SI2252597T1 - Derivati pirazina in njihova uporaba kot inhibitorji protein kinaze - Google Patents
Derivati pirazina in njihova uporaba kot inhibitorji protein kinazeInfo
- Publication number
- SI2252597T1 SI2252597T1 SI200930949T SI200930949T SI2252597T1 SI 2252597 T1 SI2252597 T1 SI 2252597T1 SI 200930949 T SI200930949 T SI 200930949T SI 200930949 T SI200930949 T SI 200930949T SI 2252597 T1 SI2252597 T1 SI 2252597T1
- Authority
- SI
- Slovenia
- Prior art keywords
- protein kinase
- kinase inhibitors
- pyrazine derivatives
- pyrazine
- derivatives
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 150000003216 pyrazines Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0800250 | 2008-02-01 | ||
| US12303908P | 2008-04-04 | 2008-04-04 | |
| SE0801185 | 2008-05-21 | ||
| EP09706385.3A EP2252597B1 (en) | 2008-02-01 | 2009-01-28 | Pyrazine derivatives and their use as protein kinase inhibitors |
| PCT/EP2009/050931 WO2009095399A2 (en) | 2008-02-01 | 2009-01-28 | Pyrazine derivatives and their use as protein kinase inhbitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2252597T1 true SI2252597T1 (sl) | 2014-07-31 |
Family
ID=40527384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200930949T SI2252597T1 (sl) | 2008-02-01 | 2009-01-28 | Derivati pirazina in njihova uporaba kot inhibitorji protein kinaze |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8436171B2 (enExample) |
| EP (2) | EP2671876A3 (enExample) |
| JP (2) | JP5562256B2 (enExample) |
| KR (1) | KR101599082B1 (enExample) |
| CN (1) | CN101970418B (enExample) |
| AU (1) | AU2009209633C1 (enExample) |
| BR (1) | BRPI0907453A2 (enExample) |
| CA (1) | CA2713553A1 (enExample) |
| CY (1) | CY1115400T1 (enExample) |
| DK (1) | DK2252597T3 (enExample) |
| ES (1) | ES2459297T3 (enExample) |
| HR (1) | HRP20140547T1 (enExample) |
| MX (1) | MX2010007973A (enExample) |
| PL (1) | PL2252597T3 (enExample) |
| PT (1) | PT2252597E (enExample) |
| RU (1) | RU2493152C2 (enExample) |
| SI (1) | SI2252597T1 (enExample) |
| WO (1) | WO2009095399A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2671876A3 (en) * | 2008-02-01 | 2014-02-05 | Akinion Pharmaceuticals AB | Pyrazine derivatives and their use as protein kinase inhbitors |
| WO2011083124A1 (en) | 2010-01-05 | 2011-07-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 receptor antagonists for the treatment or the prevention of pain disorders |
| WO2013089636A1 (en) * | 2011-12-15 | 2013-06-20 | Akinion Pharmaceuticals Ab | Processes for manufacturing of a kinase inhibitor |
| AU2013232208B2 (en) * | 2012-03-14 | 2017-04-27 | Indiana University Research And Technology Corporation | Compounds and methods for treating leukemia |
| KR101693179B1 (ko) * | 2012-04-17 | 2017-01-05 | 후지필름 가부시키가이샤 | 함질소 복소환 화합물 또는 그 염 |
| US20130310387A1 (en) * | 2012-05-16 | 2013-11-21 | Novartis Ag | Monocyclic Heteroaryl Cycloalkyldiamine Derivatives |
| DK3059227T3 (da) | 2013-10-16 | 2019-08-26 | Fujifilm Corp | Salt af en nitrogen-holdig heterocyklisk forbindelse eller krystal deraf, farmaceutisk sammensætning og flt3-hæmmer |
| EP3174859B1 (en) * | 2014-07-31 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Flt3 receptor antagonists |
| RU2727195C2 (ru) | 2014-08-22 | 2020-07-21 | Фуджифилм Корпорэйшн | Фармацевтическая композиция для лечения злокачественной опухоли, положительной по мутации flt3, ингибитор мутантного flt3 и их применение |
| CN105985322A (zh) * | 2015-03-03 | 2016-10-05 | 苏州翔实医药发展有限公司 | 氨基吡嗪化合物及其用途 |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| EP3254698A1 (en) | 2016-06-08 | 2017-12-13 | Universite De Montpellier | Flt3 receptor inhibitor at low dosage for the treatment of neuropathic pain |
