SI4028017T1 - 1,4-dihidrobenzo(d)pirazolo(3,4-f)(1,3)diazepin derivati in sorodne spojine kot modulatorji lrrk2, nuak1 in/ali tyk2 kinaze za zdravljenje npr. avtoimunske bolezni - Google Patents
1,4-dihidrobenzo(d)pirazolo(3,4-f)(1,3)diazepin derivati in sorodne spojine kot modulatorji lrrk2, nuak1 in/ali tyk2 kinaze za zdravljenje npr. avtoimunske bolezniInfo
- Publication number
- SI4028017T1 SI4028017T1 SI202030353T SI202030353T SI4028017T1 SI 4028017 T1 SI4028017 T1 SI 4028017T1 SI 202030353 T SI202030353 T SI 202030353T SI 202030353 T SI202030353 T SI 202030353T SI 4028017 T1 SI4028017 T1 SI 4028017T1
- Authority
- SI
- Slovenia
- Prior art keywords
- nuak1
- lrrk2
- npr
- dihydrobenzo
- pyrazolo
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 101000970023 Homo sapiens NUAK family SNF1-like kinase 1 Proteins 0.000 title 1
- 101000844245 Homo sapiens Non-receptor tyrosine-protein kinase TYK2 Proteins 0.000 title 1
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 title 1
- 102100032693 Leucine-rich repeat serine/threonine-protein kinase 2 Human genes 0.000 title 1
- ORQJPWRNWPJVTJ-UHFFFAOYSA-N N1N=CC2=C1C1=C(N=CN2)C=CC=C1 Chemical class N1N=CC2=C1C1=C(N=CN2)C=CC=C1 ORQJPWRNWPJVTJ-UHFFFAOYSA-N 0.000 title 1
- 102100021732 NUAK family SNF1-like kinase 1 Human genes 0.000 title 1
- 102100032028 Non-receptor tyrosine-protein kinase TYK2 Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
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- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Dermatology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962899908P | 2019-09-13 | 2019-09-13 | |
| EP20788868.6A EP4028017B1 (en) | 2019-09-13 | 2020-09-11 | 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune diseases |
| PCT/IB2020/000730 WO2021048620A1 (en) | 2019-09-13 | 2020-09-11 | 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI4028017T1 true SI4028017T1 (sl) | 2024-04-30 |
Family
ID=72801756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI202030353T SI4028017T1 (sl) | 2019-09-13 | 2020-09-11 | 1,4-dihidrobenzo(d)pirazolo(3,4-f)(1,3)diazepin derivati in sorodne spojine kot modulatorji lrrk2, nuak1 in/ali tyk2 kinaze za zdravljenje npr. avtoimunske bolezni |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20220380374A1 (https=) |
| EP (2) | EP4327884A3 (https=) |
| JP (2) | JP7796007B2 (https=) |
| KR (1) | KR20220062038A (https=) |
| CN (2) | CN114793435B (https=) |
| AU (1) | AU2020344216A1 (https=) |
| CA (1) | CA3154123A1 (https=) |
| DK (1) | DK4028017T3 (https=) |
| ES (1) | ES2969088T3 (https=) |
| FI (1) | FI4028017T3 (https=) |
| HU (1) | HUE065093T2 (https=) |
| IL (1) | IL291335A (https=) |
| PL (1) | PL4028017T3 (https=) |
| PT (1) | PT4028017T (https=) |
| RS (1) | RS65045B1 (https=) |
| SI (1) | SI4028017T1 (https=) |
| WO (1) | WO2021048620A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7796007B2 (ja) * | 2019-09-13 | 2026-01-08 | オリゲニス ゲーエムベーハー | 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物 |
| JP2022548581A (ja) * | 2019-09-13 | 2022-11-21 | オリゲニス ゲーエムベーハー | 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物 |
| EP4423086A1 (en) | 2021-10-25 | 2024-09-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2350086B1 (en) | 2008-09-23 | 2021-04-21 | The Johns Hopkins University | Fused diimidazodiazepine compounds and methods of use and manufacture thereof |
| AU2012244549B2 (en) * | 2011-04-21 | 2017-04-20 | Origenis Gmbh | Heterocyclic compounds as kinase inhibitors |
| RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| JP7796007B2 (ja) * | 2019-09-13 | 2026-01-08 | オリゲニス ゲーエムベーハー | 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物 |
| JP2022548581A (ja) | 2019-09-13 | 2022-11-21 | オリゲニス ゲーエムベーハー | 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物 |
-
2020
- 2020-09-11 JP JP2022516097A patent/JP7796007B2/ja active Active
- 2020-09-11 PL PL20788868.6T patent/PL4028017T3/pl unknown
- 2020-09-11 FI FIEP20788868.6T patent/FI4028017T3/fi active
- 2020-09-11 EP EP23205855.2A patent/EP4327884A3/en active Pending
- 2020-09-11 WO PCT/IB2020/000730 patent/WO2021048620A1/en not_active Ceased
- 2020-09-11 US US17/642,142 patent/US20220380374A1/en not_active Abandoned
- 2020-09-11 CN CN202080078998.0A patent/CN114793435B/zh active Active
- 2020-09-11 RS RS20240045A patent/RS65045B1/sr unknown
- 2020-09-11 CN CN202411291626.2A patent/CN119775277A/zh active Pending
- 2020-09-11 HU HUE20788868A patent/HUE065093T2/hu unknown
- 2020-09-11 SI SI202030353T patent/SI4028017T1/sl unknown
- 2020-09-11 AU AU2020344216A patent/AU2020344216A1/en active Pending
- 2020-09-11 CA CA3154123A patent/CA3154123A1/en active Pending
- 2020-09-11 EP EP20788868.6A patent/EP4028017B1/en active Active
- 2020-09-11 DK DK20788868.6T patent/DK4028017T3/da active
- 2020-09-11 PT PT207888686T patent/PT4028017T/pt unknown
- 2020-09-11 ES ES20788868T patent/ES2969088T3/es active Active
- 2020-09-11 KR KR1020227011532A patent/KR20220062038A/ko active Pending
-
2022
- 2022-03-13 IL IL291335A patent/IL291335A/en unknown
-
2025
- 2025-02-26 JP JP2025028912A patent/JP2025081660A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT4028017T (pt) | 2024-01-16 |
| PL4028017T3 (pl) | 2024-03-18 |
| CA3154123A1 (en) | 2021-03-18 |
| IL291335A (en) | 2022-05-01 |
| DK4028017T3 (da) | 2024-01-15 |
| FI4028017T3 (fi) | 2024-01-11 |
| EP4028017B1 (en) | 2023-12-06 |
| EP4327884A3 (en) | 2024-05-01 |
| HUE065093T2 (hu) | 2024-05-28 |
| WO2021048620A1 (en) | 2021-03-18 |
| CN114793435A (zh) | 2022-07-26 |
| RS65045B1 (sr) | 2024-02-29 |
| AU2020344216A1 (en) | 2022-03-31 |
| ES2969088T3 (es) | 2024-05-16 |
| JP2025081660A (ja) | 2025-05-27 |
| JP2022548246A (ja) | 2022-11-17 |
| EP4028017A1 (en) | 2022-07-20 |
| JP7796007B2 (ja) | 2026-01-08 |
| CN114793435B (zh) | 2024-10-01 |
| US20220380374A1 (en) | 2022-12-01 |
| CN119775277A (zh) | 2025-04-08 |
| KR20220062038A (ko) | 2022-05-13 |
| EP4327884A2 (en) | 2024-02-28 |
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