SI9010198B - Derivati tetrahidrobenzimidazola in postopek za njihovo pripravo - Google Patents
Derivati tetrahidrobenzimidazola in postopek za njihovo pripravo Download PDFInfo
- Publication number
- SI9010198B SI9010198B SI9010198A SI9010198A SI9010198B SI 9010198 B SI9010198 B SI 9010198B SI 9010198 A SI9010198 A SI 9010198A SI 9010198 A SI9010198 A SI 9010198A SI 9010198 B SI9010198 B SI 9010198B
- Authority
- SI
- Slovenia
- Prior art keywords
- compound according
- het
- tetrahydrobenzimidazole
- carbonyl
- lower alkyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (8)
- PATENTNI ZAHTEVKI 1. Tetrahidrobenzimidazolni derivat, označen s tem, da ima formulo (I): IIo kjer Het pomeni člana, izbranega iz skupine, ki jo sestavljajo pirolidin, piperidin, piperazin, morfolin, pirol, furan, tiofen, imidazol, oksazol, tiazol, pirazol, izoksazol, izotiazol, triazol, tiadiazol, oksadiazol, piridin, piridazin, pirimidin, pirazin, 4H-ciklopentatiazol, indol, izoindol, 2,3-dihidroindol, (indolin), izoindolin, hidroksiindol, indazol, indolizin, benzotiofen, benzofuran, benzotiazol, benzimidazol, benzooksazol, 4,5,6,7-tetrahidrobenzotiofen, 2,3-dihidrobenzimidazol-2-on, kinolin, izokinolin, 1,2,3,4-tetrahidrokinolin, 1,2,3,4-tetrahidroizokinolin, 1,4-benzoksazin, fenotiazin, karbazol in /3-karbolin in kjer je Het lahko substituiran z enim do tri substituenti, izbranimi iz skupine, ki jo sestavljajo nižji alkil, nižji alkenil, nižji alkinil, cikloalkil-nižji alkil, ar alkil, nižji alkoksi, nitro, hidroksil, nižji alkoksikarbonil in halo; in X pomeni enojno vez ali -ΝΗ-, ki je vezan na atom ogljika ali dušika heterocikličnega obroča navedenega Het, ali njegova farmacevtsko sprejemljiva sol.
- 2. Spojina po zahtevku 1, označena s tem, da ima Het formulo:kjer R1 pomeni vodik, nižji alkil, nižji alkenil, nižji alkinil, cikloalkil-nižji alkil ali aralkil; R2 pomeni vodik, nižji alkil ali aralkil; in R1 pomeni vodik, nižji alkoksi, nitro, hidroksil, nižji alkoksikarbonil ali halo; in X pomeni enojno vez. 1 Spojina po zahtevku 1, označena s tem, da Het pomeni heterociklično skupino, ki vsebuje dušik in je X enojna vez, vezana na atom dušika heterocikličnega obroča, ki vsebuje dušik.
- 4. Spojina po zahtevku 2, označena s tem, da je 5-[(l-metilindol-3-il)karbonil]-4,5,6,7-tetrahidrobenzimidazol.
- 5. Spojina po zahtevku 4, označena s tem, daje (R)-spojina.
- 6. Spojina po zahtevku 4, označena s tem, da je (S)-spojina.
- 7. Spojina po zahtevku 2, označena s tem, da je 5-[[l-(2-propinil)indol-3-il]karbonil]-4,5,6,7-tetrahidrobenzimidazol.
- 8. Spojina po zahtevku 3, označena s tem, da je 5-[(2,3-dihidroindol-l-il)karbonil]-4,5,6,7-tetrahidrobenzimidazol.
