PL3630729T3 - Związek pirymidynowy - Google Patents

Związek pirymidynowy

Info

Publication number
PL3630729T3
PL3630729T3 PL18732930T PL18732930T PL3630729T3 PL 3630729 T3 PL3630729 T3 PL 3630729T3 PL 18732930 T PL18732930 T PL 18732930T PL 18732930 T PL18732930 T PL 18732930T PL 3630729 T3 PL3630729 T3 PL 3630729T3
Authority
PL
Poland
Prior art keywords
pyrimidine compound
pyrimidine
compound
Prior art date
Application number
PL18732930T
Other languages
English (en)
Inventor
Tomoichi Shinohara
Shin Iwata
Kenta Arai
Nobuaki Ito
Masaki Suzuki
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of PL3630729T3 publication Critical patent/PL3630729T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL18732930T 2017-05-31 2018-05-31 Związek pirymidynowy PL3630729T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2017/020322 WO2018220762A1 (ja) 2017-05-31 2017-05-31 ピリミジン化合物
PCT/JP2018/020997 WO2018221667A1 (en) 2017-05-31 2018-05-31 Pyrimidine compound
EP18732930.5A EP3630729B1 (en) 2017-05-31 2018-05-31 Pyrimidine compound

Publications (1)

Publication Number Publication Date
PL3630729T3 true PL3630729T3 (pl) 2022-01-24

Family

ID=62685028

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18732930T PL3630729T3 (pl) 2017-05-31 2018-05-31 Związek pirymidynowy

Country Status (23)

Country Link
US (4) US10800758B2 (pl)
EP (1) EP3630729B1 (pl)
JP (1) JP6739653B2 (pl)
KR (3) KR20250065436A (pl)
CN (1) CN110603248B (pl)
AU (1) AU2018277949B2 (pl)
CY (1) CY1125073T1 (pl)
DK (1) DK3630729T3 (pl)
EA (1) EA038907B1 (pl)
ES (1) ES2901452T3 (pl)
HR (1) HRP20211913T1 (pl)
HU (1) HUE056942T2 (pl)
IL (1) IL270579B2 (pl)
LT (1) LT3630729T (pl)
MX (1) MX391338B (pl)
MY (1) MY199251A (pl)
PH (1) PH12019502639A1 (pl)
PL (1) PL3630729T3 (pl)
PT (1) PT3630729T (pl)
SA (1) SA519410563B1 (pl)
SI (1) SI3630729T1 (pl)
TW (3) TW202502754A (pl)
WO (2) WO2018220762A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6870064B2 (ja) * 2018-11-30 2021-05-12 大塚製薬株式会社 ピリミジン化合物の医薬用途
KR20260110250A (ko) 2018-11-30 2026-07-14 오츠카 세이야쿠 가부시키가이샤 간질의 치료를 위한 헤테로시클릭 화합물
JP7804407B2 (ja) * 2020-05-29 2026-01-22 大塚製薬株式会社 複素環化合物の医薬用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003249812A1 (en) * 2002-07-18 2004-02-09 Queen's University At Kingston Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents
EP2509961B1 (en) * 2009-12-11 2016-03-09 Autifony Therapeutics Limited Imidazolidinedione derivatives
NZ601547A (en) * 2010-01-25 2014-04-30 Chdi Foundation Inc Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
KR101862375B1 (ko) 2010-12-06 2018-05-29 오티포니 세라피틱스 리미티드 Kv3 억제제로서 유용한 하이단토인 유도체
US9193704B2 (en) 2011-06-07 2015-11-24 Autifony Therapeutics Limited Hydantoin derivatives as KV3 inhibitors
PH12014500239A1 (en) 2011-07-28 2014-03-31 Chdi Foundation Inc Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
PL2788339T3 (pl) * 2011-12-06 2016-09-30 Pochodne hydantoiny przydatne jako inhibitory KV3
GB201521751D0 (en) * 2015-12-10 2016-01-27 Autifony Therapeutics Ltd Novel uses

Also Published As

Publication number Publication date
WO2018220762A1 (ja) 2018-12-06
CA3064176A1 (en) 2018-12-06
AU2018277949A1 (en) 2019-12-12
DK3630729T3 (da) 2021-12-13
JP6739653B2 (ja) 2020-08-12
HUE056942T2 (hu) 2022-03-28
US20200017476A1 (en) 2020-01-16
IL270579B1 (en) 2023-04-01
BR112019023988A2 (pt) 2020-06-30
PT3630729T (pt) 2021-12-16
LT3630729T (lt) 2022-01-10
EA038907B1 (ru) 2021-11-08
HRP20211913T1 (hr) 2022-03-04
IL270579B2 (en) 2023-08-01
CN110603248B (zh) 2023-07-04
JP2020503334A (ja) 2020-01-30
WO2018221667A1 (en) 2018-12-06
US20230138411A1 (en) 2023-05-04
NZ759385A (en) 2024-11-29
KR20200011962A (ko) 2020-02-04
TWI808974B (zh) 2023-07-21
US20250361224A1 (en) 2025-11-27
CY1125073T1 (el) 2023-03-24
MX391338B (es) 2025-03-21
EA201992831A1 (ru) 2020-03-30
PH12019502639A1 (en) 2020-06-08
KR20250065436A (ko) 2025-05-12
SI3630729T1 (sl) 2022-01-31
ES2901452T3 (es) 2022-03-22
TW202502754A (zh) 2025-01-16
US10800758B2 (en) 2020-10-13
EP3630729B1 (en) 2021-11-03
IL270579A (pl) 2019-12-31
SA519410563B1 (ar) 2022-07-25
KR20240116588A (ko) 2024-07-29
US20200399245A1 (en) 2020-12-24
CN110603248A (zh) 2019-12-20
TW202346283A (zh) 2023-12-01
TW201902890A (zh) 2019-01-16
AU2018277949B2 (en) 2021-11-18
MX2019014384A (es) 2020-01-23
KR102688531B1 (ko) 2024-07-26
EP3630729A1 (en) 2020-04-08
TWI860022B (zh) 2024-10-21
MY199251A (en) 2023-10-23

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