SI0617019T1 - Process for the preparation of 3R,5S-(+)-sodium-erythro-(E)-7-4-(4-fluorophenyl)--2,6-diisopropyl-5-methoxymethyl-pyrid-3-yl-3,5-dihydroxy-hept-6-enoate - Google Patents
Process for the preparation of 3R,5S-(+)-sodium-erythro-(E)-7-4-(4-fluorophenyl)--2,6-diisopropyl-5-methoxymethyl-pyrid-3-yl-3,5-dihydroxy-hept-6-enoateInfo
- Publication number
- SI0617019T1 SI0617019T1 SI9430308T SI9430308T SI0617019T1 SI 0617019 T1 SI0617019 T1 SI 0617019T1 SI 9430308 T SI9430308 T SI 9430308T SI 9430308 T SI9430308 T SI 9430308T SI 0617019 T1 SI0617019 T1 SI 0617019T1
- Authority
- SI
- Slovenia
- Prior art keywords
- enoate
- hept
- fluorophenyl
- diisopropyl
- dihydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4309553A DE4309553A1 (de) | 1993-03-24 | 1993-03-24 | Verfahren zur Herstellung von 3R,5S-(+)-Natrium-erythro-(E)-7-(4-(4-flurophenyl)-2,6-diisopropyl-5-methoxymethyl-pyrid-3-yl)-3,5-dihydroxy-hept-6-enoat |
EP94103776A EP0617019B1 (de) | 1993-03-24 | 1994-03-11 | Verfahren zur Herstellung von 3R,5S-(+)-Natrium-erythro-(E)-7-[4-(4-fluorphenyl)--2,6-diisopropyl-5-methoxymethyl-pyrid-3-yl]-3,5-dihydroxy-hept-6-enoat |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0617019T1 true SI0617019T1 (en) | 2000-08-31 |
Family
ID=6483717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9430308T SI0617019T1 (en) | 1993-03-24 | 1994-03-11 | Process for the preparation of 3R,5S-(+)-sodium-erythro-(E)-7-4-(4-fluorophenyl)--2,6-diisopropyl-5-methoxymethyl-pyrid-3-yl-3,5-dihydroxy-hept-6-enoate |
Country Status (10)
Country | Link |
---|---|
US (1) | US5502199A (xx) |
EP (1) | EP0617019B1 (xx) |
JP (1) | JPH06321900A (xx) |
AT (1) | ATE193530T1 (xx) |
DE (2) | DE4309553A1 (xx) |
DK (1) | DK0617019T3 (xx) |
ES (1) | ES2148252T3 (xx) |
GR (1) | GR3034185T3 (xx) |
PT (1) | PT617019E (xx) |
SI (1) | SI0617019T1 (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19714343A1 (de) | 1997-04-08 | 1998-10-15 | Bayer Ag | Chromatographische Enantiomerentrennung von Lactonen |
GT199800127A (es) * | 1997-08-29 | 2000-02-01 | Combinaciones terapeuticas. | |
US20080275104A1 (en) * | 1997-11-25 | 2008-11-06 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
US6291574B1 (en) | 1999-08-27 | 2001-09-18 | General Electric Company | Polyester molded articles |
SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
DE60022525T2 (de) * | 1999-08-30 | 2006-06-14 | Sanofi Aventis Deutschland | Ramipril zur vorbeugung von kardiovaskulären vorfällen |
AU2002219175A1 (en) * | 2000-12-21 | 2002-07-01 | Ciba Speciality Chemicals Holding Inc. | Crystalline forms of cerivastatin sodium |
DE10135013A1 (de) * | 2001-07-18 | 2003-01-30 | Bayer Ag | Herstellung von Pyridylverbindungen |
DE10216967A1 (de) * | 2002-04-16 | 2003-11-13 | Bayer Ag | Verfahren zur Herstellung spezieller aromatischer Aldehyde |
WO2005007110A2 (en) * | 2003-07-11 | 2005-01-27 | Pro-Pharmaceuticals, Inc. | Compositions and methods for hydrophobic drug delivery |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
US20050053664A1 (en) * | 2003-09-08 | 2005-03-10 | Eliezer Zomer | Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer |
WO2005079314A2 (en) * | 2004-02-13 | 2005-09-01 | Pro-Pharmaceuticals, Inc. | Compositions and methods used to treat acne and candida |
