SI9200266B - Enzymatic process for the enantioselective production of optically active cyanhydrins - Google Patents
Enzymatic process for the enantioselective production of optically active cyanhydrins Download PDFInfo
- Publication number
- SI9200266B SI9200266B SI9200266A SI9200266A SI9200266B SI 9200266 B SI9200266 B SI 9200266B SI 9200266 A SI9200266 A SI 9200266A SI 9200266 A SI9200266 A SI 9200266A SI 9200266 B SI9200266 B SI 9200266B
- Authority
- SI
- Slovenia
- Prior art keywords
- cyanohydrin
- process according
- aldehyde
- hydroxynitrile
- liaise
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
- C12P13/004—Cyanohydrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (8)
1 PATENTNI ZAHTEVKI 1. Enantioselektivni postopek za pripravo S-enantiomera optično aktivnega cianohidrina s presnovo aldehida ali nesimetričnega ketona z aceton cianohidrinom, označen s tem, da presnovimo aldehid ali keton v vodnem in/ali organskem razredčilu v navzočnosti S-hidroksinitril liaze z aceton cianohidrinom, nato pa nastali S-cianohidrin izoliramo iz reakcijske zmesi, pri čemer uporabljena S-hidroksinitril liaza ni S-hidroksinitril liaza iz Sorghum bicolor.
2. Postopek po zahtevku 1, označen s tem, da presnovimo alifatski, aromatski ali heteroaromatski aldehid.
3. Postopek po zahtevku 2, označen s tem, da presnovimo alifatski ali aromatski aldehid.
4. Postopek po enem od zahtevkov 1 do 3, označen s tem, da kot razredčilo uporabimo vodno razredčilo.
5. Postopek po zahtevku 4, označen s tem, da izvedemo presnovo v vodni pufemi raztopini z vrednostjo pH od 3 do 5.
6. Postopek po enem od zahtevkov 1 do 3, označen s tem, da kot hidroksinitril liazo uporabimo S-hidroksinitril liazo iz Hevea brasiliensis.
7. Postopek po enem od zahtevkov 1 do 6, označen s tem, da tvorjeni S-cianohidrin ekstrahiramo iz reakcijske zmesi in očistimo s kromatografijo.
8. Uporaba S-hidroksinitril liaze iz Hevea brasiliensis za pripravo S-cianohidrinov.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0217491A AT396252B (de) | 1991-10-31 | 1991-10-31 | Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9200266A SI9200266A (en) | 1993-06-30 |
SI9200266B true SI9200266B (en) | 2001-12-31 |
Family
ID=3529314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9200266A SI9200266B (en) | 1991-10-31 | 1992-10-20 | Enzymatic process for the enantioselective production of optically active cyanhydrins |
Country Status (21)
Country | Link |
---|---|
US (1) | US5346816A (sl) |
EP (1) | EP0539767B1 (sl) |
JP (1) | JP3174171B2 (sl) |
KR (1) | KR100255439B1 (sl) |
AT (2) | AT396252B (sl) |
AU (1) | AU656812B2 (sl) |
CA (1) | CA2078942A1 (sl) |
CZ (1) | CZ284495B6 (sl) |
DE (1) | DE59209147D1 (sl) |
DK (1) | DK0539767T3 (sl) |
ES (1) | ES2111028T3 (sl) |
HR (1) | HRP921142B1 (sl) |
HU (1) | HU215495B (sl) |
NZ (1) | NZ244238A (sl) |
RU (1) | RU2067089C1 (sl) |
SI (1) | SI9200266B (sl) |
SK (1) | SK280163B6 (sl) |
TW (1) | TW237479B (sl) |
UA (1) | UA26382C2 (sl) |
YU (1) | YU88092A (sl) |
ZA (1) | ZA927235B (sl) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5177242A (en) * | 1991-12-17 | 1993-01-05 | Fmc Corporation | Process for preparing optically active cyanohydrins with enzymes |
US5241087A (en) * | 1992-03-09 | 1993-08-31 | Bend Research, Inc. | Enantiomeric enrichment of cyanohydrins |
AT400035B (de) * | 1993-06-01 | 1995-09-25 | Chemie Linz Gmbh | Enzymatisches verfahren zur herstellung aliphatischer s-cyanhydrine |
DE4322064A1 (de) * | 1993-07-02 | 1995-01-12 | Chemie Linz Deutschland | Enzymatisches Verfahren zur Herstellung aliphatischer S-Cyanhydrine |
AT404837B (de) * | 1995-07-12 | 1999-03-25 | Chemie Linz Gmbh | (s)-hydroxynitrillyase aus hevea brasiliensis |
DE19529116A1 (de) * | 1995-08-08 | 1997-03-06 | Chemie Linz Deutschland Gmbh I | (S)-Hydroxynitrillyase aus Hevea brasiliensis |
DE19703314A1 (de) * | 1996-02-09 | 1997-08-14 | Degussa | Verfahren zur Herstellung von (S)-Cyanhydrinen |
AT406959B (de) * | 1997-01-13 | 2000-11-27 | Chemie Linz Gmbh | Enantioselektives verfahren zur herstellung von (s)-cyanhydrinen |
