SI2838998T1 - Egfr in ros1 pri raku - Google Patents
Egfr in ros1 pri raku Download PDFInfo
- Publication number
- SI2838998T1 SI2838998T1 SI201330902T SI201330902T SI2838998T1 SI 2838998 T1 SI2838998 T1 SI 2838998T1 SI 201330902 T SI201330902 T SI 201330902T SI 201330902 T SI201330902 T SI 201330902T SI 2838998 T1 SI2838998 T1 SI 2838998T1
- Authority
- SI
- Slovenia
- Prior art keywords
- inhibitor
- ros1
- egfr
- polynucleotide encoding
- polypeptide
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Claims (12)
- EGFR IN R0S1 PRI RAKU PATENTNI ZAHTEVKI1. Metoda, ki obsega: odkrivanje v biološkem vzorcu pri človeškem bolniku, ki ima ali obstaja sum, da ima raka prisotnost ROS1 fuzijskega polipeptida, ki ima ROS1-kinazno aktivnost ali polinukleotid, ki kodira isto; in odkrivanje v biološkem vzorcu prisotnosti mutantnega EGFR polipeptida ali polinukleotida, ki kodira isto.
- 2. Metoda po zahtevku 1, kjer je vzorec iz pljučnega raka, po izbiri nedrobnoceličnega pljučnega raka.
- 3. Metoda po katerem koli od predhodnih zahtevkov, kjer mutantni EGFR polipeptid obsega mutacijo v kinazni domeni.
- 4. Metoda po katerem koli od predhodnih zahtevkov, kjer odkrivanje prisotnosti polipeptida, ki ima ROS1 kinazno aktivnost obsega uporabo protitelesa.
- 5. Metoda po katerem koli od predhodnih zahtevkov, kjer je odkrivanje prisotnosti polinukleotida, ki kodira polipeptid, ki ima ROS1 kinazno aktivnost, obsega uporabo in situ hibridizacije in/ali amplifikacijo nukleinske kisline.
- 6. Metoda po katerem koli od predhodnih zahtevkov, kjer odkrivanje prisotnosti mutiranega EGFR polipeptida obsega uporabo mutantno specifičnega protitelesa.
- 7. Metoda po katerem koli predhodnem zahtevku, kjer odkrivanje prisotnosti polinukleotida, ki kodira mutantni EGFR polipeptid obsega uporabo nukleinsko kislinskega sekvenciranja.
- 8. Metoda po katerem koli predhodnem zahtevku, kjer odkrivanje prisotnosti polinukleotida, ki kodira mutantni EGFR polipeptid obsega uporabo nukleinsko kislinske amplifikacije.
- 9. Terapevtsko učinkovita količina ROS1 inhibitorja in EGFR inhibitorja za uporabo pri zdravljenju človeškega pacienta za rakom v metodi, ki obsega: določanje da biološki vzorec iz tumorja pri bolniku obsega ROS1 fuzijski polipeptid, ki ima ROS1 kinazno aktivnost ali polinukleotid, ki kodira isto in mutantni EGFR polipeptid ali polinukleotid, ki kodira isto.
- 10. ROS1 inhibitor in EGFR inhibitor za uporabo po zahtevku 9, kjer je tumor pljučni rak, po izbiri nedrobnocelični pljučni rak.
- 11. ROS1 inhibitor in EGFR inhibitor za uporabo po zahtevku 9 ali zahtevku 10, kjer mutantni EGFR polipeptid obsega mutacijo v domeni kinaze. 12. R0S1 inhibitor in EGFR inhibitor za uporabo po katerem koli od zahtevkov 9- 11, kjer je ROS1 inhibitor izbran iz skupine, ki jo sestavljajo krizotinib, ASP3026, NVP TAE-684, CH5424802 in AP26113.
