SI8811154B - Postopek za pripravo derivatov stavrosporina,substituiranih na metilaminakem dušiku - Google Patents
Postopek za pripravo derivatov stavrosporina,substituiranih na metilaminakem dušiku Download PDFInfo
- Publication number
- SI8811154B SI8811154B SI8811154A SI8811154A SI8811154B SI 8811154 B SI8811154 B SI 8811154B SI 8811154 A SI8811154 A SI 8811154A SI 8811154 A SI8811154 A SI 8811154A SI 8811154 B SI8811154 B SI 8811154B
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- SI
- Slovenia
- Prior art keywords
- formula
- stau
- salt
- compound
- converted
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (1)
- 67 patentni zahtevek Postopek za pripravo N-substituiranih derivatov stavrosporina s splošno formulo (n, • /Stau/-N(CH3)-R kjer /Stau/ predstavlja ostanek z delno formulo H[Stau] in je R aciklični, karbociklični ali karbociklično-aciklični ogljikovodikov ostanek R°, ki ima skupno največ 30 atomov ogljika, in ki je lahko nasičen ali nenasičen in nesubstituiran ali substituiran, pri čemer lahko namesto enega, dveh ali večih atomov ogljika nastopajo enaki ali različni heteroatomi, izbrani izmed kisika, žvepla in dušika; ali acil Ac, ki ima največ 30 atomov ogljika; kot tudi soli spojin s formulo I s solotvornimi lastnostmi, označen s tem, da stavrosporin s formulo (Stauj-NH-CH^ (II), kjer ima (Stau) zgoraj navedeni pomen, ali njegovo kislinsko adicijsko sol, presnovimo z reagentom s formulo R-Y (III) - 68 - kjer ima R zgoraj navedene pomene in Y pomeni reakcije sposobno aktivirano hidroksilno skupino ali dodatno enojno vez, katere drugi konec nadomešča vodik v ostanku R, ter po želji dobljeno spojino s formulo I pretvorimo v neko drugo spojino s formulo I in/ali v prosti obliki dobljeno spojino s formulo I pretvorimo v njeno sol; in/ali spojino s formulo I, dobljeno kot sol, prevedemo v njeno prosto obliko ali neko drugo sol. Za CIBA-GEIGY AG:6
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH224487 | 1987-06-15 | ||
| CH144088 | 1988-04-19 | ||
| YU01154/88A YU115488A (en) | 1987-06-15 | 1988-06-14 | Process for preparing derivatives of stavrosporine, substituted on methylaminic nitrogen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI8811154A SI8811154A (sl) | 1996-10-31 |
| SI8811154B true SI8811154B (sl) | 1998-06-30 |
Family
ID=27172978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI8811154A SI8811154B (sl) | 1987-06-15 | 1988-06-14 | Postopek za pripravo derivatov stavrosporina,substituiranih na metilaminakem dušiku |
Country Status (2)
| Country | Link |
|---|---|
| HR (1) | HRP940452B1 (sl) |
| SI (1) | SI8811154B (sl) |
-
1988
- 1988-06-14 SI SI8811154A patent/SI8811154B/sl unknown
-
1994
- 1994-08-10 HR HRP-1154/88A patent/HRP940452B1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP940452B1 (en) | 1999-08-31 |
| HRP940452A2 (en) | 1997-04-30 |
| SI8811154A (sl) | 1996-10-31 |
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