SI2222861T1 - Retroviral vectors, modified with a polyurea tract - Google Patents
Retroviral vectors, modified with a polyurea tract Download PDFInfo
- Publication number
- SI2222861T1 SI2222861T1 SI200831929T SI200831929T SI2222861T1 SI 2222861 T1 SI2222861 T1 SI 2222861T1 SI 200831929 T SI200831929 T SI 200831929T SI 200831929 T SI200831929 T SI 200831929T SI 2222861 T1 SI2222861 T1 SI 2222861T1
- Authority
- SI
- Slovenia
- Prior art keywords
- vector
- integration
- retroviral
- sequence
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyurethanes Or Polyureas (AREA)
- Artificial Filaments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US711807P | 2007-12-11 | 2007-12-11 | |
| PCT/US2008/086409 WO2009076524A2 (en) | 2007-12-11 | 2008-12-11 | Polypurine tract modified retroviral vectors |
| EP08859393.4A EP2222861B1 (en) | 2007-12-11 | 2008-12-11 | Polypurine tract modified retroviral vectors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2222861T1 true SI2222861T1 (en) | 2018-04-30 |
Family
ID=40756119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200831929T SI2222861T1 (en) | 2007-12-11 | 2008-12-11 | Retroviral vectors, modified with a polyurea tract |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9796987B2 (enExample) |
| EP (2) | EP2222861B1 (enExample) |
| JP (2) | JP5749014B2 (enExample) |
| CY (1) | CY1119905T1 (enExample) |
| DK (1) | DK2222861T3 (enExample) |
| ES (1) | ES2664988T3 (enExample) |
| HR (1) | HRP20180184T1 (enExample) |
| HU (1) | HUE036103T2 (enExample) |
| LT (1) | LT2222861T (enExample) |
| NO (1) | NO2222861T3 (enExample) |
| PL (1) | PL2222861T3 (enExample) |
| PT (1) | PT2222861T (enExample) |
| RS (1) | RS56844B1 (enExample) |
| SI (1) | SI2222861T1 (enExample) |
| TR (1) | TR201802323T4 (enExample) |
| WO (1) | WO2009076524A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006252406B2 (en) | 2005-06-01 | 2012-05-17 | California Institute Of Technology | Method of targeted gene delivery using viral vectors |
| SG173337A1 (en) | 2006-07-21 | 2011-08-29 | California Inst Of Techn | Targeted gene delivery for dendritic cell vaccination |
| RS56844B1 (sr) | 2007-12-11 | 2018-04-30 | Univ North Carolina Chapel Hill | Retrovirusni vektori sa modifikovanim polipurinskim nizom |
| WO2011011584A1 (en) * | 2009-07-24 | 2011-01-27 | Immune Design Corp | Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein |
| SG192759A1 (en) | 2011-02-15 | 2013-09-30 | Immune Design Corp | Methods for enhancing immunogen specific immune responses by vectored vaccines |
| WO2012141984A1 (en) | 2011-04-08 | 2012-10-18 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| US9713635B2 (en) | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
| EP2831095B1 (en) | 2012-03-30 | 2018-11-28 | Immune Design Corp. | Lentiviral vector particles having improved transduction efficiency for cells expressing dc-sign |
| US8323662B1 (en) | 2012-03-30 | 2012-12-04 | Immune Design Corp. | Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein |
| LT2850431T (lt) | 2012-05-16 | 2018-06-25 | Immune Design Corp. | Vakcinos, skirtos hsv-2 |
| CA2939093A1 (en) | 2014-02-14 | 2015-08-20 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
| KR20170032373A (ko) | 2014-07-15 | 2017-03-22 | 이뮨 디자인 코포레이션 | Tlr4 작용제 보조제 및 렌티바이러스 벡터를 이용한 프라임-부스트 요법 |
