SI3172227T1 - Molekule, ki selektivno aktivirajo regulatorne T celice, za zdravljenje avtoimunskih bolezni - Google Patents
Molekule, ki selektivno aktivirajo regulatorne T celice, za zdravljenje avtoimunskih bolezniInfo
- Publication number
- SI3172227T1 SI3172227T1 SI201530968T SI201530968T SI3172227T1 SI 3172227 T1 SI3172227 T1 SI 3172227T1 SI 201530968 T SI201530968 T SI 201530968T SI 201530968 T SI201530968 T SI 201530968T SI 3172227 T1 SI3172227 T1 SI 3172227T1
- Authority
- SI
- Slovenia
- Prior art keywords
- molecules
- cells
- treatment
- autoimmune diseases
- selectively activate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Marine Sciences & Fisheries (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461999241P | 2014-07-21 | 2014-07-21 | |
PCT/US2015/041177 WO2016014428A2 (en) | 2014-07-21 | 2015-07-20 | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
EP15824955.7A EP3172227B9 (en) | 2014-07-21 | 2015-07-20 | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3172227T1 true SI3172227T1 (sl) | 2020-02-28 |
Family
ID=55163946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201530968T SI3172227T1 (sl) | 2014-07-21 | 2015-07-20 | Molekule, ki selektivno aktivirajo regulatorne T celice, za zdravljenje avtoimunskih bolezni |
Country Status (22)
Country | Link |
---|---|
US (6) | US20170037102A1 (hr) |
EP (2) | EP3172227B9 (hr) |
JP (2) | JP6768633B2 (hr) |
KR (1) | KR102493543B1 (hr) |
CN (2) | CN106795213B (hr) |
AU (3) | AU2015292889C1 (hr) |
CA (1) | CA2954847A1 (hr) |
DK (1) | DK3172227T3 (hr) |
EA (2) | EA202190903A3 (hr) |
ES (1) | ES2763198T3 (hr) |
GB (1) | GB2538666A (hr) |
HU (1) | HUE046065T2 (hr) |
IL (3) | IL289475B2 (hr) |
LT (1) | LT3172227T (hr) |
MX (2) | MX2017000821A (hr) |
PL (1) | PL3172227T3 (hr) |
PT (1) | PT3172227T (hr) |
RS (1) | RS59789B1 (hr) |
SG (2) | SG10202010158TA (hr) |
SI (1) | SI3172227T1 (hr) |
WO (1) | WO2016014428A2 (hr) |
ZA (1) | ZA201700344B (hr) |
Families Citing this family (64)
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SG10201808463RA (en) | 2012-12-11 | 2018-11-29 | Albert Einstein College Medicine Yeshiva Univ | Methods for high throughput receptor:ligand identification |
EP3172227B9 (en) * | 2014-07-21 | 2020-01-08 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
AU2015301936B2 (en) | 2014-08-11 | 2019-03-07 | Delinia, Inc. | Modified IL-2 variants that selectively activate regulatory T cells for the treatment of autoimmune diseases |
WO2016164937A2 (en) * | 2015-04-10 | 2016-10-13 | Amgen Inc. | Interleukin-2 muteins for the expansion of t-regulatory cells |
UA126270C2 (uk) | 2015-04-10 | 2022-09-14 | Емджен Інк. | Мутеїни інтерлейкіну-2 для росту регуляторних t-клітин |
US20170204154A1 (en) * | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
JP2019522466A (ja) | 2016-05-18 | 2019-08-15 | アルバート アインシュタイン カレッジ オブ メディシン,インコーポレイティド | 変異pd−l1ポリペプチド、t細胞調節多量体ポリペプチド、及びそれらの使用方法 |
BR112018073606A2 (pt) | 2016-05-18 | 2019-02-26 | Cue Biopharma, Inc. | polipeptídeos multiméricos moduladores de células t e métodos de uso dos mesmos |
WO2018089420A1 (en) * | 2016-11-08 | 2018-05-17 | Delinia, Inc. | Il-2 variants for the treatment of autoimmune diseases |
US10472405B2 (en) * | 2016-12-13 | 2019-11-12 | Delinia, Inc. | Multivalent regulatory T cell modulators |
EP3558339B1 (en) | 2016-12-22 | 2024-01-24 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
US20200010528A1 (en) | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
EP3604538A4 (en) | 2017-03-29 | 2020-12-30 | University of Miyazaki | LONG-ACTING ADRENOMEDULLINE DERIVATIVE |
KR20200010354A (ko) | 2017-05-24 | 2020-01-30 | 팬디온 테라퓨틱스, 인코포레이티드 | 표적화된 면역관용 |
WO2019112854A1 (en) * | 2017-12-06 | 2019-06-13 | Pandion Therapeutics, Inc. | Il-2 muteins and uses thereof |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
EP3728302A1 (en) | 2017-12-19 | 2020-10-28 | Xencor, Inc. | Engineered il-2 fc fusion proteins |
JP7275049B2 (ja) | 2017-12-27 | 2023-05-17 | 協和キリン株式会社 | Il-2改変体 |
EP3737689A4 (en) | 2018-01-09 | 2021-12-01 | Cue Biopharma, Inc. | MULTIMERIC T CELL-MODULATING POLYPEPTIDES AND METHOD OF USING THEREOF |
WO2019144309A1 (en) * | 2018-01-24 | 2019-08-01 | Beijing Percans Oncology Co. Ltd. | Cytokine Fusion Proteins |
US11534479B2 (en) | 2018-02-16 | 2022-12-27 | Iltoo Pharma | Use of interleukin 2 for treating Sjögren's syndrome |
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JP7427287B2 (ja) | 2019-11-05 | 2024-02-05 | メディカイン、インコーポレイテッド | 二重il-2rおよびil-7r結合化合物 |
