SI1005332T1 - Pharmaceutical composition for reducing production of mcp-1 protein - Google Patents

Pharmaceutical composition for reducing production of mcp-1 protein

Info

Publication number
SI1005332T1
SI1005332T1 SI9830573T SI9830573T SI1005332T1 SI 1005332 T1 SI1005332 T1 SI 1005332T1 SI 9830573 T SI9830573 T SI 9830573T SI 9830573 T SI9830573 T SI 9830573T SI 1005332 T1 SI1005332 T1 SI 1005332T1
Authority
SI
Slovenia
Prior art keywords
mcp
protein
pharmaceutical composition
reducing production
reducing
Prior art date
Application number
SI9830573T
Other languages
English (en)
Slovenian (sl)
Inventor
Angelo Guglielmotti
Alberto Mantovani
Original Assignee
Aziende Chimiche Riunite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite filed Critical Aziende Chimiche Riunite
Publication of SI1005332T1 publication Critical patent/SI1005332T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI9830573T 1997-07-28 1998-07-22 Pharmaceutical composition for reducing production of mcp-1 protein SI1005332T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT97MI001789A IT1293795B1 (it) 1997-07-28 1997-07-28 Farmaco attivo nel ridurre la produzione di proteina mcp-1
PCT/EP1998/004924 WO1999004770A2 (en) 1997-07-28 1998-07-22 A pharmaceutical composition active in reducing production of mcp-1 protein
EP98943862A EP1005332B1 (en) 1997-07-28 1998-07-22 Pharmaceutical composition for reducing production of mcp-1 protein

Publications (1)

Publication Number Publication Date
SI1005332T1 true SI1005332T1 (en) 2004-02-29

Family

ID=11377642

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830573T SI1005332T1 (en) 1997-07-28 1998-07-22 Pharmaceutical composition for reducing production of mcp-1 protein

Country Status (15)

Country Link
US (1) US6534534B1 (enExample)
EP (1) EP1005332B1 (enExample)
JP (2) JP4651191B2 (enExample)
AR (1) AR016382A1 (enExample)
AT (1) ATE251902T1 (enExample)
AU (1) AU744492B2 (enExample)
CA (1) CA2300289C (enExample)
DE (1) DE69819012T2 (enExample)
DK (1) DK1005332T3 (enExample)
ES (1) ES2207858T3 (enExample)
IT (1) IT1293795B1 (enExample)
PT (1) PT1005332E (enExample)
SI (1) SI1005332T1 (enExample)
WO (1) WO1999004770A2 (enExample)
ZA (1) ZA986636B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
ITMI20062254A1 (it) * 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
HRP20160457T1 (hr) 2008-03-07 2016-05-20 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Derivati 1-benzil-3-hidroksimetilindazola i njihova uporaba u liječenju bolesti baziranih na ekspresiji mcp-1 i cx3cr1
US8835481B2 (en) * 2008-03-07 2014-09-16 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40
CA2714436C (en) * 2008-03-07 2017-06-27 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
US8350052B2 (en) 2009-08-03 2013-01-08 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required magnesium intermediates
UA108742C2 (uk) * 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US9250253B2 (en) 2010-02-25 2016-02-02 Prairie Ventures, L.L.C. System and method for anatomical pathology sample handling, storage, and analysis
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
ES2789849T3 (es) * 2014-05-15 2020-10-26 Translatum Medicus Inc Composiciones y procedimientos para el tratamiento y diagnóstico de trastornos oculares
EP3307068B1 (en) 2015-06-12 2021-08-25 Vettore, LLC Mct4 inhibitors for treating disease
ES2986065T3 (es) 2016-12-12 2024-11-08 Vettore Llc Inhibidores heterocíclicos de MCT4
EP3990433A4 (en) 2019-06-25 2023-07-26 Translatum Medicus Inc. METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230441B (it) * 1989-02-07 1991-10-23 Acraf Eteri della serie dell'indazolo
US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
IT1253703B (it) 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
AU5537994A (en) * 1992-10-22 1994-05-09 Mallinckrodt Medical, Inc. Therapeutic treatment for inhibiting vascular restenosis
US5563145A (en) * 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
JPH08333262A (ja) * 1995-04-07 1996-12-17 Chugai Pharmaceut Co Ltd 免疫抑制剤
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
DE19538402A1 (de) * 1995-10-14 1997-04-17 Boehringer Mannheim Gmbh Lipidalkohole als neue immunsuppressive und antivirale Arzneimittel
JPH09165339A (ja) * 1995-10-27 1997-06-24 American Home Prod Corp ラパマイシンを付与したドナー脾細胞を用いる臓器移植の延長
IT1276031B1 (it) 1995-10-31 1997-10-24 Angelini Ricerche Spa Composizione farmaceutica per il trattamento delle malattie autoimmuni
US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1

Also Published As

Publication number Publication date
DK1005332T3 (da) 2004-02-09
WO1999004770A2 (en) 1999-02-04
EP1005332B1 (en) 2003-10-15
AU9160198A (en) 1999-02-16
DE69819012T2 (de) 2004-08-12
ATE251902T1 (de) 2003-11-15
EP1005332A2 (en) 2000-06-07
AU744492B2 (en) 2002-02-28
AR016382A1 (es) 2001-07-04
US6534534B1 (en) 2003-03-18
ES2207858T3 (es) 2004-06-01
DE69819012D1 (de) 2003-11-20
IT1293795B1 (it) 1999-03-10
HK1028561A1 (en) 2001-02-23
JP4651191B2 (ja) 2011-03-16
CA2300289C (en) 2007-11-20
JP5086322B2 (ja) 2012-11-28
JP2010047609A (ja) 2010-03-04
PT1005332E (pt) 2004-03-31
WO1999004770A3 (en) 1999-04-15
ITMI971789A1 (it) 1999-01-28
ZA986636B (en) 1999-02-04
JP2001510793A (ja) 2001-08-07
CA2300289A1 (en) 1999-02-04

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