| KR101607282B1 (ko) | 2014-12-18 | 2016-03-29 | 충남대학교산학협력단 | 유리형 산화환원조절단백-1 및 이를 함유하는 항염증 약학조성물 |
| JP6734283B2 (ja) | 2015-01-21 | 2020-08-05 | フレッド ハッチンソン キャンサー リサーチ センター | 遺伝子治療用ポイントオブケア及び／又はポータブルプラットフォーム |
| US11078495B2 (en) | 2015-10-15 | 2021-08-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for integration defective lentiviral vectors |
| KR20180108567A (ko) | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
| CA3004132A1 (en) | 2015-11-09 | 2017-05-18 | Immune Design Corp. | A retroviral vector for the administration and expression of replicon rna expressing heterologous nucleic acids |
| MX2018005467A (es) | 2015-11-09 | 2018-12-11 | Immune Design Corp | Composiciones que comprenden vectores lentivirales que expresan interleucina-12, y metodos de uso de las mismas. |
| MX2018010061A (es) | 2016-02-23 | 2019-07-04 | Immune Design Corp | Preparaciones de vectores retrovirales de genomas multiples, y metodos y sistemas para producir y usar las mismas. |
| EP3443000B1 (en) | 2016-04-15 | 2025-11-12 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| KR102824067B1 (ko) | 2016-04-15 | 2025-06-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
| US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
| CN110088127A (zh) | 2016-07-28 | 2019-08-02 | 高山免疫科学股份有限公司 | Cd155变体免疫调节蛋白及其用途 |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| US11421287B2 (en) | 2016-07-29 | 2022-08-23 | Juno Therapeutics, Inc. | Methods for assessing the presence or absence of replication competent virus |
| CN110249046A (zh) | 2016-12-05 | 2019-09-17 | 朱诺治疗学股份有限公司 | 用于过继细胞疗法的工程化细胞的产生 |
| LT3596116T (lt) | 2017-03-16 | 2023-11-10 | Alpine Immune Sciences, Inc. | Imunomoduliacinių baltymų pd-l1 variantai ir jų naudojimo būdai |
| CN110809581A (zh) | 2017-03-16 | 2020-02-18 | 高山免疫科学股份有限公司 | Pd-l2变体免疫调节蛋白及其用途 |
| CA3054068A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
| MX2020000900A (es) | 2017-07-29 | 2021-01-08 | Juno Therapeutics Inc | Reactivos para expandir celulas que expresan receptores recombinantes. |
| CA3070579A1 (en) | 2017-08-09 | 2019-02-14 | Juno Therapeutics, Inc. | Methods for producing genetically engineered cell compositions and related compositions |
| KR102813968B1 (ko) | 2017-10-10 | 2025-05-29 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Ctla-4 변이체 면역조절 단백질 및 이의 용도 |
| MX2020004540A (es) | 2017-10-18 | 2020-08-03 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras de ligando icos variante y composiciones y metodos relacionados. |
| WO2019089855A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| JP7258899B2 (ja) | 2017-11-01 | 2023-04-17 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞組成物を作製するための方法 |
| KR102833956B1 (ko) | 2017-12-08 | 2025-07-15 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포를 배양하기 위한 무혈청 배지 제형 및 이의 사용 방법 |
| EP3735417A1 (en) | 2018-01-03 | 2020-11-11 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| EP3746569A1 (en) | 2018-01-31 | 2020-12-09 | Juno Therapeutics, Inc. | Methods and reagents for assessing the presence or absence of replication competent virus |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| CN113544144A (zh) | 2018-09-19 | 2021-10-22 | 高山免疫科学股份有限公司 | 变体cd80融合蛋白和相关构建体的方法和用途 |
