AU (1) | AU654082B2 (de) |
| BR (1) | BR1100564A (de) |
| CA (1) | CA2092510C (de) |
| CZ (1) | CZ286590B6 (de) |
| DE (1) | DE69319955T2 (de) |
| DK (1) | DK0567767T3 (de) |
| ES (1) | ES2118846T3 (de) |
| FI (1) | FI113472B (de) |
| HR (1) | HRP930479B1 (de) |
| HU (2) | HU211075B (de) |
| IL (1) | IL105143A (de) |
| MX (1) | MX9301668A (de) |
| NO (1) | NO300975B1 (de) |
| NZ (1) | NZ247234A (de) |
| PH (1) | PH30413A (de) |
| PL (1) | PL172890B1 (de) |
| RU (1) | RU2125054C1 (de) |
| SG (1) | SG43225A1 (de) |
| SI (1) | SI9300150B (de) |
| SK (1) | SK280555B6 (de) |
| TW (1) | TW385310B (de) |
| UA (1) | UA37179C2 (de) |
| UY (2) | UY25939A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69733288T2 (de) | 1996-01-17 | 2006-01-26 | Ricoh Co., Ltd. | Fixiergerät für ein Bilderzeugungsgerät |
| JPH1039679A (ja) * | 1996-05-24 | 1998-02-13 | Ricoh Co Ltd | 定着装置 |
| PE20001420A1 (es) | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| WO2011085389A1 (en) * | 2010-01-11 | 2011-07-14 | Astraea Therapeutics, Llc | Nicotinic acetylcholine receptor modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136189A (en) * | 1975-09-16 | 1979-01-23 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | 2-(5-nitro-furfurylidene)-amino-benzimidoles and fungicidal compositions containing the same |
| US5223511A (en) * | 1987-09-23 | 1993-06-29 | Boehringer Ingelheim Italia S.P.A. | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists |
| IT1231413B (it) * | 1987-09-23 | 1991-12-04 | Angeli Inst Spa | Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht |
| GB9121835D0 (en) * | 1991-10-15 | 1991-11-27 | Smithkline Beecham Plc | Pharmaceuticals |
| DE69319939T2 (de) * | 1992-02-04 | 1999-02-18 | Eisai Co., Ltd., Tokio/Tokyo | Aminobenzoesäure Derivate |
-
1993
- 1993-03-11 PH PH45858A patent/PH30413A/en unknown
- 1993-03-19 DE DE69319955T patent/DE69319955T2/de not_active Expired - Lifetime
- 1993-03-19 DK DK93104564T patent/DK0567767T3/da active
- 1993-03-19 AT AT93104564T patent/ATE169016T1/de active
- 1993-03-19 ES ES93104564T patent/ES2118846T3/es not_active Expired - Lifetime
- 1993-03-19 EP EP93104564A patent/EP0567767B1/de not_active Expired - Lifetime
- 1993-03-19 CZ CZ1993443A patent/CZ286590B6/cs not_active IP Right Cessation
- 1993-03-19 SG SG1996005867A patent/SG43225A1/en unknown
- 1993-03-22 SK SK226-93A patent/SK280555B6/sk not_active IP Right Cessation
- 1993-03-23 HR HRMI92A000723A patent/HRP930479B1/xx not_active IP Right Cessation
- 1993-03-24 NZ NZ247234A patent/NZ247234A/en not_active IP Right Cessation
- 1993-03-24 TW TW082102205A patent/TW385310B/zh not_active IP Right Cessation
- 1993-03-24 IL IL10514393A patent/IL105143A/en not_active IP Right Cessation
- 1993-03-24 AU AU35413/93A patent/AU654082B2/en not_active Ceased
- 1993-03-25 NO NO931112A patent/NO300975B1/no not_active IP Right Cessation
- 1993-03-25 JP JP06649293A patent/JP3279707B2/ja not_active Expired - Lifetime
- 1993-03-25 CA CA002092510A patent/CA2092510C/en not_active Expired - Lifetime
- 1993-03-25 MX MX9301668A patent/MX9301668A/es not_active IP Right Cessation
- 1993-03-25 HU HU9300868A patent/HU211075B/hu not_active IP Right Cessation
- 1993-03-25 RU RU93004710A patent/RU2125054C1/ru not_active IP Right Cessation
- 1993-03-25 PL PL93298263A patent/PL172890B1/pl not_active IP Right Cessation
- 1993-03-25 FI FI931329A patent/FI113472B/fi not_active IP Right Cessation
- 1993-03-26 SI SI9300150A patent/SI9300150B/sl not_active IP Right Cessation
- 1993-06-08 UA UA93002686A patent/UA37179C2/uk unknown
-
1994
- 1994-06-22 US US08/264,104 patent/US5468758A/en not_active Expired - Lifetime
-
1995
- 1995-06-30 HU HU95P/P00677P patent/HU211131A9/hu unknown
-
1997
- 1997-05-13 BR BR1100564-5A patent/BR1100564A/pt active IP Right Grant
-
2000
- 2000-01-17 UY UY25939A patent/UY25939A1/es not_active Application Discontinuation
- 2000-01-17 UY UY25938A patent/UY25938A1/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |