SI21745A - Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina - Google Patents

Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina Download PDF

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Publication number
SI21745A
SI21745A SI200400112A SI200400112A SI21745A SI 21745 A SI21745 A SI 21745A SI 200400112 A SI200400112 A SI 200400112A SI 200400112 A SI200400112 A SI 200400112A SI 21745 A SI21745 A SI 21745A
Authority
SI
Slovenia
Prior art keywords
phenyl
methylethyl
butyl ester
tertiary butyl
dihydroxy
Prior art date
Application number
SI200400112A
Other languages
English (en)
Slovenian (sl)
Inventor
Anton Timac
Rok Zupet
Marija Gr�man
Matej Smrkolj
Renata Jak�e
Original Assignee
Krka, Tovarna Zdravil, D.D., Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, Tovarna Zdravil, D.D., Novo Mesto filed Critical Krka, Tovarna Zdravil, D.D., Novo Mesto
Priority to SI200400112A priority Critical patent/SI21745A/sl
Priority to AT05729986T priority patent/ATE459602T1/de
Priority to PCT/EP2005/003733 priority patent/WO2005097742A1/en
Priority to CN2009101368132A priority patent/CN101538238B/zh
Priority to EP05729986A priority patent/EP1732886B1/en
Priority to DE602005019703T priority patent/DE602005019703D1/de
Priority to SI200531002T priority patent/SI1732886T1/sl
Priority to ES05729986T priority patent/ES2339570T3/es
Priority to CN200580012246XA priority patent/CN1946687B/zh
Priority to EA200601651A priority patent/EA010166B1/ru
Priority to PT05729986T priority patent/PT1732886E/pt
Priority to RSP-2010/0173A priority patent/RS51259B/sr
Priority to DK05729986.9T priority patent/DK1732886T3/da
Priority to PL05729986T priority patent/PL1732886T3/pl
Priority to UAA200610957A priority patent/UA86059C2/ru
Publication of SI21745A publication Critical patent/SI21745A/sl
Priority to NO20065146A priority patent/NO20065146L/no
Priority to HR20100217T priority patent/HRP20100217T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200400112A 2004-04-09 2004-04-09 Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina SI21745A (sl)

Priority Applications (17)

Application Number Priority Date Filing Date Title
SI200400112A SI21745A (sl) 2004-04-09 2004-04-09 Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina
ES05729986T ES2339570T3 (es) 2004-04-09 2005-04-08 Polimorfos de ester terc-butilo de la atorvastatina y su utilizacion como intermediarios para la preparacion de la atorvastatina.
PT05729986T PT1732886E (pt) 2004-04-09 2005-04-08 Polimorfos de éster de tert-butilo de atorvastatina e utilização como intermediários para a preparação de atorvastatina
CN2009101368132A CN101538238B (zh) 2004-04-09 2005-04-08 阿托伐他汀叔丁基酯的多晶型物及其作为中间体在制备阿托伐他汀中的应用
EP05729986A EP1732886B1 (en) 2004-04-09 2005-04-08 Polymorphs of atorvastatin tert.-butylester and use as intermediates for the preparation of atorvastatin
DE602005019703T DE602005019703D1 (de) 2004-04-09 2005-04-08 Polymorphe von atorvastatin-tert.-butylester und deren verwendung als zwischenprodukte für die herstellung von atorvastatin
SI200531002T SI1732886T1 (sl) 2004-04-09 2005-04-08 Polimorfi terc butil estra atorvastatina in uporaba kot intermediati za pripravo atorvastatina
AT05729986T ATE459602T1 (de) 2004-04-09 2005-04-08 Polymorphe von atorvastatin-tert.-butylester und deren verwendung als zwischenprodukte für die herstellung von atorvastatin
CN200580012246XA CN1946687B (zh) 2004-04-09 2005-04-08 阿托伐他汀叔丁基酯的多晶型物及其作为中间体在制备阿托伐他汀中的应用
EA200601651A EA010166B1 (ru) 2004-04-09 2005-04-08 Полиморфные формы трет-бутилового эфира аторвастатина и их использование в качестве промежуточных соединений для получения аторвастатина
PCT/EP2005/003733 WO2005097742A1 (en) 2004-04-09 2005-04-08 Polymorphs of atorvastatin tert.-butylester and use as intermediates for the preparation of atorvastatin
RSP-2010/0173A RS51259B (sr) 2004-04-09 2005-04-08 Polimorf atorvastatin tert.-butilestra i korišćenje intermediata za dobijanje atorvastatina
DK05729986.9T DK1732886T3 (da) 2004-04-09 2005-04-08 Polymorfer af atorvastasin-tert.-butylester og anvendelse som intermediære til fremstilling af atorvastatin
PL05729986T PL1732886T3 (pl) 2004-04-09 2005-04-08 Odmiany polimorficzne estru tert.-butylowego atorwastatyny i ich zastosowanie jako związków pośrednich do wytwarzania atorwastatyny
UAA200610957A UA86059C2 (ru) 2004-04-09 2005-08-04 Полиморфные формы трет-бутилового эфира аторвастатина и их использование как промежуточных соединений для получения аторвастатина
NO20065146A NO20065146L (no) 2004-04-09 2006-11-08 Polymorfer av atorvastatin tert.-butylester og anvendelse derav som mellomprodukter for fremstilling av atorvastatin
HR20100217T HRP20100217T1 (hr) 2004-04-09 2010-04-16 POLIMORFI tert-BUTILNOG ESTERA ATORVASTATINA I NJIHOVA UPOTREBA KAO MEĐUPRODUKATA U DOBIVANJU ATORVASTATINA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200400112A SI21745A (sl) 2004-04-09 2004-04-09 Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina

Publications (1)

Publication Number Publication Date
SI21745A true SI21745A (sl) 2005-10-31

Family

ID=34963800

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200400112A SI21745A (sl) 2004-04-09 2004-04-09 Polimorfi derivata 1-pirol-1-heptanojske kisline, intermediata za pripravo atorvastatina
SI200531002T SI1732886T1 (sl) 2004-04-09 2005-04-08 Polimorfi terc butil estra atorvastatina in uporaba kot intermediati za pripravo atorvastatina

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200531002T SI1732886T1 (sl) 2004-04-09 2005-04-08 Polimorfi terc butil estra atorvastatina in uporaba kot intermediati za pripravo atorvastatina

Country Status (15)

Country Link
EP (1) EP1732886B1 (pt)
CN (2) CN101538238B (pt)
AT (1) ATE459602T1 (pt)
DE (1) DE602005019703D1 (pt)
DK (1) DK1732886T3 (pt)
EA (1) EA010166B1 (pt)
ES (1) ES2339570T3 (pt)
HR (1) HRP20100217T1 (pt)
NO (1) NO20065146L (pt)
PL (1) PL1732886T3 (pt)
PT (1) PT1732886E (pt)
RS (1) RS51259B (pt)
SI (2) SI21745A (pt)
UA (1) UA86059C2 (pt)
WO (1) WO2005097742A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101329112B1 (ko) * 2005-11-08 2013-11-14 랜박시 래보러터리스 리미티드 (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
WO2009007856A2 (en) * 2007-07-11 2009-01-15 Actavis Group Ptc Ehf Novel polymorph of atorvastatin calcium and use thereof for the preparation of amorphous atorvastatin calcium
WO2009023260A2 (en) * 2007-08-15 2009-02-19 Teva Pharmaceutical Industries Ltd. An improved process for synthesis of pyrrole derivative, an intermediate for atorvastatin
CN101560177B (zh) * 2008-04-16 2012-10-03 北京万全阳光医学技术有限公司 一种阿托伐他汀钙的制备方法
WO2010112222A1 (en) 2009-03-31 2010-10-07 Krka, D.D., Novo Mesto Progressive emulsion crystallization
CN105693587A (zh) * 2016-01-15 2016-06-22 安徽悦康凯悦制药有限公司 一种阿托伐他汀钙的生产工艺
CN109280024A (zh) * 2018-10-09 2019-01-29 河南师范大学 一种高纯度阿托伐他汀叔丁酯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
PT1341785E (pt) * 2000-11-16 2009-01-16 Teva Pharma Hidrólise de ésteres de ácidos r(r*,r*)-2-(4-fluorofenil)-beta,delta-di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico com hidróxido de cálcio
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
CA2450820C (en) * 2001-08-16 2011-03-15 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins

Also Published As

Publication number Publication date
NO20065146L (no) 2006-11-08
PL1732886T3 (pl) 2010-08-31
ATE459602T1 (de) 2010-03-15
EP1732886B1 (en) 2010-03-03
RS51259B (sr) 2010-12-31
DE602005019703D1 (de) 2010-04-15
ES2339570T3 (es) 2010-05-21
EP1732886A1 (en) 2006-12-20
CN1946687A (zh) 2007-04-11
HRP20100217T1 (hr) 2010-05-31
DK1732886T3 (da) 2010-06-14
SI1732886T1 (sl) 2010-06-30
CN1946687B (zh) 2011-09-28
CN101538238A (zh) 2009-09-23
WO2005097742A1 (en) 2005-10-20
CN101538238B (zh) 2012-08-29
UA86059C2 (ru) 2009-03-25
EA010166B1 (ru) 2008-06-30
EA200601651A1 (ru) 2007-02-27
PT1732886E (pt) 2010-03-12

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OO00 Grant of patent

Effective date: 20041118

KO00 Lapse of patent

Effective date: 20071207