| AU2019372331A1 (en) | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| CA3120118A1 (en) | 2018-11-16 | 2020-05-22 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
| CN113727998A (zh) | 2018-11-30 | 2021-11-30 | 高山免疫科学股份有限公司 | Cd86变体免疫调节蛋白及其用途 |
| IL283298B2 (en) | 2018-11-30 | 2025-03-01 | Juno Therapeutics Inc | Methods for dosing and treating B-cell malignancies with adoptive cell therapy |
| WO2020113194A2 (en) | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
| AU2020257238A1 (en) | 2019-04-17 | 2021-12-02 | Alpine Immune Sciences, Inc. | Methods and uses of variant ICOS Ligand (ICOSL) fusion proteins |
| AU2020287882A1 (en) | 2019-06-07 | 2022-01-20 | Juno Therapeutics, Inc. | Automated T cell culture |
| MA56206A (fr) | 2019-06-12 | 2022-04-20 | Juno Therapeutics Inc | Combinaison thérapeutique d'une thérapie cytotoxique à médiation cellulaire et d'un inhibiteur d'une protéine de la famille bcl2 pro-survie |
| JP2022545467A (ja) | 2019-08-22 | 2022-10-27 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法とｚｅｓｔｅホモログ２エンハンサー（ＥＺＨ２）阻害剤との併用療法および関連方法 |
| EP4055383A1 (en) | 2019-11-05 | 2022-09-14 | Juno Therapeutics, Inc. | Methods of determining attributes of therapeutic t cell compositions |
| AU2020395318A1 (en) | 2019-12-06 | 2022-06-09 | Juno Therapeutics, Inc. | Methods related to toxicity and response associated with cell therapy for treating B cell malignancies |
| MX2022009041A (es) | 2020-01-24 | 2022-10-07 | Juno Therapeutics Inc | Metodos de dosificacion y tratamiento de linfoma folicular y linfoma de zona marginal en terapia celular adoptiva. |
| KR20220146480A (ko) | 2020-01-28 | 2022-11-01 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｔ 세포 형질도입 방법 |
| KR20230009386A (ko) | 2020-04-10 | 2023-01-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｂ-세포 성숙 항원을 표적화하는 키메라 항원 수용체로 조작된 세포 요법 관련 방법 및 용도 |
| CN115812077A (zh) | 2020-05-08 | 2023-03-17 | 高山免疫科学股份有限公司 | April和baff抑制性免疫调节蛋白及其使用方法 |
| JP7727662B2 (ja) | 2020-05-13 | 2025-08-21 | ジュノー セラピューティクス インコーポレイテッド | 臨床応答に関連する特徴量の特定方法およびその使用 |
| CA3197730A1 (en) | 2020-10-15 | 2022-04-21 | F. Hoffman-La Roche Ag | Nucleic acid constructs for va rna transcription |
| WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
| CA3210581A1 (en) | 2021-03-22 | 2022-09-29 | Neil HAIG | Methods of determining potency of a therapeutic cell composition |
| AU2022244229A1 (en) | 2021-03-22 | 2023-09-14 | Juno Therapeutics, Inc. | Method to assess potency of viral vector particles |
| KR20240005700A (ko) | 2021-03-29 | 2024-01-12 | 주노 쎄러퓨티크스 인코퍼레이티드 | 체크포인트 억제제 요법 및 car t 세포 요법의 조합을 사용한 투여 및 치료 방법 |
| WO2022236335A1 (en) | 2021-05-07 | 2022-11-10 | Alpine Immune Sciences, Inc. | Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein |
| US20250059560A1 (en) | 2021-12-16 | 2025-02-20 | Sana Biotechnology, Inc. | Methods and systems of particle production |
| WO2023147515A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Methods of manufacturing cellular compositions |
| WO2023172883A1 (en) | 2022-03-07 | 2023-09-14 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses |
| US20250345432A1 (en) | 2022-05-25 | 2025-11-13 | Celgene Corporation | Method for predicting response to a t cell therapy |
| JP2025521543A (ja) | 2022-06-22 | 2025-07-10 | ジュノー セラピューティクス インコーポレイテッド | Ｃｄ１９標的ｃａｒ ｔ細胞のセカンドライン治療のための処置方法 |
