ES2179414T3 - Procedimiento mejorado de estabilizacion de proteinas. - Google Patents

Procedimiento mejorado de estabilizacion de proteinas.

Info

Publication number
ES2179414T3
ES2179414T3 ES98121684T ES98121684T ES2179414T3 ES 2179414 T3 ES2179414 T3 ES 2179414T3 ES 98121684 T ES98121684 T ES 98121684T ES 98121684 T ES98121684 T ES 98121684T ES 2179414 T3 ES2179414 T3 ES 2179414T3
Authority
ES
Spain
Prior art keywords
protein
compartmenting
waterproofed
protein stabilization
improved protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98121684T
Other languages
English (en)
Inventor
Klaus Hellerbrand
Apollon Papadimitriou
Gerhard Winter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26145913&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2179414(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Application granted granted Critical
Publication of ES2179414T3 publication Critical patent/ES2179414T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

UN PROCEDIMIENTO MEJORADO PARA EVITAR LA FORMACION DE AGREGADOS DE PROTEINAS EN UN LIOFILIZADO RECONSTITUIDO DE UNA COMPOSICION FARMACEUTICA DE UNA PROTEINA, HELANDO UNA SOLUCION ACUOSA AMORTIGUADA DE LA PROTEINA, DESCONGELANDOLA, DISTRIBUYENDOLA EN COMPARTIMENTOS DE CANTIDADES INYECTABLES, Y LIOFILIZANDO ESTOS COMPARTIMENTOS, CARACTERIZADO PORQUE LA SOLUCION ACUOSA AMORTIGUADA DE LA PROTEINA CONTIENE FOSFATO DE POTASIO COMO SUSTANCIA AMORTIGUADORA, Y LA RELACION IONES DE POTASIO CON RESPECTO A IONES DE SODIO EN LA SOLUCION ES DE AL MENOS 10 : 1; SE PUEDE UTILIZAR DE MANERA VENTAJOSA PARA LA PREPARACION DE LIOFILIZADOS ESTABLES DE COMPOSICIONES FARMACEUTICAS.
ES98121684T 1997-11-22 1998-11-13 Procedimiento mejorado de estabilizacion de proteinas. Expired - Lifetime ES2179414T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97120528 1997-11-22
EP98102846 1998-02-19

Publications (1)

Publication Number Publication Date
ES2179414T3 true ES2179414T3 (es) 2003-01-16

Family

ID=26145913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98121684T Expired - Lifetime ES2179414T3 (es) 1997-11-22 1998-11-13 Procedimiento mejorado de estabilizacion de proteinas.

Country Status (16)

Country Link
US (1) US6238664B1 (es)
EP (1) EP0917879B1 (es)
JP (1) JP3105494B2 (es)
KR (1) KR100315908B1 (es)
CN (1) CN1220270A (es)
AR (2) AR018020A1 (es)
AT (1) ATE220558T1 (es)
AU (1) AU714264B2 (es)
BR (1) BRPI9805021B8 (es)
CA (1) CA2254145C (es)
DE (1) DE59804785D1 (es)
DK (1) DK0917879T3 (es)
ES (1) ES2179414T3 (es)
PT (1) PT917879E (es)
TR (1) TR199802394A2 (es)
ZA (1) ZA9810650B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
CN1258379C (zh) * 2000-02-08 2006-06-07 阿勒根公司 肉毒杆菌毒素药物组合物
US7780967B2 (en) * 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
DE10149030A1 (de) * 2001-10-05 2003-04-10 Viscum Ag Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin
US20040185040A1 (en) * 2001-11-21 2004-09-23 Celltech R & D Limited Modulating immune responses
US20030175827A1 (en) * 2002-03-14 2003-09-18 Stillman Brett A. Stable thin film dried protein composition or device and related methods
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
JP4607010B2 (ja) 2003-02-28 2011-01-05 中外製薬株式会社 タンパク質含有安定化製剤
EP1909838A2 (en) * 2005-07-29 2008-04-16 Amgen Inc. Formulations that inhibit protein aggregation
AU2007308145A1 (en) * 2006-10-12 2008-04-17 Wyeth Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates
AU2010263058A1 (en) * 2009-06-18 2012-01-12 Wyeth Llc Lyophilized formulations for small modular immunopharmaceuticals
HUE049282T2 (hu) 2012-09-07 2020-09-28 Coherus Biosciences Inc Adalimumab stabil vizes formulációi
WO2016069173A2 (en) * 2014-09-29 2016-05-06 Cook General Biotechnology Llc Uses of trehalose in cell suspensions
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
US11071782B2 (en) 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
CN111781345A (zh) * 2020-06-30 2020-10-16 上海透景生命科技股份有限公司 化学发光标记物标记抗原稳定剂及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3064888D1 (en) 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
US4783441A (en) 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
US4362661A (en) 1979-08-09 1982-12-07 Teijin Limited Immunoglobulin composition having a high monomer content, and process for production thereof
CA1329760C (en) 1987-10-29 1994-05-24 Ted C. K. Lee Plasma and recombinant protein formulations in high ionic strength media
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
US4877608A (en) 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
EP0318081B1 (en) 1987-11-27 1991-07-24 Akzo N.V. Stabilization of antibodies
GB8920534D0 (en) * 1989-09-11 1989-10-25 Wellcome Found Antiviral compounds
US5164296A (en) * 1990-08-31 1992-11-17 University Of Maryland At Baltimore Assay methods involving ouabain
DE4126983A1 (de) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
RU2109290C1 (ru) * 1996-04-09 1998-04-20 Государственный научный центр вирусологии и биотехнологии "Вектор" Стабилизирующий состав для получения лиофилизированных препаратов на основе конъюгата антииммуноглобулина g и пероксидазы хрена
EP0852951A1 (de) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern

