SI9010607B - Farmakolosko aktivne CNS spojine - Google Patents
Farmakolosko aktivne CNS spojine Download PDFInfo
- Publication number
- SI9010607B SI9010607B SI9010607A SI9010607A SI9010607B SI 9010607 B SI9010607 B SI 9010607B SI 9010607 A SI9010607 A SI 9010607A SI 9010607 A SI9010607 A SI 9010607A SI 9010607 B SI9010607 B SI 9010607B
- Authority
- SI
- Slovenia
- Prior art keywords
- compound
- formula
- salt
- methylpiperazin
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 6
- 238000000034 method Methods 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 5
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- -1 2,3,5-trichlorophenyl Chemical group 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000003125 aqueous solvent Substances 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- PEDBWYZDQIQHNH-UHFFFAOYSA-N 2-(2,3,5-trichlorophenyl)pyrimidine Chemical compound ClC1=CC(Cl)=C(Cl)C(C=2N=CC=CN=2)=C1 PEDBWYZDQIQHNH-UHFFFAOYSA-N 0.000 claims 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 1
- 244000248349 Citrus limon Species 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 claims 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 235000014786 phosphorus Nutrition 0.000 claims 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 235000001508 sulfur Nutrition 0.000 claims 1
- 235000014101 wine Nutrition 0.000 claims 1
- OXPDQFOKSZYEMJ-UHFFFAOYSA-N 2-phenylpyrimidine Chemical class C1=CC=CC=C1C1=NC=CC=N1 OXPDQFOKSZYEMJ-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898908561A GB8908561D0 (en) | 1989-04-14 | 1989-04-14 | Pharmaceutically active cns compounds |
| YU60790A YU47557B (sh) | 1989-04-14 | 1990-03-28 | Postupak za dobijanje 5-fenilpirimidin jedinjenja i njihovih soli |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9010607A SI9010607A (en) | 1997-06-30 |
| SI9010607B true SI9010607B (sl) | 2006-06-30 |
Family
ID=10655105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9010607A SI9010607B (sl) | 1989-04-14 | 1990-03-28 | Farmakolosko aktivne CNS spojine |
Country Status (5)
| Country | Link |
|---|---|
| CZ (1) | CZ287351B6 (cs) |
| GB (1) | GB8908561D0 (cs) |
| HR (1) | HRP940540B1 (cs) |
| SI (1) | SI9010607B (cs) |
| YU (1) | YU47557B (cs) |
-
1989
- 1989-04-14 GB GB898908561A patent/GB8908561D0/en active Pending
-
1990
- 1990-03-28 YU YU60790A patent/YU47557B/sh unknown
- 1990-03-28 SI SI9010607A patent/SI9010607B/sl not_active IP Right Cessation
-
1994
- 1994-09-16 HR HR940540A patent/HRP940540B1/xx not_active IP Right Cessation
-
1998
- 1998-12-07 CZ CZ19984011A patent/CZ287351B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| YU60790A (sh) | 1994-04-05 |
| SI9010607A (en) | 1997-06-30 |
| CZ287351B6 (cs) | 2000-10-11 |
| HRP940540B1 (en) | 2000-12-31 |
| GB8908561D0 (en) | 1989-06-01 |
| YU47557B (sh) | 1995-10-03 |
| HRP940540A2 (en) | 1996-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20060509 |
|
| KO00 | Lapse of patent |
Effective date: 20060525 |