| EP4598557A2 (en) | 2022-10-04 | 2025-08-13 | Alpine Immune Sciences, Inc. | Mutated taci-fc fusion proteins for use in the treatment of autoantibody-mediated diseases |
| WO2024220588A1 (en) | 2023-04-18 | 2024-10-24 | Juno Therapeutics, Inc. | Cytotoxicity assay for assessing potency of therapeutic cell compositions |
| WO2024226858A1 (en) | 2023-04-26 | 2024-10-31 | Juno Therapeutics, Inc. | Methods for viral vector manufacturing |
| WO2024243365A2 (en) | 2023-05-23 | 2024-11-28 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
| WO2024263991A2 (en) * | 2023-06-22 | 2024-12-26 | Arc Research Institute | Methods and compositions for integration deficient viral vectors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861161A (en) | 1994-09-07 | 1999-01-19 | Universite De Montreal | Chimeric proteins comprising a Vpr/Vpx virion incorporation domain for targeting into HIV-1 or HIV-2 virions |
| CN100390291C (zh) | 1995-11-28 | 2008-05-28 | 约翰斯·霍普金斯大学医学院 | 条件复制型病毒载体及其用法 |
| AU1100201A (en) | 1999-10-28 | 2001-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Methods of in vivo gene transfer using a sleeping beauty transposon system |
| US6673567B2 (en) | 2000-03-23 | 2004-01-06 | E. I. Du Pont De Nemours And Company | Method of determination of gene function |
| US20030003565A1 (en) * | 2000-11-27 | 2003-01-02 | Dubensky Thomas W. | Functional lentiviral vector from an MLV-based backbone |
| EP1534847B1 (en) | 2002-09-03 | 2015-10-28 | Oxford Biomedica (UK) Limited | Retroviral vector and stable packaging cell lines |
| US7220578B2 (en) | 2002-11-27 | 2007-05-22 | Tal Kafri | Single LTR lentivirus vector |
| WO2005023313A1 (en) * | 2003-09-09 | 2005-03-17 | Virxsys Corporation | Lentivirus vector-based approaches for generating an immune response to hiv humans |
| GB0325379D0 (en) | 2003-10-30 | 2003-12-03 | Oxford Biomedica Ltd | Vectors |
| WO2005056057A1 (en) * | 2003-12-04 | 2005-06-23 | Childrens Hospital Los Angeles Research Institute | Minimal lentiviral vector system |
| US20070048285A1 (en) * | 2005-08-24 | 2007-03-01 | Christopher Baum | Self-inactivating retroviral vector |
| EP1757703A3 (en) | 2005-08-24 | 2007-12-05 | Medizinische Hochschule Hannover | Self-inactivating retroviral vector |
| RS56844B1 (sr) | 2007-12-11 | 2018-04-30 | Univ North Carolina Chapel Hill | Retrovirusni vektori sa modifikovanim polipurinskim nizom |
-
2008
- 2008-12-11 RS RS20180107A patent/RS56844B1/sr unknown
- 2008-12-11 WO PCT/US2008/086409 patent/WO2009076524A2/en not_active Ceased
- 2008-12-11 ES ES08859393.4T patent/ES2664988T3/es active Active
- 2008-12-11 PL PL08859393T patent/PL2222861T3/pl unknown
- 2008-12-11 NO NO08859393A patent/NO2222861T3/no unknown
- 2008-12-11 HU HUE08859393A patent/HUE036103T2/hu unknown
- 2008-12-11 HR HRP20180184TT patent/HRP20180184T1/hr unknown
- 2008-12-11 PT PT88593934T patent/PT2222861T/pt unknown
- 2008-12-11 TR TR2018/02323T patent/TR201802323T4/tr unknown
- 2008-12-11 SI SI200831929T patent/SI2222861T1/en unknown
- 2008-12-11 US US12/747,076 patent/US9796987B2/en active Active
- 2008-12-11 LT LTEP08859393.4T patent/LT2222861T/lt unknown
- 2008-12-11 EP EP08859393.4A patent/EP2222861B1/en active Active
