SG85670A1 - Water-soluble pharmaceutical composition in an ionic complex and the use thereof - Google Patents

Water-soluble pharmaceutical composition in an ionic complex and the use thereof

Info

Publication number
SG85670A1
SG85670A1 SG9904209A SG1999004209A SG85670A1 SG 85670 A1 SG85670 A1 SG 85670A1 SG 9904209 A SG9904209 A SG 9904209A SG 1999004209 A SG1999004209 A SG 1999004209A SG 85670 A1 SG85670 A1 SG 85670A1
Authority
SG
Singapore
Prior art keywords
water
pharmaceutical composition
ionic complex
soluble pharmaceutical
soluble
Prior art date
Application number
SG9904209A
Other languages
English (en)
Inventor
Apollon Papadimitriou
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG85670A1 publication Critical patent/SG85670A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Botany (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG9904209A 1998-09-01 1999-08-27 Water-soluble pharmaceutical composition in an ionic complex and the use thereof SG85670A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98116494 1998-09-01

Publications (1)

Publication Number Publication Date
SG85670A1 true SG85670A1 (en) 2002-01-15

Family

ID=8232558

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9904209A SG85670A1 (en) 1998-09-01 1999-08-27 Water-soluble pharmaceutical composition in an ionic complex and the use thereof

Country Status (30)

Country Link
US (3) US6867182B2 (xx)
EP (1) EP1002547B1 (xx)
JP (1) JP3664373B2 (xx)
KR (1) KR100403075B1 (xx)
CN (1) CN1325118C (xx)
AR (1) AR023044A1 (xx)
AT (1) ATE318616T1 (xx)
AU (1) AU755930B2 (xx)
BR (1) BR9903984B1 (xx)
CA (1) CA2281049C (xx)
CO (1) CO5271726A1 (xx)
DE (1) DE69930033T2 (xx)
ES (1) ES2258830T3 (xx)
GC (1) GC0000107A (xx)
HR (1) HRP990272B1 (xx)
HU (1) HUP9902952A1 (xx)
ID (1) ID22964A (xx)
IL (1) IL131626A0 (xx)
MA (1) MA26682A1 (xx)
MY (1) MY127935A (xx)
NO (1) NO994214L (xx)
NZ (1) NZ337527A (xx)
PE (1) PE20001027A1 (xx)
PL (1) PL194218B1 (xx)
RU (1) RU2180855C2 (xx)
SG (1) SG85670A1 (xx)
TR (1) TR199902103A2 (xx)
TW (1) TW570805B (xx)
YU (1) YU42399A (xx)
ZA (1) ZA995601B (xx)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
MXPA05013398A (es) * 2003-06-10 2006-03-09 Lg Life Sciences Ltd Solucion estable acuosa de eritropoyetina de origen humano, que no contiene albumina de suero.
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
EP2422789B1 (en) * 2004-05-19 2017-11-22 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Injectable coposition comprising sodium deoxycholate
JPWO2007010900A1 (ja) * 2005-07-15 2009-01-29 Ｔｔｉ・エルビュー株式会社 貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置
JP2007037868A (ja) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc 経皮投与装置及びその制御方法
US20070042041A1 (en) * 2005-08-17 2007-02-22 Board Of Trustees Of The University Of Arkansas Drug-surfactant complexes for sustained release
US20090216177A1 (en) * 2005-09-16 2009-08-27 Tti Ellebeau,Inc Catheter-type iontophoresis device
CN101277737A (zh) * 2005-09-30 2008-10-01 Tti优而美株式会社 将多种活性剂输送至生物界面的离子电渗装置
US20080033338A1 (en) * 2005-12-28 2008-02-07 Smith Gregory A Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
US7848801B2 (en) * 2005-12-30 2010-12-07 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
CN101495105A (zh) * 2006-07-05 2009-07-29 Tti优而美株式会社 具有自组装树枝状聚合物的输送装置及其使用方法
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
US20080193514A1 (en) * 2006-11-02 2008-08-14 Transcu Ltd. Compostions and methods for iontophoresis delivery of active ingredients through hair follicles
FR2908414B1 (fr) * 2006-11-13 2012-01-20 Centre Nat Rech Scient Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile
WO2008087803A1 (ja) * 2007-01-16 2008-07-24 Hokkaido University 抗酸化成分を封入したイオントフォレーシス用リポソーム製剤
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
CN101677944A (zh) * 2007-06-01 2010-03-24 诺沃-诺迪斯克有限公司 稳定的非含水药物组合物
JP2010187707A (ja) * 2007-06-12 2010-09-02 Hokkaido Univ インスリンを封入したイオントフォレーシス用リポソーム製剤
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
EP2910571B1 (en) 2008-03-18 2016-10-05 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
WO2010030738A2 (en) * 2008-09-10 2010-03-18 Transcu Ltd. Apparatus and method to dispense hpc-based viscous liquids into porous substrates, e.g., continuous web-based process
WO2012134540A2 (en) * 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
CN107412754A (zh) * 2009-12-22 2017-12-01 塞尔德克斯医疗公司 疫苗组合物
MX363465B (es) 2011-02-18 2019-03-25 Kythera Biopharmaceuticals Inc Tratamiento de la grasa submental.
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
RU2680959C2 (ru) 2012-03-23 2019-03-01 Амикроб, Инк. Композиции и применение противомикробных материалов со свойствами биологической совместимости
CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂
ES2676065T3 (es) 2013-10-07 2018-07-16 Novo Nordisk A/S Nuevo derivado de un análogo de la insulina
EP3372247B1 (en) * 2015-11-04 2022-01-05 Postech Academy-Industry Foundation Composition for skin permeation comprising cationic molecular transporter and protein
MA49116A (fr) 2016-12-16 2020-03-25 Novo Nordisk As Compositions pharmaceutiques contenant de l'insuline
KR20200018400A (ko) 2017-04-06 2020-02-19 아미크로베, 인코포레이티드. 개선된 성능 및 안전성을 가진 국소적으로 적용된 항균제의 조성물 및 용도
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device
CA3133652A1 (en) * 2019-04-01 2020-10-08 Genentech, Inc. Compositions and methods for stabilizing protein-containing formulations

