SI0711348T1 - Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca - Google Patents

Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca

Info

Publication number
SI0711348T1
SI0711348T1 SI9430443T SI9430443T SI0711348T1 SI 0711348 T1 SI0711348 T1 SI 0711348T1 SI 9430443 T SI9430443 T SI 9430443T SI 9430443 T SI9430443 T SI 9430443T SI 0711348 T1 SI0711348 T1 SI 0711348T1
Authority
SI
Slovenia
Prior art keywords
adca
pct
carboxyethylthio
propionyl
date
Prior art date
Application number
SI9430443T
Other languages
English (en)
Slovenian (sl)
Inventor
Roelof Ary Lans Bovenberg
Bertus Pieter Koekman
Andreas Hoekema
Der Laan Jan Metske Van
Jan Verweij
Vroom Erik De
Original Assignee
Dsm N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm N.V. filed Critical Dsm N.V.
Publication of SI0711348T1 publication Critical patent/SI0711348T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
SI9430443T 1993-07-30 1994-07-29 Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca SI0711348T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP93202260 1993-07-30
EP93203695 1993-12-24
PCT/EP1994/002544 WO1995004149A1 (en) 1993-07-30 1994-07-29 Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca
EP94926136A EP0711348B1 (de) 1993-07-30 1994-07-29 Prozess zur effizienten produktion von 7-adca via 3-(carboxyethylthio)propionyl-7-adca

Publications (1)

Publication Number Publication Date
SI0711348T1 true SI0711348T1 (en) 2003-08-31

Family

ID=26133941

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9430443T SI0711348T1 (en) 1993-07-30 1994-07-29 Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca

Country Status (17)

Country Link
US (1) US5795733A (de)
EP (1) EP0711348B1 (de)
JP (1) JP3574453B2 (de)
KR (1) KR100327881B1 (de)
CN (1) CN1087780C (de)
AT (1) ATE234926T1 (de)
BR (1) BR9407104A (de)
CA (1) CA2168004A1 (de)
CZ (1) CZ285622B6 (de)
DE (1) DE69432303D1 (de)
ES (1) ES2194873T3 (de)
HU (1) HU219265B (de)
PL (1) PL180565B1 (de)
PT (1) PT711348E (de)
SI (1) SI0711348T1 (de)
SK (1) SK282617B6 (de)
WO (1) WO1995004149A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
DK0828850T3 (da) * 1995-06-02 2002-05-21 Dsm Nv Fremgangsmåde til fremstilling af 7-ADCA via indvirkning af en expandase på pencillin G
EP0863989A2 (de) * 1995-11-27 1998-09-16 Gist-Brocades B.V. Verbessertes verfahren zur herstellung von halb-synthetischen cephalosporinen mittels einer auf penicilin g wirkenden expandaseaktivität
ZA983395B (en) 1997-04-22 1999-01-27 Gist Brocades Bv Process for the fermentative production of deacylated cephalosporins
ATE278032T1 (de) 1997-04-22 2004-10-15 Dsm Ip Assets Bv Verfahren zur fermentativen herstellung von deacylierten cephalosporinen
CN101353660A (zh) 1998-05-19 2009-01-28 Dsm公司 体内生产头孢菌素的改良
US6455603B1 (en) 1998-06-30 2002-09-24 Dow Global Technologies Inc. Polymer polyols and a process for the production thereof
AU3042600A (en) * 1998-12-22 2000-07-12 Dsm N.V. Improved (in vivo) production of cephalosporins
WO2007073947A2 (en) 2005-12-28 2007-07-05 Dsm Ip Assets B.V. Mutant type ii beta- lactam acylases
EP2123772A1 (de) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-Lactamantibiotikum produzierende Stämme
WO2010015625A1 (en) * 2008-08-05 2010-02-11 Dsm Ip Assets B.V. Adipoyl-7-adca producing strains
WO2010015627A2 (en) 2008-08-05 2010-02-11 Dsm Ip Assets B.V. Adipoyl-7-adca producing strains
EP2414530A1 (de) 2009-04-03 2012-02-08 DSM Sinochem Pharmaceuticals Netherlands B.V. Fermentationsverfahren
WO2011161004A1 (en) 2010-06-22 2011-12-29 Dsm Ip Assets B.V. Air bubble fermentation process
WO2012032040A1 (en) * 2010-09-07 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
WO2012117038A1 (en) 2011-03-03 2012-09-07 Dsm Sinochem Pharmaceuticals Netherlands B.V. Degradation of penicillin compounds
CN104093831A (zh) 2012-01-31 2014-10-08 中化帝斯曼制药有限公司荷兰公司 半合成抗生素生产中的类MbtH蛋白
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
US5082772A (en) * 1988-10-24 1992-01-21 Eli Lilly And Company Process for preparing deacetylcephalosporin c
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정

Also Published As

Publication number Publication date
JP3574453B2 (ja) 2004-10-06
KR960704048A (ko) 1996-08-31
BR9407104A (pt) 1996-08-27
PL180565B1 (pl) 2001-02-28
SK9896A3 (en) 1996-09-04
EP0711348B1 (de) 2003-03-19
CA2168004A1 (en) 1995-02-09
WO1995004149A1 (en) 1995-02-09
DE69432303D1 (de) 2003-04-24
EP0711348A1 (de) 1996-05-15
PL312747A1 (en) 1996-05-13
CN1087780C (zh) 2002-07-17
ATE234926T1 (de) 2003-04-15
HUT75367A (en) 1997-05-28
KR100327881B1 (ko) 2002-07-02
ES2194873T3 (es) 2003-12-01
CZ15796A3 (en) 1996-07-17
CZ285622B6 (cs) 1999-10-13
SK282617B6 (sk) 2002-10-08
HU219265B (en) 2001-03-28
US5795733A (en) 1998-08-18
HU9600195D0 (en) 1996-03-28
JPH09503908A (ja) 1997-04-22
CN1128545A (zh) 1996-08-07
PT711348E (pt) 2003-08-29

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