SI3630729T1 - Pirimidinska spojina - Google Patents

Pirimidinska spojina

Info

Publication number
SI3630729T1
SI3630729T1 SI201830499T SI201830499T SI3630729T1 SI 3630729 T1 SI3630729 T1 SI 3630729T1 SI 201830499 T SI201830499 T SI 201830499T SI 201830499 T SI201830499 T SI 201830499T SI 3630729 T1 SI3630729 T1 SI 3630729T1
Authority
SI
Slovenia
Prior art keywords
pyrimidine compound
pyrimidine
compound
Prior art date
Application number
SI201830499T
Other languages
English (en)
Inventor
Tomoichi Shinohara
Shin Iwata
Kenta Arai
Nobuaki Ito
Masaki Suzuki
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of SI3630729T1 publication Critical patent/SI3630729T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201830499T 2017-05-31 2018-05-31 Pirimidinska spojina SI3630729T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2017/020322 WO2018220762A1 (ja) 2017-05-31 2017-05-31 ピリミジン化合物
PCT/JP2018/020997 WO2018221667A1 (en) 2017-05-31 2018-05-31 Pyrimidine compound
EP18732930.5A EP3630729B1 (en) 2017-05-31 2018-05-31 Pyrimidine compound

Publications (1)

Publication Number Publication Date
SI3630729T1 true SI3630729T1 (sl) 2022-01-31

Family

ID=62685028

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201830499T SI3630729T1 (sl) 2017-05-31 2018-05-31 Pirimidinska spojina

Country Status (24)

Country Link
US (3) US10800758B2 (sl)
EP (1) EP3630729B1 (sl)
JP (1) JP6739653B2 (sl)
KR (2) KR20240116588A (sl)
CN (1) CN110603248B (sl)
AU (1) AU2018277949B2 (sl)
BR (1) BR112019023988A2 (sl)
CA (1) CA3064176A1 (sl)
CY (1) CY1125073T1 (sl)
DK (1) DK3630729T3 (sl)
EA (1) EA038907B1 (sl)
ES (1) ES2901452T3 (sl)
HR (1) HRP20211913T1 (sl)
HU (1) HUE056942T2 (sl)
IL (1) IL270579B2 (sl)
LT (1) LT3630729T (sl)
MX (1) MX2019014384A (sl)
PH (1) PH12019502639A1 (sl)
PL (1) PL3630729T3 (sl)
PT (1) PT3630729T (sl)
SA (1) SA519410563B1 (sl)
SI (1) SI3630729T1 (sl)
TW (1) TWI808974B (sl)
WO (2) WO2018220762A1 (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210097148A (ko) * 2018-11-30 2021-08-06 오츠카 세이야쿠 가부시키가이샤 간질의 치료를 위한 헤테로시클릭 화합물
JP6870064B2 (ja) * 2018-11-30 2021-05-12 大塚製薬株式会社 ピリミジン化合物の医薬用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003249812A1 (en) * 2002-07-18 2004-02-09 Queen's University At Kingston Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents
ES2575215T3 (es) * 2009-12-11 2016-06-27 Autifony Therapeutics Limited Derivados de imidazolidindiona
EP2528441A4 (en) * 2010-01-25 2013-07-10 Chdi Foundation Inc CERTAIN KYNURENIN-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
JP5913357B2 (ja) 2010-12-06 2016-04-27 アウトイフオンイ トヘラペウトイクス リミテッド Kv3阻害剤として有用なヒダントイン誘導体
EP2718285B1 (en) * 2011-06-07 2016-03-16 Autifony Therapeutics Limited Hydantoin derivatives as kv3 inhibitors
EP2736337A4 (en) 2011-07-28 2014-12-17 Chdi Foundation Inc CYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF
EP2788339B1 (en) * 2011-12-06 2016-03-09 Autifony Therapeutics Limited Hydantoin derivatives useful as kv3 inhibitors
GB201521751D0 (en) * 2015-12-10 2016-01-27 Autifony Therapeutics Ltd Novel uses

Also Published As

Publication number Publication date
PL3630729T3 (pl) 2022-01-24
WO2018220762A1 (ja) 2018-12-06
US20230138411A1 (en) 2023-05-04
TWI808974B (zh) 2023-07-21
US20200399245A1 (en) 2020-12-24
LT3630729T (lt) 2022-01-10
TW202346283A (zh) 2023-12-01
KR102688531B1 (ko) 2024-07-26
KR20240116588A (ko) 2024-07-29
DK3630729T3 (da) 2021-12-13
EA201992831A1 (ru) 2020-03-30
CY1125073T1 (el) 2023-03-24
TW201902890A (zh) 2019-01-16
AU2018277949B2 (en) 2021-11-18
JP2020503334A (ja) 2020-01-30
PT3630729T (pt) 2021-12-16
KR20200011962A (ko) 2020-02-04
ES2901452T3 (es) 2022-03-22
AU2018277949A1 (en) 2019-12-12
MX2019014384A (es) 2020-01-23
IL270579B1 (en) 2023-04-01
EP3630729B1 (en) 2021-11-03
US10800758B2 (en) 2020-10-13
US20200017476A1 (en) 2020-01-16
CN110603248B (zh) 2023-07-04
CN110603248A (zh) 2019-12-20
IL270579A (sl) 2019-12-31
SA519410563B1 (ar) 2022-07-25
HRP20211913T1 (hr) 2022-03-04
BR112019023988A2 (pt) 2020-06-30
IL270579B2 (en) 2023-08-01
WO2018221667A1 (en) 2018-12-06
HUE056942T2 (hu) 2022-03-28
CA3064176A1 (en) 2018-12-06
JP6739653B2 (ja) 2020-08-12
PH12019502639A1 (en) 2020-06-08
EP3630729A1 (en) 2020-04-08
EA038907B1 (ru) 2021-11-08

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