DK2252597T3 - Pyrazinderivater og deres anvendelse som proteinkinaseinhibitorer - Google Patents
Pyrazinderivater og deres anvendelse som proteinkinaseinhibitorerInfo
- Publication number
- DK2252597T3 DK2252597T3 DK09706385.3T DK09706385T DK2252597T3 DK 2252597 T3 DK2252597 T3 DK 2252597T3 DK 09706385 T DK09706385 T DK 09706385T DK 2252597 T3 DK2252597 T3 DK 2252597T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazine derivatives
- proteinkinase inhibitors
- proteinkinase
- inhibitors
- pyrazine
- Prior art date
Links
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0800250 | 2008-02-01 | ||
| US12303908P | 2008-04-04 | 2008-04-04 | |
| SE0801185 | 2008-05-21 | ||
| PCT/EP2009/050931 WO2009095399A2 (en) | 2008-02-01 | 2009-01-28 | Pyrazine derivatives and their use as protein kinase inhbitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2252597T3 true DK2252597T3 (da) | 2014-04-28 |
Family
ID=40527384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09706385.3T DK2252597T3 (da) | 2008-02-01 | 2009-01-28 | Pyrazinderivater og deres anvendelse som proteinkinaseinhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8436171B2 (enExample) |
| EP (2) | EP2671876A3 (enExample) |
| JP (2) | JP5562256B2 (enExample) |
| KR (1) | KR101599082B1 (enExample) |
| CN (1) | CN101970418B (enExample) |
| AU (1) | AU2009209633C1 (enExample) |
| BR (1) | BRPI0907453A2 (enExample) |
| CA (1) | CA2713553A1 (enExample) |
| CY (1) | CY1115400T1 (enExample) |
| DK (1) | DK2252597T3 (enExample) |
| ES (1) | ES2459297T3 (enExample) |
| HR (1) | HRP20140547T1 (enExample) |
| MX (1) | MX2010007973A (enExample) |
| PL (1) | PL2252597T3 (enExample) |
| PT (1) | PT2252597E (enExample) |
| RU (1) | RU2493152C2 (enExample) |
| SI (1) | SI2252597T1 (enExample) |
| WO (1) | WO2009095399A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101599082B1 (ko) * | 2008-02-01 | 2016-03-02 | 어키니언 파마슈티칼스 아베 | 피라진 유도체 및 단백질 키나아제 억제제로서의 이의 용도 |
| EP2521782B1 (en) | 2010-01-05 | 2019-04-10 | INSERM - Institut National de la Santé et de la Recherche Médicale | Flt3 receptor antagonists for the treatment or the prevention of pain disorders |
| WO2013089636A1 (en) * | 2011-12-15 | 2013-06-20 | Akinion Pharmaceuticals Ab | Processes for manufacturing of a kinase inhibitor |
| RU2672553C2 (ru) * | 2012-03-14 | 2018-11-16 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Соединения и способы лечения лейкемии |
| PL2840080T3 (pl) * | 2012-04-17 | 2018-06-29 | Fujifilm Corporation | Zawierający azot związek heterocykliczny lub jego sól |
| US20130310387A1 (en) * | 2012-05-16 | 2013-11-21 | Novartis Ag | Monocyclic Heteroaryl Cycloalkyldiamine Derivatives |
| KR101744033B1 (ko) | 2013-10-16 | 2017-06-07 | 후지필름 가부시키가이샤 | 함질소 복소환 화합물의 염 또는 그 결정, 의약 조성물 및 flt3 저해제 |
