SI2751279T1 - Procedures and compositions for detecting the level of activity of lysosomal exocytosis and application procedures - Google Patents
Procedures and compositions for detecting the level of activity of lysosomal exocytosis and application procedures Download PDFInfo
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- SI2751279T1 SI2751279T1 SI201231157T SI201231157T SI2751279T1 SI 2751279 T1 SI2751279 T1 SI 2751279T1 SI 201231157 T SI201231157 T SI 201231157T SI 201231157 T SI201231157 T SI 201231157T SI 2751279 T1 SI2751279 T1 SI 2751279T1
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- 230000000694 effects Effects 0.000 title claims abstract 12
- 238000000034 method Methods 0.000 title claims abstract 12
- 230000028023 exocytosis Effects 0.000 title claims abstract 6
- 230000002132 lysosomal effect Effects 0.000 title claims abstract 6
- 239000000203 mixture Substances 0.000 title claims 15
- 102100028760 Sialidase-1 Human genes 0.000 claims abstract 13
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract 6
- 206010012289 Dementia Diseases 0.000 claims abstract 4
- 238000011282 treatment Methods 0.000 claims abstract 3
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- 101001123859 Homo sapiens Sialidase-1 Proteins 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102100028524 Lysosomal protective protein Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 2
- 102000005572 Cathepsin A Human genes 0.000 claims 1
- 108010059081 Cathepsin A Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108010006232 Neuraminidase Proteins 0.000 claims 1
- 102000005348 Neuraminidase Human genes 0.000 claims 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960003530 donepezil Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 229960003980 galantamine Drugs 0.000 claims 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 229960004136 rivastigmine Drugs 0.000 claims 1
- 229960001685 tacrine Drugs 0.000 claims 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims 1
- 101710128612 Sialidase-1 Proteins 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 238000002512 chemotherapy Methods 0.000 abstract 3
- 238000003745 diagnosis Methods 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 2
- 238000004393 prognosis Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000009450 sialylation Effects 0.000 abstract 1
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- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529675P | 2011-08-31 | 2011-08-31 | |
| US201161544855P | 2011-10-07 | 2011-10-07 | |
| PCT/US2012/052629 WO2013033074A2 (en) | 2011-08-31 | 2012-08-28 | Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use |
| EP12761845.2A EP2751279B1 (en) | 2011-08-31 | 2012-08-28 | Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2751279T1 true SI2751279T1 (en) | 2018-01-31 |
Family
ID=46881159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231157T SI2751279T1 (en) | 2011-08-31 | 2012-08-28 | Procedures and compositions for detecting the level of activity of lysosomal exocytosis and application procedures |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9399791B2 (enExample) |
| EP (1) | EP2751279B1 (enExample) |
| JP (1) | JP6228121B2 (enExample) |
| AU (1) | AU2012300252B2 (enExample) |
| CA (1) | CA2847057C (enExample) |
| CY (1) | CY1119689T1 (enExample) |
| DK (1) | DK2751279T3 (enExample) |
| ES (1) | ES2653918T3 (enExample) |
| HR (1) | HRP20171909T1 (enExample) |
| HU (1) | HUE037829T2 (enExample) |
| LT (1) | LT2751279T (enExample) |
| PL (1) | PL2751279T3 (enExample) |
| PT (1) | PT2751279T (enExample) |
| SI (1) | SI2751279T1 (enExample) |
| WO (1) | WO2013033074A2 (enExample) |
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| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| SI2751279T1 (en) * | 2011-08-31 | 2018-01-31 | St. Jude Children's Research Hospital | Procedures and compositions for detecting the level of activity of lysosomal exocytosis and application procedures |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| WO2015035184A1 (en) | 2013-09-06 | 2015-03-12 | Xenoport, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016179481A1 (en) | 2015-05-07 | 2016-11-10 | Cardelli James Allen | Cancer treatment via repositioned tricyclic anti-depressant-like drugs as anti-cancer agents and new combinations of such drugs |
| JP2018532748A (ja) * | 2015-10-30 | 2018-11-08 | ウルトラジェニクス ファーマシューティカル インク．Ｕｌｔｒａｇｅｎｙｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｃ． | アミロイドーシス治療のための方法及び組成物 |
| JP2019508044A (ja) * | 2016-03-18 | 2019-03-28 | ナントセル，インコーポレイテッド | 樹状細胞感染のための多モードベクター |
| CA3047859C (en) * | 2017-01-04 | 2022-09-27 | Telefonaktiebolaget Lm Ericsson (Publ) | Method, base station and user equipment for transceiving system information |
| US20220364101A1 (en) | 2019-07-05 | 2022-11-17 | Tokushima University | Modified neuraminidase |
| JP2025504704A (ja) * | 2022-01-31 | 2025-02-14 | センス リサーチ ファウンデーション | 老化細胞表面マーカー |
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| AU5546898A (en) * | 1997-01-14 | 1998-08-07 | Hopital Sainte-Justine | Human lysosomal sialidase and therapeutic uses thereof |
| US20020006959A1 (en) * | 2000-05-01 | 2002-01-17 | Henderson Samuel T. | Use of medium chain triglycerides for the treatment and prevention of Alzheimer's Disease and other diseases resulting from reduced Neuronal Metabolism |
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| PT3252161T (pt) | 2007-06-06 | 2022-02-01 | Genzyme Corp | Terapia genética para doenças do armazenamento lisossomal |
| PL2490712T3 (pl) * | 2009-10-19 | 2015-12-31 | Amicus Therapeutics Inc | Sposób leczenia choroby Alzheimera przy zastosowaniu chaperonów farmakologicznych dla zwiększenia aktywności gangliozydaz |
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| SI2751279T1 (en) * | 2011-08-31 | 2018-01-31 | St. Jude Children's Research Hospital | Procedures and compositions for detecting the level of activity of lysosomal exocytosis and application procedures |
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- 2012-08-28 LT LTEP12761845.2T patent/LT2751279T/lt unknown
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| CY1119689T1 (el) | 2018-04-04 |
| US20180057854A1 (en) | 2018-03-01 |
| PT2751279T (pt) | 2017-12-29 |
| WO2013033074A2 (en) | 2013-03-07 |
| US20220406435A1 (en) | 2022-12-22 |
| JP6228121B2 (ja) | 2017-11-08 |
| PL2751279T3 (pl) | 2018-03-30 |
| JP2014526904A (ja) | 2014-10-09 |
| CA2847057A1 (en) | 2013-03-07 |
| DK2751279T3 (da) | 2017-11-20 |
| CA2847057C (en) | 2019-06-11 |
| US20160304933A1 (en) | 2016-10-20 |
| EP2751279B1 (en) | 2017-10-04 |
| HRP20171909T1 (hr) | 2018-01-26 |
| US20140193392A1 (en) | 2014-07-10 |
| WO2013033074A3 (en) | 2013-04-25 |
| US20200087704A1 (en) | 2020-03-19 |
| US20140377245A9 (en) | 2014-12-25 |
| HUE037829T2 (hu) | 2018-09-28 |
| ES2653918T3 (es) | 2018-02-09 |
| AU2012300252B2 (en) | 2017-10-19 |
| US9399791B2 (en) | 2016-07-26 |
| AU2012300252A1 (en) | 2014-03-20 |
| US10533208B2 (en) | 2020-01-14 |
| LT2751279T (lt) | 2017-12-11 |
| EP2751279A2 (en) | 2014-07-09 |
| US9840727B2 (en) | 2017-12-12 |
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