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004328A1 (en) * 1984-03-28 1985-10-10 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
WO1995018856A1 (en) * 1993-12-30 1995-07-13 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing hedgehog-like proteins
WO1996036352A1 (en) * 1995-05-16 1996-11-21 Pankaj Modi Liquid formulations for proteinic pharmaceuticals comprising at least 2 absorption enhancers
WO1998020298A1 (en) * 1996-11-08 1998-05-14 Northern Magnetics, Inc. Sensing and controlling the location of elements of a linear motor
WO1998021227A1 (en) * 1996-11-13 1998-05-22 The Regents Of The University Of California Mutant human hedgehog gene
WO1998030234A1 (en) * 1997-01-14 1998-07-16 Masahiro Iwamoto Compositions for osteogenesis and chondrogenesis
WO1998030576A1 (en) * 1996-10-07 1998-07-16 The Johns Hopkins University School Of Medicine Novel hedgehog-derived polypeptides
EP0874048A2 (en) * 1997-04-25 1998-10-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Human hedgehog protein
EP0947201A1 (en) * 1998-02-04 1999-10-06 Roche Diagnostics GmbH (HRB 3962 - vormals Boehringer Mannheim GmbH) Pharmaceutical composition of hedgehog proteins and use thereof
EP0953576A1 (en) * 1998-04-30 1999-11-03 Boehringer Mannheim Gmbh Active hedgehog protein conjugate, process for its production and use