| CN107001283B (zh) * | 2014-07-31 | 2021-05-25 | 国家健康与医学研究院 | Flt3受体拮抗剂 |
| JP6257782B2 (ja) | 2014-08-22 | 2018-01-10 | 富士フイルム株式会社 | Ｆｌｔ３変異陽性癌を処置するための医薬組成物、変異型ｆｌｔ３阻害剤およびそれらの応用 |
| CN105985322A (zh) * | 2015-03-03 | 2016-10-05 | 苏州翔实医药发展有限公司 | 氨基吡嗪化合物及其用途 |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| EP3254698A1 (en) | 2016-06-08 | 2017-12-13 | Universite De Montpellier | Flt3 receptor inhibitor at low dosage for the treatment of neuropathic pain |
| JP2020519665A (ja) | 2017-05-17 | 2020-07-02 | アンセルム（アンスティテュト ナショナル ド ラ サンテ エ ド ラ ルシェルシュ メディカル） | オピオイドによる痛みの処置を改善する為のｆｌｔ３阻害剤 |
| JP2020527588A (ja) | 2017-07-18 | 2020-09-10 | ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎ Ｂｉｏ Ｉｎｃ． | アデノシンアンタゴニストとしてのヘテロ環式化合物 |
| WO2019057649A1 (en) | 2017-09-19 | 2019-03-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA |
| CN110483366B (zh) * | 2018-05-14 | 2022-09-16 | 中国医学科学院药物研究所 | 吲哚类化合物及其制备方法、药物组合物和用途 |
| EP3911324A4 (en) | 2019-01-18 | 2022-08-17 | Nuvation Bio Inc. | 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES |
| KR20210116550A (ko) | 2019-01-18 | 2021-09-27 | 누베이션 바이오 인크. | 아데노신 길항제로서의 헤테로시클릭 화합물 |
| JP2022517418A (ja) * | 2019-01-18 | 2022-03-08 | ニューベイション・バイオ・インコーポレイテッド | アデノシンアンタゴニストとしてのヘテロ環式化合物 |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN112574192B (zh) * | 2020-12-24 | 2021-10-01 | 烟台大学 | 氨基酸衍生联噻唑-色胺类抗癌化合物和应用 |
| KR20250075302A (ko) * | 2023-11-21 | 2025-05-28 | (주)신테카바이오 | 크레놀라닙 또는 이의 약학적으로 허용 가능한 염을 포함하는 아토피 피부염의 예방 또는 치료용 조성물 |
| KR20250075303A (ko) * | 2023-11-21 | 2025-05-28 | (주)신테카바이오 | 크레놀라닙 또는 이의 약학적으로 허용 가능한 염을 포함하는 건선의 예방 또는 치료용 조성물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (enExample) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| EP1513821B1 (en) * | 2002-05-23 | 2007-10-31 | Cytopia PTY Ltd | Protein kinase inhibitors |
| AUPS251502A0 (en) * | 2002-05-23 | 2002-06-13 | Cytopia Pty Ltd | Protein kinase inhibitors |
| GB2400101A (en) * | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| AU2004278382B2 (en) * | 2003-09-30 | 2008-09-18 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2005058876A1 (en) * | 2003-12-16 | 2005-06-30 | Gpc Biotech Ag | Pyrazine derivatives as effective compounds against infectious diseases |
| DE602005019556D1 (de) | 2004-04-13 | 2010-04-08 | Icagen Inc | Polycyclische pyrazine als kaliumionenkanal-modulatoren |
| WO2006000020A1 (en) | 2004-06-29 | 2006-01-05 | European Nickel Plc | Improved leaching of base metals |
| GB0428082D0 (en) | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| ATE517868T1 (de) * | 2006-08-16 | 2011-08-15 | Boehringer Ingelheim Int | Pyrazinverbindungen, ihre verwendung und herstellungsverfahren |
| CA2701959C (en) * | 2006-11-15 | 2016-01-05 | Ym Biosciences Australia Pty Ltd | Inhibitors of kinase activity |
