SI9010198B - Derivati tetrahidrobenzimidazola in postopek za njihovo pripravo - Google Patents

Derivati tetrahidrobenzimidazola in postopek za njihovo pripravo Download PDF

Info

Publication number
SI9010198B
SI9010198B SI9010198A SI9010198A SI9010198B SI 9010198 B SI9010198 B SI 9010198B SI 9010198 A SI9010198 A SI 9010198A SI 9010198 A SI9010198 A SI 9010198A SI 9010198 B SI9010198 B SI 9010198B
Authority
SI
Slovenia
Prior art keywords
compound according
het
tetrahydrobenzimidazole
carbonyl
lower alkyl
Prior art date
Application number
SI9010198A
Other languages
English (en)
Other versions
SI9010198A (sl
Inventor
Mitsuaki Ohta
Tokuo Koide
Takeshi Suzuki
Akira Matsuhisa
Keiji Miyata
Junya Ohmori
Isao Yanagisawa
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Priority claimed from YU19890A external-priority patent/YU47555B/sh
Publication of SI9010198A publication Critical patent/SI9010198A/sl
Publication of SI9010198B publication Critical patent/SI9010198B/sl

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (8)

  1. PATENTNI ZAHTEVKI 1. Tetrahidrobenzimidazolni derivat, označen s tem, da ima formulo (I): II
    o kjer Het pomeni člana, izbranega iz skupine, ki jo sestavljajo pirolidin, piperidin, piperazin, morfolin, pirol, furan, tiofen, imidazol, oksazol, tiazol, pirazol, izoksazol, izotiazol, triazol, tiadiazol, oksadiazol, piridin, piridazin, pirimidin, pirazin, 4H-ciklopentatiazol, indol, izoindol, 2,3-dihidroindol, (indolin), izoindolin, hidroksiindol, indazol, indolizin, benzotiofen, benzofuran, benzotiazol, benzimidazol, benzooksazol, 4,5,6,7-tetrahidrobenzotiofen, 2,3-dihidrobenzimidazol-2-on, kinolin, izokinolin, 1,2,3,4-tetrahidrokinolin, 1,2,3,4-tetrahidroizokinolin, 1,4-benzoksazin, fenotiazin, karbazol in /3-karbolin in kjer je Het lahko substituiran z enim do tri substituenti, izbranimi iz skupine, ki jo sestavljajo nižji alkil, nižji alkenil, nižji alkinil, cikloalkil-nižji alkil, ar alkil, nižji alkoksi, nitro, hidroksil, nižji alkoksikarbonil in halo; in X pomeni enojno vez ali -ΝΗ-, ki je vezan na atom ogljika ali dušika heterocikličnega obroča navedenega Het, ali njegova farmacevtsko sprejemljiva sol.
  2. 2. Spojina po zahtevku 1, označena s tem, da ima Het formulo:
    kjer R1 pomeni vodik, nižji alkil, nižji alkenil, nižji alkinil, cikloalkil-nižji alkil ali aralkil; R2 pomeni vodik, nižji alkil ali aralkil; in R1 pomeni vodik, nižji alkoksi, nitro, hidroksil, nižji alkoksikarbonil ali halo; in X pomeni enojno vez. 1 Spojina po zahtevku 1, označena s tem, da Het pomeni heterociklično skupino, ki vsebuje dušik in je X enojna vez, vezana na atom dušika heterocikličnega obroča, ki vsebuje dušik.
  3. 4. Spojina po zahtevku 2, označena s tem, da je 5-[(l-metilindol-3-il)karbonil]-4,5,6,7-tetrahidrobenzimidazol.
  4. 5. Spojina po zahtevku 4, označena s tem, daje (R)-spojina.
  5. 6. Spojina po zahtevku 4, označena s tem, da je (S)-spojina.
  6. 7. Spojina po zahtevku 2, označena s tem, da je 5-[[l-(2-propinil)indol-3-il]karbonil]-4,5,6,7-tetrahidrobenzimidazol.
  7. 8. Spojina po zahtevku 3, označena s tem, da je 5-[(2,3-dihidroindol-l-il)karbonil]-4,5,6,7-tetrahidrobenzimidazol.
  8. 9. Spojina po zahtevku 3, označena s tem, daje l-[(4,5,6,7-tetrahidrobenzimidazol--5-il)karbonil]-2,3-dihidrobenzimidazol-2-on. Za YAMANOUCHIPHARMACEUTICAL CO., Ltd.:
    PATENTNA PISARNA, d.o.o. LJUBLJANA, ČOPOVA 14
SI9010198A 1989-02-02 1990-02-02 Derivati tetrahidrobenzimidazola in postopek za njihovo pripravo SI9010198B (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2539789 1989-02-02
JP4889789 1989-02-28
JP27344489 1989-10-20
JP34293989 1989-12-28
YU19890A YU47555B (sh) 1989-02-02 1990-02-02 Derivati tetrahidrobenzimidazola i postupak za njihovo dobijanje