| WO2018211018A1 (en) | 2017-05-17 | 2018-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 inhibitors for improving pain treatments by opioids |
| WO2019018584A1 (en) | 2017-07-18 | 2019-01-24 | GiraFpharma LLC | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS |
| WO2019057649A1 (en) | 2017-09-19 | 2019-03-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA |
| CN110483366B (zh) * | 2018-05-14 | 2022-09-16 | 中国医学科学院药物研究所 | 吲哚类化合物及其制备方法、药物组合物和用途 |
| JP2022517419A (ja) | 2019-01-18 | 2022-03-08 | ニューベイション・バイオ・インコーポレイテッド | アデノシンアンタゴニストとしてのヘテロ環式化合物 |
| EP3911325A4 (en) * | 2019-01-18 | 2022-10-12 | Nuvation Bio Inc. | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS |
| JP2022523473A (ja) | 2019-01-18 | 2022-04-25 | ニューベイション・バイオ・インコーポレイテッド | １，８－ナフチリジジノン化合物およびそれらの使用 |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN112574192B (zh) * | 2020-12-24 | 2021-10-01 | 烟台大学 | 氨基酸衍生联噻唑-色胺类抗癌化合物和应用 |
| KR20250075302A (ko) * | 2023-11-21 | 2025-05-28 | (주)신테카바이오 | 크레놀라닙 또는 이의 약학적으로 허용 가능한 염을 포함하는 아토피 피부염의 예방 또는 치료용 조성물 |
| KR20250075303A (ko) * | 2023-11-21 | 2025-05-28 | (주)신테카바이오 | 크레놀라닙 또는 이의 약학적으로 허용 가능한 염을 포함하는 건선의 예방 또는 치료용 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (enExample) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| CA2436487A1 (en) * | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd. | Methods of inhibiting kinases |
| IL165264A0 (en) | 2002-05-23 | 2005-12-18 | Cytopia Pty Ltd | Protein kinase inhibitors |
| AUPS251502A0 (en) * | 2002-05-23 | 2002-06-13 | Cytopia Pty Ltd | Protein kinase inhibitors |
| GB2400101A (en) * | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| JP2007533635A (ja) * | 2003-09-30 | 2007-11-22 | アムジエン・インコーポレーテツド | バニロイド受容体リガンドおよび治療おけるこれらの使用 |
| US20080194574A1 (en) | 2003-12-16 | 2008-08-14 | Axxima Pharmaceuticals Ag | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases |
| DE602005019556D1 (de) | 2004-04-13 | 2010-04-08 | Icagen Inc | Polycyclische pyrazine als kaliumionenkanal-modulatoren |
| EP1769092A4 (en) | 2004-06-29 | 2008-08-06 | Europ Nickel Plc | IMPROVED LIXIVIATION OF BASE METALS |
| GB0428082D0 (en) | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| WO2008022164A2 (en) | 2006-08-16 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Pyrazine compounds, their use and methods of preparation |
| LT2848610T (lt) | 2006-11-15 | 2017-11-10 | Ym Biosciences Australia Pty Ltd | Kinazės aktyvumo inhibitoriai |
| EP2671876A3 (en) * | 2008-02-01 | 2014-02-05 | Akinion Pharmaceuticals AB | Pyrazine derivatives and their use as protein kinase inhbitors |
-
2009
- 2009-01-28 EP EP13182880.8A patent/EP2671876A3/en not_active Withdrawn
- 2009-01-28 ES ES09706385.3T patent/ES2459297T3/es active Active
- 2009-01-28 PL PL09706385T patent/PL2252597T3/pl unknown
- 2009-01-28 EP EP09706385.3A patent/EP2252597B1/en active Active
- 2009-01-28 RU RU2010136653/04A patent/RU2493152C2/ru not_active IP Right Cessation
- 2009-01-28 CA CA2713553A patent/CA2713553A1/en not_active Abandoned
- 2009-01-28 SI SI200930949T patent/SI2252597T1/sl unknown
- 2009-01-28 DK DK09706385.3T patent/DK2252597T3/da active
- 2009-01-28 BR BRPI0907453-8A patent/BRPI0907453A2/pt not_active Application Discontinuation
- 2009-01-28 MX MX2010007973A patent/MX2010007973A/es active IP Right Grant
- 2009-01-28 WO PCT/EP2009/050931 patent/WO2009095399A2/en not_active Ceased
- 2009-01-28 US US12/865,359 patent/US8436171B2/en not_active Expired - Fee Related
- 2009-01-28 AU AU2009209633A patent/AU2009209633C1/en not_active Ceased
- 2009-01-28 KR KR1020107017417A patent/KR101599082B1/ko not_active Expired - Fee Related