Also Published As

Publication number Publication date
BRPI9805021A (pt) 2000-03-21
CA2254145A1 (en) 1999-05-22
KR19990045460A (ko) 1999-06-25
CN1220270A (zh) 1999-06-23
AR018020A1 (es) 2001-10-31
BRPI9805021B8 (pt) 2021-07-06
AU714264B2 (en) 1999-12-23
DE59804785D1 (de) 2002-08-22
PT917879E (pt) 2002-12-31
EP0917879B1 (de) 2002-07-17
EP0917879A3 (de) 1999-06-09
EP0917879A2 (de) 1999-05-26
KR100315908B1 (ko) 2002-04-24
TR199802394A3 (tr) 1999-06-21
DK0917879T3 (da) 2002-11-04
ZA9810650B (en) 1999-05-24
AU9406098A (en) 1999-06-10
US6238664B1 (en) 2001-05-29
CA2254145C (en) 2002-10-08
BRPI9805021B1 (pt) 2011-05-31
AR034226A2 (es) 2004-02-04
TR199802394A2 (xx) 1999-06-21
JP3105494B2 (ja) 2000-10-30
ATE220558T1 (de) 2002-08-15
JPH11240895A (ja) 1999-09-07

Similar Documents

Publication Publication Date Title
ES2179414T3 (es) Procedimiento mejorado de estabilizacion de proteinas.
MX9703609A (es) Uso de fragmentos de angiotensina ii y analogos de la misma para la preparacion de composiciones en la preparacion de tejido.
UY27320A1 (es) Nuevas composiciones farmacéuticas
EA200100184A1 (ru) Новые гидратные формы алендроната натрия, способы их получения и фармацевтические композиции
MX9702146A (es) Preparaciones de enzimas estabilizadas con sal.
ZA947338B (en) Use of angiotensin II and analogs thereof in tissue repair
UA37191C2 (uk) Водна структурована композиція поверхнево-активної речовини
EA199900194A1 (ru) Реминерализующая композиция
BR9906903A (pt) Composição com liberação sustentada, processos para produzir a mesma, para suprimir a brusca liberação inicial da susbtância bioativa de uma composição com liberação sustentada e para aumentar a eficiência da inclusão da substância bioativa em uma composição com liberação sustentada, produto farmacêutico, agente para prevenir ou tratar câncer prostático, hipertrofia prostática, endometriose, histeromioma, metrofibroma, puberdade precoce, dismenorréia, ou câncer do seio, ou um contraceptivo, e, composto
JPS5326806A (en) Low irritating detergent composition
MA24137A1 (fr) Fabrication d'agents de surface ramifies .
ES2186792T3 (es) Metodos de fabricar liposomas que contienen fotosensibilizantes hidro-monobenzoporfirinicos.
EA200300508A1 (ru) Противовоспалительные агенты
PT80303B (pt) Processo para a preparacao de composicoes para a higiene bucal
BR9913433A (pt) Sistema desinfetante estabilizado composto de duas partes e composições e métodos a ele relacionado
PT877602E (pt) Processo para o fabrico de composicoes de surfactantes pulmonares em po
BR9713612A (pt) Composição bastão antitranspirante ou desodorante substancialmente anidra, e, processo para fabricação de um bastão antitranspirante substanciamente anidro
AR018357A1 (es) Acido petroselinico en una composicion y en un metodo para reducir o eliminar la irritacion o la picazon de la piel inducida por los alfa-hidroxiacidos
ATE233484T1 (de) Desinfizierende zusammensetzung
ATE297402T1 (de) Phospholipide mit ungesattigten alkyl- und acylketten
ES2101334T3 (es) Utilizacion terapeutica de la fosforil-l-serina-n-acil-esfingosina.
PA8486601A1 (es) Formulaciones antiparasitos
EA199900710A1 (ru) Кристаллическая гидратированная натриевая соль (е)-4,6-дихлор-3-(2-оксо-1-фенилпирролидин-3-илиденметил)-1н-индол-2-карбоновой кислоты
AR008764A1 (es) Sales hidratadas de n,n'-diacetilcistina, proceso para su preparacion, y composiciones terapeuticas que comprenden a dichas sales como ingredienteactivo.
EA200001106A1 (ru) Композиция для повышения фертильности и ее применение