- 9. Spojina po zahtevku 3, označena s tem, daje l-[(4,5,6,7-tetrahidrobenzimidazol--5-il)karbonil]-2,3-dihidrobenzimidazol-2-on. Za YAMANOUCHIPHARMACEUTICAL CO., Ltd.:PATENTNA PISARNA, d.o.o. LJUBLJANA, ČOPOVA 14
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2539789 | 1989-02-02 | ||
JP4889789 | 1989-02-28 | ||
JP27344489 | 1989-10-20 | ||
JP34293989 | 1989-12-28 | ||
YU19890A YU47555B (sh) | 1989-02-02 | 1990-02-02 | Derivati tetrahidrobenzimidazola i postupak za njihovo dobijanje |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9010198A SI9010198A (sl) | 1997-06-30 |
SI9010198B true SI9010198B (sl) | 1998-10-31 |
Family
ID=27520734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9010198A SI9010198B (sl) | 1989-02-02 | 1990-02-02 | Derivati tetrahidrobenzimidazola in postopek za njihovo pripravo |
Country Status (1)
Country | Link |
---|---|
SI (1) | SI9010198B (sl) |
-
1990
- 1990-02-02 SI SI9010198A patent/SI9010198B/sl unknown
Also Published As
Publication number | Publication date |
---|---|
SI9010198A (sl) | 1997-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK169674B1 (da) | 1-Aryl-3-tetrahydropyridyl-, 1-aryl-3-piperidyl- eller 1-aryl-3-piperazinyl-indolderivater, fremgangsmåde til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser | |
CA2224062C (en) | Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors | |
DK168600B1 (da) | Piperidin-3-yl eller (1,2,5,6-tetrahydro-pyrid-3-yl)-substituerede heterocykliske forbindelser, farmaceutiske kompositioner deraf, og fremgangsmåder til deres fremstilling | |
AU2003272979B2 (en) | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | |
KR910021399A (ko) | 치료제로서 유용한 3-아릴카르보닐-1h-인돌 및 그의 제조방법 | |
RS50424B (sr) | Supstituisani indoli za moduliranje nfkb aktivnosti | |
AR032279A1 (es) | Metodo para inhibir una o mas actividades de quinasa proteinica, compuesto de 2 - pirazolin-5-ona inhibidor de quinasa proteinica y composicion farmaceutica que lo comprende | |
KR100389785B1 (ko) | 시그마및/또는5에이취티1에이수용체에대한친화성을가진테트라히드로피리딘알킬아졸또는4-히드록시피페리딘알킬아졸 | |
MX9605367A (es) | Aminometil-2,3,8,9-tetrahidro-7h-1, 4-dioxino[2,3-e]-indol-8 onas y derivados. | |
CA2628233A1 (en) | 5-lipoxygenase-activating protein (flap) inhibitors | |
JP2019537594A5 (sl) | ||
MX2009001634A (es) | Compuestos heterociclicos adecuados para el tratamiento de enfermedades relacionadas con el nivel elevado de lipidos. | |
JP2011088894A (ja) | ヘテロアリール置換された1,3−ジヒドロインドール−2−オン誘導体および該誘導体を含有する医薬品 | |
NO20062105L (no) | Derivater av N-"fenyl(piperidin-2-yl) metylbenzamid, fremgangsmate for fremstilling derav og anvendelse av forbindelsene innenfor terapi | |
CA2569611A1 (en) | Indole derivatives as histamine receptor antagonists | |
RU2007120519A (ru) | Арилоксизамещенное производное бензимидазола | |
PE20011039A1 (es) | Tiazoles e imidazopiridinas como inhibidores de la produccion de tnf | |
EP0863881A1 (en) | Benzimidazole derivatives and their use in the prevention and/or the treatment of bone diseases | |
US5393761A (en) | 3-arylindole compounds | |
CA2494962A1 (en) | Tyrosine kinase inhibitors | |
KR970705559A (ko) | 신규한 벤즈이미다졸 유도체(novel benzimidazole derivatives having cgmp-phosphodisterase inhibiting activity) | |
Kaur et al. | Benzoxazole: The molecule of diverse pharmacological importance | |
BRPI0615201A2 (pt) | derivado de indol ou um sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, uso de um derivativo de (indol-3-il) heterociclo, e, mÉtodo de tratamento da dor | |
IL98574A (en) | Pharmaceutical compositions for the treatment of anxiety comprising a piperidyl indole derivative and some such novel compounds | |
AU2170401A (en) | 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF | Valid on the event date | ||
SP73 | Change of data on owner |
Owner name: ASTELLAS PHARMA INC.; JP Effective date: 20060302 |