- 2009-01-28 JP JP2010544683A patent/JP5562256B2/ja not_active Expired - Fee Related
- 2009-01-28 PT PT97063853T patent/PT2252597E/pt unknown
- 2009-01-28 HR HRP20140547AT patent/HRP20140547T1/hr unknown
- 2009-01-28 CN CN2009801038291A patent/CN101970418B/zh not_active Expired - Fee Related
-
2013
- 2013-03-15 US US13/833,231 patent/US20130203774A1/en not_active Abandoned
-
2014
- 2014-04-04 JP JP2014077470A patent/JP2014148522A/ja active Pending
- 2014-06-17 CY CY20141100435T patent/CY1115400T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20130203774A1 (en) | 2013-08-08 |
| EP2252597A2 (en) | 2010-11-24 |
| KR20100116599A (ko) | 2010-11-01 |
| KR101599082B1 (ko) | 2016-03-02 |
| AU2009209633A1 (en) | 2009-08-06 |
| CY1115400T1 (el) | 2017-01-04 |
| CA2713553A1 (en) | 2009-08-06 |
| JP2014148522A (ja) | 2014-08-21 |
| RU2010136653A (ru) | 2012-03-10 |
| EP2671876A2 (en) | 2013-12-11 |
| AU2009209633C1 (en) | 2014-01-23 |
| PL2252597T3 (pl) | 2014-09-30 |
| JP2011510948A (ja) | 2011-04-07 |
| ES2459297T3 (es) | 2014-05-08 |
| AU2009209633B2 (en) | 2013-07-18 |
| WO2009095399A2 (en) | 2009-08-06 |
| CN101970418A (zh) | 2011-02-09 |
| JP5562256B2 (ja) | 2014-07-30 |
| BRPI0907453A2 (pt) | 2015-07-14 |
| MX2010007973A (es) | 2010-11-09 |
| PT2252597E (pt) | 2014-04-30 |
| RU2493152C2 (ru) | 2013-09-20 |
| EP2252597B1 (en) | 2014-03-19 |
| DK2252597T3 (da) | 2014-04-28 |
| CN101970418B (zh) | 2013-07-03 |
| HK1149268A1 (en) | 2011-09-30 |
| EP2671876A3 (en) | 2014-02-05 |
| US8436171B2 (en) | 2013-05-07 |
| WO2009095399A3 (en) | 2009-10-01 |
| HRP20140547T1 (hr) | 2014-07-18 |
| US20110098310A1 (en) | 2011-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2252597T3 (pl) | Pochodne pirazyny i ich zastosowanie jako inhibitorów kinaz białkowych | |
| HUS1900014I1 (hu) | Proteinkináz inhibitorok | |
| IL211549A0 (en) | Aminotriazolopyridines and their use as kinase inhibitors | |
| PL2610256T3 (pl) | Pochodne pirymidyny jako inhibitory kinaz białkowych | |
| IL219646A0 (en) | Novelnaphthyridine derivatives and the use thereof as kinase inhibitors | |
| IL207415A0 (en) | Protein kinase inhibitors and use thereof | |
| IL206416A0 (en) | Benzofuropyrimidinones as protein kinase inhibitors | |
| SI2193133T1 (sl) | Imidazolotiadiazoli za uporabo kot zaviralci protein-kinaze | |
| ZA200901593B (en) | Pyrimidines derivatives and their use as kinase inhibitors | |
| PT2200436E (pt) | Pirimidinilaminas substituídas como inibidoras da proteína quinase | |
| IL218543A0 (en) | Pyrimidine derivatives as protein tyrosine kinase 2 inhibitors | |
| IL212755A0 (en) | Pyrazinopyrazines and derivatives as kinase inhibitors | |
| EP2387572A4 (en) | PROTEIN KINASE C HEMMER AND ITS USE | |
| IL233040A0 (en) | Pyridine and pyrazine derivatives as protein kinase modulators | |
| IL210073A0 (en) | Protein kinase inhibitors | |
| ZA201003420B (en) | Protein kinase inhibitors and use thereof | |
| IL210069A0 (en) | Protein kinase inhibitors | |
| IL210124A0 (en) | Pyrimidine derivatives as kinase inhibitors | |
| IL216411A0 (en) | Pyrazolopyrimidines and related heterocycles as kinase inhibitors | |
| IL209840A0 (en) | Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors | |
| HU0900798D0 (en) | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity | |
| ZA200807490B (en) | Thiazolyldihydroindazole derivatives as protein kinase inhibitors | |
| ZA201002885B (en) | Quinoline derivatives and their use as tyrosine kinase inhibitors | |
| GB0807642D0 (en) | IKK- serine-threonine protein kinase inhibitors | |
| GB0715470D0 (en) | IKK- serine-threonine protein kinase inhibitors |