AT406961B (de) | 1997-12-29 | 2000-11-27 | Dsm Fine Chem Austria Gmbh | Enzymatisches verfahren zur herstellung von (s)-cyanhydrinen |
AT407397B (de) | 1998-07-02 | 2001-02-26 | Dsm Fine Chem Austria Gmbh | (s)-hydroxynitrillyasen mit verbesserter substratakzeptanz und deren verwendung |
JP2002142792A (ja) * | 2000-11-01 | 2002-05-21 | Clariant Gmbh | 光学活性シアノヒドリンおよび二次生成物の製造法 |
AT410792B (de) * | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3701383A1 (de) * | 1987-01-20 | 1988-07-28 | Degussa | Verfahren zur herstellung von optisch aktiven cyanhydrinen |
DE3823864A1 (de) * | 1988-01-29 | 1989-08-10 | Kernforschungsanlage Juelich | Enymatisches verfahren zur herstellung von optisch aktiven cyanhydrinen |
DE3823866A1 (de) * | 1988-07-14 | 1990-02-15 | Kernforschungsanlage Juelich | Verfahren zur herstellung von s-cyanhydrinen |
DE59106876D1 (de) * | 1990-03-16 | 1995-12-21 | Forschungszentrum Juelich Gmbh | Verfahren zur enzymatischen Herstellung optisch aktiver Cyanhydrine. |
DE4139987C1 (sl) * | 1991-12-04 | 1993-04-15 | Uwe Dr. 5303 Bornheim De Niedermeyer | |
US5177242A (en) * | 1991-12-17 | 1993-01-05 | Fmc Corporation | Process for preparing optically active cyanohydrins with enzymes |
US5241087A (en) * | 1992-03-09 | 1993-08-31 | Bend Research, Inc. | Enantiomeric enrichment of cyanohydrins |
-
1991
- 1991-10-31 AT AT0217491A patent/AT396252B/de not_active IP Right Cessation
-
1992
- 1992-09-01 US US07/943,376 patent/US5346816A/en not_active Expired - Fee Related
- 1992-09-07 NZ NZ244238A patent/NZ244238A/en unknown
- 1992-09-10 TW TW081107182A patent/TW237479B/zh active
- 1992-09-22 ZA ZA927235A patent/ZA927235B/xx unknown
- 1992-09-23 CA CA002078942A patent/CA2078942A1/en not_active Abandoned
- 1992-09-30 YU YU88092A patent/YU88092A/sh unknown
- 1992-10-07 EP EP92117082A patent/EP0539767B1/de not_active Expired - Lifetime
- 1992-10-07 ES ES92117082T patent/ES2111028T3/es not_active Expired - Lifetime
- 1992-10-07 AT AT92117082T patent/ATE162554T1/de not_active IP Right Cessation
- 1992-10-07 AU AU26288/92A patent/AU656812B2/en not_active Ceased
- 1992-10-07 DK DK92117082.5T patent/DK0539767T3/da active
- 1992-10-07 DE DE59209147T patent/DE59209147D1/de not_active Expired - Fee Related
- 1992-10-20 SI SI9200266A patent/SI9200266B/sl unknown
- 1992-10-26 RU RU9292004358A patent/RU2067089C1/ru active
- 1992-10-28 JP JP29025592A patent/JP3174171B2/ja not_active Expired - Fee Related
- 1992-10-29 HR HRA2174/91A patent/HRP921142B1/xx not_active IP Right Cessation
- 1992-10-29 KR KR1019920020000A patent/KR100255439B1/ko not_active IP Right Cessation
- 1992-10-30 CZ CS923268A patent/CZ284495B6/cs not_active IP Right Cessation
- 1992-10-30 HU HU9203428A patent/HU215495B/hu not_active IP Right Cessation
- 1992-10-30 SK SK3268-92A patent/SK280163B6/sk unknown
-
1993
- 1993-06-18 UA UA93003017A patent/UA26382C2/uk unknown
Also Published As
Publication number | Publication date |
---|---|
ATA217491A (de) | 1992-11-15 |
YU88092A (sh) | 1995-10-24 |
AU2628892A (en) | 1993-05-06 |
SK280163B6 (sk) | 1999-09-10 |
CZ284495B6 (cs) | 1998-12-16 |
ZA927235B (en) | 1993-03-24 |
AU656812B2 (en) | 1995-02-16 |
AT396252B (de) | 1993-07-26 |
SK326892A3 (en) | 1995-11-08 |
HU215495B (hu) | 1999-01-28 |
KR930008156A (ko) | 1993-05-21 |
EP0539767B1 (de) | 1998-01-21 |
HRP921142B1 (en) | 1999-06-30 |
US5346816A (en) | 1994-09-13 |
DE59209147D1 (de) | 1998-02-26 |
KR100255439B1 (ko) | 2000-05-01 |
RU2067089C1 (ru) | 1996-09-27 |
HUT63659A (en) | 1993-09-28 |
JPH05219988A (ja) | 1993-08-31 |
HU9203428D0 (en) | 1993-01-28 |
EP0539767A1 (de) | 1993-05-05 |
JP3174171B2 (ja) | 2001-06-11 |
ATE162554T1 (de) | 1998-02-15 |
TW237479B (sl) | 1995-01-01 |
NZ244238A (en) | 1994-12-22 |
SI9200266A (en) | 1993-06-30 |
DK0539767T3 (da) | 1998-02-09 |
ES2111028T3 (es) | 1998-03-01 |
UA26382C2 (uk) | 1999-08-30 |
CA2078942A1 (en) | 1993-05-01 |
CZ326892A3 (en) | 1993-05-12 |
HRP921142A2 (en) | 1995-12-31 |
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