- 2008-12-11 JP JP2010538155A patent/JP5749014B2/ja not_active Expired - Fee Related
- 2008-12-11 DK DK08859393.4T patent/DK2222861T3/en active
- 2008-12-11 EP EP17204678.1A patent/EP3342872A1/en not_active Withdrawn
-
2015
- 2015-01-28 JP JP2015013974A patent/JP6001702B2/ja not_active Expired - Fee Related
-
2017
- 2017-10-23 US US15/790,530 patent/US10017785B2/en active Active
-
2018
- 2018-02-09 CY CY20181100167T patent/CY1119905T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1119905T1 (el) | 2018-06-27 |
| JP2011505835A (ja) | 2011-03-03 |
| TR201802323T4 (tr) | 2018-03-21 |
| NO2222861T3 (enExample) | 2018-05-05 |
| HUE036103T2 (hu) | 2018-06-28 |
| EP2222861B1 (en) | 2017-12-06 |
| EP3342872A1 (en) | 2018-07-04 |
| JP5749014B2 (ja) | 2015-07-15 |
| LT2222861T (lt) | 2018-03-26 |
| DK2222861T3 (en) | 2018-02-05 |
| US10017785B2 (en) | 2018-07-10 |
| EP2222861A2 (en) | 2010-09-01 |
| JP6001702B2 (ja) | 2016-10-05 |
| US20180119170A1 (en) | 2018-05-03 |
| US9796987B2 (en) | 2017-10-24 |
| EP2222861A4 (en) | 2011-12-28 |
| US20100323403A1 (en) | 2010-12-23 |
| JP2015119715A (ja) | 2015-07-02 |
| ES2664988T3 (es) | 2018-04-24 |
| WO2009076524A3 (en) | 2009-09-11 |
| PT2222861T (pt) | 2018-02-16 |
| PL2222861T3 (pl) | 2018-04-30 |
| HRP20180184T1 (hr) | 2018-04-06 |
| WO2009076524A2 (en) | 2009-06-18 |
| RS56844B1 (sr) | 2018-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI2222861T1 (en) | Retroviral vectors, modified with a polyurea tract | |
| JP7472121B2 (ja) | アルブミン遺伝子座からの導入遺伝子発現のための組成物及び方法 | |
| Izsvák et al. | Efficient stable gene transfer into human cells by the Sleeping Beauty transposon vectors | |
| CN105705645B (zh) | 逆转录病毒载体 | |
| US8865467B2 (en) | Single lentiviral vector system for induced pluripotent (iPS) stem cells derivation | |
| US5354674A (en) | Method of gene transfer using retrotransposons | |
| US20170145438A1 (en) | Viral Vectors for Gene Editing | |
| JP2011505835A5 (enExample) | ||
| ES2886919T3 (es) | Partícula para la encapsidación de un sistema de ingeniería del genoma | |
| US20160076000A1 (en) | Polycistronic Vector for Human Induced Pluripotent Stem Cell Production | |
| JP2010063463A (ja) | 細胞を形質転換するための方法および組成物 | |
| EP3730616A1 (en) | Split single-base gene editing systems and application thereof | |
| RU2012130149A (ru) | Векторная система на основе aslv | |
| van Heuvel et al. | Establishment of a novel stable human suspension packaging cell line producing ecotropic retroviral MLV (PVC-211) vectors efficiently transducing murine hematopoietic stem and progenitor cells | |
| US20250340866A1 (en) | A screening method | |
| IL152527A (en) | Retroviral vectors containing termination termination with increased efficiency | |
| US20240352485A1 (en) | Compositions and methods for the production of libraries | |
| US20070042494A1 (en) | Heterologous retroviral packaging system | |
| JP4766297B2 (ja) | 非ウィルス由来のエンハンサーと、ｃＰＰＴと、ＣＴＳとを含むことを特徴とするベクター | |
| van Heuvel | Optimization of retroviral packaging cells for scale-up of vector production | |
| CN1447858A (zh) | 复合物 | |
| WO2021022308A2 (en) | Non-viral transgenesis | |
| Heuvel | Optimization of retroviral packaging cells for scale-up of vector production | |
| AU2302701A (en) | Natural or synthetic retroelements enabling nucleotide sequence insertion into a eukaryotic cell |