SI2205620T1 - Amorfna oblika (11 beta,16alfa)-9-fluoro-11-hidroksi-16,17-((1-metiletiliden) bis(oksi))-21-((4-(nitrooksi)metil)benzoil)oksi)-pregna-1,4-dien-3,20- diona - Google Patents

Amorfna oblika (11 beta,16alfa)-9-fluoro-11-hidroksi-16,17-((1-metiletiliden) bis(oksi))-21-((4-(nitrooksi)metil)benzoil)oksi)-pregna-1,4-dien-3,20- diona

Info

Publication number
SI2205620T1
SI2205620T1 SI200830287T SI200830287T SI2205620T1 SI 2205620 T1 SI2205620 T1 SI 2205620T1 SI 200830287 T SI200830287 T SI 200830287T SI 200830287 T SI200830287 T SI 200830287T SI 2205620 T1 SI2205620 T1 SI 2205620T1
Authority
SI
Slovenia
Prior art keywords
nitrooxy
amorphous form
åoxy
åbenzoyl
methylethyliden
Prior art date
Application number
SI200830287T
Other languages
English (en)
Inventor
Luis Anglada
Carlos Albet
Antonio Guglietta
Original Assignee
Ferrer Int
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int, Nicox Sa filed Critical Ferrer Int
Publication of SI2205620T1 publication Critical patent/SI2205620T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/12Keratolytics, e.g. wart or anti-corn preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/0026Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
SI200830287T 2007-10-25 2008-10-23 Amorfna oblika (11 beta,16alfa)-9-fluoro-11-hidroksi-16,17-((1-metiletiliden) bis(oksi))-21-((4-(nitrooksi)metil)benzoil)oksi)-pregna-1,4-dien-3,20- diona SI2205620T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200702796A ES2324007A1 (es) 2007-10-25 2007-10-25 Una forma amorfa de un compuesto antiinflamatorio.
EP08841744A EP2205620B1 (en) 2007-10-25 2008-10-23 Amorphous form of (11beta,16alpha)-9-fluoro-11-hydroxy-16,17-[(1-methylethyliden)bis(oxy)]-21-[[4- [(nitrooxy)methyl]benzoyl]oxy]-pregna-1,4-dien-3,20-dione
PCT/EP2008/064387 WO2009053439A2 (en) 2007-10-25 2008-10-23 An amorphous form of an anti-inflammatory compound

Publications (1)

Publication Number Publication Date
SI2205620T1 true SI2205620T1 (sl) 2011-08-31

Family

ID=40377713

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200830287T SI2205620T1 (sl) 2007-10-25 2008-10-23 Amorfna oblika (11 beta,16alfa)-9-fluoro-11-hidroksi-16,17-((1-metiletiliden) bis(oksi))-21-((4-(nitrooksi)metil)benzoil)oksi)-pregna-1,4-dien-3,20- diona

Country Status (19)

Country Link
US (1) US20100261691A1 (sl)
EP (1) EP2205620B1 (sl)
JP (1) JP2011500762A (sl)
KR (1) KR20100091159A (sl)
CN (1) CN101861327B (sl)
AT (1) ATE505477T1 (sl)
AU (1) AU2008316471A1 (sl)
BR (1) BRPI0818822A2 (sl)
CA (1) CA2703441A1 (sl)
CY (1) CY1112540T1 (sl)
DE (1) DE602008006244D1 (sl)
DK (1) DK2205620T3 (sl)
ES (2) ES2324007A1 (sl)
MX (1) MX2010004423A (sl)
PL (1) PL2205620T3 (sl)
PT (1) PT2205620E (sl)
RU (1) RU2010120844A (sl)
SI (1) SI2205620T1 (sl)
WO (1) WO2009053439A2 (sl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2318427T3 (da) * 2008-07-31 2014-01-20 Nicox Sa Glucocorticoider bundet til nitratestere via en aromatisk linker i position 21 og deres anvendelse i oftalmologi
ES2359708B1 (es) * 2009-11-16 2012-03-30 Ferrer Internacional S.A. Procedimiento de preparación de la (11beta,16alfa)-9-fluoro-11-hidroxi-16,17-[1-metil-etilidenebis(oxi)]-21-[1-oxo-[4-(nitrooximetil)benzoxi]]preña-1,4-dien-3,20-diona.
RU2629601C1 (ru) * 2016-11-03 2017-08-30 Государственное бюджетное образовательное учреждение дополнительного профессионального образования "Казанская государственная медицинская академия" Министерства здравоохранения Российской Федерации Способ лечения больных красным плоским лишаем
RU2709534C1 (ru) * 2018-07-12 2019-12-18 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) Способ лечения хронических дерматозов

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1312115B1 (it) * 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
US8313504B2 (en) * 2000-09-18 2012-11-20 Cordis Corporation Foam matrix embolization device
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
IL154370A0 (en) * 2003-02-10 2003-09-17 Chemagis Ltd Solid amorphous mixtures, processes for the preparation thereof and pharmaceutical compositions containing the same
US20060045850A1 (en) * 2004-08-30 2006-03-02 Qpharma, Llc Nasal delivery of cyclodextrin complexes of anti-inflammatory steroids
EP1940863B1 (en) * 2005-09-02 2012-09-05 Nicox S.A. Nitrooxy derivatives of glucocorticoids

Also Published As

Publication number Publication date
ES2364953T3 (es) 2011-09-19
DE602008006244D1 (de) 2011-05-26
CY1112540T1 (el) 2015-12-09
US20100261691A1 (en) 2010-10-14
DK2205620T3 (da) 2011-07-25
AU2008316471A1 (en) 2009-04-30
CN101861327A (zh) 2010-10-13
RU2010120844A (ru) 2011-11-27
MX2010004423A (es) 2010-09-10
JP2011500762A (ja) 2011-01-06
PT2205620E (pt) 2011-07-12
EP2205620A2 (en) 2010-07-14
ATE505477T1 (de) 2011-04-15
CA2703441A1 (en) 2009-04-30
BRPI0818822A2 (pt) 2015-04-22
WO2009053439A2 (en) 2009-04-30
ES2324007A1 (es) 2009-07-28
PL2205620T3 (pl) 2011-10-31
KR20100091159A (ko) 2010-08-18
CN101861327B (zh) 2012-10-31
WO2009053439A3 (en) 2009-07-16
EP2205620B1 (en) 2011-04-13

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