JP2014526904A5 - - Google Patents
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- JP2014526904A5 JP2014526904A5 JP2014528515A JP2014528515A JP2014526904A5 JP 2014526904 A5 JP2014526904 A5 JP 2014526904A5 JP 2014528515 A JP2014528515 A JP 2014528515A JP 2014528515 A JP2014528515 A JP 2014528515A JP 2014526904 A5 JP2014526904 A5 JP 2014526904A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
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- disease
- subject
- ppca
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100022166 E3 ubiquitin-protein ligase NEURL1 Human genes 0.000 claims description 7
- 102100028524 Lysosomal protective protein Human genes 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 4
- 101001123859 Homo sapiens Sialidase-1 Proteins 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 17
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- 101000973232 Homo sapiens E3 ubiquitin-protein ligase NEURL1 Proteins 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 102100028760 Sialidase-1 Human genes 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000028023 exocytosis Effects 0.000 claims 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 2
- 230000002132 lysosomal effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000005572 Cathepsin A Human genes 0.000 claims 1
- 108010059081 Cathepsin A Proteins 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 1
- 101710128612 Sialidase-1 Proteins 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical group O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 229960003980 galantamine Drugs 0.000 claims 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004640 memantine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229960004136 rivastigmine Drugs 0.000 claims 1
- 229960001685 tacrine Drugs 0.000 claims 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims 1
- 101710162021 Lysosomal protective protein Proteins 0.000 description 3
- 101150024252 Neu1 gene Proteins 0.000 description 3
- 238000011818 5xFAD mouse Methods 0.000 description 2
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 102000046216 human NEU1 Human genes 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529675P | 2011-08-31 | 2011-08-31 | |
| US61/529,675 | 2011-08-31 | ||
| US201161544855P | 2011-10-07 | 2011-10-07 | |
| US61/544,855 | 2011-10-07 | ||
| PCT/US2012/052629 WO2013033074A2 (en) | 2011-08-31 | 2012-08-28 | Methods and compositions to detect the level of lysosomal exocytosis activity and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526904A JP2014526904A (ja) | 2014-10-09 |
| JP2014526904A5 true JP2014526904A5 (enExample) | 2017-06-29 |
| JP6228121B2 JP6228121B2 (ja) | 2017-11-08 |
Family
ID=46881159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528515A Active JP6228121B2 (ja) | 2011-08-31 | 2012-08-28 | リソソームエキソサイトーシス活性のレベルを検出する方法及び組成物並びに使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9399791B2 (enExample) |
| EP (1) | EP2751279B1 (enExample) |
| JP (1) | JP6228121B2 (enExample) |
| AU (1) | AU2012300252B2 (enExample) |
| CA (1) | CA2847057C (enExample) |
| CY (1) | CY1119689T1 (enExample) |
| DK (1) | DK2751279T3 (enExample) |
| ES (1) | ES2653918T3 (enExample) |
| HR (1) | HRP20171909T1 (enExample) |
| HU (1) | HUE037829T2 (enExample) |
| LT (1) | LT2751279T (enExample) |
| PL (1) | PL2751279T3 (enExample) |
| PT (1) | PT2751279T (enExample) |
| SI (1) | SI2751279T1 (enExample) |
| WO (1) | WO2013033074A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| SI2751279T1 (en) * | 2011-08-31 | 2018-01-31 | St. Jude Children's Research Hospital | Procedures and compositions for detecting the level of activity of lysosomal exocytosis and application procedures |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| WO2015035184A1 (en) | 2013-09-06 | 2015-03-12 | Xenoport, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016179481A1 (en) | 2015-05-07 | 2016-11-10 | Cardelli James Allen | Cancer treatment via repositioned tricyclic anti-depressant-like drugs as anti-cancer agents and new combinations of such drugs |
| JP2018532748A (ja) * | 2015-10-30 | 2018-11-08 | ウルトラジェニクス ファーマシューティカル インク．Ｕｌｔｒａｇｅｎｙｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｃ． | アミロイドーシス治療のための方法及び組成物 |
| JP2019508044A (ja) * | 2016-03-18 | 2019-03-28 | ナントセル，インコーポレイテッド | 樹状細胞感染のための多モードベクター |
| CA3047859C (en) * | 2017-01-04 | 2022-09-27 | Telefonaktiebolaget Lm Ericsson (Publ) | Method, base station and user equipment for transceiving system information |
