HRP20200698T1 - Rekombinantni hcmv i rhcmv vektori koji kodiraju heterologni antigen izoliran iz hepatitis b virusa i njihove uporabe - Google Patents

Rekombinantni hcmv i rhcmv vektori koji kodiraju heterologni antigen izoliran iz hepatitis b virusa i njihove uporabe Download PDF

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Publication number
HRP20200698T1
HRP20200698T1 HRP20200698TT HRP20200698T HRP20200698T1 HR P20200698 T1 HRP20200698 T1 HR P20200698T1 HR P20200698T T HRP20200698T T HR P20200698TT HR P20200698 T HRP20200698 T HR P20200698T HR P20200698 T1 HRP20200698 T1 HR P20200698T1
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HR
Croatia
Prior art keywords
rhcmv
hcmv
vector according
recombinant
recombinant rhcmv
Prior art date
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HRP20200698TT
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English (en)
Inventor
Louis Picker
Jay A. Nelson
Klaus Frueh
Michael A. Jarvis
Scott G. Hansen
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Oregon Health & Science University
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Priority claimed from PCT/US2011/029930 external-priority patent/WO2011119920A2/en
Application filed by Oregon Health & Science University filed Critical Oregon Health & Science University
Publication of HRP20200698T1 publication Critical patent/HRP20200698T1/hr

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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Claims (16)

1. Rekombinantni RhCMV ili HCMV vektor koji sadrži sekvencu nukleinske kiseline koja kodira heterologni antigen, naznačen time što je heterologni antigen ljudski patogen specifičan antigen izoliran iz hepatitis B virusa (HBV), pri čemu vektor uključuje brisanje jednog ili više RhCMV ili HCMV gena koji su esencijalni za ili povećavanje replikacije.
2. Rekombinantni RhCMV ili HCMV vektor prema zahtjevu 1, naznačen time što je najmanje jedan esencijalni ili povećavajući gen odabran od UL82, UL94, UL32, UL99, UL115, ili UL44, ili njihovog homologa.
3. Rekombinantni RhCMV ili HCMV vektor prema zahtjevu 1 ili 2, naznačen time što najmanje jedan esencijalni ili povećavajući gen je UL82 ili njegov homolog.
4. Rekombinantni RhCMV ili HCMV vektor prema bilo kojem od zahtjeva 1-3, sadrži brisanje US2, US3, US6 ili US11, ili njihovog homologa, ili sadrži brisanje Rh158-166 ili njegovog homologa.
5. Rekombinantni HCMV vektor prema bilo kojem od zahtjeva 1-4, sadrži brisanje UL64 ili US29, ili njihovu kombinaciju.
6. Rekombinantni RhCMV ili HCMV vektor prema bilo kojem od zahtjeva 1-5, naznačen time što RhCMV vektor ili HCMV vektor imaju brisanje u područjima gena koja nisu neophodna za rast in vivo, naročito pri čemu su područja gena odabrana iz skupine koja se sastoji od RL11 obitelji, pp65 obitelji, US12 obitelji i 2828 obitelji.
7. Rekombinantni RhCMV vektor prema zahtjevu 6, naznačen time što su područja gena RhCMV odabrana iz skupine koja se sastoji od: Rh13-Rh29, Rh111-Rh112, Rh191-Rh202 i Rh214-Rh220, posebno pri čemu su područja gena RhCMV odabrana iz skupine koja se sastoji od Rh13.1, Rh19, Rh20, Rh23, Rh24, Rh112, Rh190, Rh192, Rh196, Rh198, Rh199, Rh200, Rh201, Rh202 i Rh220.
8. Rekombinantni HCMV vektor prema zahtjevu 6, naznačen time što su područja gena HCMV odabrana iz skupine koja se sastoji od RL11, UL6, UL7, UL9, UL11, UL83 (pp65), US12, US13, US14, US17, US18, US19, US20, US21, US21 i UL28.
9. Rekombinantni RhCMV ili HCMV vektor prema bilo kojem od zahtjeva 1-8, naznačen time što vektor sadrži LoxP mjesta koja okružuju esencijalni gen ili područje RhCMV ili HCMV genoma.
10. Rekombinantni RhCMV ili HCMV vektor prema bilo kojem od zahtjeva 1-9, naznačen time što vektor sadrži sekvencu nukleinske kiseline koja kodira tetraciklin (Tet)-reguliranu Cre rekombinazu.
11. Rekombinantni RhCMV ili HCMV vektor prema zahtjevu 1, naznačen time što vektor nadalje sadrži metu za tkivno specifičnu mikro-RNA u genu neophodnom za virusnu replikaciju.
12. Rekombinantni RhCMV ili HCMV vektor prema zahtjevu 11, naznačen time što mikro-RNA je miR-124.
13. Rekombinantni RhCMV ili HCMV vektor prema zahtjevu 1, naznačen time što vektor uključuje brisanje u UL128 i UL130.
14. Pripravak koji sadrži rekombinantni RhCMV ili HCMV vektor prema bilo kojem od zahtjeva 1-13 i farmaceutski prihvatljiv nosač.
15. Rekombinantni RhCMV ili HCMV vektor prema bilo kojem od zahtjeva 1-13, ili pripravak prema zahtjevu 14, za uporabu u postupku inhibicije ili liječenja HBV-a kod subjekta kojem to treba.
16. Rekombinantni RhCMV ili HCMV vektor prema bilo kojem od zahtjeva 1-13, ili pripravak prema zahtjevu 14, za uporabu u postupku liječenja subjekta izloženog riziku od zaraze HBV-om.
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