Publications (2)

Publication Number Publication Date
SI9010198A SI9010198A (sl) 1997-06-30
SI9010198B true SI9010198B (sl) 1998-10-31

Family

ID=27520734

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9010198A SI9010198B (sl) 1989-02-02 1990-02-02 Derivati tetrahidrobenzimidazola in postopek za njihovo pripravo

Country Status (1)

Country Link
SI (1) SI9010198B (sl)

Also Published As

Publication number Publication date
SI9010198A (sl) 1997-06-30

Similar Documents

Publication Publication Date Title
DK169674B1 (da) 1-Aryl-3-tetrahydropyridyl-, 1-aryl-3-piperidyl- eller 1-aryl-3-piperazinyl-indolderivater, fremgangsmåde til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser
CA2224062C (en) Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors
DK168600B1 (da) Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling
AU2003272979B2 (en) 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles
KR910021399A (ko) 치료제로서 유용한 3-아릴카르보닐-1h-인돌 및 그의 제조방법
RS50424B (sr) Supstituisani indoli za moduliranje nfkb aktivnosti
AR032279A1 (es) Metodo para inhibir una o mas actividades de quinasa proteinica, compuesto de 2 - pirazolin-5-ona inhibidor de quinasa proteinica y composicion farmaceutica que lo comprende
KR100389785B1 (ko) 시그마및/또는5에이취티1에이수용체에대한친화성을가진테트라히드로피리딘알킬아졸또는4-히드록시피페리딘알킬아졸
MX9605367A (es) Aminometil-2,3,8,9-tetrahidro-7h-1, 4-dioxino[2,3-e]-indol-8 onas y derivados.
CA2628233A1 (en) 5-lipoxygenase-activating protein (flap) inhibitors
JP2019537594A5 (sl)
MX2009001634A (es) Compuestos heterociclicos adecuados para el tratamiento de enfermedades relacionadas con el nivel elevado de lipidos.
JP2011088894A (ja) ヘテロアリール置換された１，３−ジヒドロインドール−２−オン誘導体および該誘導体を含有する医薬品
NO20062105L (no) Derivater av N-"fenyl(piperidin-2-yl) metylbenzamid, fremgangsmate for fremstilling derav og anvendelse av forbindelsene innenfor terapi
CA2569611A1 (en) Indole derivatives as histamine receptor antagonists
RU2007120519A (ru) Арилоксизамещенное производное бензимидазола
PE20011039A1 (es) Tiazoles e imidazopiridinas como inhibidores de la produccion de tnf
EP0863881A1 (en) Benzimidazole derivatives and their use in the prevention and/or the treatment of bone diseases
US5393761A (en) 3-arylindole compounds
CA2494962A1 (en) Tyrosine kinase inhibitors
KR970705559A (ko) 신규한 벤즈이미다졸 유도체(novel benzimidazole derivatives having cgmp-phosphodisterase inhibiting activity)
Kaur et al. Benzoxazole: The molecule of diverse pharmacological importance
BRPI0615201A2 (pt) derivado de indol ou um sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, uso de um derivativo de (indol-3-il) heterociclo, e, mÉtodo de tratamento da dor
IL98574A (en) Pharmaceutical compositions for the treatment of anxiety comprising a piperidyl indole derivative and some such novel compounds
AU2170401A (en) 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Legal Events

Date Code Title Description
IF Valid on the event date
SP73 Change of data on owner

Owner name: ASTELLAS PHARMA INC.; JP

Effective date: 20060302