SG11201405608QA - Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone - Google Patents
Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetoneInfo
- Publication number
- SG11201405608QA SG11201405608QA SG11201405608QA SG11201405608QA SG11201405608QA SG 11201405608Q A SG11201405608Q A SG 11201405608QA SG 11201405608Q A SG11201405608Q A SG 11201405608QA SG 11201405608Q A SG11201405608Q A SG 11201405608QA SG 11201405608Q A SG11201405608Q A SG 11201405608QA
- Authority
- SG
- Singapore
- Prior art keywords
- chloroacetone
- propanal
- dimethylphenyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/02—Monocyclic aromatic halogenated hydrocarbons
- C07C25/125—Halogenated xylenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/105—Saturated compounds containing keto groups bound to acyclic carbon atoms containing rings
- C07C49/11—Saturated compounds containing keto groups bound to acyclic carbon atoms containing rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
- C07D301/26—Y being hydrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665528P | 2012-06-28 | 2012-06-28 | |
| EP12174104 | 2012-06-28 | ||
| EP12189239 | 2012-10-19 | ||
| PCT/EP2012/070879 WO2012172122A2 (en) | 2012-06-28 | 2012-10-22 | Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal |
| EP12192627 | 2012-11-14 | ||
| PCT/EP2012/072799 WO2013011158A2 (en) | 2012-06-28 | 2012-11-15 | Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201405608QA true SG11201405608QA (en) | 2014-11-27 |
Family
ID=47558545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201405608QA SG11201405608QA (en) | 2012-06-28 | 2012-11-15 | Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9126914B1 (en) |
| EP (1) | EP2867195B1 (en) |
| JP (1) | JP5779298B2 (en) |
| KR (1) | KR101537203B1 (en) |
| CN (1) | CN104220408B (en) |
| AU (1) | AU2012285678B2 (en) |
| BR (1) | BR112014022268A8 (en) |
| CA (1) | CA2866441C (en) |
| CL (1) | CL2014002906A1 (en) |
| CY (1) | CY1117491T1 (en) |
| DK (1) | DK2867195T3 (en) |
| EA (1) | EA024425B1 (en) |
| ES (1) | ES2565065T3 (en) |
| HK (1) | HK1200810A1 (en) |
| HR (1) | HRP20160250T1 (en) |
| HU (1) | HUE027383T2 (en) |
| IN (1) | IN2014DN08121A (en) |
| MY (1) | MY165118A (en) |
| PL (1) | PL2867195T3 (en) |
| SG (1) | SG11201405608QA (en) |
| TW (1) | TWI535692B (en) |
| WO (1) | WO2013011158A2 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2847173B1 (en) | 2012-05-08 | 2015-12-30 | Lonza Ltd | Method for preparation of medetomidine |
| SG11201405611SA (en) * | 2012-05-08 | 2014-11-27 | Lonza Ag | Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal |
| CA2866441C (en) * | 2012-06-28 | 2017-01-17 | Lonza Ltd. | Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone |
| JP5777841B2 (en) | 2012-06-28 | 2015-09-09 | ロンザ・リミテッド | Process for the preparation of medetomidine using chloroacetone |
| US11221599B2 (en) | 2014-11-28 | 2022-01-11 | Signify Holding B.V. | Systems and methods for managing environmental conditions |
| CN106518812A (en) * | 2016-10-25 | 2017-03-22 | 湖南大学 | Preparation method of medetomidine and intermediate thereof |
| CN106749030B (en) * | 2016-12-15 | 2019-02-12 | 禚修洁 | A kind of preparation method of the dexmedetomidine hydrochloride for ICU sedation and analgesia |
| KR102148289B1 (en) * | 2018-07-04 | 2020-08-26 | 에스에프씨주식회사 | An organic light emitting diode with high efficiency |
