SG69977A1 - Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof - Google Patents
Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereofInfo
- Publication number
- SG69977A1 SG69977A1 SG1996007579A SG1996007579A SG69977A1 SG 69977 A1 SG69977 A1 SG 69977A1 SG 1996007579 A SG1996007579 A SG 1996007579A SG 1996007579 A SG1996007579 A SG 1996007579A SG 69977 A1 SG69977 A1 SG 69977A1
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- novel
- proteolytic enzyme
- enzyme inhibitors
- aryl carboxylates
- Prior art date
Links
- -1 2-saccharinylmethyl aryl carboxylates Chemical class 0.000 title 1
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000002532 enzyme inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60806890A | 1990-11-01 | 1990-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG69977A1 true SG69977A1 (en) | 2000-01-25 |
Family
ID=24434891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996007579A SG69977A1 (en) | 1990-11-01 | 1991-10-30 | Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0483928A1 (fi) |
| JP (1) | JPH04273866A (fi) |
| KR (1) | KR920009807A (fi) |
| AU (1) | AU642537B2 (fi) |
| CA (1) | CA2054653A1 (fi) |
| FI (1) | FI103112B1 (fi) |
| HU (2) | HUT63399A (fi) |
| IE (1) | IE913827A1 (fi) |
| IL (1) | IL99913A (fi) |
| MX (1) | MX9101861A (fi) |
| MY (1) | MY131053A (fi) |
| NO (1) | NO300373B1 (fi) |
| NZ (1) | NZ240444A (fi) |
| PT (1) | PT99411B (fi) |
| RU (1) | RU2114843C1 (fi) |
| SG (1) | SG69977A1 (fi) |
| TW (1) | TW221294B (fi) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE159720T1 (de) * | 1989-05-04 | 1997-11-15 | Sanofi Sa | Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellung |
| US5512589A (en) * | 1990-11-01 | 1996-04-30 | Sterling Winthrop Inc. | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5306818A (en) * | 1990-11-01 | 1994-04-26 | Sterling Winthrop Inc. | Tetrahydro 2-saccharinylmerthyl aryl carboxylates |
| AU656027B2 (en) * | 1991-11-15 | 1995-01-19 | Sanofi | Saccharin derivative proteolytic enzime inhibitors |
| US5378720A (en) * | 1991-12-19 | 1995-01-03 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
| AU668694B2 (en) * | 1991-12-19 | 1996-05-16 | Sanofi-Synthelabo | Saccharin derivative proteolytic enzyme inhibitors |
| US5296496A (en) * | 1991-12-27 | 1994-03-22 | Sterling Winthrop Inc. | 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5187173A (en) * | 1991-12-27 | 1993-02-16 | Sterling Winthrop Inc. | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| TW226016B (fi) * | 1991-12-30 | 1994-07-01 | Sterling Winthrop Inc | |
| US5684195A (en) * | 1994-07-14 | 1997-11-04 | G. D. Searle & Co. | Method of preparing sulfmonamides from sulfones |
| DE4427996A1 (de) * | 1994-08-08 | 1996-02-15 | Basf Ag | Verfahren zur Herstellung von Saccharincarbonsäuren und -carbonsäureestern |
| DE19533643A1 (de) * | 1995-09-12 | 1997-03-13 | Nycomed Arzneimittel Gmbh | Neue cyclische Derivate von Benzolsulfonamiden |
| JP6239458B2 (ja) * | 2014-07-22 | 2017-11-29 | 日本曹達株式会社 | ２−（ベンジルスルフィニル）−１−シクロアルケン−１−カルボン酸エステルの製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| DE3617976A1 (de) * | 1986-05-28 | 1988-01-14 | Alter Sa | 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten |
| ATE159720T1 (de) * | 1989-05-04 | 1997-11-15 | Sanofi Sa | Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellung |
-
1991
- 1991-10-24 AU AU86083/91A patent/AU642537B2/en not_active Ceased
- 1991-10-30 MX MX9101861A patent/MX9101861A/es not_active IP Right Cessation
- 1991-10-30 EP EP91202809A patent/EP0483928A1/en not_active Withdrawn
- 1991-10-30 SG SG1996007579A patent/SG69977A1/en unknown
- 1991-10-31 IL IL9991391A patent/IL99913A/en not_active IP Right Cessation
- 1991-10-31 HU HU913430A patent/HUT63399A/hu unknown
- 1991-10-31 PT PT99411A patent/PT99411B/pt not_active IP Right Cessation
- 1991-10-31 CA CA002054653A patent/CA2054653A1/en not_active Abandoned
- 1991-11-01 FI FI915163A patent/FI103112B1/fi active
- 1991-11-01 NZ NZ240444A patent/NZ240444A/en unknown
- 1991-11-01 MY MYPI91002030A patent/MY131053A/en unknown
- 1991-11-01 NO NO914288A patent/NO300373B1/no unknown
- 1991-11-01 JP JP3288080A patent/JPH04273866A/ja active Pending
- 1991-11-01 KR KR1019910019381A patent/KR920009807A/ko not_active Application Discontinuation
- 1991-11-01 RU SU5010338A patent/RU2114843C1/ru active
- 1991-11-01 IE IE382791A patent/IE913827A1/en not_active Application Discontinuation
- 1991-11-04 TW TW080108649A patent/TW221294B/zh active
-
1995
- 1995-06-29 HU HU95P/P00542P patent/HU211929A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU642537B2 (en) | 1993-10-21 |
| NO914288D0 (no) | 1991-11-01 |
| TW221294B (fi) | 1994-02-21 |
| HU211929A9 (en) | 1996-01-29 |
| FI103112B (fi) | 1999-04-30 |
| NZ240444A (en) | 1994-06-27 |
| HUT63399A (en) | 1993-08-30 |
| NO914288L (no) | 1992-05-04 |
| HU913430D0 (en) | 1992-01-28 |
| RU2114843C1 (ru) | 1998-07-10 |
| CA2054653A1 (en) | 1992-05-02 |
| PT99411B (pt) | 1999-04-30 |
| FI915163A (fi) | 1992-05-02 |
| MX9101861A (es) | 1992-07-08 |
| IL99913A (en) | 1996-11-14 |
| IE913827A1 (en) | 1992-05-22 |
| MY131053A (en) | 2007-07-31 |
| IL99913A0 (en) | 1992-08-18 |
| KR920009807A (ko) | 1992-06-25 |
| EP0483928A1 (en) | 1992-05-06 |
| FI915163A0 (fi) | 1991-11-01 |
| FI103112B1 (fi) | 1999-04-30 |
| AU8608391A (en) | 1992-05-07 |
| NO300373B1 (no) | 1997-05-20 |
| JPH04273866A (ja) | 1992-09-30 |
| PT99411A (pt) | 1992-10-30 |
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