SI1101756T1 - Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them - Google Patents

Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them

Info

Publication number
SI1101756T1
SI1101756T1 SI200030067T SI200030067T SI1101756T1 SI 1101756 T1 SI1101756 T1 SI 1101756T1 SI 200030067 T SI200030067 T SI 200030067T SI 200030067 T SI200030067 T SI 200030067T SI 1101756 T1 SI1101756 T1 SI 1101756T1
Authority
SI
Slovenia
Prior art keywords
alkyl
aryl
processes
preparation
pharmaceutical compositions
Prior art date
Application number
SI200030067T
Other languages
English (en)
Slovenian (sl)
Inventor
Pascal Bousquet
Jean-Daniel Ehrhardt
Veronique Bruban
Josiane Feldman
Stephan Schann
Elizabeth Scalbert
Bruno Pfeiffer
Pierre Renard
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1101756T1 publication Critical patent/SI1101756T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
SI200030067T 1999-11-17 2000-11-09 Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them SI1101756T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9914434A FR2801051B1 (fr) 1999-11-17 1999-11-17 Nouveaux composes aminopyrroline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP00403106A EP1101756B1 (fr) 1999-11-17 2000-11-09 Nouveaux composés aminopyrroline, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
SI1101756T1 true SI1101756T1 (en) 2003-06-30

Family

ID=9552203

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030067T SI1101756T1 (en) 1999-11-17 2000-11-09 Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them

Country Status (23)

Country Link
US (1) US6300366B1 (hu)
EP (1) EP1101756B1 (hu)
JP (1) JP3274456B2 (hu)
KR (1) KR100453981B1 (hu)
CN (1) CN1158257C (hu)
AT (1) ATE234815T1 (hu)
AU (1) AU771745B2 (hu)
BR (1) BR0005442A (hu)
CA (1) CA2325781C (hu)
DE (1) DE60001706T2 (hu)
DK (1) DK1101756T3 (hu)
EA (1) EA004042B1 (hu)
ES (1) ES2194691T3 (hu)
FR (1) FR2801051B1 (hu)
HK (1) HK1036454A1 (hu)
HU (1) HUP0004543A3 (hu)
MX (1) MXPA00011239A (hu)
NO (1) NO317987B1 (hu)
NZ (1) NZ508228A (hu)
PL (1) PL343920A1 (hu)
PT (1) PT1101756E (hu)
SI (1) SI1101756T1 (hu)
ZA (1) ZA200006731B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1517688A2 (de) 2002-06-19 2005-03-30 Solvay Pharmaceuticals GmbH Arzneimittel zur behandlung von eine inhibition oder aktivitätsverminderung von ph-wert-regulierenden bikarbonat-transporter-proteinen erfordernden erkrangungen
GB0521083D0 (en) * 2005-10-17 2005-11-23 Novartis Ag Organic compounds
CN105979959B (zh) 2013-08-09 2021-11-30 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
GB201318886D0 (en) * 2013-10-25 2013-12-11 Givaudan Sa Improvements i or relating to organic compounds
CN114716359B (zh) * 2022-04-28 2023-01-17 广东医科大学 一种氢化吲哚亚胺非对映异构体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2029297A1 (de) * 1970-06-13 1971-12-30 Farbenfabriken Bayer Ag, 5090 Leverkusen Neue Aminophenyl-cycloamidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US3887569A (en) * 1970-10-30 1975-06-03 Mcneilab Inc 2-Imino-piperidines
NL7412695A (nl) * 1974-09-26 1976-03-30 Stamicarbon De bereiding van een 2-amino-pyrrolinederivaat.
US4579951A (en) * 1984-03-19 1986-04-01 G. D. Searle & Co. Substituted (azacycloalk-2-yl)iminophenols and esters thereof
DE4425070A1 (de) * 1994-07-15 1996-01-18 Degussa Verfahren zur Herstellung optisch aktiver l-substituierter 2-(Aminomethyl)pyrrolidine

