SI1572725T1 - Hi-konotoksin peptidi, ki imajo N-terminalno piroglutaminsko kislino - Google Patents
Hi-konotoksin peptidi, ki imajo N-terminalno piroglutaminsko kislinoInfo
- Publication number
- SI1572725T1 SI1572725T1 SI200332154T SI200332154T SI1572725T1 SI 1572725 T1 SI1572725 T1 SI 1572725T1 SI 200332154 T SI200332154 T SI 200332154T SI 200332154 T SI200332154 T SI 200332154T SI 1572725 T1 SI1572725 T1 SI 1572725T1
- Authority
- SI
- Slovenia
- Prior art keywords
- cys
- xaa1
- peptides
- terminal
- amino acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical group OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 title abstract 2
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 title 1
- YKKHFPGOZXQAGK-QWRGUYRKSA-N Cys-Gly-Tyr Chemical compound SC[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 YKKHFPGOZXQAGK-QWRGUYRKSA-N 0.000 abstract 1
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- DKJWUIYLMLUBDX-XPUUQOCRSA-N Gly-Val-Cys Chemical compound NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)O DKJWUIYLMLUBDX-XPUUQOCRSA-N 0.000 abstract 1
- HBGKOLSGLYMWSW-DCAQKATOSA-N His-Pro-Cys Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)N)C(=O)N[C@@H](CS)C(=O)O HBGKOLSGLYMWSW-DCAQKATOSA-N 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- PINHPJWGVBKQII-SRVKXCTJSA-N Lys-Leu-Cys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](CCCCN)N PINHPJWGVBKQII-SRVKXCTJSA-N 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 108010004073 cysteinylcysteine Proteins 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 108010059898 glycyl-tyrosyl-lysine Proteins 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 229940043131 pyroglutamate Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43030602P | 2002-12-02 | 2002-12-02 | |
| PCT/AU2003/001605 WO2004050690A1 (en) | 2002-12-02 | 2003-12-02 | NOVEL χ-CONOTOXIN PEPTIDES (-I) |
| EP03812100A EP1572725B1 (en) | 2002-12-02 | 2003-12-02 | Chi-conotoxin peptides having a n-terminal pyroglutamic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1572725T1 true SI1572725T1 (sl) | 2012-08-31 |
Family
ID=32469446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200332154T SI1572725T1 (sl) | 2002-12-02 | 2003-12-02 | Hi-konotoksin peptidi, ki imajo N-terminalno piroglutaminsko kislino |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7851444B2 (enExample) |
| EP (1) | EP1572725B1 (enExample) |
| JP (1) | JP4565087B2 (enExample) |
| AT (1) | ATE547424T1 (enExample) |
| AU (1) | AU2003302609B9 (enExample) |
| CA (1) | CA2508129C (enExample) |
| CY (1) | CY1112839T1 (enExample) |
| DK (1) | DK1572725T3 (enExample) |
| ES (1) | ES2383358T3 (enExample) |
| NZ (1) | NZ540518A (enExample) |
| PT (1) | PT1572725E (enExample) |
| SI (1) | SI1572725T1 (enExample) |
| WO (1) | WO2004050690A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP627498A0 (en) * | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
| WO2004050688A1 (en) * | 2002-12-02 | 2004-06-17 | Xenome Ltd | NOVEL χ-CONOTOXIN PEPTIDES (-II) |
| US8062623B2 (en) * | 2004-10-15 | 2011-11-22 | Velocys | Stable, catalyzed, high temperature combustion in microchannel, integrated combustion reactors |
| US20070154360A1 (en) * | 2005-10-13 | 2007-07-05 | Velocys Inc. | Microchannel apparatus comprising a platinum aluminide layer and chemical processes using the apparatus |
| CN102752032B (zh) * | 2011-04-22 | 2015-04-22 | 艾利森电话股份有限公司 | 同频负载均衡方法及其设备 |
| CA2986704C (en) * | 2015-05-22 | 2022-03-01 | Clemson University Research Foundation | Conotoxin peptides for use in biofouling deterrence |
| CN119462881A (zh) * | 2024-12-20 | 2025-02-18 | 深圳肽盛生物科技有限公司 | μ型芋螺毒素肽及其药物组合物和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051403A (en) | 1989-11-22 | 1991-09-24 | Neurex Corporation | Method of treating ischemia-related neuronal damage |
