SI2403953T1 - Postopek za stereoselektivno encimatsko redukcijo keto spojin - Google Patents

Postopek za stereoselektivno encimatsko redukcijo keto spojin

Info

Publication number
SI2403953T1
SI2403953T1 SI201031509T SI201031509T SI2403953T1 SI 2403953 T1 SI2403953 T1 SI 2403953T1 SI 201031509 T SI201031509 T SI 201031509T SI 201031509 T SI201031509 T SI 201031509T SI 2403953 T1 SI2403953 T1 SI 2403953T1
Authority
SI
Slovenia
Prior art keywords
enzymatic reduction
keto compounds
stereoselective enzymatic
stereoselective
keto
Prior art date
Application number
SI201031509T
Other languages
English (en)
Inventor
Antje Gupta
Maria Dupont
Anke Tschentscher
Original Assignee
Cambrex Iep Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambrex Iep Gmbh filed Critical Cambrex Iep Gmbh
Publication of SI2403953T1 publication Critical patent/SI2403953T1/sl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06Ethanol, i.e. non-beverage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16Butanols
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201031509T 2009-03-05 2010-03-03 Postopek za stereoselektivno encimatsko redukcijo keto spojin SI2403953T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09450050A EP2226386A1 (de) 2009-03-05 2009-03-05 Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
PCT/EP2010/052701 WO2010100195A1 (de) 2009-03-05 2010-03-03 Verfahren zur stereoselektiven enzymatischen reduktion von ketoverbindungen
EP10706255.6A EP2403953B1 (de) 2009-03-05 2010-03-03 Verfahren zur stereoselektiven enzymatischen reduktion von ketoverbindungen

Publications (1)

Publication Number Publication Date
SI2403953T1 true SI2403953T1 (sl) 2017-08-31

Family

ID=40934907

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031509T SI2403953T1 (sl) 2009-03-05 2010-03-03 Postopek za stereoselektivno encimatsko redukcijo keto spojin

Country Status (15)

Country Link
US (1) US9045780B2 (sl)
EP (2) EP2226386A1 (sl)
JP (1) JP5852885B2 (sl)
KR (1) KR101780510B1 (sl)
CN (1) CN102341501B (sl)
CA (1) CA2753634C (sl)
DK (1) DK2403953T3 (sl)
ES (1) ES2636473T3 (sl)
HU (1) HUE033100T2 (sl)
IL (1) IL214972A (sl)
PL (1) PL2403953T3 (sl)
PT (1) PT2403953T (sl)
SI (1) SI2403953T1 (sl)
TW (1) TWI589696B (sl)
WO (1) WO2010100195A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103276027A (zh) * 2013-05-10 2013-09-04 苏州汉酶生物技术有限公司 一种手性n-保护哌啶醇的生物制备方法
CN106754775B (zh) * 2016-12-23 2019-08-20 华东理工大学 一种羰基还原酶突变体及其基因与应用
CN109576313B (zh) * 2017-09-29 2022-02-22 尚科生物医药(上海)有限公司 一种制备(s)- 2-氯-1-(3-羟基苯基)乙醇的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4014573C1 (sl) 1990-05-07 1991-10-10 Forschungszentrum Juelich Gmbh, 5170 Juelich, De
WO1993018138A1 (de) 1992-03-13 1993-09-16 Forschungszentrum Jülich GmbH Neue ketoester-reduktase, deren herstellung und verwendung für enzymatische redoxreaktionen
JP3574682B2 (ja) 1993-09-24 2004-10-06 ダイセル化学工業株式会社 新規な酵素、該酵素を製造する方法、該酵素をコードするdna、該dnaを含む形質転換体、該酵素による光学活性アルコール等の製造方法
DE19610984A1 (de) 1996-03-21 1997-09-25 Boehringer Mannheim Gmbh Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen
HUP0105331A3 (en) 1999-12-03 2005-10-28 Kaneka Corp Novel carbonyl reductase, gene thereof and method of using the same
TWI275645B (en) 2000-02-16 2007-03-11 Daicel Chemical Industries Ltd. (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes
EP1320826A2 (en) * 2000-08-07 2003-06-25 Bionetworks GmbH Identification of short chain dehydrogenases/reductases (sdr)
DE10119274A1 (de) 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
WO2004027055A1 (ja) 2002-09-19 2004-04-01 Kaneka Corporation 新規カルボニル還元酵素、その遺伝子、およびその利用法
JP4366097B2 (ja) 2003-02-28 2009-11-18 住友化学株式会社 還元酵素遺伝子及びその利用
DE10327454A1 (de) 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata
DE10345772A1 (de) 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
JP4757804B2 (ja) 2004-10-27 2011-08-24 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
AT501496B1 (de) 2005-02-21 2007-03-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
AT502395B1 (de) 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
DE102005044736A1 (de) 2005-09-19 2007-03-22 Basf Ag Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen
AT502185B1 (de) 2005-09-23 2007-02-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
AT503017B1 (de) * 2005-12-19 2007-07-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen

Also Published As

Publication number Publication date
TW201043696A (en) 2010-12-16
EP2226386A1 (de) 2010-09-08
KR101780510B1 (ko) 2017-09-22
JP2012519473A (ja) 2012-08-30
JP5852885B2 (ja) 2016-02-03
IL214972A (en) 2017-04-30
DK2403953T3 (en) 2017-07-24
HUE033100T2 (en) 2017-11-28
IL214972A0 (en) 2011-11-30
CA2753634A1 (en) 2010-09-10
EP2403953A1 (de) 2012-01-11
PT2403953T (pt) 2017-08-09
CN102341501B (zh) 2015-07-08
ES2636473T3 (es) 2017-10-05
PL2403953T3 (pl) 2017-10-31
EP2403953B1 (de) 2017-05-10
CA2753634C (en) 2017-12-05
TWI589696B (zh) 2017-07-01
KR20110134890A (ko) 2011-12-15
US20120040425A1 (en) 2012-02-16
US9045780B2 (en) 2015-06-02
CN102341501A (zh) 2012-02-01
WO2010100195A1 (de) 2010-09-10

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