SI0843679T1 - 1-(1,2-disubstituiran piperidinil)-4-(fuzioniran imidazol)-piperidinski derivati - Google Patents

1-(1,2-disubstituiran piperidinil)-4-(fuzioniran imidazol)-piperidinski derivati

Info

Publication number
SI0843679T1
SI0843679T1 SI9630419T SI9630419T SI0843679T1 SI 0843679 T1 SI0843679 T1 SI 0843679T1 SI 9630419 T SI9630419 T SI 9630419T SI 9630419 T SI9630419 T SI 9630419T SI 0843679 T1 SI0843679 T1 SI 0843679T1
Authority
SI
Slovenia
Prior art keywords
piperidine derivatives
fused imidazole
disubstituted piperidinyl
disubstituted
piperidinyl
Prior art date
Application number
SI9630419T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Joseph Elisabeth Leenaerts
Roosbroeck Yves Emiel Maria Van
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of SI0843679T1 publication Critical patent/SI0843679T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI9630419T 1995-12-27 1996-12-20 1-(1,2-disubstituiran piperidinil)-4-(fuzioniran imidazol)-piperidinski derivati SI0843679T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95203652 1995-12-27
EP96944693A EP0843679B1 (en) 1995-12-27 1996-12-20 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
PCT/EP1996/005885 WO1997024356A1 (en) 1995-12-27 1996-12-20 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Publications (1)

Publication Number Publication Date
SI0843679T1 true SI0843679T1 (sl) 2002-06-30

Family

ID=8221024

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630419T SI0843679T1 (sl) 1995-12-27 1996-12-20 1-(1,2-disubstituiran piperidinil)-4-(fuzioniran imidazol)-piperidinski derivati

Country Status (30)

Country Link
US (1) US6251894B1 (sl)
EP (1) EP0843679B1 (sl)
JP (1) JP4097043B2 (sl)
KR (1) KR100485147B1 (sl)
CN (1) CN1066733C (sl)
AR (2) AR005278A1 (sl)
AT (1) ATE208392T1 (sl)
AU (1) AU716071B2 (sl)
BR (1) BR9612307A (sl)
CA (1) CA2238817C (sl)
CY (1) CY2271B1 (sl)
CZ (1) CZ295861B6 (sl)
DE (1) DE69616802T2 (sl)
DK (1) DK0843679T3 (sl)
EA (1) EA001374B1 (sl)
ES (1) ES2167619T3 (sl)
HK (1) HK1011206A1 (sl)
HU (1) HU229766B1 (sl)
IL (2) IL124642A (sl)
MY (1) MY117680A (sl)
NO (1) NO310916B1 (sl)
NZ (1) NZ325845A (sl)
PL (1) PL183767B1 (sl)
PT (1) PT843679E (sl)
SI (1) SI0843679T1 (sl)
SK (1) SK283540B6 (sl)
TR (1) TR199801210T2 (sl)
TW (1) TW382017B (sl)
WO (1) WO1997024356A1 (sl)
ZA (1) ZA9610889B (sl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW527186B (en) * 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
JP3775780B2 (ja) * 1997-09-18 2006-05-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 薬剤の経口的バイオアベイラビリテイを向上させるための縮合イミダゾール誘導体
ID29268A (id) 1998-12-19 2001-08-16 Janssen Pharmaceutica Nv Senyawa spiro yang bersifat antihistamin
AU7788500A (en) * 1999-10-25 2001-05-08 Janssen Pharmaceutica N.V. Use of substance p antagonists for influencing the circadian timing system
PT1401838E (pt) 2001-06-12 2014-06-09 Janssen Pharmaceutica Nv Novos derivados de imidazole tetracíclicos substituidos, processos para a sua preparação, composições farmacêuticas que as compreendem e a sua utilização como um fármaco
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
DE60231351D1 (de) * 2001-11-23 2009-04-09 Janssen Pharmaceutica Nv Verwendung von Histaminrezeptorantagonisten für die Senkung des intrakranialen Druckes
JPWO2003050123A1 (ja) * 2001-12-10 2005-04-21 杏林製薬株式会社 タキキニン受容体拮抗剤としての縮合二環式ピリジン誘導体
US20050085510A1 (en) * 2002-01-16 2005-04-21 Telefonaktiebolaget Lm Ericsson (Publ) Prucalopride-n-oxide
AU2003201885B2 (en) * 2002-01-18 2007-08-30 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyrimidine derivatives
CN1310922C (zh) * 2002-03-26 2007-04-18 杏林制药株式会社 作为速激肽受体拮抗剂的稠合双环吡啶衍生物
JO2696B1 (en) 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
ES2310260T3 (es) * 2002-12-23 2009-01-01 Janssen Pharmaceutica Nv Derivados sustituidos de 4-(4-piperidin-4-il-piperazin-1-il)-azepan y su uso como antagonistas de la neuroquinina.
JO2676B1 (en) 2004-04-06 2012-06-17 جانسين فارماسوتيكا ان. في Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
ES2346147T3 (es) 2005-03-03 2010-10-11 Janssen Pharmaceutica Nv Derivados de oxa-diaza-espiro-(5.5)-undecanona sustituidos y su uso como antagonistas de las neuroquininas.
JP5078869B2 (ja) 2005-03-08 2012-11-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ニューロキニン(nk1)拮抗物質としてのジアザ−スピロ−[4.4]−ノナン誘導体
CA2700477A1 (en) * 2007-07-19 2009-01-22 Adelaide Research & Innovation Pty Ltd Method for reducing intracranial pressure
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2729147B1 (en) 2011-07-04 2017-09-06 IRBM - Science Park S.p.A. Nk-1 receptor antagonists for treating corneal neovascularisation
WO2019162519A1 (en) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
JPH089616B2 (ja) * 1990-10-10 1996-01-31 シェリング・コーポレーション 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
PT708776E (pt) * 1993-07-13 2001-06-29 Janssen Pharmaceutica Nv Imidazoazepinas anti-alergicas
TW397831B (en) 1994-07-15 2000-07-11 Meiji Seika Kaisha The anti-platelet-agglutination hexahydrogenated pyridine and its derivatives
NZ321575A (en) 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

