SI2797945T1 - 2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hidroksiprop-1-il)-4-metoksi-3-(fenil sulfonilmetil)tetrahidrofuran-2-il)acetaldehidni derivati in posptopek za njihovo pripravo - Google Patents
2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hidroksiprop-1-il)-4-metoksi-3-(fenil sulfonilmetil)tetrahidrofuran-2-il)acetaldehidni derivati in posptopek za njihovo pripravoInfo
- Publication number
- SI2797945T1 SI2797945T1 SI201230582A SI201230582A SI2797945T1 SI 2797945 T1 SI2797945 T1 SI 2797945T1 SI 201230582 A SI201230582 A SI 201230582A SI 201230582 A SI201230582 A SI 201230582A SI 2797945 T1 SI2797945 T1 SI 2797945T1
- Authority
- SI
- Slovenia
- Prior art keywords
- phenylsulfonylmethyl
- hydroxyprop
- tetrahydrofuran
- methoxy
- amino
- Prior art date
Links
- QQCRPBGBXNFIGE-ZZTPXLKCSA-N 2-[(2s,3s,4r,5r)-5-[(2s)-3-amino-2-hydroxypropyl]-3-(benzenesulfonylmethyl)-4-methoxyoxolan-2-yl]acetaldehyde Chemical class CO[C@H]1[C@@H](C[C@H](O)CN)O[C@@H](CC=O)[C@@H]1CS(=O)(=O)C1=CC=CC=C1 QQCRPBGBXNFIGE-ZZTPXLKCSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161581164P | 2011-12-29 | 2011-12-29 | |
| EP12863099.3A EP2797945B1 (en) | 2011-12-29 | 2012-12-24 | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
| PCT/CA2012/050939 WO2013097042A1 (en) | 2011-12-29 | 2012-12-24 | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2797945T1 true SI2797945T1 (sl) | 2016-07-29 |
Family
ID=48696142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201230582A SI2797945T1 (sl) | 2011-12-29 | 2012-12-24 | 2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hidroksiprop-1-il)-4-metoksi-3-(fenil sulfonilmetil)tetrahidrofuran-2-il)acetaldehidni derivati in posptopek za njihovo pripravo |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9062020B2 (OSRAM) |
| EP (1) | EP2797945B1 (OSRAM) |
| JP (1) | JP6300030B2 (OSRAM) |
| CN (1) | CN104080793B (OSRAM) |
| AU (1) | AU2012363334B2 (OSRAM) |
| CA (1) | CA2860446C (OSRAM) |
| IN (1) | IN2014MN01521A (OSRAM) |
| SI (1) | SI2797945T1 (OSRAM) |
| WO (1) | WO2013097042A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104053645A (zh) | 2011-11-30 | 2014-09-17 | 阿方拉研究股份有限公司 | 用于制备(3r)-2,4-二-离去基团-3-甲基丁-1-烯的工艺 |
| WO2013086634A1 (en) | 2011-12-16 | 2013-06-20 | Alphora Research Inc. | Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof |
| IN2014MN02106A (OSRAM) | 2012-03-30 | 2015-09-11 | Alphora Res Inc | |
| TW201617326A (zh) | 2014-03-06 | 2016-05-16 | Ａｌｐｈｏｒａ研發股份有限公司 | （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物 |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10147463B2 (en) | 2014-12-10 | 2018-12-04 | Nxp Usa, Inc. | Video processing unit and method of buffering a source video stream |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| CA3013791A1 (en) | 2016-03-02 | 2017-09-08 | Eisai R&D Management Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| PT3606928T (pt) | 2017-04-05 | 2022-12-05 | Harvard College | Composto macrocíclico e utilizações deste |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| MX2020000142A (es) | 2017-07-06 | 2020-07-22 | Harvard College | Sintesis de halicondrinas. |
| EP4403560A3 (en) | 2017-11-15 | 2024-10-23 | President And Fellows Of Harvard College | Macrocyclic compounds and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| RU2153491C2 (ru) | 1993-07-09 | 2000-07-27 | Лаборатуар Терамекс С.А. | Аналоги витамина d, соединения, способы их получения и фармацевтическая композиция |
| EP2272840B1 (en) | 1998-06-17 | 2012-08-22 | Eisai R&D Management Co., Ltd. | Intermediate compound for the preparation of halichondrin analogs |
| US7001982B2 (en) | 2003-03-31 | 2006-02-21 | Council Of Scientific And Industrial Research | Non-natural C-linked carbo-β-peptides with robust secondary structures |
| KR101434673B1 (ko) | 2004-06-03 | 2014-08-26 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 ｂ 유사체의 제조를 위한 중간체 |
| CN1993342A (zh) * | 2004-06-03 | 2007-07-04 | 卫材株式会社 | 用于制备软海绵素b的中间体 |
| US8598373B2 (en) * | 2008-04-04 | 2013-12-03 | Eisai R&D Management Co., Ltd. | Halichondrin B analogs |
| CN104053645A (zh) | 2011-11-30 | 2014-09-17 | 阿方拉研究股份有限公司 | 用于制备(3r)-2,4-二-离去基团-3-甲基丁-1-烯的工艺 |
| WO2013086634A1 (en) | 2011-12-16 | 2013-06-20 | Alphora Research Inc. | Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof |
| IN2014MN02106A (OSRAM) | 2012-03-30 | 2015-09-11 | Alphora Res Inc | |
| CA2909209A1 (en) | 2013-05-15 | 2014-11-20 | Alphora Research Inc. | 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
-
2012
- 2012-12-24 WO PCT/CA2012/050939 patent/WO2013097042A1/en active Application Filing
- 2012-12-24 AU AU2012363334A patent/AU2012363334B2/en not_active Ceased
- 2012-12-24 SI SI201230582A patent/SI2797945T1/sl unknown
- 2012-12-24 CN CN201280064611.1A patent/CN104080793B/zh not_active Expired - Fee Related
- 2012-12-24 JP JP2014549284A patent/JP6300030B2/ja not_active Expired - Fee Related
- 2012-12-24 CA CA2860446A patent/CA2860446C/en active Active
- 2012-12-24 IN IN1521MUN2014 patent/IN2014MN01521A/en unknown
- 2012-12-24 US US14/369,442 patent/US9062020B2/en not_active Expired - Fee Related
- 2012-12-24 EP EP12863099.3A patent/EP2797945B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| CA2860446A1 (en) | 2013-07-04 |
| US20150011776A1 (en) | 2015-01-08 |
| IN2014MN01521A (OSRAM) | 2015-05-01 |
| CA2860446C (en) | 2017-01-10 |
| EP2797945B1 (en) | 2016-03-16 |
| AU2012363334B2 (en) | 2017-02-02 |
| EP2797945A4 (en) | 2015-06-03 |
| CN104080793A (zh) | 2014-10-01 |
| JP6300030B2 (ja) | 2018-03-28 |
| CN104080793B (zh) | 2017-09-19 |
| AU2012363334A1 (en) | 2014-08-21 |
| WO2013097042A1 (en) | 2013-07-04 |
| US9062020B2 (en) | 2015-06-23 |
| EP2797945A1 (en) | 2014-11-05 |
| JP2015503525A (ja) | 2015-02-02 |
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