| KR102495135B1 (en) * | 2019-04-03 | 2023-02-02 | 주식회사 엘지에너지솔루션 | Electrolyte for lithium secondary battery and lithium secondary battery comprising the same |
| US10889536B1 (en) | 2019-09-04 | 2021-01-12 | Eastman Chemical Company | Enol ethers |
| US10544076B1 (en) | 2019-09-04 | 2020-01-28 | Eastman Chemical Company | Method of making a dialdeyhde |
| US10815179B1 (en) | 2019-09-04 | 2020-10-27 | Eastman Chemical Company | Aromatic dicarbinols |
| US10550057B1 (en) * | 2019-09-04 | 2020-02-04 | Eastman Chemical Company | Method of making a dialdeyhde |
| US11312873B2 (en) | 2019-09-04 | 2022-04-26 | Eastman Chemical Company | Aromatic enol ether paint additives |
| US10865172B1 (en) | 2019-09-04 | 2020-12-15 | Eastman Chemical Company | Aromatic enol ethers |
| US11518899B2 (en) | 2019-09-04 | 2022-12-06 | Eastman Chemical Company | Aromatic enol ether paint additives |
| US10858304B1 (en) | 2019-09-04 | 2020-12-08 | Eastman Chemical Company | Aromatic enol ethers |
| US10865171B1 (en) | 2019-09-04 | 2020-12-15 | Eastman Chemical Company | Process to make aromatic enol ethers and olefin isomers of aromatic enol ethers |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790604A (en) | 1971-10-28 | 1973-04-26 | Sandoz Sa | NEW AMINOALCANOLS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| JPS51100042A (en) * | 1975-02-26 | 1976-09-03 | Kanebo Ltd | 22 * 44 isobuchirufueniru * puropionsanno seizoho |
| JPS51100041A (en) * | 1975-02-26 | 1976-09-03 | Kanebo Ltd | 22 * 44 isobuchirufueniru * puropionsanno seizoho |
| GB2092569B (en) | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| GB2101114B (en) | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| ATE78722T1 (en) * | 1984-02-24 | 1992-08-15 | Sagami Chem Res | METHOD OF ISOMERIZING A GLYCIDATE. |
| JPS62103037A (en) * | 1985-10-29 | 1987-05-13 | Hamari Yakuhin Kogyo Kk | Production of 2-(4-isobutylphenyl)-propionaldehyde |
| DE19714042A1 (en) | 1997-04-05 | 1998-10-08 | Henkel Kgaa | Process for the preparation of aromatic aldehydes |
| SE513474C2 (en) | 1999-01-25 | 2000-09-18 | Hans Elwing Instutionen Foer C | Method for preventing crustaceans, especially sea turtles, establishment on solid surfaces by a substance that disturbs nerve signals, the substance being medetomidine, ie (+) - 4- / 1- (2,3-dimethylphenyl) -ethyl / -IH- imidazole |
| EP1918282A1 (en) | 2006-11-06 | 2008-05-07 | "Joint Stock Company Grindeks" | Method for preparing medetomidine and its salts |
| GB2453982B (en) | 2007-10-24 | 2009-09-16 | Norbrook Lab Ltd | Chemical process for the preparation of Medetomidine |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| CN102753532B (en) | 2009-12-09 | 2015-05-13 | I-技术有限公司 | Process for preparation of medetomidine |
| WO2012172120A2 (en) | 2012-05-08 | 2012-12-20 | Lonza Ltd | 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume |
| SG11201405611SA (en) * | 2012-05-08 | 2014-11-27 | Lonza Ag | Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal |
| EP2847173B1 (en) * | 2012-05-08 | 2015-12-30 | Lonza Ltd | Method for preparation of medetomidine |
| WO2012172119A2 (en) * | 2012-05-08 | 2012-12-20 | Lonza Ltd | Method for the preparation of medetomidine |