- 13. ROS1 inhibitor in EGFR inhibitor za uporabo po katerem koli od zahtevkov 9- 12, kjer je EGFR inhibitor izbran iz skupine, ki jo sestavljajo gefitinib, erlotinib, cetuksimab, afatinib, necitumumab, nimotuzumab, PF299804, RO5083945, ABT-806 in AP26113.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261635057P | 2012-04-18 | 2012-04-18 | |
US201361787033P | 2013-03-15 | 2013-03-15 | |
EP13778278.5A EP2838998B1 (en) | 2012-04-18 | 2013-04-18 | Egfr and ros1 in cancer |
PCT/US2013/037139 WO2013158859A1 (en) | 2012-04-18 | 2013-04-18 | Egfr and ros1 in cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2838998T1 true SI2838998T1 (sl) | 2018-04-30 |
Family
ID=49384066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201330902T SI2838998T1 (sl) | 2012-04-18 | 2013-04-18 | Egfr in ros1 pri raku |
Country Status (10)
Country | Link |
---|---|
US (2) | US20150056193A1 (sl) |
EP (2) | EP2838998B1 (sl) |
DK (1) | DK2838998T3 (sl) |
ES (1) | ES2655842T3 (sl) |
HK (2) | HK1206056A1 (sl) |
HU (1) | HUE037856T2 (sl) |
PL (1) | PL2838998T3 (sl) |
PT (1) | PT2838998T (sl) |
SI (1) | SI2838998T1 (sl) |
WO (1) | WO2013158859A1 (sl) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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SG10201704588XA (en) | 2012-09-25 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Ret inhibitor |
CN105566307B (zh) * | 2014-10-11 | 2019-04-23 | 中国科学院上海药物研究所 | 一类杂环取代的吲哚并萘酮衍生物、其制备方法、药物组合物及其用途 |
WO2017037220A1 (en) * | 2015-09-03 | 2017-03-09 | Ist Austria | Ros1 positive cancer treatment |
WO2020016266A1 (en) * | 2018-07-17 | 2020-01-23 | Ventana Medical Systems, Inc. | Materials and methods for detecting fusion proteins |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2021057882A1 (zh) * | 2019-09-26 | 2021-04-01 | 贝达药业股份有限公司 | Egfr抑制剂、组合物及其制备方法 |
JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
EP4139440A1 (en) | 2020-04-22 | 2023-03-01 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
CN113186291B (zh) * | 2021-05-26 | 2022-04-29 | 嘉兴允英医学检验有限公司 | 基于多重pcr的引物组和试剂盒 |
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-
2013
- 2013-04-18 SI SI201330902T patent/SI2838998T1/sl unknown
- 2013-04-18 ES ES13778278.5T patent/ES2655842T3/es active Active
- 2013-04-18 US US14/394,793 patent/US20150056193A1/en not_active Abandoned
- 2013-04-18 DK DK13778278.5T patent/DK2838998T3/en active
- 2013-04-18 WO PCT/US2013/037139 patent/WO2013158859A1/en active Application Filing
- 2013-04-18 HU HUE13778278A patent/HUE037856T2/hu unknown
- 2013-04-18 EP EP13778278.5A patent/EP2838998B1/en active Active
- 2013-04-18 PL PL13778278T patent/PL2838998T3/pl unknown
- 2013-04-18 EP EP17189679.8A patent/EP3336181B1/en active Active
- 2013-04-18 PT PT137782785T patent/PT2838998T/pt unknown
-
2015
- 2015-07-08 HK HK15106509.4A patent/HK1206056A1/xx unknown
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2018
- 2018-11-29 HK HK18115288.9A patent/HK1256196A1/zh unknown
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2021
- 2021-10-13 US US17/500,122 patent/US20220267854A1/en active Pending
Also Published As
Publication number | Publication date |
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EP2838998A1 (en) | 2015-02-25 |
EP2838998A4 (en) | 2015-10-07 |
US20150056193A1 (en) | 2015-02-26 |
PL2838998T3 (pl) | 2018-04-30 |
EP3336181A1 (en) | 2018-06-20 |
EP3336181B1 (en) | 2022-01-12 |
HUE037856T2 (hu) | 2018-09-28 |
US20220267854A1 (en) | 2022-08-25 |
ES2655842T3 (es) | 2018-02-21 |
HK1206056A1 (en) | 2015-12-31 |
DK2838998T3 (en) | 2018-01-15 |
PT2838998T (pt) | 2018-01-16 |
EP2838998B1 (en) | 2017-10-11 |
HK1256196A1 (zh) | 2019-09-13 |
WO2013158859A1 (en) | 2013-10-24 |
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