| KR101599082B1 (ko) * | 2008-02-01 | 2016-03-02 | 어키니언 파마슈티칼스 아베 | 피라진 유도체 및 단백질 키나아제 억제제로서의 이의 용도 |
-
2009
- 2009-01-28 KR KR1020107017417A patent/KR101599082B1/ko not_active Expired - Fee Related
- 2009-01-28 JP JP2010544683A patent/JP5562256B2/ja not_active Expired - Fee Related
- 2009-01-28 MX MX2010007973A patent/MX2010007973A/es active IP Right Grant
- 2009-01-28 SI SI200930949T patent/SI2252597T1/sl unknown
- 2009-01-28 BR BRPI0907453-8A patent/BRPI0907453A2/pt not_active Application Discontinuation
- 2009-01-28 AU AU2009209633A patent/AU2009209633C1/en not_active Ceased
- 2009-01-28 PL PL09706385T patent/PL2252597T3/pl unknown
- 2009-01-28 HR HRP20140547AT patent/HRP20140547T1/hr unknown
- 2009-01-28 PT PT97063853T patent/PT2252597E/pt unknown
- 2009-01-28 CA CA2713553A patent/CA2713553A1/en not_active Abandoned
- 2009-01-28 ES ES09706385.3T patent/ES2459297T3/es active Active
- 2009-01-28 DK DK09706385.3T patent/DK2252597T3/da active
- 2009-01-28 CN CN2009801038291A patent/CN101970418B/zh not_active Expired - Fee Related
- 2009-01-28 RU RU2010136653/04A patent/RU2493152C2/ru not_active IP Right Cessation
- 2009-01-28 EP EP13182880.8A patent/EP2671876A3/en not_active Withdrawn
- 2009-01-28 EP EP09706385.3A patent/EP2252597B1/en active Active
- 2009-01-28 US US12/865,359 patent/US8436171B2/en not_active Expired - Fee Related
- 2009-01-28 WO PCT/EP2009/050931 patent/WO2009095399A2/en not_active Ceased
-
2013
- 2013-03-15 US US13/833,231 patent/US20130203774A1/en not_active Abandoned
-
2014
- 2014-04-04 JP JP2014077470A patent/JP2014148522A/ja active Pending
- 2014-06-17 CY CY20141100435T patent/CY1115400T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20130203774A1 (en) | 2013-08-08 |
| PT2252597E (pt) | 2014-04-30 |
| AU2009209633B2 (en) | 2013-07-18 |
| CN101970418B (zh) | 2013-07-03 |
| HRP20140547T1 (hr) | 2014-07-18 |
| WO2009095399A3 (en) | 2009-10-01 |
| SI2252597T1 (sl) | 2014-07-31 |
| CA2713553A1 (en) | 2009-08-06 |
| JP2014148522A (ja) | 2014-08-21 |
| CY1115400T1 (el) | 2017-01-04 |
| AU2009209633C1 (en) | 2014-01-23 |
| JP5562256B2 (ja) | 2014-07-30 |
| EP2671876A3 (en) | 2014-02-05 |
| KR101599082B1 (ko) | 2016-03-02 |
| CN101970418A (zh) | 2011-02-09 |
| HK1149268A1 (en) | 2011-09-30 |
| RU2493152C2 (ru) | 2013-09-20 |
| MX2010007973A (es) | 2010-11-09 |
| EP2252597A2 (en) | 2010-11-24 |
| EP2671876A2 (en) | 2013-12-11 |
| PL2252597T3 (pl) | 2014-09-30 |
| EP2252597B1 (en) | 2014-03-19 |
| WO2009095399A2 (en) | 2009-08-06 |
| AU2009209633A1 (en) | 2009-08-06 |
| US20110098310A1 (en) | 2011-04-28 |
| ES2459297T3 (es) | 2014-05-08 |
| BRPI0907453A2 (pt) | 2015-07-14 |
| JP2011510948A (ja) | 2011-04-07 |
| US8436171B2 (en) | 2013-05-07 |
| RU2010136653A (ru) | 2012-03-10 |
| KR20100116599A (ko) | 2010-11-01 |
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