SG10201704588XA - Ret inhibitor - Google Patents

Ret inhibitor

Info

Publication number
SG10201704588XA
SG10201704588XA SG10201704588XA SG10201704588XA SG10201704588XA SG 10201704588X A SG10201704588X A SG 10201704588XA SG 10201704588X A SG10201704588X A SG 10201704588XA SG 10201704588X A SG10201704588X A SG 10201704588XA SG 10201704588X A SG10201704588X A SG 10201704588XA
Authority
SG
Singapore
Prior art keywords
ret inhibitor
ret
inhibitor
Prior art date
Application number
SG10201704588XA
Inventor
Tatsushi KODAMA
Hiroshi Sakamoto
Toshiyuki Tsukaguchi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50388182&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201704588X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG10201704588XA publication Critical patent/SG10201704588XA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
SG10201704588XA 2012-09-25 2013-09-24 Ret inhibitor SG10201704588XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012211040 2012-09-25

Publications (1)

Publication Number Publication Date
SG10201704588XA true SG10201704588XA (en) 2017-07-28

Family

ID=50388182

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201502211QA SG11201502211QA (en) 2012-09-25 2013-09-24 Ret inhibitor
SG10201704588XA SG10201704588XA (en) 2012-09-25 2013-09-24 Ret inhibitor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201502211QA SG11201502211QA (en) 2012-09-25 2013-09-24 Ret inhibitor

Country Status (27)

Country Link
US (2) US10668075B2 (en)
EP (1) EP2902029B1 (en)
JP (2) JP5759568B2 (en)
KR (1) KR102225016B1 (en)
CN (2) CN104640548A (en)
AR (1) AR092661A1 (en)
AU (1) AU2013321235B2 (en)
CA (2) CA2885722C (en)
DK (1) DK2902029T3 (en)
ES (1) ES2692664T3 (en)
HK (1) HK1210427A1 (en)
HR (1) HRP20181527T1 (en)
HU (1) HUE040055T2 (en)
IL (1) IL237849B (en)
LT (1) LT2902029T (en)
MX (1) MX2015003704A (en)
MY (1) MY170904A (en)
NZ (1) NZ705705A (en)
PL (1) PL2902029T3 (en)
PT (1) PT2902029T (en)
RU (1) RU2648818C2 (en)
SG (2) SG11201502211QA (en)
SI (1) SI2902029T1 (en)
TR (1) TR201815994T4 (en)
TW (1) TWI603733B (en)
WO (1) WO2014050781A1 (en)
ZA (1) ZA201501974B (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9126931B2 (en) * 2009-06-10 2015-09-08 Chugai Seiyaku Kabushiki Kaisha Tetracyclic compound
RU2594742C2 (en) 2010-05-20 2016-08-20 Эррэй Биофарма Инк. Macrocyclic compounds as trk kinase inhibitors
EP3698788A1 (en) 2010-08-20 2020-08-26 Chugai Seiyaku Kabushiki Kaisha Composition comprising tetracyclic compound
CA2885722C (en) 2012-09-25 2020-06-02 Chugai Seiyaku Kabushiki Kaisha Ret inhibitor
ES2756175T3 (en) * 2013-12-27 2020-04-27 Chugai Pharmaceutical Co Ltd Fgfr guardian mutant genes and drugs that target them
SG11201607623XA (en) 2014-04-25 2016-11-29 Chugai Pharmaceutical Co Ltd Preparation containing tetracyclic compound at high dose
JP6873698B2 (en) * 2014-04-25 2021-05-19 中外製薬株式会社 New crystals of tetracyclic compound
TWI718102B (en) 2014-08-08 2021-02-11 日商中外製藥股份有限公司 Amorphous body of tetracyclic compound
JP6741596B2 (en) 2015-01-16 2020-08-19 中外製薬株式会社 Concomitant medication
WO2016127074A1 (en) 2015-02-06 2016-08-11 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
WO2016204261A1 (en) 2015-06-17 2016-12-22 中外製薬株式会社 Aminopyrazole derivatives
MX2018000577A (en) 2015-07-16 2018-09-05 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors.
CN105255927B (en) * 2015-09-30 2018-07-27 温州医科大学附属第一医院 A kind of KIAA1217-RET fusions
EA038890B1 (en) * 2015-11-02 2021-11-03 Блюпринт Медсинс Корпорейшн Inhibitors of ret
RU2611658C1 (en) * 2016-03-15 2017-02-28 Юлия Алексеевна Щепочкина Crude mixture for making concrete
WO2017161269A1 (en) 2016-03-17 2017-09-21 Blueprint Medicines Corporation Inhibitors of ret receptor tyrosine kinases
JP7000349B2 (en) 2016-05-13 2022-02-04 インスティテュート デ メディシナ モレキュラー ジョアオ ロボ アントゥネス How to Treat Diseases Related to ILC3 Cells
US10227329B2 (en) 2016-07-22 2019-03-12 Blueprint Medicines Corporation Compounds useful for treating disorders related to RET
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
EP3548007A4 (en) * 2016-12-01 2020-08-12 Ignyta, Inc. Methods for the treatment of cancer
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JP6888101B2 (en) 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド Substituted pyrazolo [1,5-a] pyrazine compounds as RET kinase inhibitors
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
US20210290620A1 (en) 2017-05-15 2021-09-23 Blueprint Medicines Corporation Combinations of RET Inhibitors and mTORC1 Inhibitors and Uses Thereof for the Treatment of Cancer Mediated by Aberrant RET Activity
TWI812649B (en) 2017-10-10 2023-08-21 美商絡速藥業公司 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
TWI791053B (en) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 Crystalline forms of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile and pharmaceutical composition thereof
JP7060694B2 (en) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Substituted pyrolo [2,3-D] pyrimidine compounds as RET kinase inhibitors
CN111630054B (en) 2018-01-18 2023-05-09 奥瑞生物药品公司 Substituted pyrazolo [3,4-d ] pyrimidine compounds as RET kinase inhibitors
CN111615514B (en) 2018-01-18 2022-10-11 奥瑞生物药品公司 Substituted pyrazolo [4,3-C ] pyridine compounds as RET kinase inhibitors
SI3773589T1 (en) 2018-04-03 2024-03-29 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
CN109096264B (en) * 2018-08-28 2019-08-23 山东理工职业学院 RET inhibitor and preparation method thereof, composition and purposes
EP3848361A4 (en) 2018-09-04 2022-06-15 Chugai Seiyaku Kabushiki Kaisha Method of producing tetracyclic compound
JP2022500383A (en) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Condensed heterocyclic compound as a RET kinase inhibitor
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111233899B (en) * 2020-03-27 2020-12-29 苏州信诺维医药科技有限公司 RET inhibitor
CA3222177A1 (en) 2021-06-03 2022-12-08 Fundacao D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit
CA3234317A1 (en) 2021-10-22 2023-12-14 Wa Xian Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues
CN114317775B (en) * 2022-01-12 2023-06-30 中国人民解放军军事科学院军事医学研究院 Application of RNA m6A modification of NCOA4 as gamma-ray radiation marker
CN117144016A (en) * 2023-10-27 2023-12-01 神州医疗科技股份有限公司 Primer probe, kit and detection system for detecting RET fusion gene in peripheral blood circulation tumor RNA

