KR20220062038A - 예를 들어 자가면역 질환의 치료를 위한 lrrk2, nuak1 및/또는 tyk2 키나제 조정제로서의 1,4-디히드로벤조[d]피라졸로[3,4-f][1,3]디아제핀 유도체 및 관련 화합물 - Google Patents

예를 들어 자가면역 질환의 치료를 위한 lrrk2, nuak1 및/또는 tyk2 키나제 조정제로서의 1,4-디히드로벤조[d]피라졸로[3,4-f][1,3]디아제핀 유도체 및 관련 화합물 Download PDF

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KR20220062038A
KR20220062038A KR1020227011532A KR20227011532A KR20220062038A KR 20220062038 A KR20220062038 A KR 20220062038A KR 1020227011532 A KR1020227011532 A KR 1020227011532A KR 20227011532 A KR20227011532 A KR 20227011532A KR 20220062038 A KR20220062038 A KR 20220062038A
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compound
heterocycloalkyl
alkyl
nrr
cycloalkyl
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롤란트 쾨스틀러
미카엘 토르만
장 타셀
나세르 예히아
안드레아스 트레믈
미카엘 알름스테터
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오리제니스 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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KR1020227011532A 2019-09-13 2020-09-11 예를 들어 자가면역 질환의 치료를 위한 lrrk2, nuak1 및/또는 tyk2 키나제 조정제로서의 1,4-디히드로벤조[d]피라졸로[3,4-f][1,3]디아제핀 유도체 및 관련 화합물 Pending KR20220062038A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962899908P 2019-09-13 2019-09-13
US62/899,908 2019-09-13
PCT/IB2020/000730 WO2021048620A1 (en) 2019-09-13 2020-09-11 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease

Publications (1)

Publication Number Publication Date
KR20220062038A true KR20220062038A (ko) 2022-05-13

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KR1020227011532A Pending KR20220062038A (ko) 2019-09-13 2020-09-11 예를 들어 자가면역 질환의 치료를 위한 lrrk2, nuak1 및/또는 tyk2 키나제 조정제로서의 1,4-디히드로벤조[d]피라졸로[3,4-f][1,3]디아제핀 유도체 및 관련 화합물

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US (1) US20220380374A1 (https=)
EP (2) EP4327884A3 (https=)
JP (2) JP7796007B2 (https=)
KR (1) KR20220062038A (https=)
CN (2) CN114793435B (https=)
AU (1) AU2020344216A1 (https=)
CA (1) CA3154123A1 (https=)
DK (1) DK4028017T3 (https=)
ES (1) ES2969088T3 (https=)
FI (1) FI4028017T3 (https=)
HU (1) HUE065093T2 (https=)
IL (1) IL291335A (https=)
PL (1) PL4028017T3 (https=)
PT (1) PT4028017T (https=)
RS (1) RS65045B1 (https=)
SI (1) SI4028017T1 (https=)
WO (1) WO2021048620A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7796007B2 (ja) * 2019-09-13 2026-01-08 オリゲニス ゲーエムベーハー 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物
JP2022548581A (ja) * 2019-09-13 2022-11-21 オリゲニス ゲーエムベーハー 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物
EP4423086A1 (en) 2021-10-25 2024-09-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof

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EP2350086B1 (en) 2008-09-23 2021-04-21 The Johns Hopkins University Fused diimidazodiazepine compounds and methods of use and manufacture thereof
AU2012244549B2 (en) * 2011-04-21 2017-04-20 Origenis Gmbh Heterocyclic compounds as kinase inhibitors
RU2722149C1 (ru) 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
JP7796007B2 (ja) * 2019-09-13 2026-01-08 オリゲニス ゲーエムベーハー 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物
JP2022548581A (ja) 2019-09-13 2022-11-21 オリゲニス ゲーエムベーハー 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物

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PT4028017T (pt) 2024-01-16
PL4028017T3 (pl) 2024-03-18
CA3154123A1 (en) 2021-03-18
IL291335A (en) 2022-05-01
DK4028017T3 (da) 2024-01-15
SI4028017T1 (sl) 2024-04-30
FI4028017T3 (fi) 2024-01-11
EP4028017B1 (en) 2023-12-06
EP4327884A3 (en) 2024-05-01
HUE065093T2 (hu) 2024-05-28
WO2021048620A1 (en) 2021-03-18
CN114793435A (zh) 2022-07-26
RS65045B1 (sr) 2024-02-29
AU2020344216A1 (en) 2022-03-31
ES2969088T3 (es) 2024-05-16
JP2025081660A (ja) 2025-05-27
JP2022548246A (ja) 2022-11-17
EP4028017A1 (en) 2022-07-20
JP7796007B2 (ja) 2026-01-08
CN114793435B (zh) 2024-10-01
US20220380374A1 (en) 2022-12-01
CN119775277A (zh) 2025-04-08
EP4327884A2 (en) 2024-02-28

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