| ZA921292B (en) | 1991-02-25 | 1993-08-23 | Lilly Co Eli | Treatment of lower urinary tract disorders. |
| CA2151741C (en) * | 1991-12-30 | 2001-12-11 | Alan Justice | Methods of producing analgesia and enhancing opiate analgesia |
| PT789580E (pt) | 1994-11-03 | 2002-09-30 | Novartis Ag | Formulacoes de ciclosporina para administracao oral com composicao simples e alta biodisponibilidade e processo para a sua producao |
| WO1996040064A1 (en) | 1995-06-07 | 1996-12-19 | Nexstar Pharmaceuticals, Inc. | Liposomal cyclosporin formulations as agents for immunosuppression and multiple drug resistant indications |
| DK0835126T3 (da) | 1995-06-27 | 2003-07-14 | Elan Pharm Inc | Sammensætninger og formuleringer til fremstilling af analgesimidler og til hamning af fremadskridende neuropatiske amertelidelser |
| TR199801641T2 (xx) | 1996-02-22 | 1998-11-23 | Neurosearch A/S | Tropan t�revleri bunlar�n haz�rlanmas� ve kullan�m� |
| GB9614902D0 (en) | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| CZ288739B6 (cs) | 1996-08-01 | 2001-08-15 | Galena, A. S. | Cyklosporin obsahující léčivé přípravky |
| JP2001505878A (ja) | 1996-11-18 | 2001-05-08 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | 心臓血管剤としてのコノトキシンペプチドＩｍＩおよびＭＩＩの使用 |
| EP0981515B1 (en) | 1997-05-14 | 2003-08-27 | Neurosearch A/S | Piperidine derivatives as neurotransmitter re-uptake inhibitors |
| AUPP627498A0 (en) | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
| US6767896B1 (en) * | 1999-01-29 | 2004-07-27 | Cognetix, Inc. | Conotoxin peptides |
| WO2000044769A1 (en) * | 1999-01-29 | 2000-08-03 | University Of Utah Research Foundation | Conotoxin peptides |
| US20010036943A1 (en) | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| WO2002060923A2 (en) * | 2001-01-29 | 2002-08-08 | Cognetix, Inc. | B-superfamily conotoxins |
| WO2002064740A2 (en) * | 2001-02-09 | 2002-08-22 | Cognetix, Inc. | Cone snail peptides |
| WO2004050688A1 (en) * | 2002-12-02 | 2004-06-17 | Xenome Ltd | NOVEL χ-CONOTOXIN PEPTIDES (-II) |
-
2003
- 2003-12-02 DK DK03812100.0T patent/DK1572725T3/da active
- 2003-12-02 WO PCT/AU2003/001605 patent/WO2004050690A1/en not_active Ceased
- 2003-12-02 NZ NZ540518A patent/NZ540518A/en not_active IP Right Cessation
- 2003-12-02 AT AT03812100T patent/ATE547424T1/de active
- 2003-12-02 PT PT03812100T patent/PT1572725E/pt unknown
- 2003-12-02 US US10/537,704 patent/US7851444B2/en not_active Expired - Fee Related
- 2003-12-02 AU AU2003302609A patent/AU2003302609B9/en not_active Ceased
- 2003-12-02 JP JP2004555869A patent/JP4565087B2/ja not_active Expired - Fee Related
- 2003-12-02 EP EP03812100A patent/EP1572725B1/en not_active Expired - Lifetime
- 2003-12-02 SI SI200332154T patent/SI1572725T1/sl unknown
- 2003-12-02 ES ES03812100T patent/ES2383358T3/es not_active Expired - Lifetime
- 2003-12-02 CA CA2508129A patent/CA2508129C/en not_active Expired - Fee Related
-
2012
- 2012-05-29 CY CY20121100484T patent/CY1112839T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2508129A1 (en) | 2004-06-17 |
| DK1572725T3 (da) | 2012-06-18 |
| ATE547424T1 (de) | 2012-03-15 |
| WO2004050690A1 (en) | 2004-06-17 |
| EP1572725B1 (en) | 2012-02-29 |
| JP2006523181A (ja) | 2006-10-12 |
| NZ540518A (en) | 2006-12-22 |
| EP1572725A4 (en) | 2008-09-24 |
| HK1080870A1 (en) | 2006-05-04 |
| AU2003302609A1 (en) | 2004-06-23 |
| US20060142201A1 (en) | 2006-06-29 |
| AU2003302609B2 (en) | 2008-03-20 |
| AU2003302609B9 (en) | 2008-05-15 |
| CA2508129C (en) | 2012-06-26 |
| ES2383358T3 (es) | 2012-06-20 |
| PT1572725E (pt) | 2012-05-28 |
| EP1572725A1 (en) | 2005-09-14 |
| CY1112839T1 (el) | 2016-02-10 |
| US7851444B2 (en) | 2010-12-14 |
| JP4565087B2 (ja) | 2010-10-20 |
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