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0892090A (en) 1994-07-26 1996-04-09 Tanabe Seiyaku Co Ltd Medicinal composition
ATE172463T1 (en) 1994-08-04 1998-11-15 Hoffmann La Roche PYRROLOCARBAZOLE
CZ347098A3 (en) 1996-05-01 1999-06-16 Eli Lilly And Company Halogen substituted compound as protein kinase c inhibitor
DE60033649D1 (en) 1999-05-14 2007-04-12 Australian Nat University Acto COMPOUNDS AND THERAPEUTIC METHODS
GB0030417D0 (en) 2000-12-13 2001-01-24 Pharma Mar Sa An anticancer lead compound isolated from a New Zealand ascidian
JP2005531488A (en) 2001-10-09 2005-10-20 ザ・ユニバーシティ・オブ・シンシナティ EGF receptor inhibitor for treating thyroid cancer
FR2841138B1 (en) 2002-06-25 2005-02-25 Cll Pharma SOLID PHARMACEUTICAL COMPOSITION COMPRISING A LIPOPHILIC ACTIVE INGREDIENT, ITS PREPARATION PROCESS
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
PL378331A1 (en) 2003-02-28 2006-03-20 Inotek Pharmaceuticals Corporation Tetracyclic benzamide derivatives and methods of use thereof
ATE328112T1 (en) 2003-03-07 2006-06-15 Ist Naz Stud Cura Dei Tumori ANAPLASTIC LYMPHOMA KINASE TESTING METHODS, REAGENTS AND COMPOSITIONS THEREOF
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
CA2532800C (en) 2003-07-23 2013-06-18 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
US7378414B2 (en) 2003-08-25 2008-05-27 Abbott Laboratories Anti-infective agents
PL1687305T3 (en) 2003-11-21 2008-12-31 Novartis Ag 1h-imidazoquinoline derivatives as protein kinase inhibitors
WO2005056529A1 (en) 2003-12-12 2005-06-23 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
CN1934082A (en) 2004-03-19 2007-03-21 斯皮德尔实验股份公司 Organic compounds
EP1730128A1 (en) 2004-03-31 2006-12-13 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
CN101023064B (en) 2004-08-26 2011-02-16 辉瑞大药厂 Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
US7091202B2 (en) 2004-09-15 2006-08-15 Bristol-Myers Squibb Company 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators
GB0517329D0 (en) 2005-08-25 2005-10-05 Merck Sharp & Dohme Stimulation of neurogenesis
RU2008122547A (en) 2005-11-07 2009-12-20 Айрм Ллк (Bm) COMPOUNDS AND COMPOSITIONS AS MODULATORS OF ARPP (ACTIVATED RECEPTORS OF PROLIFERATOR PEROXIS)
US7601716B2 (en) 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
CN101443009A (en) * 2006-05-18 2009-05-27 卫材R&D管理有限公司 Antitumor agent for thyroid cancer
US8063225B2 (en) 2006-08-14 2011-11-22 Chembridge Corporation Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
ES2555803T3 (en) 2006-10-23 2016-01-08 Cephalon, Inc. Fusion of bicyclic 2,4-diaminopyrimidine derivatives as using ALK and c-Met inhibitors
JP2010524953A (en) 2007-04-17 2010-07-22 ブリストル−マイヤーズ スクイブ カンパニー Fused heterocyclic 11-β-hydroxysteroid dehydrogenase type I inhibitor
TWI389893B (en) 2007-07-06 2013-03-21 Astellas Pharma Inc Di (arylamino) ary1 compound
CN103923072B (en) 2007-07-20 2017-05-31 内尔维阿诺医学科学有限公司 As the substituted indazole derivative with kinase inhibitory activity
WO2009073620A2 (en) 2007-11-30 2009-06-11 Newlink Genetics Ido inhibitors
JP5554699B2 (en) 2008-03-13 2014-07-23 第一三共株式会社 Improving dissolution properties of formulations containing olmesartan medoxomil
KR20120034639A (en) 2009-05-07 2012-04-12 아스트라제네카 아베 Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750
US9126931B2 (en) * 2009-06-10 2015-09-08 Chugai Seiyaku Kabushiki Kaisha Tetracyclic compound
GB0910046D0 (en) 2009-06-10 2009-07-22 Glaxosmithkline Biolog Sa Novel compositions