Also Published As

Publication number Publication date
FR2801051B1 (fr) 2001-12-14
HUP0004543A3 (en) 2001-11-28
DE60001706T2 (de) 2004-02-05
PT1101756E (pt) 2003-06-30
DK1101756T3 (da) 2003-07-14
KR20010051776A (ko) 2001-06-25
AU771745B2 (en) 2004-04-01
JP3274456B2 (ja) 2002-04-15
CN1298872A (zh) 2001-06-13
CA2325781C (fr) 2006-07-18
CN1158257C (zh) 2004-07-21
EA200001077A3 (ru) 2001-08-27
HK1036454A1 (en) 2002-01-04
EP1101756B1 (fr) 2003-03-19
BR0005442A (pt) 2001-07-03
DE60001706D1 (de) 2003-04-24
NO317987B1 (no) 2005-01-17
US6300366B1 (en) 2001-10-09
FR2801051A1 (fr) 2001-05-18
ZA200006731B (en) 2001-05-30
EP1101756A1 (fr) 2001-05-23
JP2001139545A (ja) 2001-05-22
EA200001077A2 (ru) 2001-06-25
EA004042B1 (ru) 2003-12-25
HUP0004543A2 (hu) 2001-10-28
NO20005797L (no) 2001-05-18
KR100453981B1 (ko) 2004-10-20
HU0004543D0 (hu) 2001-02-28
ES2194691T3 (es) 2003-12-01
PL343920A1 (en) 2001-05-21
AU7168000A (en) 2001-05-24
ATE234815T1 (de) 2003-04-15
NZ508228A (en) 2001-03-30
MXPA00011239A (es) 2002-05-23
NO20005797D0 (no) 2000-11-16
CA2325781A1 (fr) 2001-05-17

Similar Documents

Publication Publication Date Title
KR950014097A (ko) 피페라진 유도체
HUP0400888A2 (hu) Helyettesített ciklohexán-1,4-diamin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP9802694A1 (hu) Benzamidszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
AR034268A1 (es) Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion
HUP0201475A2 (hu) Heteroarilamidin-, metilamidin- és guanidinszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
SI1101756T1 (en) Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them
HUP0402076A2 (hu) Szubsztituált indolok, eljárás az előállításukra és fájdalomcsillapítókénti alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
AU2186288A (en) Novel amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same
HUP0201357A2 (hu) Aszimmetrikus rézkomplex, előállítása, és eljárás ciklopropánkarbonsav-észter-származékok előállítására felhasználásával
EP1432709B8 (en) 1-glyoxylamide indolizines for treating cancer
MXPA04005837A (es) Nuevos derivados de benzotiazina y benzotiadiazina, metodo para su preparacion y composiciones farmaceuticas que los contienen.
TW200510309A (en) Chemical compounds
HUP0301008A2 (hu) Új imidazolszármazékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
HUP9702149A2 (hu) Tachykinin receptor antagonista heterociklikus piperazinonszármazékok, intermedierjeik, előállításuk és alkalmazásuk, valamint a vegyületeket tartalmazó gyógyászati készítmények
HUP0204444A2 (en) Phenyl- and pyridyl-tetrahydro-pyridines, process for their preparation and pharmaceutical compositions containing them
HU9802645D0 (en) New metalloproteinase inhibitors, process for producing them, and pharmaceutical compositions containing them
DK0841337T3 (da) Substituerede 7,12-dioxabenzo[a]anthracenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger, der indeholder disse derivater
IL85253A0 (en) Ergoline derivatives,their preparation and pharmaceutical compositions containing them
MXPA03010597A (es) Derivados de triciclicos de dihidroquinolinas proceso para prepararlos y composiciones farmaceuticas que los contienen.
HK1024244A1 (en) 8h-thieno-(2,3-b)pyrrolizin-8-one compounds, a process for their preir preparation and pharmaceutical compositions containing them
HUT57221A (en) Process for producing pyrrolo(2,1-b)thiazol derivatives and pahrmaceutical compositions contiaining them as active components