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604377A (en) * 1984-03-28 1986-08-05 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
LU85971A1 (fr) * 1985-06-25 1987-01-13 Oreal Nouveaux composes lipidiques amphiphiles, leur procede de preparation et leurs applications,notamnent en cosmetique et en dermopharmacie
JPS62207226A (ja) 1986-03-07 1987-09-11 Sumitomo Pharmaceut Co Ltd 経鼻投与用製剤
FR2615194B1 (fr) * 1987-05-11 1991-06-14 Rhone Poulenc Chimie Particules de polymere comportant, implantees a leur surface des molecules amphiphiles portant des groupes ionogenes ou reactifs, leur procede de preparation et leur application en biologie
AU641361B2 (en) * 1988-05-02 1993-09-23 Zynaxis Technologies, Incorporated Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
FR2694559B1 (fr) * 1992-08-06 1994-10-28 Atta Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.
WO1994008599A1 (en) * 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
JP3290745B2 (ja) 1993-03-31 2002-06-10 藤平 正道 単分子膜のパターン形成方法
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
US20030186357A1 (en) * 1993-12-30 2003-10-02 Philip W. Ingham Vertebrate embryonic pattern-inducing proteins, and uses related thereto
FR2714621B1 (fr) 1994-01-06 1996-02-23 Centre Nat Rech Scient Procédé de préparation de liposomes sans utilisation de solvant organique.
GB9417524D0 (en) 1994-08-31 1994-10-19 Cortecs Ltd Pharmaceutical compositions
US5853741A (en) * 1996-06-28 1998-12-29 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Vitamin C delivery system
US6329498B1 (en) 1996-10-15 2001-12-11 Seikagaku Corporation Polypeptide transition metal salts and method of enhancing anti-HIV activity of polypeptide
US6639051B2 (en) * 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
ES2179414T3 (es) 1997-11-22 2003-01-16 Roche Diagnostics Gmbh Procedimiento mejorado de estabilizacion de proteinas.
EP0919618A1 (de) 1997-11-28 1999-06-02 Boehringer Mannheim Gmbh Aktive Hedgehog-Protein-Mutante, Verfahren zur Herstellung und Verwendung
JP4289788B2 (ja) 1997-12-03 2009-07-01 バイオジェン・アイデック・エムエイ・インコーポレイテッド 疎水性修飾されたタンパク質組成物および産生方法
JP3648051B2 (ja) * 1998-02-02 2005-05-18 富士通株式会社 関連情報検索装置及びプログラム記録媒体
CA2260423C (en) 1998-02-04 2006-06-20 Kurt Lang Pharmaceutical composition of hedgehog proteins and use thereof
US20050021440A1 (en) * 2003-04-04 2005-01-27 Scott Dresden Integrated dynamic pricing and procurement support for e-commerce advertising channels
US20070203906A1 (en) * 2003-09-22 2007-08-30 Cone Julian M Enhanced Search Engine
US20050114319A1 (en) * 2003-11-21 2005-05-26 Microsoft Corporation System and method for checking a content site for efficacy
US10515374B2 (en) * 2005-03-10 2019-12-24 Adobe Inc. Keyword generation method and apparatus

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004328A1 (en) * 1984-03-28 1985-10-10 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
WO1995018856A1 (en) * 1993-12-30 1995-07-13 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing hedgehog-like proteins
WO1996036352A1 (en) * 1995-05-16 1996-11-21 Pankaj Modi Liquid formulations for proteinic pharmaceuticals comprising at least 2 absorption enhancers
WO1998030576A1 (en) * 1996-10-07 1998-07-16 The Johns Hopkins University School Of Medicine Novel hedgehog-derived polypeptides
WO1998020298A1 (en) * 1996-11-08 1998-05-14 Northern Magnetics, Inc. Sensing and controlling the location of elements of a linear motor
WO1998021227A1 (en) * 1996-11-13 1998-05-22 The Regents Of The University Of California Mutant human hedgehog gene
WO1998030234A1 (en) * 1997-01-14 1998-07-16 Masahiro Iwamoto Compositions for osteogenesis and chondrogenesis
EP0874048A2 (en) * 1997-04-25 1998-10-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Human hedgehog protein
EP0947201A1 (en) * 1998-02-04 1999-10-06 Roche Diagnostics GmbH (HRB 3962 - vormals Boehringer Mannheim GmbH) Pharmaceutical composition of hedgehog proteins and use thereof
EP0953576A1 (en) * 1998-04-30 1999-11-03 Boehringer Mannheim Gmbh Active hedgehog protein conjugate, process for its production and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
xp002094956 *