US8609097B2 (en) 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
WO2011146945A2 (en) 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Alk and ros kinase in cancer
US20130137111A1 (en) 2010-07-26 2013-05-30 Astellas Pharma Inc. Detection method of novel ret fusion
EP3698788A1 (en) 2010-08-20 2020-08-26 Chugai Seiyaku Kabushiki Kaisha Composition comprising tetracyclic compound
JP5006987B2 (en) 2010-11-22 2012-08-22 中外製薬株式会社 Medicine containing tetracyclic compound
WO2012138783A2 (en) 2011-04-04 2012-10-11 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
US20140287931A1 (en) 2011-04-04 2014-09-25 Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis Methods and compositions for predicting resistance to anticancer treatment
EP2729144A2 (en) 2011-07-07 2014-05-14 Synta Pharmaceuticals Corp. Treating cancer with hsp90 inhibitory compounds
US9216172B2 (en) 2011-08-04 2015-12-22 National Cancer Center Method for determining effectiveness of cancer treatment by assessing the presence of a KIF5B-RET chimeric gene
ES2704126T3 (en) 2011-08-23 2019-03-14 Found Medicine Inc KIF5B-RET fusion molecules and their uses
WO2013059740A1 (en) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Novel alk and ntrk1 fusion molecules and uses thereof
US10023855B2 (en) 2011-10-31 2018-07-17 Macrogen, Inc. Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker
JP2013172706A (en) 2012-01-27 2013-09-05 Nagoya City Univ Fish assay for detecting translocation between kif5b gene and ret gene
US20150232940A1 (en) 2012-03-09 2015-08-20 Insight Genetics, Inc Methods and compositions relating to diagnosing and treating receptor tyrosine kinase related cancers
CN103305598B (en) 2012-03-16 2015-04-22 中国科学院上海生命科学研究院 Method for detecting RET (Receptor Tyrosine Kinase) gene fusion, and applications thereof
JP2015109806A (en) 2012-03-22 2015-06-18 アステラス製薬株式会社 Method for detecting new ret fused body
EP3336181B1 (en) 2012-04-18 2022-01-12 Cell Signaling Technology, Inc. Egfr and ros1 in cancer
WO2013163428A1 (en) 2012-04-25 2013-10-31 The Regents Of The University Of Colorado Detection of ret fusions in cancer
EP4026912A1 (en) 2012-05-10 2022-07-13 The General Hospital Corporation Methods for determining a nucleotide sequence
JPWO2014017491A1 (en) 2012-07-26 2016-07-11 国立研究開発法人国立がん研究センター Fusion gene of CEP55 gene and RET gene
CA2885722C (en) 2012-09-25 2020-06-02 Chugai Seiyaku Kabushiki Kaisha Ret inhibitor
AU2013337264B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
WO2014130975A1 (en) 2013-02-22 2014-08-28 Bastian Boris C Fusion polynucleotides and fusion polypeptides associated with cancer and particularly melanoma and their uses as therapeutic and diagnostic targets
CA2902167A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits
US9777333B2 (en) 2013-04-05 2017-10-03 Life Technologies Corporation Gene fusion
JP2016518123A (en) 2013-04-17 2016-06-23 ライフ テクノロジーズ コーポレーション Gene fusions and gene variants associated with cancer
JP6873698B2 (en) 2014-04-25 2021-05-19 中外製薬株式会社 New crystals of tetracyclic compound
SG11201607623XA (en) 2014-04-25 2016-11-29 Chugai Pharmaceutical Co Ltd Preparation containing tetracyclic compound at high dose
CN110960500B (en) 2014-06-18 2022-10-14 豪夫迈·罗氏有限公司 Novel pharmaceutical compositions comprising nonionic surfactants
TWI718102B (en) 2014-08-08 2021-02-11 日商中外製藥股份有限公司 Amorphous body of tetracyclic compound