US20060211752A1 (en) | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
US20110217412A1 (en) * | 2004-07-30 | 2011-09-08 | Jinis Biopharmaceuticals Co. | Cholesterol lowering supplement and low cholesterol egg produced by using the same |
KR100637762B1 (ko) * | 2004-07-30 | 2006-10-23 | 주식회사 지니스 | 저콜레스테롤 란을 생산하기 위한 가금류용 사료첨가제 및 이를 이용한 저콜레스테롤 란의 생산방법 |
US20080286251A1 (en) * | 2004-08-02 | 2008-11-20 | Propharmaceuticals, Inc. | Compositions and Methods for the Enhancement of Chemotherapy with Microbial Cytotoxins |
WO2008112887A1 (en) * | 2007-03-13 | 2008-09-18 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
EP2161024A1 (de) | 2008-09-05 | 2010-03-10 | Universitätsklinikum Hamburg-Eppendorf | Kombinationspräparat zur Behandlung von Krebs |
JP6224624B2 (ja) | 2012-02-02 | 2017-11-01 | ザ・ユニバーシティ・オブ・シドニー | 涙膜安定性における改善 |
KR101363119B1 (ko) | 2012-05-08 | 2014-02-13 | 한남대학교 산학협력단 | 활성화 비닐 에스테르를 이용한 비닐 단량체의 합성방법 |
EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
CN104031034B (zh) * | 2014-07-01 | 2017-01-04 | 上海信谊百路达药业有限公司 | 一种匹伐他汀钙原料药中间体的制备方法 |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
CN105622531A (zh) * | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
CA3125765A1 (en) | 2019-01-18 | 2020-07-23 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
WO2020243134A1 (en) | 2019-05-27 | 2020-12-03 | Immatics US, Inc. | Viral vectors and their use in adoptive cellular therapy |
DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
TW202227616A (zh) | 2020-08-21 | 2022-07-16 | 美商英麥提克斯股份有限公司 | 分離cd8+選擇t細胞的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
US4906624A (en) * | 1987-09-08 | 1990-03-06 | Warner-Lambert Company | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
DE3905518A1 (de) * | 1989-02-23 | 1990-10-11 | Bayer Ag | Substituierte phenoxyphenylpropionsaeure-derivate |
US5177080A (en) * | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
-
1993
- 1993-03-24 DE DE4309553A patent/DE4309553A1/de not_active Withdrawn
-
1994
- 1994-03-11 AT AT94103776T patent/ATE193530T1/de not_active IP Right Cessation
- 1994-03-11 SI SI9430308T patent/SI0617019T1/xx unknown
- 1994-03-11 EP EP94103776A patent/EP0617019B1/de not_active Expired - Lifetime
- 1994-03-11 DK DK94103776T patent/DK0617019T3/da active
- 1994-03-11 PT PT94103776T patent/PT617019E/pt unknown
- 1994-03-11 ES ES94103776T patent/ES2148252T3/es not_active Expired - Lifetime
- 1994-03-11 DE DE59409378T patent/DE59409378D1/de not_active Expired - Fee Related
- 1994-03-17 US US08/214,894 patent/US5502199A/en not_active Expired - Fee Related
- 1994-03-18 JP JP6072787A patent/JPH06321900A/ja active Pending
-
2000
- 2000-08-14 GR GR20000401879T patent/GR3034185T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2148252T3 (es) | 2000-10-16 |
DE4309553A1 (de) | 1994-09-29 |
ATE193530T1 (de) | 2000-06-15 |
DK0617019T3 (da) | 2000-10-23 |
EP0617019A1 (de) | 1994-09-28 |
US5502199A (en) | 1996-03-26 |
JPH06321900A (ja) | 1994-11-22 |
DE59409378D1 (de) | 2000-07-06 |
GR3034185T3 (en) | 2000-11-30 |
EP0617019B1 (de) | 2000-05-31 |
PT617019E (pt) | 2000-11-30 |
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