| US20220364101A1 (en) | 2019-07-05 | 2022-11-17 | Tokushima University | Modified neuraminidase |
| JP2025504704A (ja) * | 2022-01-31 | 2025-02-14 | センス リサーチ ファウンデーション | 老化細胞表面マーカー |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769331A (en) | 1981-09-16 | 1988-09-06 | University Patents, Inc. | Recombinant methods and materials |
| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| US5288641A (en) | 1984-06-04 | 1994-02-22 | Arch Development Corporation | Herpes Simplex virus as a vector |
| US4859587A (en) | 1984-06-04 | 1989-08-22 | Institut Merieux | Recombinant herpes simplex viruses, vaccines and methods |
| US4925673A (en) | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5328688A (en) | 1990-09-10 | 1994-07-12 | Arch Development Corporation | Recombinant herpes simplex viruses vaccines and methods |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| AU1115797A (en) | 1995-10-26 | 1997-05-15 | Alessandra D'azzo | Protective protein/cathepsin a and precursor: crystallization, x-ray diffraction, three-dimensional structure determination and rational drug design |
| AU5546898A (en) * | 1997-01-14 | 1998-08-07 | Hopital Sainte-Justine | Human lysosomal sialidase and therapeutic uses thereof |
| US20020006959A1 (en) * | 2000-05-01 | 2002-01-17 | Henderson Samuel T. | Use of medium chain triglycerides for the treatment and prevention of Alzheimer's Disease and other diseases resulting from reduced Neuronal Metabolism |
| ATE280590T1 (de) * | 2000-05-23 | 2004-11-15 | Neurologix Inc | Glutaminsäure decarboxylase (gad) abgabesystem zur behandlung neurodegeneraliver erkrankungen |
| US7232670B2 (en) | 2001-09-28 | 2007-06-19 | St. Jude Children's Research Hospital | Targeting proteins to cells expressing mannose receptors via expression in insect cells |
| AU2004286239A1 (en) | 2003-10-24 | 2005-05-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
| WO2006013013A2 (en) | 2004-08-04 | 2006-02-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with protective protein for beta-galactosidase (ppgb) |
| WO2008049058A2 (en) | 2006-10-18 | 2008-04-24 | Cornell Research Foundation, Inc. | Cln2 treatment of alzheimer's disease |
| US7951367B2 (en) | 2006-11-15 | 2011-05-31 | The J. David Gladstone Institutes | Methods and compositions for reducing amyloid beta levels |
| US8420613B2 (en) | 2006-11-15 | 2013-04-16 | The J. David Gladstone Institutes | Methods and compositions for reducing amyloid beta levels |
| PT3252161T (pt) | 2007-06-06 | 2022-02-01 | Genzyme Corp | Terapia genética para doenças do armazenamento lisossomal |
| PL2490712T3 (pl) * | 2009-10-19 | 2015-12-31 | Amicus Therapeutics Inc | Sposób leczenia choroby Alzheimera przy zastosowaniu chaperonów farmakologicznych dla zwiększenia aktywności gangliozydaz |
| US20140161896A1 (en) | 2011-08-04 | 2014-06-12 | Ramot At Tel-Aviv University Ltd. | Particles for the treatment of neurodegenerative diseases |
| SI2751279T1 (en) * | 2011-08-31 | 2018-01-31 | St. Jude Children's Research Hospital | Procedures and compositions for detecting the level of activity of lysosomal exocytosis and application procedures |
-
2012
- 2012-08-28 SI SI201231157T patent/SI2751279T1/en unknown
- 2012-08-28 WO PCT/US2012/052629 patent/WO2013033074A2/en not_active Ceased
- 2012-08-28 CA CA2847057A patent/CA2847057C/en active Active
- 2012-08-28 EP EP12761845.2A patent/EP2751279B1/en active Active
- 2012-08-28 PL PL12761845T patent/PL2751279T3/pl unknown
- 2012-08-28 US US14/239,728 patent/US9399791B2/en active Active
- 2012-08-28 PT PT127618452T patent/PT2751279T/pt unknown
- 2012-08-28 HU HUE12761845A patent/HUE037829T2/hu unknown
- 2012-08-28 JP JP2014528515A patent/JP6228121B2/ja active Active
- 2012-08-28 AU AU2012300252A patent/AU2012300252B2/en active Active
- 2012-08-28 HR HRP20171909TT patent/HRP20171909T1/hr unknown
- 2012-08-28 DK DK12761845.2T patent/DK2751279T3/da active
- 2012-08-28 LT LTEP12761845.2T patent/LT2751279T/lt unknown
- 2012-08-28 ES ES12761845.2T patent/ES2653918T3/es active Active
-
2016
- 2016-06-20 US US15/187,349 patent/US9840727B2/en active Active
-
2017
- 2017-11-09 US US15/808,075 patent/US10533208B2/en active Active
- 2017-12-18 CY CY20171101321T patent/CY1119689T1/el unknown
-
2019
- 2019-11-26 US US16/696,210 patent/US20200087704A1/en not_active Abandoned
-
2022
- 2022-08-18 US US17/820,755 patent/US20220406435A1/en active Pending
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