Also Published As

Publication number Publication date
PT843679E (pt) 2002-04-29
CY2271B1 (en) 2003-07-04
AR051817A2 (es) 2007-02-14
HU229766B1 (hu) 2014-06-30
EP0843679A1 (en) 1998-05-27
IL124642A0 (en) 1998-12-06
ATE208392T1 (de) 2001-11-15
CA2238817A1 (en) 1997-07-10
HUP9903948A2 (hu) 2000-03-28
EP0843679B1 (en) 2001-11-07
EA001374B1 (ru) 2001-02-26
CA2238817C (en) 2006-10-17
HUP9903948A3 (hu) 2000-04-28
IL124642A (en) 2002-08-14
SK83098A3 (en) 1999-01-11
PL327136A1 (en) 1998-11-23
SK283540B6 (sk) 2003-09-11
DE69616802T2 (de) 2002-07-04
ZA9610889B (en) 1998-06-23
BR9612307A (pt) 1999-07-13
PL183767B1 (pl) 2002-07-31
NZ325845A (en) 1999-06-29
WO1997024356A1 (en) 1997-07-10
KR100485147B1 (ko) 2005-09-13
TW382017B (en) 2000-02-11
JP2000506503A (ja) 2000-05-30
NO982405L (no) 1998-08-19
NO982405D0 (no) 1998-05-27
EA199800603A1 (ru) 1998-12-24
IL124641A0 (en) 1998-12-06
NO310916B1 (no) 2001-09-17
AR005278A1 (es) 1999-04-28
IL124641A (en) 2001-11-25
CZ186598A3 (cs) 1998-11-11
CN1066733C (zh) 2001-06-06
HK1011206A1 (en) 1999-07-09
DK0843679T3 (da) 2002-02-25
CZ295861B6 (cs) 2005-11-16
TR199801210T2 (xx) 1999-10-21
KR19990076715A (ko) 1999-10-15
AU1308697A (en) 1997-07-28
JP4097043B2 (ja) 2008-06-04
US6251894B1 (en) 2001-06-26
DE69616802D1 (de) 2001-12-13
CN1206417A (zh) 1999-01-27
ES2167619T3 (es) 2002-05-16
MY117680A (en) 2004-07-31
AU716071B2 (en) 2000-02-17

Similar Documents

Publication Publication Date Title
CZ186498A3 (cs) 1-(1,2-Disubstituovaný piperidinyl)-4-substituované deriváty piperidinu
IL124641A0 (en) 1-(1,2-Disubstituted piperidinyl)-4- (fused imidazole)- piperidine derivatives
HRP960507B1 (en) 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives
PL342732A1 (en) 1-(heteroarylpropyl- or -prop-2-enyl)-4 benzylpiperidine as antagopnists nmda receptor
EG23791A (en) 1-(4-(1-4-Fluorophenyl-1H-indole-3-yl-1-butyl spiro (isobenzofuran 1-(3H), 4-Piperidine) hydrohalogenides
ZA96702B (en) 4-(1H-indol-1-yl)-1-piperidinyl derivatives.
ZA978792B (en) N-substituted azaheterocyclic compounds.
ID15912A (id) Turunan-turunan 1-(1,2-piperidinil yang didwisubstitusi)-4-(imidazol yang dilebur)-piperidin
GB2297749B (en) 1-[2-(substituted vinyl)]-3-4--dihydro-5h-2,3-benzodiazepine derivatives
IT1277329B1 (it) Procedimento per la metilazione del 2,2,6,6-tetrametil-4-piperidone (triacetonammina)
ZA9610894B (en) 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives.
ZA944720B (en) 2-[1-(1,3-thiazolin-2-yl) azetidin-3-yl] thio-carbapenem derivatives
SI0765311T1 (en) 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidines, tetrahydropyridines or piperazines
GB2297750B (en) 1-[2-(Substituted vinyl)]-5h-2,3-benzodiazepine derivatives
HU9204117D0 (en) Method for producing new 1,4-substituted piperidine derivatives