SI2569436T1 - Rekombinantni vektorji hcmv in rhcmv in njihove uporabe - Google Patents

Rekombinantni vektorji hcmv in rhcmv in njihove uporabe Download PDF

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Publication number
SI2569436T1
SI2569436T1 SI201131428T SI201131428T SI2569436T1 SI 2569436 T1 SI2569436 T1 SI 2569436T1 SI 201131428 T SI201131428 T SI 201131428T SI 201131428 T SI201131428 T SI 201131428T SI 2569436 T1 SI2569436 T1 SI 2569436T1
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Slovenia
Prior art keywords
hcmv
rhcmv
vector
recombinant
deletion
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SI201131428T
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English (en)
Inventor
Louis Picker
Jay A. Nelson
Klaus Frueh
Michael A. Jarvis
Scott G. Hansen
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Oregon Health & Science University
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Publication date
Priority claimed from PCT/US2011/029930 external-priority patent/WO2011119920A2/en
Application filed by Oregon Health & Science University filed Critical Oregon Health & Science University
Publication of SI2569436T1 publication Critical patent/SI2569436T1/sl

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Claims (12)

  1. REKOMBINANTNI VEKTORJI HCMV IN RHCMV IN NJIHOVE UPORABE PATENTNI ZAHTEVKI
    1. Rekombinantni RhCMV ali HCMV vektor, ki obsega sekvenco nukleinske kisline, ki kodira heterologni antigen, kjer je heterologni antigen humani patogen-specifičen antigen, izoliran iz virusa človeške imunske pomanjkljivosti (HIV), kjer vektor vključuje delecijo enega ali več RhCMV ali HCMV genov, ki so bistveni za ali povečanje replikacije.
  2. 2. Rekombinantni RhCMV ali HCMV vektor po zahtevku 1, kjer je vsaj en esencialni ali povečujoči gen izbran izmed UL82, UL94, UL32, UL99, UL115 ali UL44 ali njegovega homologa.
  3. 3. Rekombinantni RhCMV ali HCMV vektor po katerem koli od zahtevkov 1-2, ki obsega delecijo US2, US3, US6 ali US11 ali njegovega homologa, zlasti obsega delecijo Rh158-166 ali njegovega homologa.
  4. 4. Rekombinantni HCMV vektor po katerem koli od zahtevkov 1-3, ki obsega delecijo UL64 ali US29 ali kombinacijo le-teh.
  5. 5. Rekombinantni RhCMV vektor ali HCMV vektor po katerem koli od zahtevkov 1-4, kjer ima RhCMV vektor ali HCMV vektor delecije v genskih regijah, ne-esencialnih za rast in vivo, zlasti kjer so genske regije izbrane iz skupine, ki jo sestavljajo družina RL11, družina pp65, družina US12 in družina US28.
  6. 6. Rekombinantni RhCMV vektor po zahtevku 5, kjer so RhCMV genske regije izbrane iz skupine, ki sestoji iz Rh13-Rh29, Rh111-Rh112, Rh191-Rh202 in Rh214-Rh220, zlasti kjer so regije RhCMV genov izbrane iz skupine, ki jo sestavljajo Rh13.1, Rh19, Rh20, Rh23, Rh24, Rh112, Rh190, Rh192, Rh196, Rh198, Rh199, Rh200, Rh201, Rh202 in Rh220.
  7. 7. Rekombinantni HCMV vektor po zahtevku 5, kjer so HCMV genske regije izbrane iz skupine, ki jo sestavljajo RL11, UL6, UL7, UL9, UL11, UL83 (pp65), US12, US13, US14, US17, US18, US19 , US20, US21 in UL28.
  8. 8. Rekombinantni RhCMV ali HCMV vektor po katerem koli od zahtevkov 1-7, kjer vektor obsega LoxP mesta, sosednji in esencialni gen ali regijo RhCMV ali HCMV genoma.
  9. 9. Rekombinantni RhCMV ali HCMV vektor po katerem koli od zahtevkov 1-7, kjer vektor obsega nukleinsko kislinsko sekvenco, ki kodira tetraciklin (Tet) regulirano Cre rekombinazo.
  10. 10. Sestavek, ki obsega rekombinantni RhCMV ali HCMV vektor po katerem koli od zahtevkov 1-9 in farmacevtsko sprejemljiv nosilec.
  11. 11. Rekombinantni RhCMV ali HCMV vektor po katerem koli od zahtevkov 1-9 ali sestavek po zahtevku 10, za uporabo pri metodi zdravljenja subjekta z nalezljivo boleznijo, pri čemer je nalezljiva bolezen povzročena z virusom človeške imunske pomanjkljivosti (HIV).
  12. 12.Rekombinantni RhCMV ali HCMV vektor po katerem koli od zahtevkov 1-9 ali sestavek po zahtevku 10, za uporabo pri metodi za zdravljenje subjekta, ki ji grozi okužba z nalezljivo boleznijo, pri čemer je nalezljiva bolezen povzročena s HIV.
SI201131428T 2010-05-14 2011-05-16 Rekombinantni vektorji hcmv in rhcmv in njihove uporabe SI2569436T1 (sl)

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SI201131464T SI2772265T1 (sl) 2010-05-14 2011-05-16 Rekombinantni vektorji hcmv in rhcmv in njihove uporabe
SI201131912T SI3351636T1 (sl) 2010-05-14 2011-05-16 Rekombinantni HCMV in RHCMV vektorji, ki kodirajo heterologni antigen izoliran iz paramyxoviridae virusa njihove uporabe

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