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BR112022011414A2 (pt) | 2019-12-12 | 2022-08-30 | Iltoo Pharma | Construção quimérica, proteína homodimérica, proteína heterodimérica, ácido nucleico, vetor, célula hospedeira, métodos para produzir uma proteína dimérica e para produzir uma proteína heterodimérica |
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TW202417475A (zh) | 2020-02-03 | 2024-05-01 | 美商麥地金公司 | IL-7Rα結合化合物 |
US11746139B2 (en) | 2020-02-03 | 2023-09-05 | Medikine, Inc. | IL-7Rαγc binding compounds |
US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
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JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ, インコーポレイテッド | 1型真性糖尿病(t1d)を治療するためのmhcクラスii t細胞調節多量体ポリペプチド及びその使用方法 |
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BR112023020597A2 (pt) | 2021-04-09 | 2023-12-12 | Selecta Biosciences Inc | Nanocarreadores sintéticos que compreendem um imunossupressante em combinação com agonistas do receptor de il-2 de alta afinidade para aumentar a tolerância imune |
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CN102174111B (zh) * | 2011-01-25 | 2013-01-09 | 江苏省弗泰生物科技有限公司 | 人白介素2-Fc融合蛋白及其用途 |
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JP2014094898A (ja) * | 2012-11-07 | 2014-05-22 | Univ Of Tsukuba | 炎症性腸疾患に関連する、CD300a発現細胞の活性調節剤を含有する医薬品、ならびにCD300a遺伝子欠損マウスおよびCD300a発現細胞の活性調節剤の使用 |
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EP3172227B9 (en) * | 2014-07-21 | 2020-01-08 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
US20170204154A1 (en) * | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
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2015
- 2015-07-20 EP EP15824955.7A patent/EP3172227B9/en active Active
- 2015-07-20 HU HUE15824955A patent/HUE046065T2/hu unknown
- 2015-07-20 EA EA202190903A patent/EA202190903A3/ru unknown
- 2015-07-20 KR KR1020177001922A patent/KR102493543B1/ko active IP Right Grant
- 2015-07-20 CN CN201580050979.6A patent/CN106795213B/zh active Active
- 2015-07-20 CA CA2954847A patent/CA2954847A1/en active Pending
- 2015-07-20 PT PT158249557T patent/PT3172227T/pt unknown
- 2015-07-20 DK DK15824955T patent/DK3172227T3/da active
- 2015-07-20 SG SG10202010158TA patent/SG10202010158TA/en unknown
- 2015-07-20 JP JP2017504096A patent/JP6768633B2/ja active Active
- 2015-07-20 WO PCT/US2015/041177 patent/WO2016014428A2/en active Application Filing
- 2015-07-20 EA EA201790213A patent/EA038361B1/ru unknown
- 2015-07-20 GB GB1615553.3A patent/GB2538666A/en not_active Withdrawn
- 2015-07-20 LT LTEP15824955.7T patent/LT3172227T/lt unknown
- 2015-07-20 CN CN202111371055.XA patent/CN114133456A/zh active Pending
- 2015-07-20 IL IL289475A patent/IL289475B2/en unknown
- 2015-07-20 SI SI201530968T patent/SI3172227T1/sl unknown
- 2015-07-20 SG SG11201700514SA patent/SG11201700514SA/en unknown
- 2015-07-20 EP EP19188596.1A patent/EP3587444A1/en active Pending
- 2015-07-20 ES ES15824955T patent/ES2763198T3/es active Active
- 2015-07-20 PL PL15824955T patent/PL3172227T3/pl unknown
- 2015-07-20 RS RS20191448A patent/RS59789B1/sr unknown
- 2015-07-20 MX MX2017000821A patent/MX2017000821A/es unknown
- 2015-07-20 AU AU2015292889A patent/AU2015292889C1/en not_active Withdrawn - After Issue
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2016
- 2016-09-14 US US15/265,764 patent/US20170037102A1/en not_active Abandoned
- 2016-09-14 US US15/265,770 patent/US20170051029A1/en not_active Abandoned
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2017
- 2017-01-10 IL IL250024A patent/IL250024B/en active IP Right Grant
- 2017-01-16 ZA ZA2017/00344A patent/ZA201700344B/en unknown
- 2017-01-18 MX MX2021000083A patent/MX2021000083A/es unknown
- 2017-07-28 US US15/662,633 patent/US20170327555A1/en not_active Abandoned
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2019
- 2019-01-17 US US16/250,255 patent/US20190375812A1/en not_active Abandoned
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2020
- 2020-04-07 US US16/841,815 patent/US20210047382A1/en not_active Abandoned
- 2020-05-27 AU AU2020203480A patent/AU2020203480A1/en not_active Abandoned
- 2020-09-02 JP JP2020147441A patent/JP2021006038A/ja active Pending
- 2020-10-26 IL IL278299A patent/IL278299B/en unknown
-
2021
- 2021-12-20 US US17/556,208 patent/US20220112260A1/en not_active Abandoned
-
2022
- 2022-07-11 AU AU2022204946A patent/AU2022204946A1/en not_active Withdrawn
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