Also Published As

Publication number Publication date
IL237849A0 (en) 2015-05-31
JP5759568B2 (en) 2015-08-05
HRP20181527T1 (en) 2018-11-16
TWI603733B (en) 2017-11-01
JP2015155411A (en) 2015-08-27
CA2885722A1 (en) 2014-04-03
US10668075B2 (en) 2020-06-02
DK2902029T3 (en) 2018-10-29
KR102225016B1 (en) 2021-03-08
CA2885722C (en) 2020-06-02
EP2902029A4 (en) 2016-03-16
AU2013321235A1 (en) 2015-04-16
AR092661A1 (en) 2015-04-29
RU2015115151A (en) 2016-11-20
IL237849B (en) 2020-01-30
WO2014050781A1 (en) 2014-04-03
AU2013321235B2 (en) 2017-07-20
MX2015003704A (en) 2015-07-06
RU2648818C2 (en) 2018-03-28
SG11201502211QA (en) 2015-05-28
US11633402B2 (en) 2023-04-25
CA3077553C (en) 2022-08-02
JPWO2014050781A1 (en) 2016-08-22
LT2902029T (en) 2018-10-25
US20200246349A1 (en) 2020-08-06
NZ705705A (en) 2018-08-31
CN104640548A (en) 2015-05-20
ZA201501974B (en) 2016-10-26
EP2902029B1 (en) 2018-08-08
TW201417813A (en) 2014-05-16
HK1210427A1 (en) 2016-04-22
KR20150060809A (en) 2015-06-03
SI2902029T1 (en) 2018-11-30
HUE040055T2 (en) 2019-02-28
CN111388478A (en) 2020-07-10
EP2902029A1 (en) 2015-08-05
CA3077553A1 (en) 2014-04-03
MY170904A (en) 2019-09-13
TR201815994T4 (en) 2018-11-21
ES2692664T3 (en) 2018-12-04
PT2902029T (en) 2018-10-29
PL2902029T3 (en) 2019-01-31
US20150272958A1 (en) 2015-10-01
JP6080878B2 (en) 2017-02-15

Similar Documents

Publication Publication Date Title
HRP20181527T1 (en) Ret inhibitor
HK1211921A1 (en) Inhibitor compounds
DK3327112T3 (en) Agse-deficient stamme
EP2754580A4 (en) Dumptruck
DK2830816T3 (en) Hidtil ukendt coatingkoncept
EP2935220A4 (en) Peri-carbinols
HK1209422A1 (en) Fbxo3 inhibitors fbxo3
EP2920142A4 (en) Methanofullerenes
EP2812698A4 (en) Dual-acceptor time-resolved-fret
EP2920157A4 (en) Di-macrocycles
EP2873363A4 (en) Diopsimeter
GB201211019D0 (en) Inhibitor compounds
EP2834250A4 (en) Lithiumsilicate
HK1212895A1 (en) Saquinavir-no for immunomodulation -no
AU345893S (en) Treehouse
GB201213825D0 (en) Damper-device for bouncing-device
GB201202208D0 (en) Easomark
GB201201767D0 (en) Pop-tops
GB201201668D0 (en) LOCnlatch
GB201201023D0 (en) Sharkbitze
GB201201085D0 (en) Hit-a-pair
GB201200939D0 (en) Drinc-pinc
GB201200644D0 (en) Visualiser
GB201200608D0 (en) Torsocooler
GB201200605D0 (en) Buttermesh