| JP5777841B2 (en) * | 2012-06-28 | 2015-09-09 | ロンザ・リミテッド | Process for the preparation of medetomidine using chloroacetone |
| WO2012172121A1 (en) * | 2012-06-28 | 2012-12-20 | Lonza Ltd | Method for the preparation of medetomidine with chloroacetone |
| CA2866441C (en) * | 2012-06-28 | 2017-01-17 | Lonza Ltd. | Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone |
| WO2012172122A2 (en) * | 2012-06-28 | 2012-12-20 | Lonza Ltd | Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal |
-
2012
- 2012-11-15 CA CA2866441A patent/CA2866441C/en not_active Expired - Fee Related
- 2012-11-15 MY MYPI2014002562A patent/MY165118A/en unknown
- 2012-11-15 SG SG11201405608QA patent/SG11201405608QA/en unknown
- 2012-11-15 ES ES12784615.2T patent/ES2565065T3/en active Active
- 2012-11-15 EA EA201400938A patent/EA024425B1/en not_active IP Right Cessation
- 2012-11-15 EP EP12784615.2A patent/EP2867195B1/en not_active Not-in-force
- 2012-11-15 IN IN8121DEN2014 patent/IN2014DN08121A/en unknown
- 2012-11-15 DK DK12784615.2T patent/DK2867195T3/en active
- 2012-11-15 KR KR1020147029606A patent/KR101537203B1/en active IP Right Grant
- 2012-11-15 WO PCT/EP2012/072799 patent/WO2013011158A2/en active Application Filing
- 2012-11-15 JP JP2015510663A patent/JP5779298B2/en not_active Expired - Fee Related
- 2012-11-15 HU HUE12784615A patent/HUE027383T2/en unknown
- 2012-11-15 PL PL12784615T patent/PL2867195T3/en unknown
- 2012-11-15 BR BR112014022268A patent/BR112014022268A8/en not_active IP Right Cessation
- 2012-11-15 US US14/385,789 patent/US9126914B1/en not_active Expired - Fee Related
- 2012-11-15 CN CN201280072221.9A patent/CN104220408B/en not_active Expired - Fee Related
- 2012-11-15 AU AU2012285678A patent/AU2012285678B2/en not_active Ceased
-
2013
- 2013-06-26 TW TW102122677A patent/TWI535692B/en not_active IP Right Cessation
-
2014
- 2014-10-27 CL CL2014002906A patent/CL2014002906A1/en unknown
-
2015
- 2015-02-11 HK HK15101494.2A patent/HK1200810A1/en not_active IP Right Cessation
-
2016
- 2016-03-09 HR HRP20160250TT patent/HRP20160250T1/en unknown
- 2016-03-21 CY CY20161100236T patent/CY1117491T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101537203B1 (en) | 2015-07-22 |
| EP2867195B1 (en) | 2015-12-30 |
| TW201402533A (en) | 2014-01-16 |
| MY165118A (en) | 2018-02-28 |
| IN2014DN08121A (en) | 2015-05-01 |
| WO2013011158A2 (en) | 2013-01-24 |
| NZ700643A (en) | 2016-03-31 |
| HUE027383T2 (en) | 2016-10-28 |
| CY1117491T1 (en) | 2017-04-26 |
| US20150239816A1 (en) | 2015-08-27 |
| CA2866441C (en) | 2017-01-17 |
| AU2012285678A1 (en) | 2014-09-25 |
| WO2013011158A3 (en) | 2013-05-10 |
| HK1200810A1 (en) | 2015-08-14 |
| CA2866441A1 (en) | 2013-01-24 |
| PL2867195T3 (en) | 2016-06-30 |
| CL2014002906A1 (en) | 2014-12-12 |
| US9126914B1 (en) | 2015-09-08 |
| TWI535692B (en) | 2016-06-01 |
| DK2867195T3 (en) | 2016-04-04 |
| EP2867195A2 (en) | 2015-05-06 |
| JP2015517475A (en) | 2015-06-22 |
| EA024425B1 (en) | 2016-09-30 |
| CN104220408A (en) | 2014-12-17 |
| JP5779298B2 (en) | 2015-09-16 |
| EA201400938A1 (en) | 2015-01-30 |
| ES2565065T3 (en) | 2016-03-31 |
| KR20140131599A (en) | 2014-11-13 |
| HRP20160250T1 (en) | 2016-04-08 |
| BR112014022268A8 (en) | 2019-05-28 |
| AU2012285678B2 (en) | 2016-02-25 |
| CN104220408B (en) | 2016-01-20 |
| BR112014022268A2 (en) | 2017-06-20 |
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