Also Published As

Publication number Publication date
KR100403075B1 (ko) 2003-10-30
US6867182B2 (en) 2005-03-15
EP1002547A1 (en) 2000-05-24
ES2258830T3 (es) 2006-09-01
DE69930033T2 (de) 2006-10-12
US20020028766A1 (en) 2002-03-07
KR20000022777A (ko) 2000-04-25
NZ337527A (en) 2000-12-22
HUP9902952A1 (hu) 2000-06-28
NO994214L (no) 2000-03-02
CN1250669A (zh) 2000-04-19
CA2281049A1 (en) 2000-03-01
PL194218B1 (pl) 2007-05-31
US20050123610A1 (en) 2005-06-09
TW570805B (en) 2004-01-11
MY127935A (en) 2007-01-31
AR023044A1 (es) 2002-09-04
PE20001027A1 (es) 2000-10-13
HRP990272A2 (en) 2000-06-30
HRP990272B1 (en) 2006-11-30
BR9903984A (pt) 2001-03-13
CO5271726A1 (es) 2003-04-30
US20080064854A1 (en) 2008-03-13
PL335203A1 (en) 2000-03-13
CA2281049C (en) 2010-11-02
AU755930B2 (en) 2003-01-02
EP1002547B1 (en) 2006-03-01
JP3664373B2 (ja) 2005-06-22
JP2000086532A (ja) 2000-03-28
ZA995601B (en) 2000-09-27
MA26682A1 (fr) 2004-12-20
AU4486699A (en) 2000-03-16
ATE318616T1 (de) 2006-03-15
NO994214D0 (no) 1999-08-31
IL131626A0 (en) 2001-01-28
RU2180855C2 (ru) 2002-03-27
ID22964A (id) 1999-12-23
DE69930033D1 (de) 2006-04-27
HU9902952D0 (en) 1999-10-28
TR199902103A2 (xx) 2000-04-21
US8519098B2 (en) 2013-08-27
BR9903984B1 (pt) 2011-04-19
CN1325118C (zh) 2007-07-11
GC0000107A (en) 2005-06-29
YU42399A (sh) 2001-05-28

Similar Documents

Publication Publication Date Title
SG85670A1 (en) Water-soluble pharmaceutical composition in an ionic complex and the use thereof
HUP0103267A2 (hu) Glifozát-tartalmú készítmények és alkalmazásuk
HK1112180A1 (en) Pharmaceutical use and compositions involving isoflavones
HU0500549D0 (en) Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
HUP9901929A3 (en) New oligomer-organosilane-polisulphanates and their uses in caoutchouc-compounds and for making form bodies
HUP0103884A3 (en) Arylsulfonanilide urea-derivatives, pharmaceutical compositions containing them and their use
IL142634A0 (en) Modified exosomes and uses
IL133097A0 (en) Aroyl-piperazine derivatives pharmaceutical compositions containing the same and the use thereof
HUP0103636A3 (en) 2-methyl-thieno-benzodiazepine formulation and its use
CY2291B1 (en) 1H-pyridoa3,4-buindole-4-carboxamide derivatives preparation and application thereof in therapeutics
ZA955781B (en) New chemical compound the preparation thereof and its use in pharmaceutical compositions
AU4900797A (en) Conformationally restricted polyamines and their use as antineoplastic agents
HUP0104852A3 (en) Oktahydro-pyrido-pyrazine derivatives and pharmaceutical compositions containing the same and their use
GB9811168D0 (en) Direct hair-colouring compositions and the use thereof
IL147645A0 (en) Rest-breaking composition and use thereof
IL139874A0 (en) Coating agent and the use thereof
IL130752A0 (en) Polymer composition its preparation and use thereof
IT1291823B1 (it) Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche
ZA9711047B (en) Formulation and use.
IL133536A0 (en) 6-pyrrolidin-2-ylpyridine derivatives, their preparation and application in therapy
AU7681498A (en) Pharmaceutical composition and use thereof
AU3283299A (en) Probiotic composition and the use thereof
IL129546A0 (en) N-(imidazolylbutyl)benzenesulphonamide derivatives their preparation and their application in therapeutics
ZA982358B (en) Benzenesulphonamide derivatives their preparation and their application in therapeutics
ZA9811105B (en) Cosmetic and pharmaceutical composition